Previous studies have shown substantial effect thermal damage can have on new bone formation following osteotomy.
In this study we evaluated the extent of thermal damage which occurs in four ...different methods of osteotomy and the effects
it can have on bone healing. We further wanted to test whether a special osteotomy plate we constructed can lead to
diminished heat generation during osteotomy and enhanced bone healing. The four methods evaluated included osteotomy
performed by chisel, a newly constructed osteotomy plate, Gigly and oscillating saw. Twelve adult sheep underwent
osteotomy performed on both tibiae. Bone fragments were stabilized using a fixation plate. Callus size was assessed using
standard radiographs. Densitometry and histological evaluation were performed at 8 weeks following osteotomy. Temperature
measurements were performed both in vivo during the operation, and ex vivo on explanted tibiae. The defects
healed without complications and showed typical course of secondary fracture healing with callus ingrowth into the
osteotomy gap. Radiographic examination of bone healing showed a tendency towards more callus formation in bones
osteotomized using Gigly and oscillating saw, but this difference lacked significance. Use of Gigly and oscillating saw
elicited much higher temperatures at the bone cortex surface, which subsequently lead to slightly impaired bone healing
according to histological analysis. BMD was equal among all bones. In conclusion, the time required for complete healing
of the defect differed depended greatly on the instruments used. The newly constructed osteotomy plate showed best
results based on histological findings of capillary and osteoblast density.
U radu je prikazana neuobičajena lokalizacija granuliranog mioblastoma.
Granulirani mioblastom ili mioblastom zrnatih stanica je tumor kontroverzne etiologije, ali i po rijetkosti pojavljivanja u ...tkivima entitet je sam za sebe. Najčešće se javlja u subkutanim tkivima, koži, grudima, te skeletnim mišićima, a od intraoralnih tkiva najčešće u jeziku.
U prikazanom slučaju tumor je nastao na gornjoj usnici, na granici usnog crvenila, i nakon ekscizione biopsije ustanovilo se je da se radi o granulocelularnom mioblastomu. Tumor je histološki po svim kriterijima odgovarao opisanome tumoru, a kako se je djelomice nalazio i subkutano, nastala je psudoepiteliomatozna hiperplazija epitela. Budući da je promjena ekscidirana u cijelosti, nije bilo razloga ni za kakvu daljnju terapiju, te dvije godine po operativnom zahvatu nije bilo recidiva.
Razlozi nastanka toga tumora i njegovo histogenetsko podrijetlo do danas nisu točno razjašnjeni, ali nove imunocistokemijske pretrage ipak se priklanjaju neuralnoj teoriji nastanka.
Tu je promjenu važno imati na umu u diferencijalnoj dijagnostici promjena koje imponiraju kao mukokele, fibromi, piogeni granulomi, papilomi, angiomi planocelularni karcinomi.
Sluznica usne šupljine prekrivena višeslojnim pločastim epitelom izvorište je benignih i malignih promjena, od jednostavnog fibroma pa do karcinoma usne šupljine. Doktori stomatologije mogu, s ...obzirom na dostupnost patoloških promjena rutinskom kliničkom pregledu, bez dodatnih dijagnostičkih metoda postaviti dijagnozu i uputiti bolesnika oralnom ili maksilofacijalnom kirurgu. U ranom otkrivanju i liječenju različitih tvorbi najvažnije je bolesnika uputiti pravodobno, kako bi se i manjim kirurškim zahvatima mogao izliječiti.
Na sluznici se manifestiraju i patološki procesi dubljih slojeva. U malim žlijezdama slinovnicama svih dijelova usne šupljine mogu se razviti mukozne ciste, benigni i maligni tumori. Tumori žlijezda slinovnica čine oko 3% svih tumora u tijelu, dakle razmjerno su rijetki. No važno je znati da 10 do 20% svih navedenih tumora nastaje u malim žlijezdama, najčešće na nepcu. Jednako tako važan je podatak da razmjerna čestoća malignih tumora raste kako se veličina žlijezda u kojima se pojavljuje smanjuje.
Prikaz slučaja
Bolesnik u dobi od 21 godine dolazi na pregled zbog bezbolne izrasline na tvrdome nepcu u visini kutnjaka, promjera 2 cm, široke baze, egzulcerirane površine i zadebljalih rubova. Iz anamneze saznajemo da bez subjektivnih tegoba traje oko 2 godine. Prije šest mjeseci tvorba je egzulcerirala i osjetio je da iz nje izlazi tekućina. Učinjena biopsija pokazala je da je riječ o mukoepidermoidnom karcinomu, o malignoj neoplazmi male žlijezde slinovnice koja nastaje u svakoj životnoj dobi, no ipak je najčešća u djece. Tumor je odstranjen elektroskalpelom, a patohistološki nalaz potvrdio je dijagnozu te pokazao da je riječ o prvome stupnju malignosti (G-1). Takve vrste tumora rjeđe recidiviraju i metastaziraju, a prema podatcima iz literature stupanj izliječenja unutar 5 godina iznosi 90%.
Malignome malih žlijezda slinovnica često je teško klinički međusobno razlikovati, a mogu sličiti i benignom pleomorfnom adenomu. Pravodoban dolazak bolesnika na pregled, pravodobno upućivanje specijalistu te pravodobna biopsija i kirurški zahvat povećavaju izglede za izlječenje.
Concerning the important differences in the ethiopathology of hepatocelular carcinomas (HCC) in humans and dogs, our work describes the expression of epidermal growth factor receptor (EGFr), ...cytokeratine 19 (CK19), vascular endothelial growth factor (VEGF) and transforming growth factor beta receptor (TGFb-r) in tumors arising in both species. Investigation included 25 cases of human and 8 cases of dog tumors. All human cases were noted in cirrhotic livers, while in dogs the tissue adjacent to tumor was not changed. In humans in two cases hepatitis B virus (HBV) and in one case hepatitis C virus (HCV) were determined. Investigation showed lack of TGFb-r reaction in six cases of canine HCC, while in humans only one case was negative. In most tumors specific hepatocyte antigen Hepatocyte Paraffin 1 marker (Hep Par 1) was mainly positive with markedly decreased reaction compared to the normal hepatocytes, while cytokeratine 19 for billiary epithelium was negative. The result of our investigation rise the question about the possible role of tumor suppressor gene TGFb-r in the development of HCC in dogs and in the same time emphasizes its importance in human diseases.
The aim of this study is to test the possible prognostic significance of p53 and Ki67 expression in inverted papilloma
of the lateral nasal wall and adjacent sinuses regarding their malignant ...potential and recurrence. 49 biopsies of the lateral
nasal wall and adjacent sinuses obtained from 41 patients from three hospitals were investigated. Immunohistochemically
demonstrated p53 and Ki67 expression was measured and statistically valuated. p53 immunoreactivity
was demonstrated in most of papillomas with carcinomas but only in two benign papillomas, while Ki67 demonstrated
stronger immunoreactivity in carcinomas and surrounding epithelium. Immunohistochemical staining of inverted sinonasal
papillomas for p53 and Ki67 can give useful information concerning the existence of synchronous carcinoma and,
in case of high Ki67, a hint toward possible recurrence.
Intratumoral angiogenesis quantified by microvessel density (MVD) has been shown to be a strong prognostic indicator in a number of malignant tumors. Its association with prognosis in bone sarcomas ...has been subject to less extensive research. The aim of this study was to investigate prognostic significance of angiogenesis in osteosarcoma. Thirty-nine patients with osteosarcoma were included in a retrospective immunohistochemical study. Sections from diagnostic biopsies were immunostained using anti von Willebrand factor antibody and microvessels were counted at 400× magnification on 3 microscopic fields per patient. MVD was correlated with overall and disease-free survival by Kaplan-Meier and log-rank analysis. Correlation between clinicopathological variables and the degree of angiogenesis was tested using a χ
2
test. Significant statistical difference was found regarding overall survival and disease-free survival between patients with high (>32.3 vessels/field) and low (≤32.3 vessels/field) microvessel counts (log-rank test p =. 0196 and p =. 0147, respectively). The rate of metastasis was significantly higher in patients with high microvessel counts (p =. 042). These findings strongly suggest that angiogenesis quantified by microvessel density is predictive of metastasis and poor prognosis in osteosarcoma.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Inverted papilloma is an epithelial neoplasm of the lateral nasal wall and adjacent
sinuses characterized by a marked propensity for recurrence and a significant association
with carcinoma In this ...retrospective study we present 31 cases treated by our departments
between 1982 and 1999. The aim was to compare our results to those of other
authors especially regarding surgical management. The male to female ratio of these
patients was 2:1 and most patients were in the 6th and 7th decades of life. Conservative
surgery was used in most cases as the initial treatment. The overall recurrence rate was
low and there were 3 cases associated with carcinoma. We conclude that the results of
conservative surgery in selected cases are comparable to those using radical methods. A
review of the literature is presented and particular attention is dedicated to the literature
concerning analysis of p53 expression, HPV and Epstein-Barr infection and apoptosis
in inverted papilloma.
Prikaz slučaja inzulinoma u psa Džaja, Petar; Matijatko, Vesna; Šimec, Zoran ...
Veterinarski arhiv,
02/2000, Letnik:
70, Številka:
1
Book Review
Odprti dostop
U radu je opisan inzulinom u osmogodišnje kuje, pasmine irski seter. Vlasnici su životinju doveli na pregled u Kliniku za unutarnje bolesti Veterinarskog fakulteta u Zagrebu zbog povremenih ...epileptiformnih napada. Temeljem analize poremećaja u koncentraciji inzulina (316,64 pmol/l) koja je bila znatno povećana u istodobnoj nazočnosti hipoglikemije (1,8 mmol/l), postavljena je dijagnoza tumora beta stanica gušterače ili inzulinoma. S obzirom da terapija nije bila uspješna, vlasnici su se odlučili za eutanaziju. Razudbom je utvrđen tumor desnog režnja gušterače za koji je patološkohistološkom pretragom dokazano da se radi o inzulinomu.
