The recent pandemic situation transpired due to coronavirus novel strain SARS-CoV-2 has become a global concern. This human coronavirus (HCov-19) has put the world on high alert as the numbers of ...confirmed cases are continuously increasing. The world is now fighting against this deadly virus and is leaving no stone unturned to find effective treatments through testing of various available drugs, including those effective against flu, malaria, etc. With an urgent need for the development of potential strategies, two recent studies from China using Mesenchymal Stem Cells (MSCs) to treat COVID-19 pneumonia have shed some light on a potential cure for the COVID-19 infected patients. However, MSCs, despite being used in various other clinical trials have always been questioned for their tendency to aggregate or form clumps in the injured or disease microenvironment. It has also been reported in various studies that exosomes secreted by these MSCs, contribute towards the cell's biological and therapeutic efficacy. There have been reports evaluating the safety and feasibility of these exosomes in various lung diseases, thereby proposing them as a cell-free therapeutic agent. Also, attractive features like cell targeting, low-immunogenicity, safety, and high biocompatibility distinguish these exosomes from other synthetic nano-vesicles and thus potentiate their role as a drug delivery nano-platform. Building upon these observations, herein, efforts are made to give an overview of stem cell-derived exosomes as an appealing therapeutic agent and drug delivery nano-carrier. In this review, we briefly recapitulate the recent evidence and developments in understanding exosomes as a promising candidate for novel nano-intervention in the current pandemic scenario. Furthermore, this review will highlight and discuss mechanistic role of exosomes to combat severe lung pathological conditions. We have also attempted to dwell into the nano-formulation of exosomes for its better applicability, storage, and stability thereby conferring them as off the shelf therapeutic.
Abstract
Tidal disruption events (TDEs) offer a unique way to study dormant black holes. While the number of observed TDEs has grown thanks to the emergence of wide-field surveys in the past few ...decades, questions regarding the nature of the observed optical, UV, and X-ray emission remain. We present a uniformly selected sample of 30 spectroscopically classified TDEs from the Zwicky Transient Facility Phase I survey operations with follow-up Swift UV and X-ray observations. Through our investigation into correlations between light-curve properties, we recover a shallow positive correlation between the peak bolometric luminosity and decay timescales. We introduce a new spectroscopic class of TDE, TDE-featureless, which are characterized by featureless optical spectra. The new TDE-featureless class shows larger peak bolometric luminosities, peak blackbody temperatures, and peak blackbody radii. We examine the differences between the X-ray bright and X-ray faint populations of TDEs in this sample, finding that X-ray bright TDEs show higher peak blackbody luminosities than the X-ray faint subsample. This sample of optically selected TDEs is the largest sample of TDEs from a single survey yet, and the systematic discovery, classification, and follow-up of this sample allows for robust characterization of TDE properties, an important stepping stone looking forward toward the Rubin era.
Mesenchymal Stem Cells are potent therapeutic candidates in the field of regenerative medicine, owing to their immunomodulatory and differentiation potential. However, several complications come with ...their translational application like viability, duration, and degree of expansion, long-term storage, and high maintenance cost. Therefore, drawbacks of cell-based therapy can be overcome by a novel therapeutic modality emerging in translational research and application, i.e., exosomes. These small vesicles derived from mesenchymal stem cells are emerging as new avenues in the field of nano-medicine. These nano-vesicles have caught the attention of researchers with their potency as regenerative medicine both in nanotherapeutics and drug delivery systems. In this review, we discuss the current knowledge in the biology and handling of exosomes, with their limitations and future applications. Additionally, we highlight current perspectives that primarily focus on their effect on various diseases and their potential as a drug delivery vehicle.
Abstract
We conduct a systematic tidal disruption event (TDE) demographics analysis using the largest sample of optically selected TDEs. A flux-limited, spectroscopically complete sample of 33 TDEs ...is constructed using the Zwicky Transient Facility over 3 yr (from 2018 October to 2021 September). We infer the black hole (BH) mass (
M
BH
) with host galaxy scaling relations, showing that the sample
M
BH
ranges from 10
5.1
M
⊙
to 10
8.2
M
⊙
. We developed a survey efficiency corrected maximum volume method to infer the rates. The rest-frame
g
-band luminosity function can be well described by a broken power law of
ϕ
(
L
g
)
∝
L
g
/
L
bk
0.3
+
L
g
/
L
bk
2.6
−
1
, with
L
bk
= 10
43.1
erg s
−1
. In the BH mass regime of 10
5.3
≲ (
M
BH
/
M
⊙
) ≲ 10
7.3
, the TDE mass function follows
ϕ
(
M
BH
)
∝
M
BH
−
0.25
, which favors a flat local BH mass function (
dn
BH
/
d
log
M
BH
≈
constant
). We confirm the significant rate suppression at the high-mass end (
M
BH
≳ 10
7.5
M
⊙
), which is consistent with theoretical predictions considering direct capture of hydrogen-burning stars by the event horizon. At a host galaxy mass of
M
gal
∼ 10
10
M
⊙
, the average optical TDE rate is ≈3.2 × 10
−5
galaxy
−1
yr
−1
. We constrain the optical TDE rate to be 3.7, 7.4, and 1.6 × 10
−5
galaxy
−1
yr
−1
in galaxies with red, green, and blue colors.
We present results from a search for a radio transient associated with the LIGO/Virgo source S190814bv, a likely neutron star-black hole (NSBH) merger, with the Australian Square Kilometre Array ...Pathfinder. We imaged a 30 deg2 field at ΔT = 2, 9, and 33 days post-merger at a frequency of 944 MHz, comparing them to reference images from the Rapid ASKAP Continuum Survey observed 110 days prior to the event. Each epoch of our observations covers 89% of the LIGO/Virgo localization region. We conducted an untargeted search for radio transients in this field, resulting in 21 candidates. For one of these, AT2019osy, we performed multiwavelength follow-up and ultimately ruled out the association with S190814bv. All other candidates are likely unrelated variables, but we cannot conclusively rule them out. We discuss our results in the context of model predictions for radio emission from NSBH mergers and place constrains on the circum-merger density and inclination angle of the merger. This survey is simultaneously the first large-scale radio follow-up of an NSBH merger, and the most sensitive widefield radio transients search to-date.
Abstract
The detonation of a thin (≲0.03
M
⊙
) helium shell (He-shell) atop a ∼1
M
⊙
white dwarf (WD) is a promising mechanism to explain normal Type Ia supernovae (SNe Ia), while thicker He-shells ...and less massive WDs may explain some recently observed peculiar SNe Ia. We present observations of SN 2020jgb, a peculiar SN Ia discovered by the Zwicky Transient Facility (ZTF). Near maximum brightness, SN 2020jgb is slightly subluminous (ZTF
g
-band absolute magnitude −18.7 mag ≲
M
g
≲ −18.2 mag depending on the amount of host-galaxy extinction) and shows an unusually red color (0.2 mag ≲
g
ZTF
−
r
ZTF
≲ 0.4 mag) due to strong line-blanketing blueward of ∼5000 Å. These properties resemble those of SN 2018byg, a peculiar SN Ia consistent with an He-shell double detonation (DDet) SN. Using detailed radiative transfer models, we show that the optical spectroscopic and photometric evolution of SN 2020jgb is broadly consistent with a ∼0.95–1.00
M
⊙
(C/O core + He-shell) progenitor ignited by a ≳0.1
M
⊙
He-shell. However, one-dimensional radiative transfer models without non-local-thermodynamic-equilibrium treatment cannot accurately characterize the line-blanketing features, making the actual shell mass uncertain. We detect a prominent absorption feature at ∼1
μ
m in the near-infrared (NIR) spectrum of SN 2020jgb, which might originate from unburnt helium in the outermost ejecta. While the sample size is limited, we find similar 1
μ
m features in all the peculiar He-shell DDet candidates with NIR spectra obtained to date. SN 2020jgb is also the first peculiar He-shell DDet SN discovered in a star-forming dwarf galaxy, indisputably showing that He-shell DDet SNe occur in both star-forming and passive galaxies, consistent with the normal SN Ia population.
Abstract
The fate of stars in the zero-age main-sequence (ZAMS) range ≈8–12
M
⊙
is unclear. They could evolve to form white dwarfs or explode as electron-capture supernovae (SNe) or iron ...core-collapse SNe (CCSNe). Even though the initial mass function indicates that this mass range should account for over 40% of all CCSN progenitors, few have been observationally confirmed, likely due to the faintness and rapid evolution of some of these transients. In this paper, we present a sample of nine Ca-rich/O-poor Type IIb SNe detected by the Zwicky Transient Facility with progenitors likely in this mass range. These sources have a Ca
ii
λ
λ
7291, 7324/O
i
λ
λ
6300, 6364 flux ratio of ≳2 in their nebular spectra. Comparing the measured O
i
luminosity (≲10
39
erg s
−1
) and derived oxygen mass (≈0.01
M
⊙
) with theoretical models, we infer that the progenitor ZAMS mass for these explosions is less than 12
M
⊙
. The ejecta properties (
M
ej
≲ 1
M
⊙
and
E
kin
∼ 10
50
erg) are also consistent. The low ejecta mass of these sources indicates a class of strongly-stripped SNe that is a transition between the regular stripped-envelope SNe and ultra-stripped SNe. The progenitor could be stripped by a main-sequence companion and result in the formation of a neutron star−main sequence binary. Such binaries have been suggested to be progenitors of neutron star−white dwarf systems that could merge within a Hubble time and be detectable with LISA.
Abstract
SN 1987A was an unusual hydrogen-rich core-collapse supernova originating from a blue supergiant star. Similar blue supergiant explosions remain a small family of events, and are broadly ...characterized by their long rises to peak. The Zwicky Transient Facility Census of the Local Universe (CLU) experiment aims to construct a spectroscopically complete sample of transients occurring in galaxies from the CLU galaxy catalog. We identify 13 long-rising (>40 days) Type II supernovae from the volume-limited CLU experiment during a 3.5 yr period from 2018 June to 2021 December, approximately doubling the previously known number of these events. We present photometric and spectroscopic data of these 13 events, finding peak
r
-band absolute magnitudes ranging from −15.6 to −17.5 mag and the tentative detection of Ba
ii
lines in nine events. Using our CLU sample of events, we derive a long-rising Type II supernova rate of
1.37
−
0.30
+
0.26
×
10
−
6
Mpc
−3
yr
−1
, ≈1.4% of the total core-collapse supernova rate. This is the first volumetric rate of these events estimated from a large, systematic, volume-limited experiment.
Abstract
Luminous red novae (LRNe) are transients characterized by low luminosities and expansion velocities, and they are associated with mergers or common-envelope ejections in stellar binaries. ...Intermediate-luminosity red transients (ILRTs) are an observationally similar class with unknown origins, but they are generally believed to be either electron-capture supernovae in super-asymptotic giant branch stars or outbursts in dusty luminous blue variables (LBVs). In this paper, we present a systematic sample of eight LRNe and eight ILRTs detected as part of the Census of the Local Universe (CLU) experiment on the Zwicky Transient Facility (ZTF). The CLU experiment spectroscopically classifies ZTF transients associated with nearby (<150 Mpc) galaxies, achieving 80% completeness for
m
r
< 20 mag. Using the ZTF-CLU sample, we derive the first systematic LRNe volumetric rate of
7.8
−
3.7
+
6.5
×
10
−
5
Mpc
−3
yr
−1
in the luminosity range −16 ≤
M
r
≤ −11 mag. We find that, in this luminosity range, the LRN rate scales as
dN
/
dL
∝
L
−
2.5
±
0.3
—significantly steeper than the previously derived scaling of
L
−1.4±0.3
for lower-luminosity LRNe (
M
V
≥ −10 mag). The steeper power law for LRNe at high luminosities is consistent with the massive merger rates predicted by binary population synthesis models. We find that the rates of the brightest LRNe (
M
r
≤ −13 mag) are consistent with a significant fraction of them being progenitors of double compact objects that merge within a Hubble time. For ILRTs, we derive a volumetric rate of
2.6
−
1.4
+
1.8
×
10
−
6
Mpc
−3
yr
−1
for
M
r
≤ −13.5 mag, which scales as
dN
/
dL
∝
L
−
2.5
±
0.5
. This rate is ∼1%–5% of the local core-collapse supernova rate and is consistent with theoretical ECSN rate estimates.
Abstract Multipeaked supernovae with precursors, dramatic light-curve rebrightenings, and spectral transformation are rare, but are being discovered in increasing numbers by modern night-sky ...transient surveys like the Zwicky Transient Facility. Here, we present the observations and analysis of SN 2023aew, which showed a dramatic increase in brightness following an initial luminous (−17.4 mag) and long (∼100 days) unusual first peak (possibly precursor). SN 2023aew was classified as a Type IIb supernova during the first peak but changed its type to resemble a stripped-envelope supernova (SESN) after the marked rebrightening. We present comparisons of SN 2023aew’s spectral evolution with SESN subtypes and argue that it is similar to SNe Ibc during its main peak. P-Cygni Balmer lines are present during the first peak, but vanish during the second peak’s photospheric phase, before H α resurfaces again during the nebular phase. The nebular lines (O i , Ca ii , Mg i , H α ) exhibit a double-peaked structure that hints toward a clumpy or nonspherical ejecta. We analyze the second peak in the light curve of SN 2023aew and find it to be broader than that of normal SESNe as well as requiring a very high 56 Ni mass to power the peak luminosity. We discuss the possible origins of SN 2023aew including an eruption scenario where a part of the envelope is ejected during the first peak and also powers the second peak of the light curve through interaction of the SN with the circumstellar medium.
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