Dipyridamole has extensively been administered as a substitute for physical activity in cardiovascular assessment. The aim of this study was to evaluate the association of dipyridamole side effects ...with hemodynamic oscillations, scanning results, and electrocardiography (ECG) findings.
Overall, 590 patients referred to the nuclear medicine center for myocardial perfusion imaging were evaluated for adverse dipyridamole effects concurrent with a low level of exercise. Before and during dipyridamole infusion, the patients' vital signs, electrocardiogram, heart rate, systolic blood pressure, and diastolic blood pressure were monitored; all patients underwent stress-rest (99m)Tc-sestamibi gated SPECT using a 2-d protocol.
Eighty-eight patients (14.9%) experienced at least one side effect during dipyridamole infusion, and abnormal ECG and scan results were observed in 32.4% and 48.6% of patients, respectively. We observed a positive correlation between a higher incidence of chest discomfort, headache, and dyspnea and abnormalities on ECG and myocardial perfusion imaging. In addition, these 3 side effects were also associated with a higher postinfusion heart rate, lower preinfusion systolic blood pressure, and lower postinfusion diastolic blood pressure. There were significant differences between pre- and postinfusion heart rate, preinfusion systolic blood pressure, and postinfusion diastolic blood pressure among patients with or without side effects, whereas no significant difference was observed in any of the hemodynamic parameters between patients with normal and abnormal ECG results or myocardial perfusion imaging results.
This study demonstrated a correlation between hemodynamic variables and side effects but not with imaging findings or ECG findings.
Application of inorganic pesticides cause many hazards on human health and nature. Annually undesirable damages are caused to agricultural products. However, fumigation with methylbromide and ...phosphine has been a major method of disinfestation of food. Up to 2005, methylbromide will be phased out as disinfestant agent of food, therefore plant extracts can replace it. In this research, powders and essential oils of some medicinal herbs were investigated against the bruchid stored product pests Callosobruchus maculatus on lentil. Seed powder from Azadirachta indica and its leaves, oregano leaf powder(Sataria multiflora), garlic powder from Sabzan and Grandis company and essential oils of oregano(Sataria multiflora) and eucaliptus(Eucaliptus globulus) were tested at %0.02-%2, %0.02-%2, %0.02-%2,%0.01-%1,2-200ppm and 2-20 ppm on lentil. Their lethal doses(LD%) were very high and could not be used industrially, therefore the dose for controling laying eggs .Powders were mixed and essential oils were fumigated onto grains, untreated lentils were used as controls. After determination of the dose for controlling egg laying, treated packages were stored under ambient conditions and after 1,2 and 3 months sensory evaluation was performed on them. Maximuml control dose of laying eggs for neem seed powder and its leaves, leaf powder of oregano and eucalyptus, garlic powder, essential oil of oregano and eucalyptus were determined %0.18, %0.34, %0.54, %0.34, %0.16,46 ppm and 4.6ppm , respectively. Neem seed powder was not suitable for consumers. There were not significant differences in results of sensory evaluation with panelists group between treated baked lentil with oregano and garlic powders, essential oils of oregano and eucaliptus and untreated baked lentil. Producers can produce these packages with labelling of different flavors.
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