Introdução: Rosácea é afecção crônica da face caracterizada por eritema, edema, telangiectasias, pápulas e eventualmente pústulas e nódulos. Existem quatro subtipos: rosácea eritêmato-telangiectásica ...(I), rosácea papulopustulosa (II), rosácea fimatosa (III) e rosácea ocular (IV). A patogênese é multifatorial, e os tratamentos são diversos. Objetivo: Demonstrar o efeito da toxina botulínica na melhora do flushing e eritema, em pacientes com rosácea eritêmato-telangiectásica. Métodos: Foram selecionadas seis pacientes com rosácea do subtipo I, no ambulatório do Departamento de Dermatologia de um serviço universitário. As pacientes receberam aplicações de toxina botulínica tipo A, em diluição de 100 unidades para 5ml de solução salina, com aplicação intradérmica de 0,2 a 0,5 unidades por ponto de aplicação na região acometida, tendo sido avaliadas após um, dois, três e seis meses consecutivos. Resultados: Observou-se melhora do eritema facial e do flushing nos três meses consecutivos à aplicação, com retorno dos sintomas por volta do sexto mês após o tratamento, adequado ao tempo estimado de atuação da toxina. Conclusões: Houve melhora dos sintomas e satisfação das pacientes, sendo um tratamento de fácil aplicação, com baixo índice de efeitos adversos e duração prolongada do resultado.
Apresento, nesta intervenção, alguns aspectos da minha atuação como linguista tradutor-intérprete em contextos de saúde junto a povos indígenas, sobretudo aos Avá-Canoeiro e a povos indígenas da ...Amazônia Brasileira. Atuei de 2014 a 2017, a pedido da FUNAI e da SESAI, como acompanhante de indígenas Avá-Canoeiro em hospitais. Trata-se de um povo de recente contato com alto grau de vulnerabilidade. Busquei oferecer um acompanhamento sensível às diferenças culturais na concepção de saúde e doença, fazendo com que a minha função de tradutor-intérprete também desse conta dessas diferenças. No âmbito da pandemia de Covid-19, tive a oportunidade de prestar consultoria à COIAB, na supervisão da tradução de materiais sobre a doença, sobre violência contra crianças, adolescentes e mulheres, e sobre saúde mental indígena para aproximadamente vinte línguas indígenas da Amazônia Brasileira.
We previously discovered that palmitic acid methyl ester (PAME) is a potent vasodilator released from the sympathetic ganglion with vasoactive properties. Post-treatment with PAME can enhance ...cortical cerebral blood flow and functional learning and memory, while inhibiting neuronal cell death in the CA1 region of the hippocampus under pathological conditions (i.e. cerebral ischemia). Since mechanisms underlying PAME-mediated neuroprotection remain unclear, we investigated the possible neuroprotective mechanisms of PAME after 6 min of asphyxial cardiac arrest (ACA, an animal model of global cerebral ischemia). Our results from capillary-based immunoassay (for the detection of proteins) and cytokine array suggest that PAME (0.02 mg/kg) can decrease neuroinflammatory markers, such as ionized calcium binding adaptor molecule 1 (Iba1, a specific marker for microglia/macrophage activation) and inflammatory cytokines after cardiopulmonary resuscitation. Additionally, the mitochondrial oxygen consumption rate (OCR) and respiratory function in the hippocampal slices were restored following ACA (via Seahorse XF24 Extracellular Flux Analyzer) suggesting that PAME can ameliorate mitochondrial dysfunction. Finally, hippocampal protein arginine methyltransferase 1 (PRMT1) and PRMT8 are enhanced in the presence of PAME to suggest a possible pathway of methylated fatty acids to modulate arginine-based enzymatic methylation. Altogether, our findings suggest that PAME can provide neuroprotection in the presence of ACA to alleviate neuroinflammation and ameliorate mitochondrial dysfunction.
We examine 288 gamma-ray bursts (GRBs) detected by the Fermi Gamma-ray Space Telescope's Gamma-ray Burst Monitor (GBM) that fell within the field of view of Fermi's Large Area Telescope (LAT) during ...the first 2.5 years of observations, which showed no evidence for emission above 100 MeV. We report the photon flux upper limits in the 0.1-10 GeV range during the prompt emission phase as well as for fixed 30 s and 100 s integrations starting from the trigger time for each burst. Approximately 20% of this spectroscopic subsample show statistically significant evidence for a cutoff in their high-energy spectra, which if assumed to be due to gamma gamma attenuation, places limits on the maximum Lorentz factor associated with the relativistic outflow producing this emission.
Apesar das questões relativas à sustentabilidade e ecoeficiência estarem na ordem do dia das organizações, muitos gestores enfrentam dificuldades ao adotarem práticas ecoeficientes, por conta do ...descrédito de colaboradores. Este artigo realizou um estudo empírico pioneiro e comprovou que a Ecofont contribui significativamente para a economia de recursos (naturais e materiais), além de reduzir a emissão de dióxido de carbono. Optou-se pelo estudo de caso na Câmara Municipal de Belo Horizonte, porque a organização é responsável por um volume significativo de impressão de documentos. Foram utilizados dados primários, cálculos, testes e softwares, como Word 2003 e APFILL.
Cardiac arrest causes neuronal damage and functional impairments that can result in learning/memory dysfunction after ischemia. We previously identified a saturated fatty acid (stearic acid methyl ...ester, SAME) that was released from the superior cervical ganglion (sympathetic ganglion). The function of stearic acid methyl ester is currently unknown. Here, we show that SAME can inhibit the detrimental effects of global cerebral ischemia (i.e. cardiac arrest). Treatment with SAME in the presence of asphyxial cardiac arrest (ACA) revived learning and working memory deficits. Similarly, SAME-treated hippocampal slices after oxygen-glucose deprivation inhibited neuronal cell death. Moreover, SAME afforded neuroprotection against ACA in the CA1 region of the hippocampus, reduced ionized calcium-binding adapter molecule 1 expression and inflammatory cytokines/chemokines, with restoration in mitochondria respiration. Altogether, we describe a unique and uncharted role of saturated fatty acids in the brain that may have important implications against cerebral ischemia.
The literature analyzing the spatial distribution of scientific and technological production in Brazil identifies differences in the regional distribution of scientific and technological resources. ...In this paper, we contribute to this discussion, by analyzing the dynamics of the production of new scientific knowledge in the states that contributed the most to national scientific production in the period 2000–10: Sao Paulo, Rio de Janeiro, Minas Gerais and Rio Grande do Sul, also known as the ‘scientific quartet’. Our hypothesis is that even with federal policies aimed at the expansion and decentralization of the production of new scientific knowledge, this production is still strongly anchored in the ‘scientific quartet’. We further identify a concentration of scientific production in three major areas of knowledge: agricultural, biological and health sciences.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
We report results from a reanalysis of data from the Cryogenic Dark Matter Search (CDMS II) experiment at the Soudan Underground Laboratory. Data taken between October 2006 and September 2008 using ...eight germanium detectors are reanalyzed with a lowered, 2 keV recoil-energy threshold, to give increased sensitivity to interactions from weakly interacting massive particles (WIMPs) with masses below ∼10 GeV/c(2). This analysis provides stronger constraints than previous CDMS II results for WIMP masses below 9 GeV/c(2) and excludes parameter space associated with possible low-mass WIMP signals from the DAMA/LIBRA and CoGeNT experiments.
The Fermi Gamma-ray Space Telescope has opened a new high-energy window in the study of gamma-ray bursts (GRBs). Here we present a thorough analysis of GRB 080825C, which triggered the Fermi ...Gamma-ray Burst Monitor (GBM), and was the first firm detection of a GRB by the Fermi Large Area Telescope (LAT). We discuss the LAT event selections, background estimation, significance calculations, and localization for Fermi GRBs in general and GRB 080825C in particular. We show the results of temporal and time-resolved spectral analysis of the GBM and LAT data. We also present some theoretical interpretation of GRB 080825C observations as well as some common features observed in other LAT GRBs.
There is a growing interest in cryogenic calorimeters with macroscopic absorbers for applications such as dark matter direct detection and rare event search experiments. The physics of energy ...transport in calorimeters with absorber masses exceeding several grams is made complex by the anisotropic nature of the absorber crystals as well as the changing mean free paths as phonons decay to progressively lower energies. We present a Monte Carlo model capable of simulating anisotropic phonon transport in cryogenic crystals. We have initiated the validation process and discuss the level of agreement between our simulation and experimental results reported in the literature, focusing on heat pulse propagation in germanium. The simulation framework is implemented using Geant4, a toolkit originally developed for high-energy physics Monte Carlo simulations. Geant4 has also been used for nuclear and accelerator physics, and applications in medical and space sciences. We believe that our current work may open up new avenues for applications in material science and condensed matter physics.
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