Charmed Baryons Spectroscopy Solovieva, E
Journal of physics. Conference series,
01/2017, Letnik:
798, Številka:
1
Journal Article
Recenzirano
Odprti dostop
In the paper the classification of charmed baryons is presented, a quark model for ground states is briefly described, and the energy levels of excited states are analyzed. Moreover a present status ...of experimentally observed states of charmed baryons is given.
Cobalamin is an essential nutrient required for the normal functioning of cells. Its deficiency can lead to various pathological states. Hydroxocobalamin (HOCbl) and cyanocobalamin (CNCbl) are the ...forms of vitamin B12 that are most commonly used for supplementation. There is substantial evidence indicating that cobalamins can both suppress and promote oxidative stress; however, the mechanisms underlying these effects are poorly understood. Here, it was shown that the oxidation of thiols catalyzed by HOCbl and CNCbl is accompanied by reactive oxygen species (ROS) production and induces, under certain conditions, oxidative stress and cell death. The form of vitamin B12 and the structure of thiol play a decisive role in these processes. It was found that the mechanisms and kinetics of thiol oxidation catalyzed by HOCbl and CNCbl differ substantially. HOCbl increased the rate of oxidation of thiols to a greater extent than CNCbl, but quenched ROS in combination with certain thiols. Oxidation catalyzed by CNCbl was generally slower. Yet, the absence of ROS quenching resulted in their higher accumulation. The aforementioned results might explain a more pronounced cytotoxicity induced by combinations of thiols with CNCbl. On the whole, the data obtained provide a new insight into the redox processes in which cobalamins are involved. Our results might also be helpful in developing new approaches to the treatment of some cobalamin-responsive disorders in which oxidative stress is an important component.
Abstract
This article is dedicated to increasing of removing of nitrogen and phosphorus in DENIFO technology, and the removing of phosphorus by reagents. Removal of nitrogen and phosphorus from ...municipal wastewater prevents eutrophication of open water, which has become a global problem. A list of conditions that provide maximum efficiency of the processes of wastewater treatment and sludge treatment is completed. Functions of primary settlers, air tanks (based on technology DENIFO), and secondary settlers is reviewed. Pre-denitrification of the returned active sludge with the partial flow of waste water improves anaerobiosis in the anaerobic zone of biological block, and promotes intensive dephosphorization. The work was made under normal conditions of wastewater treatment plant. Unfavorable periods (snowmelt, torrential rains, floods) are not taken into consideration. Mathematical equations are made for the average flow of wastewater during dry weather. Combined dehydratation of the sludge and sediments (the long stay in the tank) leads to rapid displacement phosphorus phosphate to drain water, and a corresponded increase the content of phosphorus in the treated water. Also recommendations for changing the operating mode of the block of sludge treatment given. The important results included in article was taken on the really functioned wastewater treatment plants of Saint Petersburg. This work is aimed at a comprehensive assessment, development and improvement of technology of removing nitrogen and phosphorus from municipal wastewater, including from secondary pollution coming from the return flow from the sludge treatment units.
Family case of Potocki-Lupski syndrome Kolbasin, L N; Dubrovskaya, T A; Salnikova, G B ...
Molecular cytogenetics,
03/2024, Letnik:
17, Številka:
1
Journal Article
Recenzirano
Odprti dostop
Potocki-Lupski syndrome (PTLS, OMIM # 610883) is a rare genetic developmental disorder resulting from a partial heterozygous microduplication at chromosome 17p11.2. The condition is characterized by ...a wide variability of clinical expression, which can make its clinical and molecular diagnosis challenging.
We report here a family (mother and her two children) diagnosed with PTLS. When examining children, neurological and psychological (neuropsychiatric) manifestations (speech delay, mild mental retardation), motor disorders, craniofacial dysmorphism (microcephaly, dolichocephaly, triangular face, wide bulging forehead, long chin, antimongoloid slant, "elfin" ears) were revealed. The suspected clinical diagnosis was confirmed by MLPA and CMA molecular genetic testing which revealed the presence of a segmental aneusomy; microduplication in the 17p11.2 region.
Children with PTLS can have a clinically recognizable and specific phenotype: craniofacial dysmorphism, motor and neurological manifestations, which may implicate a possible genetic disease to the attending physician. Moreover, each child with this syndrome is unique and may have a different clinical picture. The management of such patients requires a multidisciplinary team approach, including medical genetic counseling.
The macrocyclic ligand calix4arene (
L1
) and its sulphur-containing analogue thia4calixarene (
L2
) are promising precursors for functional molecular materials as they offer rational ...functionalization with various organic groups. Here, we present the first example of lanthanide-based coordination polymers built from the macrocyclic thiacalix4arene backbone bearing four carboxylic moieties, namely, ligand
H
4
L3
. The combination of
H
4
L3
with the Tb
3+
and Dy
3+
cations led to the formation of 1D ladder-type coordination polymers with the formula Ln
III
HL3
DMF
3
·(DMF) (where DMF = dimethylformamide and Ln = Tb or Dy, denoted as
HL3-Tb
and
HL3-Dy
), which resulted from the coordination of the lanthanide cations with the partially deprotonated ligand
HL3
3−
that behaved as a T-shape connector. The coordination sphere around the metal was completed by the coordinated DMF solvent molecules. By combining both Tb
3+
and Dy
3+
cations, isostructural heterobimetallic solid solutions
HL3-Tb
1−
x
Dy
x
were also prepared.
HL3-Tb
and
HL3-Dy
showed visible light photoluminescence originating from the f-f electronic transitions of pale green emissive Tb
3+
and pale yellow emissive Dy
3+
with efficient sensitization by the functionalized thia4calixarene ligand
HL3
. In the
HL3-Tb
1−
x
Dy
x
solid solutions, the Tb/Dy ratio governed both the emission colour as well as the emission quantum yield, which reached even 28% at room temperature for
HL3-Tb
. Moreover,
HL3-Dy
exhibited a slow magnetic relaxation effect related to the magnetic anisotropy of the dodecahedral Dy
3+
complexes, which were well isolated in the crystal lattice by expanded organic spacers.
The single crystals of the two isostructural Tb
3+
- and Dy
3+
-based coordination polymers (
HL3-Tb
and
HL3-Dy
) were structurally characterized, and their photophysical properties were investigated, together with their corresponding solid solutions.
Elaboration of a convenient route towards donor-substituted pyrazoles from heteropropargyl precursors is challenging due to a number of thermodynamically favorable side reactions (e.g., ...acetylene-allene isomerization and Glaser homocoupling). In this work, Sonogashira cross-coupling conditions of 4-
-butylphenyl propargyl ether with benzoyl chloride followed by tandem Michael addition/cyclocondensation with hydrazine into 3,5-disubstituted pyrazole (kinetic control), as well as cycloisomerization conditions of ketoacetylene intermediate into 2,5-disubstituted furan (thermodynamic control), were established through a variation of the catalyst loading, solvent polarity, excess of triethylamine, and time of reaction. During the optimization of process parameters, a number of by-products represented by a monophosphine binuclear complex (PPh
PdI
)
with two bridging iodine atoms and diyne were identified and isolated in the pure form. The quantum-chemical calculations and solution-state
H/
C NMR spectroscopy suggested that the 5(3)-(4-
-butylphenyloxy)methoxy-3(5)-phenyl-1
-pyrazole exists in the tautomeric equilibrium in a polar methanol solvent and that individual tautomers could be characterized in case aprotic solvents employed. The pyrazole features a unique tetramer motif in the crystal phase formed by alternating 3(5)-phenyl-1
-pyrazole tautomers, which was stabilized by N-H···N bonds and stacking interactions of pyrazole rings, whereas pyrazole dimers were identified in the gas phase.
A modern classification of charmed baryons is presented, and the quark model is briefly described for the ground states and energy levels of excited states. In addition, a survey of experimentally ...observed states of strange charmed baryons is given.
New fluorescent systems for photocatalysis, sensors, labeling, etc., are in great demand. Amphiphilic ones are of special interest since they can form functional colloidal systems that can be used in ...aqueous solutions. A new macrocycle platform for click chemistry and its adduct with o-propargylfluoresceine was synthesized and characterized using modern physical techniques. Nanosized solid lipid nanoparticles (SLNs) from the calixarene-fluoresceine adduct were synthesized through the solvent injection technique and well-characterized in the solution and in solid state using light-scattering and microscopy methods. The maximum fluorescence intensity of the SLNs was found to be in the pH range from 7 to 10. The Förster resonance energy transfer (FRET) efficiency from SLNs to rhodamine 6g was found to be 97.8%. Finally, pure SLNs and the FRET system SLNs-Rh6G were tested in model photocatalytic ipso oxidative hydroxylation of phenylboronic acid under blue LED light. The SLNs-Rh6G system was found to be the best, giving an almost qualitative phenol yield, which was shown by HPLC-UV analysis.
A series of new 2-hydroxy-3-methoxybenzylidenethiazolo3,2-
pyrimidines with different aryl substituents at the 5 position are synthesized and characterized by
H/
C NMR and IR-spectroscopy and ...mass-spectrometry, as well as single crystal X-ray diffraction (SCXRD). It was demonstrated that the type of hydrogen bonding can play a key role in the chiral discrimination of these compounds in the crystalline phase. The hydrogen bond of the O-H...N type leads to 1D supramolecular heterochiral chains or conglomerate crystallization in the case of the formation of homochiral chains. The hydrogen bond of O-H...O type gave racemic dimers, which are packed into 2D supramolecular layers with a parallel or angular dimers arrangement. Halogen bonding of the N...Br or O...Br type brings a new motif into supramolecular self-assembly in the crystalline phase: the formation of 1D supramolecular homochiral chains instead 2D supramolecular layers. The study of cytotoxicity against various tumor cells in vitro was carried out. It was found that 2-hydroxy-3-methoxybenzylidenethiazolo3,2-
pyrimidines with 3-nitrophenyl substituent at C5 carbon atom demonstrated a high efficiency against M-HeLa (cervical adenocarcinoma) and low cytotoxicity against normal liver cells.
A series of new thiazolo3,2-
pyrimidines different by aryl substituents in 2 and 5 positions are synthesized and characterized in solution as well as in the crystalline phase using
H and
C NMR-, ...IR-spectroscopies, mass-spectrometry methods, and single crystal X-ray diffraction (SCXRD). The SCXRD study revealed the role of intermolecular H-bonding in the formation of supramolecular architectures (racemic monomers, centrosymmetric racematic dimers, or homochiral 1D chains) of obtained thiazolo3,2-
pyrimidines derivatives depending on solvents (aprotic DMSO or protic EtOH) used upon the crystallization process. Moreover, the in vitro study of cytotoxicity toward different tumor cells showed their high or moderate efficiency with moderate cytotoxicity against normal liver cells which allows to consider the obtained thiazolo3,2-
pyrimidine derivatives as promising candidates for application as antitumor agents.
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