Frailty is a state of vulnerability to poor resolution of homeostasis following a stressor event, such as chemotherapy or cancer surgery. Better knowledge of the epidemiology of frailty could help ...drive a global cancer care strategy for older people. The aim of this review was to establish the prevalence and outcomes of frailty and pre-frailty in older cancer patients.
Observational studies that reported data on the prevalence and/or outcomes of frailty in older cancer patients with any stage of solid or haematological malignancy were considered. We searched Medline, CINAHL, Cochrane Library, EMBASE, Web of Science, Allied and Complementary medicine, Psychinfo and ProQuest (1 January 1996 to 30 June 2013). The primary outcomes were prevalence of frailty, treatment-related side-effects, unplanned hospitalization and mortality. Risk of bias was assessed using the Newcastle–Ottawa checklist.
Data from 20 studies evaluating 2916 participants are included. The median reported prevalence of frailty and pre-frailty was 42% (range 6%–86%) and 43% (range 13%–79%), respectively. A median of 32% (range 11%–78%) of patients were classified as fit. Frailty was independently associated with increased all-cause mortality adjusted 5-year hazard ratio (HR) 1.87, 95% confidence interval (CI) 1.36–2.57. There was evidence of increased risk of postoperative mortality for both frailty (adjusted 30-day HR 2.67, 95% CI 1.08–6.62) and pre-frailty (adjusted HR 2.33, 95% CI 1.20–4.52). Treatment complications were more frequent in those with frailty, including intolerance to cancer treatment (adjusted odds ratio 4.86, 95% CI 2.19–10.78) and postoperative complications (adjusted 30-day HR 3.19, 95% CI 1.68–6.04).
More than half of older cancer patients have pre-frailty or frailty and these patients are at increased risk of chemotherapy intolerance, postoperative complications and mortality. The findings of this review support routine assessment of frailty in older cancer patients to guide treatment decisions, and the development of multidisciplinary geriatric oncology services.
We present the third data release from the Australia Telescope Large Area Survey. These data combine the observations at 1.4 GHz before and after upgrades to the Australia Telescope Compact Array ...reaching a sensitivity of 14 μJy beam−1 in 3.6 deg2 over the Chandra Deep Field South (CDFS) and of 17 μJy beam−1 in 2.7 deg2 over the European Large Area ISO Survey South 1 (ELAIS-S1). We used a variety of array configurations to maximize the uv coverage resulting in a resolution of 16 by 7 arcsec in CDFS and of 12 by 8 arcsec in ELAIS-S1. After correcting for peak bias and bandwidth smearing, we find a total of 3034 radio source components above 5σ in CDFS, of which 514 (17 per cent) are considered to be extended. The number of components detected above 5σ in ELAIS-S1 is 2084, of which 392 (19 per cent) are classified as extended. The catalogues include reliable spectral indices (Δα < 0.2) between 1.40 and 1.71 GHz for ∼350 of the brightest components.
The Interleukin (IL)-33 is important in several inflammatory diseases and its cellular receptor is the Interleukin 1 receptor-like 1 (IL1RL1), also called suppression of tumorigenicity 2 ligand ...(ST2L). This study investigated associations between single nucleotide variants (SNVs) in the IL33 gene and in the IL1RL1 (ST2) gene with periodontitis. Additionally, aimed to determine the role of Aggregatibacter actinomycetemcomitans (Aa) relative amount in the subgingival biofilm in these associations. A cross-sectional study was carried out with 506 individuals that answered a structured questionnaire used to collect their health status, socioeconomic-demographic, and behavioral characteristics. Periodontal examination was performed to determine the presence and severity of periodontitis, and subgingival biofilm samples were collected to quantify the relative amount of Aa by real time polymerase chain reaction. Human genomic DNA was extracted from whole blood cells and SNV genotyping was performed. Logistic regression estimated the association measurements, odds ratio (OR), and 95% confidence interval (95%CI), between the IL33 and ST2 genes with periodontitis, and subgroup analyses assessed the relative amount of Aa in these associations. 23% of individuals had periodontitis. Adjusted measurements showed a statistically significant inverse association between two SNVs of the ST2; rs148548829 (C allele) and rs10206753 (G allele). These two alleles together with a third SNV, the rs11693204 (A allele), were inversely associated with moderate periodontitis. One SNV of the IL33 gene also showed a statistically significant inverse association with moderate periodontitis. Nine SNVs of the ST2 gene were inversely associated with the relative amount of Aa. In the high Aa subgroup, there was a direct association between 11 SNVs of the ST2 gene and moderate periodontitis and two SNVs of the ST2 gene and severe periodontitis, and eight SNVs of the ST2 gene and periodontitis. These exploratory findings of genetic variants in IL-33/ST2 axis support the concept that the different tissue responses among individuals with periodontitis may be modulated by the host's genetics, influencing the physiopathology of the disease.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Several previous studies have suggested that basic decoding skills may develop less effectively in English than in some other European orthographies. The origins of this effect in the early ...(foundation) phase of reading acquisition are investigated through assessments of letter knowledge, familiar word reading, and simple nonword reading in English and 12 other orthographies. The results confirm that children from a majority of European countries become accurate and fluent in foundation level reading before the end of the first school year. There are some exceptions, notably in French, Portuguese, Danish, and, particularly, in English. The effects appear not to be attributable to differences in age of starting or letter knowledge. It is argued that fundamental linguistic differences in syllabic complexity and orthographic depth are responsible. Syllabic complexity selectively affects decoding, whereas orthographic depth affects both word reading and nonword reading. The rate of development in English is more than twice as slow as in the shallow orthographies. It is hypothesized that the deeper orthographies induce the implementation of a dual (logographic + alphabetic) foundation which takes more than twice as long to establish as the single foundation required for the learning of a shallow orthography.
Patients with diffuse large B-cell lymphoma treated with first-line anthracycline-based immunochemotherapy and remaining in remission at 2 years have excellent outcomes. This study assessed overall ...survival (OS) stratified by progression-free survival (PFS) at 24months (PFS24) using individual patient data from patients with DLBCL enrolled in multi-center, international randomized clinical trials as part of the Surrogate Endpoint for Aggressive Lymphoma (SEAL) Collaboration.
PFS24 was defined as being alive and PFS24 after study entry. OS from PFS24 was defined as time from identified PFS24 status until death due to any cause. OS was compared with each patient’s age-, sex-, and country-matched general population using expected survival and standardized mortality ratios (SMRs).
A total of 5853 patients enrolled in trials in the SEAL database received rituximab as part of induction therapy and were included in this analysis. The median age was 62years (range 18–92), and 56% were greater than 60years of age. At a median follow-up of 4.4years, 1337 patients (23%) had disease progression, 1489 (25%) had died, and 5101 had sufficient follow-up to evaluate PFS24. A total of 1423 assessable patients failed to achieve PFS24 with a median OS of 7.2months (95% CI 6.8–8.1) after progression; 5-year OS after progression was 19% and SMR was 32.1 (95% CI 30.0–34.4). A total of 3678 patients achieved PFS24; SMR after achieving PFS24 was 1.22 (95% CI 1.09–1.37). The observed OS versus expected OS at 3, 5, and 7years after achieving PFS24 was 93.1% versus 94.4%, 87.6% versus 89.5%, and 80.0% versus 83.7%, respectively.
Patients treated with rituximab containing anthracycline-based immunochemotherapy on clinical trials who are alive without progression at 24months from the onset of initial therapy have excellent outcomes with survival that is marginally lower but clinically indistinguishable from the age-, sex-, and country-matched background population for 7 years after achieving PFS24.
We present a robust calibration of the 1.4 GHz radio continuum star formation rate (SFR) using a combination of the Galaxy And Mass Assembly (GAMA) survey and the Faint Images of the Radio Sky at ...Twenty-cm (FIRST) survey. We identify individually detected 1.4 GHz GAMA-FIRST sources and use a late-type, non-active galactic nucleus, volume-limited sample from GAMA to produce stellar mass-selected samples. The latter are then combined to produce FIRST-stacked images. This extends the robust parametrization of the 1.4 GHz-SFR relation to faint luminosities. For both the individually detected galaxies and our stacked samples, we compare 1.4 GHz luminosity to SFRs derived from GAMA to determine a new 1.4 GHz luminosity-to-SFR relation with well-constrained slope and normalization. For the first time, we produce the radio SFR-M* relation over 2 decades in stellar mass, and find that our new calibration is robust, and produces a SFR-M* relation which is consistent with all other GAMA SFR methods. Finally, using our new 1.4 GHz luminosity-to-SFR calibration we make predictions for the number of star-forming GAMA sources which are likely to be detected in the upcoming Australian Square Kilometre Array Pathfinder surveys, Evolutionary Map of the Universe and Deep Investigation of Neutral Gas Origins.
ABSTRACT
We present a new image of the 9.0 GHz radio emission from the extended Chandra Deep Field South. A total of 181 h of integration with the Australia Telescope Compact Array has resulted in a ...0.276 deg2 image with a median sensitivity of ∼20 µJy beam−1 rms, for a synthesized beam of 4.0 × 1.3 arcsec. We present a catalogue of the 9.0 GHz radio sources, identifying 70 source components and 55 individual radio galaxies. Source counts derived from this sample are consistent with those reported in the literature. The observed source counts are also generally consistent with the source counts from simulations of the faint radio population. Using the wealth of multiwavelength data available for this region, we classify the faint 9 GHz population and find that 91 per cent are radio-loud active galactic nuclei (AGNs), 7 per cent are radio-quiet AGNs, and 2 per cent are star-forming galaxies. The 9.0 GHz radio sources were matched to 5.5 and 1.4 GHz sources in the literature and we find a significant fraction of flat or inverted spectrum sources, with 36 per cent of the 9 GHz sources having $\alpha _{5.5\,\mathrm{ GHz}}^{9.0\,\mathrm{ GHz}}$ > −0.3 (for S ∝ να). This flat or inverted population is not well reproduced by current simulations of radio source populations.
We analyse a 154 MHz image made from a 12 h observation with the Murchison Widefield Array (MWA) to determine the noise contribution and behaviour of the source counts down to 30 mJy. The MWA image ...has a bandwidth of 30.72 MHz, a field-of-view within the half-power contour of the primary beam of 570 deg2, a resolution of 2.3 arcmin and contains 13 458 sources above 5σ. The rms noise in the centre of the image is 4–5 mJy beam−1. The MWA counts are in excellent agreement with counts from other instruments and are the most precise ever derived in the flux density range 30–200 mJy due to the sky area covered. Using the deepest available source count data, we find that the MWA image is affected by sidelobe confusion noise at the ≈3.5 mJy beam−1 level, due to incompletely peeled and out-of-image sources, and classical confusion becomes apparent at ≈1.7 mJy beam−1. This work highlights that (i) further improvements in ionospheric calibration and deconvolution imaging techniques would be required to probe to the classical confusion limit and (ii) the shape of low-frequency source counts, including any flattening towards lower flux densities, must be determined from deeper ≈150 MHz surveys as it cannot be directly inferred from higher frequency data.
We present a new image of the 5.5 GHz radio emission from the extended Chandra Deep Field South. Deep radio observations at 5.5 GHz were obtained in 2010 and presented in the first data release. A ...further 76 h of integration has since been obtained, nearly doubling the integration time. This paper presents a new analysis of all the data. The new image reaches 8.6 μJy rms, an improvement of about 40 per cent in sensitivity. We present a new catalogue of 5.5 GHz sources, identifying 212 source components, roughly 50 per cent more than were detected in the first data release. Source counts derived from this sample are consistent with those reported in the literature for S
5.5 GHz > 0.1 mJy but significantly lower than published values in the lowest flux density bins (S
5.5 GHz < 0.1 mJy), where we have more detected sources and improved statistical reliability. The 5.5 GHz radio sources were matched to 1.4 GHz sources in the literature and we find a mean spectral index of −0.35 ± 0.10 for S
5.5 GHz > 0.5 mJy, consistent with the flattening of the spectral index observed in 5 GHz sub-mJy samples. The median spectral index of the whole sample is αmed = −0.58, indicating that these observations may be starting to probe the star-forming population. However, even at the faintest levels (0.05 < S
5.5 GHz < 0.1 mJy), 39 per cent of the 5.5 GHz sources have flat or inverted radio spectra. Four flux density measurements from our data, across the full 4.5–6.5 GHz bandwidth, are combined with those from literature and we find 10 per cent of sources (S
5.5 GHz ≳ 0.1 mJy) show significant curvature in their radio spectral energy distribution spanning 1.4–9 GHz.
ABSTRACT
Spectral variability of radio sources encodes information about the conditions of intervening media, source structure, and emission processes. With new low-frequency radio interferometers ...observing over wide fractional bandwidths, studies of spectral variability for a large population of extragalactic radio sources are now possible. Using two epochs of observations from the GaLactic and Extragalactic All-sky Murchison Widefield Array (GLEAM) survey that were taken one year apart, we search for spectral variability across 100–230 MHz for 21 558 sources. We present methodologies for detecting variability in the spectrum between epochs and for classifying the type of variability: either as a change in spectral shape or as a uniform change in flux density across the bandwidth. We identify 323 sources with significant spectral variability over a year-long time-scale. Of the 323 variable sources, we classify 51 of these as showing a significant change in spectral shape. Variability is more prevalent in peaked-spectrum sources, analogous to gigahertz-peaked spectrum and compact steep-spectrum sources, compared to typical radio galaxies. We discuss the viability of several potential explanations of the observed spectral variability, such as interstellar scintillation and jet evolution. Our results suggest that the radio sky in the megahertz regime is more dynamic than previously suggested.
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