In this paper, we investigate the coverage performance of a reference user equipment (UE) in a finite network of multiple three-dimensional (3D) mobile unmanned aerial vehicles (UAVs). Specifically, ...following the general theory on mobile ad hoc networks (MANETs), we propose a mixed mobility (MM) model which characterizes the movement process of a UAV in the 3D cylindrical region. In this paper, we invoke the random waypoint mobility (RWPM) and uniform mobility (UM) models to represent the movement of a UAV in vertical and spatial directions, respectively. By employing this MM model, we analyze the coverage probability of a reference UE in a finite network of multiple UAVs under the uniform UAV association and closest UAV association policies in one snapshot. According to the former policy, the UE connects to a random UAV while in the latter policy it connects to the closest UAV. Furthermore, all the non-serving UAVs act as the interferers to UE. To facilitate coverage probability analysis, we determine the serving and interfering UAVs-to-UE distance distributions under two association policies for Nakagami-<inline-formula> <tex-math notation="LaTeX">{m} </tex-math></inline-formula> fading. We quantify the coverage performance of UE for various system and mobility parameters to exemplify the closest UAV association policy. Moreover, the analytical results are verified through simulations.
Mutations in GBA1, the gene encoding the lysosomal enzyme glucocerebrosidase, are among the most common known genetic risk factors for the development of Parkinson disease and related ...synucleinopathies. A great deal is known about GBA1, as mutations in GBA1 are causal for the rare autosomal storage disorder Gaucher disease. Over the past decades, significant progress has been made in understanding the genetics and cell biology of glucocerebrosidase. A least 495 different mutations, found throughout the 11 exons of the gene are reported, including both common and rare variants. Mutations in GBA1 may lead to degradation of the protein, disruptions in lysosomal targeting and diminished performance of the enzyme in the lysosome.Gaucher disease is phenotypically diverse and has both neuronopathic and non-neuronopathic forms. Both patients with Gaucher disease and heterozygous carriers are at increased risk of developing Parkinson disease and Dementia with Lewy Bodies, although our understanding of the mechanism for this association remains incomplete. There appears to be an inverse relationship between glucocerebrosidase and α-synuclein levels, and even patients with sporadic Parkinson disease have decreased glucocerebrosidase. Glucocerebrosidase may interact with α-synuclein to maintain basic cellular functions, or impaired glucocerebrosidase could contribute to Parkinson pathogenesis by disrupting lysosomal homeostasis, enhancing endoplasmic reticulum stress or contributing to mitochondrial impairment. However, the majority of patients with GBA1 mutations never develop parkinsonism, so clearly other risk factors play a role. Treatments for Gaucher disease have been developed that increase visceral glucocerebrosidase levels and decrease lipid storage, although they have yet to properly address the neurological defects associated with impaired glucocerebrosidase. Mouse and induced pluripotent stem cell derived models have improved our understanding of glucocerebrosidase function and the consequences of its deficiency. These models have been used to test novel therapies including chaperone proteins, histone deacetylase inhibitors, and gene therapy approaches that enhance glucocerebrosidase levels and could prove efficacious in the treatment of forms of parkinsonism. Consequently, this rare monogenic disorder, Gaucher disease, provides unique insights directly applicable to our understanding and treatment of Parkinson disease, a common and complex neurodegenerative disorder.
Abstract
There is an urgent need to develop a national program and allocation of resources to improve stroke care in India. Management of stroke requires a multidisciplinary approach and close ...collaboration not only among physicians from different specialties but also among paramedical personnel and patient transport services. Here we propose a healthcare model of providing acute stroke therapies to patients in central India to minimize the wide supply mismatch we face in providing adequate care to our patients. Observations and the proposed model presented below were based on personal experience and a review of the literature on stroke care available in central India.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The bacteriophage capsid protein, Psu (polarity suppression), inhibits the bacterial transcription terminator, Rho. In an effort to find nontraditional antibacterial agents, we previously designed ...peptides from the Psu C terminus that function as inhibitors of Rho. Here, we demonstrated that these peptides have positive surface-charge densities, and they downregulate many genes in Escherichia coli. We hypothesized that these peptides could bind to nucleic acids and repress gene expression. One of these peptides, peptide 33, represses in vitro transcription from the T7A1 and Plac promoters efficiently by blocking the access of RNA polymerase to the promoter, a mode of transcription repression akin to many bacterial repressors. In vivo, expressions of the peptides reduce the total RNA level as well as transcription from Plac and Posm promoters significantly. However, they are less efficient in repressing transcription from the rRNA promoters with a very high turnover of RNA polymerase. The peptide 33 binds to both single and dsDNA as well as to RNA with dissociation constants ranging from 1 to 5 μM exhibiting preferences for the single-stranded DNA and RNAs. These interactions are salt-resistant and not sequence-specific. Interactions with dsDNA are entropy-driven, while it is enthalpy-driven for the ssDNA. This mode of interaction with nucleic acids is similar to many nonspecific ssDNA-binding proteins. Expression of peptide 33 induces cell elongation and impaired cell division, possibly due to the dislodging of the DNA-binding proteins. Overall, we surmised that these synthetic transcription repressors would function like bacterial nucleoid-associated proteins.
In this paper, we propose a novel decode-and-forward (DF)-based secure 3D mobile unmanned aerial vehicle (UAV) relaying for hybrid satellite-terrestrial networks (HSTNs) in the presence of an aerial ...eavesdropper lying around a serving UAV relay in a circular plane. Herein, we adopt a stochastic mixed mobility (MM) model for mobilizing the UAV relays in a 3D cylindrical cell with a ground user equipment (UE). We consider the deployment of eavesdropper under the cases: (a) the eavesdropper is located at certain fixed distance around a serving UAV relay; (b) the eavesdropper is located uniformly random around the relay. By considering the opportunistic closest-, uniform-, and maximum-signal-to-noise ratio (maximum-SNR) UAV relay selection (URS) strategies, we analyze the secrecy performance of the considered HSTN in terms of probability of non-zero secrecy capacity (PNZSC) and secrecy outage probability (SOP). In particular, we derive exact PNZSC and SOP for the closest-URS (CURS) and uniform-URS (UURS). While, we derive analytical lower and upper bounds on PNZSC and SOP for maximum-SNR URS (MURS). We further carry out the corresponding asymptotic SOP analysis to assess the secrecy diversity order and coding gain of aforementioned URS strategies. Simulations are performed to corroborate the analysis.
Solar water splitting is a promising approach to transform sunlight into renewable, sustainable and green hydrogen energy. There are three representative ways of transforming solar radiation into ...molecular hydrogen, which are the photocatalytic (PC), photoelectrochemical (PEC), and photovoltaic-electrolysis (PV-EC) routes. Having the future perspective of green hydrogen economy in mind, this review article discusses devices and systems for solar-to-hydrogen production including comparison of the above solar water splitting systems. The focus is placed on a critical assessment of the key components needed to scale up PEC water splitting systems such as materials efficiency, cost, elemental abundancy, stability, fuel separation, device operability, cell architecture, and techno-economic aspects of the systems. The review follows a stepwise approach and provides (i) a summary of the basic principles and photocatalytic materials employed for PEC water splitting, (ii) an extensive discussion of technologies, procedures, and system designs, and (iii) an introduction to international demonstration projects, and the development of benchmarked devices and large-scale prototype systems. The task of scaling up of laboratory overall water splitting devices to practical systems may be called "an artificial photosynthetic leaf-to-farm challenge".
This review provides insight into the different aspects and challenges associated with the realization of sustainable solar hydrogen production systems on a practical large scale.
This letter investigates a hybrid satellite-terrestrial network where multiple decode-and-forward (DF) three-dimensional (3-D) mobile unmanned aerial vehicle (UAV) relays assist a satellite to ...communicate with a ground user equipment (UE). We apply a stochastic mixed mobility model to randomly position the UAV relays in a 3-D cylindrical region around the UE. Based on a novel analytical framework for 3-D mobile UAV relaying, we evaluate the outage probability of considered system under opportunistic UAV relay selection. We compare the performance of 3-D mobile UAV relays with the static relays placed at maximum flying distance of UAVs. Simulations confirm the analytical results.
The effluent water of many industries, such as textiles, leather, paper, printing, cosmetics, etc., contains large amount of hazardous dyes. There is huge number of treatment processes as well as ...adsorbent which are available for the processing of this effluent water-containing dye content. The applicability of naturally available low cast and eco-friendly adsorbents, for the removal of hazardous dyes from aqueous waste by adsorption treatment, has been reviewed. In this review paper, we have provided a compiled list of low-cost, easily available, safe to handle, and easy-to-dispose-off adsorbents. These adsorbents have been classified into five different categories on the basis of their state of availability: (1) waste materials from agriculture and industry, (2) fruit waste, (3) plant waste, (4) natural inorganic materials, and (5) bioadsorbents. Some of the treated adsorbents have shown good adsorption capacities for methylene blue, congo red, crystal violet, rhodamine B, basic red, etc., but this adsorption process is highly pH dependent, and the pH of the medium plays an important role in the treatment process. Thus, in this review paper, we have made some efforts to discuss the role of pH in the treatment of wastewater.
Big Data Sarangi, Saswat
2019, 2020, 20190909, 2019-09-09
eBook
Big Data is everywhere. It shapes our lives in more ways than we know and understand. This comprehensive introduction unravels the complex terabytes that will continue to shape our lives in ways ...imagined and unimagined.
Drawing on case studies like Amazon, Facebook, the FIFA World Cup and the Aadhaar scheme, this book looks at how Big Data is changing the way we behave, consume and respond to situations in the digital age. It looks at how Big Data has the potential to transform disaster management and healthcare, as well as prove to be authoritarian and exploitative in the wrong hands.
The latest offering from the authors of Artificial Intelligence: Evolution, Ethics and Public Policy, this accessibly written volume is essential for the researcher in science and technology studies, media and culture studies, public policy and digital humanities, as well as being a beacon for the general reader to make sense of the digital age.
In this paper, we consider a hybrid satellite-terrestrial network (HSTN) where a multiantenna satellite communicates with a ground user equipment (UE) with the help of multiple cache-enabled ...amplify-and-forward (AF) three-dimensional (3D) mobile unmanned aerial vehicle (UAV) relays. Herein, we employ the two fundamental most popular content (MPC) and uniform content (UC) caching schemes for two types of mobile UAV relays, namely fully 3D and fixed height. Taking into account the multiantenna satellite links and the random 3D distances between UAV relays and UE, we analyze the outage probability (OP) of considered system with MPC and UC caching schemes. We further carry out the corresponding asymptotic OP analysis to present the insights on achievable performance gains of two schemes for both types of 3D mobile UAV relaying. Specifically, we show the following: (a) MPC caching dominates the UC and no caching schemes; (b) fully 3D mobile UAV relaying outperforms its fixed height counterpart. We finally corroborate the theoretic analysis by simulations.
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