We performed a retrospective single-center analysis to investigate the diagnostic yield of bone marrow puncture in patients with liver cirrhosis and cytopenia. Liver cirrhosis patients receiving bone ...marrow aspiration or biopsy for the diagnostic work-up of otherwise unexplained peripheral blood cytopenia at our institution between 2004 and 2020 were enrolled in this study. We evaluated findings from cytologic, histologic and immunologic assessment and final diagnostic outcomes. A total of 118 patients with a median age of 55 years and a median Child-Pugh score of B (8 points) were enrolled. The main etiologies of liver cirrhosis were viral hepatitis (B and C) or chronic alcohol consumption. The majority of patients (60%) exhibited concurrent anemia, leukocytopenia and thrombocytopenia. Bone marrow assessment revealed normal, unspecific or reactive alterations in 117 out of 118 patients (99%). One patient was diagnosed with myelodysplastic syndrome. Our findings suggest that peripheral blood cytopenia in patients with liver cirrhosis is rarely associated with a primary bone marrow pathology.
Ground state properties of Ni-excess Co2Ni1+xZ1−x (Z= Al, Ga, In, Sn) full Heusler alloys are investigated by abinitio calculations. We consider the effect of different structural motives and ...chemical disorder on structural stability and magnetic characteristics of these alloys. Co-Ni-(In, Sn) are found to be unstable with respect to decomposition into pure bulk elements. Co2Ni(Al, Ga) are stable, however, introducing the Ni excess destabilizes these alloys making off-stoichiometric Co2Ni1+xAl1−x and Co2Ni1+xGa1−x unstable at x>0.5 and x>0.25, respectively. Saturation magnetization Ms of Co2Ni(Al, Ga) is of the same order like other Co2Ni-based Heusler alloys. Our study showed that an effective way to increase Ms is the introducing of chemical disorder. For stable compounds in which a tetragonal structure with alternating planes of Co and Ni exists, we calculate the magnetocrystalline anisotropy energy (MAE) given large values about −2 MJ/m3 with in-plane favorable spin configuration. The deviation from stoichiometry reduces the MAE by a factor of two.
•New layered order in tetragonal structure of Co2Ni(Al, Ga) is proposed.•The magnetocrystalline anisotropy energy (MAE) for such structure is calculated.•MAE values are about −2 MJ/m3 with in-plane favorable spin configuration.
