To evaluate the quality of reporting of diagnostic accuracy studies using optical coherence tomography (OCT) in glaucoma.
Descriptive series of published studies.
Published studies reporting a ...measure of the diagnostic accuracy of OCT for glaucoma.
Review of English language papers reporting measures of diagnostic accuracy of OCT for glaucoma. Papers were identified from a Medline literature search performed in June 2006. Articles were appraised using the 25 items provided by the Standards for Reporting of Diagnostic Accuracy (STARD) initiative. Each item was recorded as full, partially, or not reported.
Degree of compliance with the STARD guidelines.
Thirty papers were appraised. Eight papers (26.7%) fully reported more than half of the STARD items. The lowest number of fully reported items in a study was 5 and the highest was 17. Descriptions of key aspects of methodology frequently were missing. For example, details of participant sampling (e.g., consecutive or random selection) were described in only 8 (26.7%) of 30 publications. Measures of statistical uncertainty were reported in 18 (60%) of 30 publications. No single STARD item was fully reported by all the papers.
The standard of reporting of diagnostic accuracy studies in glaucoma using OCT was suboptimal. It is hoped that adoption of the STARD guidelines will lead to an improvement in reporting of diagnostic accuracy studies, enabling clearer evidence to be produced for the usefulness of OCT for the diagnosis of glaucoma.
To characterise the predisposing pathology and clinical features in the fellow eyes of patients recruited as part of the Scottish Retinal Detachment Study.
The Scottish Retinal Detachment Study was a ...2-year prospectively recruited population-based epidemiology study that sought to recruit all incident cases of primary rhegmatogenous retinal detachment (RRD) in Scotland.
A total of 1202 incident cases of primary RRD were recruited in Scotland, over a 2-year period and in 94% (1130 cases) detailed data on the clinical features of fellow eyes with RRD were available. Full-thickness retinal breaks were found in 8.4% (95/1130) of fellow eyes on presentation. Lattice degeneration was present in 14.5% (164/1130) of fellow eyes. Thirteen per cent (148/1130) of affected fellow eyes had a best corrected visual acuity of 6/18 or worse with previous RRD, the second most common cause of poor vision. Overall, 7.3% (88/1202) of cases had RRD in both eyes; 60% of cases with consecutive bilateral RRD presented before the macula were affected.
Rhegmatogenous pathology in the fellow eye represents an important threat to vision. Fellow-eye detachments are more common in pseudophakic individuals and those with a more myopic refractive error. Fellow-eye RRD has a greater likelihood of prompt presentation.
PURPOSETo evaluate the effect of cataract extraction on Swedish Interactive Thresholding Algorithm (SITA) perimetry in patients with coexisting cataract and glaucoma.
PATIENTS AND METHODSThis is a ...retrospective noncomparative interventional study. Thirty-seven consecutive patients with open-angle glaucoma who had cataract extraction alone or combined with trabeculectomy were included. All patients had SITA-standard 24-2 visual fields before and after the surgery. The main outcome measures were changes in mean deviation (MD) and pattern standard deviation (PSD). Additionally, changes in best-corrected visual acuity, intraocular pressure, and number of glaucoma medications were also studied.
RESULTSVisual field tests were performed 3.9±4.4 months before surgery and 4.1±2.8 months after surgery. Mean visual acuity improved after the surgery, from 0.41±0.21 to 0.88±0.32 (P<0.001). After cataract extraction, SITA-standard mean MD improved from −12.3±5.8 to −11.1±6.3 (P=0.023), whereas the change in mean PSD was statistically nonsignificant (from 7.2±3.0 to 7.3±3.6; P=0.84).
CONCLUSIONSIn glaucoma patients examined with SITA-standard, MD improved but PSD change was statistically nonsignificant, after the cataract surgery. SITA-standard PSD can be used to monitor glaucoma progression in patients with coexisting glaucoma and cataract.
Heavy ocular tamponade agents have been shown to be an effective tamponade in complicated retinal detachments. Combined oil removal and cataract surgery may be performed and ultrasound (US) provides ...a reliable means to measure the axial length of eyes. The aim of this study was to evaluate the velocity of US in various tamponade agents.
Five tamponade agents (SO 1000, SO 5000, Oxane HD, Densiron 68 and F-Decalin) were studied in vitro. Time of flight (T(1)) was measured between a US transducer and the bottom of a container of the agent, and remeasured (T(2)) after reducing the separation by 1 cm. The speed of sound in the particular material was calculated from the difference between T(2) and T(1). Measurements were repeated over a range of temperatures from 18°C to 42°C.
The speed of sound at 37°C ranged from 645 ± 8 m/s to 976 ± 10 m/s depending on the tamponade agent. In Densiron 68 and F-Decalin, the speed of sound was markedly reduced to 914 ± 10 m/s and 645 ± 8 m/s, respectively. The temperature dependence of speed of sound varied between -2.2 and -3.6 m/s per °C depending on the particular oil. With 95% confidence, the true speed is believed to lie within ± 5 m/s of these values. The deviation from intended refraction was between 0.38 to 30.15 D depending on the tamponade agent by using correction factor (CF) for SO 1000 cs.
Variability in the velocity of US should be taken into account when performing biometry. Biometry machines should be adjusted for various tamponade media when calculating intraocular lens power.
Herein, a hydrothermal synthesis of nanocrystalline cobalt tungstate (m-CoWO4) with mesoporous texture in the presence of amphiphilic organosilane surfactant is described. As-prepared nanocrystals ...are spherical in shape with size between 8 and 10nm consisting of monoclinic (wolframite structure) phase. In addition, these nanocrystals are endowed with high surface area (50m2g−1), textured mesoporous surface and absorption threshold into visible region. Furthermore, these textured and fine nanocrystals exhibit improved photoelectrochemical activity (PEC), as compared to non-mesoporous CoWO4, under visible light (λ>420nm) for water oxidation in a photoelectrochemical cell.
•Synthesis of mesoporous CoWO4 nanoparticles.•Amphiphilic organosilane surfactant was utilized to generate mesoporosity.•Significantly improved visible-light-driven photoelectrochemical water oxidation with mesoporous CoWO4.
Purpose: Diabetic retinopathy (DR) is a common cause of blindness among the working age group in the developed world. To identify potentially treatable DR, systematic screening is recommended. The ...aim of this study was to evaluate the quality of reporting of diagnostic accuracy studies in DR screening.
Methods: We conducted a systematic literature survey in which a highly sensitive MEDLINE search was performed. The aim was to identify reports of diagnostic accuracy for DR screening published during 1995–2006. Two reviewers appraised all selected papers independently. The Standards for Reporting of Diagnostic Accuracy (STARD) checklist was used to evaluate the quality of reporting of each publication. For every manuscript, each item was scored as completely reported (score = 2), partly reported (score = 1) or not reported (score = 0). We calculated the total number of reported STARD items per article, summary scores for each STARD item and the average number of reported STARD items per year.
Results: A total of 5887 citations were identified from Medline search. Seventy‐six fulfilled the criteria for inclusion. The mean score ± SD of articles included in our study was 19.8 ± 6.5 out of a maximum of 50. The mean number ± SD of fully reported items among included studies was 8 ± 3.3. Only 9 (11.8%) manuscripts completely reported at least 50% of the STARD items. Descriptions of key aspects of the methodology were frequently missing. Only 8% (6/76) of the manuscripts had a flow chart describing flow of participants within a study.
Conclusion: The quality of reporting of diagnostic‐accuracy studies for DR screening is suboptimal. Adherence to STARD guidelines may improve the quality of reporting of DR screening studies.
Eyelid schwannoma in a male adult Siddiqui, MA Rehman; Leslie, Thorfinn; Scott, Christopher ...
Clinical & experimental ophthalmology,
August 2005, Letnik:
33, Številka:
4
Journal Article
Recenzirano
Schwannomas (neurilemmomas) are benign tumours of peripheral nerves arising from Schwann cells. These tumours along with neurofibromas form the two most common primary peripheral nerve tumours. ...Solitary lesions can occur sporadically in the general population but multiple neurofibromas are distinctive feature of neurofibromatosis type 1 and bilateral acoustic schwannomas are a feature of neurofibromatosis type 2. Schwannomas of ophthalmic interest are rare although they have been reported in relation to the orbit, and infrequently uveal tract and conjunctiva. Isolated eyelid schwannomas appear infrequent; only four cases in adults and one in a child in the published literature have been found. Herein, a case of eyelid schwannoma in a 53‐year‐old man is described.
The purpose of this study was to evaluate "in vivo" safety of trypan blue (TB) in patients undergoing TB-assisted internal limiting membrane or epiretinal membrane peeling.
Prospective study ...including 21 patients (21 eyes) with full-thickness macular hole and/or epiretinal membrane undergoing TB-assisted internal limiting membrane/epiretinal membrane peeling. Main outcome measures included distance visual acuity, near visual acuity, amplitude of P50 and N95 of the pattern electroretinogram, and fundus autofluorescence; these were assessed preoperatively, at 6 months (n = 21) and 12 months (n = 10) postoperatively.
There was a statistically significant improvement in distance visual acuity, near visual acuity, P50, and N95 amplitude at 6 months and 12 months postoperatively. The mean logarithm of the minimum angle of resolution distance visual acuity and near visual acuity improved from baseline by 0.31 (SD 0.37) and 0.17 (SD 0.31) at 6 months, respectively, and by 0.4 (SD 0.25) and 0.35 (SD 0.28) at 12 months, respectively. The mean P50 and N95 component amplitudes improved by 28% compared with baseline at 6 months (P50 0.4 SD 0.8; N95 0.53 SD 1.07) and by 63% at 12 months (P50 0.9 0.85; N95 1.04 1.34). Autofluorescence did not demonstrate damage to the retinal pigment epithelium attributable to TB.
No deleterious effects of TB were observed in this study.
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