To reduce adverse impact potential and improve diversity outcomes from personnel selection, one promising technique is De Corte, Lievens, and Sackett's (2007) Pareto-optimal weighting strategy. De ...Corte et al.'s strategy has been demonstrated on (a) a composite of cognitive and noncognitive (e.g., personality) tests (De Corte, Lievens, & Sackett, 2008) and (b) a composite of specific cognitive ability subtests (Wee, Newman, & Joseph, 2014). Both studies illustrated how Pareto-weighting (in contrast to unit weighting) could lead to substantial improvement in diversity outcomes (i.e., diversity improvement), sometimes more than doubling the number of job offers for minority applicants. The current work addresses a key limitation of the technique-the possibility of shrinkage, especially diversity shrinkage, in the Pareto-optimal solutions. Using Monte Carlo simulations, sample size and predictor combinations were varied and cross-validated Pareto-optimal solutions were obtained. Although diversity shrinkage was sizable for a composite of cognitive and noncognitive predictors when sample size was at or below 500, diversity shrinkage was typically negligible for a composite of specific cognitive subtest predictors when sample size was at least 100. Diversity shrinkage was larger when the Pareto-optimal solution suggested substantial diversity improvement. When sample size was at least 100, cross-validated Pareto-optimal weights typically outperformed unit weights-suggesting that diversity improvement is often possible, despite diversity shrinkage. Implications for Pareto-optimal weighting, adverse impact, sample size of validation studies, and optimizing the diversity-job performance tradeoff are discussed.
The present study was conducted to evaluate the effects of different rearing methods and stocking densities on carcass yield and proximate composition of meat in small-sized meat ducks. A total of ...555 one-day-old birds were randomly allocated to six treatment groups (three replicates per treatment, sex ratio 1/1) with a 2 × 3 factorial arrangement of two rearing methods (reared in cage or net) and three stocking densities (5 low, 7 medium, or 9 high birds/m2) until day 70. Five male and five female birds from each replicate were randomly selected and processed to determine the carcass yield. Proximate composition was determined by proximate analysis using the breast and thigh muscles. There was no interaction effect between the rearing method and stocking density on carcass yield. The rearing method affected the thigh muscle rate, which was higher in the cage groups (P < 0.05). The final BW and abdominal fat rate decreased with increasing density (P < 0.05), whereas the thigh muscle rate increased (P < 0.05). There were significant interaction effects (P < 0.05) between the rearing method and stocking density on the content of protein, fat, and collagen. The content of fat and moisture was greater and lower, respectively, in the cage groups (P < 0.05). The content of moisture, fat, and collagen with a medium density was higher (P < 0.05). In addition, the content of protein and fat was lower in the ducks fed in nets at low and high densities (P < 0.05), respectively; the collagen content of breast and thigh muscle was lower in the ducks fed in cages and nets, respectively, at a low density (P < 0.05). Our findings provide valuable insights into the single and interactive effects of the rearing method and stocking density on duck slaughter performance and proximate composition of meat. The results indicate that a rearing system with a cage pattern and a medium density is better than other arrangements for small-sized meat ducks.
Aim
To evaluate the comparative effects of sodium‐glucose co‐transporter 2 (SGLT2) inhibitors on risk of bone fracture in patients with type 2 diabetes mellitus (T2DM).
Methods
PubMed, EMBASE, ...CENTRAL and ClinicalTrials.gov were systematically searched from inception to 27 January 2016 to identify randomized controlled trials (RCTs) reporting the outcome of fracture in patients with T2DM treated with SGLT2 inhibitors. Pairwise and network meta‐analyses, as well as a cumulative meta‐analysis, were performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs).
Results
A total of 38 eligible RCTs (10 canagliflozin, 15 dapagliflozin and 13 empagliflozin) involving 30 384 patients, with follow‐ups ranging from 24 to 160 weeks, were included. The fracture event rates were 1.59% in the SGLT2 inhibitor groups and 1.56% in the control groups. The incidence of fracture events was similar among these three SGLT2 inhibitor groups. Compared with placebo, canagliflozin (OR 1.15; 95% CI 0.71‐1.88), dapagliflozin (OR 0.68; 95% CI 0.37‐1.25) and empagliflozin (OR 0.93; 95% CI 0.74‐1.18) were not significantly associated with an increased risk of fracture. Our cumulative meta‐analysis indicated the robustness of the null findings with regard to SGLT2 inhibitors.
Conclusions
Our meta‐analysis based on available RCT data does not support the harmful effect of SGLT2 inhibitors on fractures, although future safety monitoring from RCTs and real‐world data with detailed information on bone health is warranted.
We demonstrate the formation of long-lived resonances via external coupling in open nanostructures. In the examples of three dielectric nanorods or strips, external coupling of modes is induced by ...tuning of the rod spacing and increases the lifetime over an order of magnitude. Such an enhancement results from the destructive interference of fields that minimizes light leakage. Our results illustrate an effective way of storing light in nanostructures, and have potential applications to nanoscale photonic devices.
Microsatellite DNA markers are consistently found to be more informative than other classes of markers in hexaploid wheat. The objectives of this research were to develop new primers flanking wheat ...microsatellites and to position the associated loci on the wheat genome map by genetic linkage mapping in the ITMI W7984 x Opata85 recombinant inbred line (RIL) population and/or by physical mapping with cytogenetic stocks. We observed that the efficiency of marker development could be increased in wheat by creating libraries from sheared rather than enzyme-digested DNA fragments for microsatellite screening, by focusing on microsatellites with the ATT/TAAn motif, and by adding an untemplated G-C clamp to the 5'-end of primers. A total of 540 microsatellite-flanking primer pairs were developed, tested, and annotated from random genomic libraries. Primer pairs and associated loci were assigned identifiers prefixed with BARC (the acronym for the USDA-ARS Beltsville Agricultural Research Center) or Xbarc, respectively. A subset of 315 primer sets was used to map 347 loci. One hundred and twenty-five loci were localized by physical mapping alone. Of the 222 loci mapped with the ITMI population, 126 were also physically mapped. Considering all mapped loci, 126, 125, and 96 mapped to the A, B, and D genomes, respectively. Twenty-three of the new loci were positioned in gaps larger than 10 cM in the map based on pre-existing markers, and 14 mapped to the ends of chromosomes. The length of the linkage map was extended by 80.7 cM. Map positions were consistent for 111 of the 126 loci positioned by both genetic and physical mapping. The majority of the 15 discrepancies between genetic and physical mapping involved chromosome group 5.
Feed efficiency (FE) is a major economic trait of meat duck. This study aimed to evaluate the effects of residual feed intake (RFI) divergence on growth performance, carcass traits, meat quality, and ...blood biochemical parameters in small-sized meat ducks. A total of 500 healthy 21-day-old male ducks were housed in individual cages until slaughter at 63 d of age. The growth performance was determined for all the ducks. The carcass yield, meat quality, and blood biochemical parameters were determined for the selected 30 high-RFI (HRFI) and 30 low-RFI (LRFI) ducks. In terms of growth performance, the RFI, feed conversion ratio (FCR), and average daily feed intake (ADFI) were found to be significantly lower in the LRFI group (P < 0.01), whereas no differences were observed in the BW and body weight gain (P > 0.05). For slaughter performance, no differences were observed in the carcass traits between the LRFI and HRFI groups (P > 0.05). For meat quality, the shear force of breast muscle was significantly lower in the LRFI group (P < 0.05), while the other meat quality traits of breast and thigh muscles demonstrated no differences (P > 0.05). For blood biochemical parameters, the serum concentrations of triglycerides (TG) and glucose (GLU) were significantly lower in the LRFI group (P < 0.05), while the other parameters showed no differences (P > 0.05). The correlation analysis demonstrated a high positive correlation between RFI, FCR, and ADFI (P < 0.01). The RFI demonstrated a negative effect on the breast muscle and lean meat yields, but a positive effect on the shear force of breast muscle (P < 0.05). Further, the RFI demonstrated a positive effect on the TG and GLU levels (P < 0.05). These results indicate that the selection for low RFI could improve the FE of small-sized meat ducks without affecting the production performance. This study provides valuable insight into the biological processes underlying the variations in FE in small-sized meat ducks.
Polyamide thin film composite (PA TFC) membranes are synthesized from interfacial polymerization using two amines in the aqueous phase. The conventional monomer, m-phenelynediamine (MPD), is ...partially replaced by a linear monomer, 1,3–diamino-2-hydroxypropane (DAHP). The water permeability of the membranes improves by around 22% (to 2.67±0.09Lm−2h−1bar−1) while keeping the same high salt rejection (96–98%) at an optimum DAHP/MPD ratio of 12.8%. While developing the control PA TFC membrane we introduce a washing step and show that the support surface should be free from surface protective coatings to achieve high water flux (2.18±0.08Lm−2h−1bar−1). Incorporating DAHP units into the polyamide network improves the water flux through the membranes fabricated on both original and washed supports. The surface morphologies of polyamide films change significantly with introduction of DAHP, from large ridge-and-valley structure to enlarged nodular structures. High resolution SEM images show an ultrathin polyamide thin film with a thickness that is reduced with addition of DAHP. These influences of DAHP, namely a reduction in the selective layer thickness, an alteration in surface morphology, changes in internal molecular packing and hydrophilicity, are suggested as factors behind the improved water permeability.
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•We develop thin film composite (TFC) RO membranes via interfacial polymerization.•We use a blend of two aqueous phase monomers, one containing an aliphatic moiety.•Tuning the reactant blend conditions enhances water permeability.•The structural causality for the enhanced permeability is explored.•Improvement of support conditions significantly enhances TFC performances.
In personnel selection practice, one useful technique for reducing adverse impact and enhancing diversity is the Pareto-optimal weighting approach of De Corte et al. (2007). This approach produces a ...series of hiring solutions that characterize a diversity-job performance trade-off and can lead to more optimal selection outcomes (sometimes doubling the number of job offers for minority applicants without changing the job performance outcomes of personnel selection). Despite these advantages, recent research has identified a potential problem with the Pareto-weighting technique-Pareto solutions suffer from shrinkage upon cross-validation. To address the problem of shrinkage in the Pareto trade-off curve (i.e., diversity shrinkage and validity shrinkage), we offer two contributions. First, a shrinkage approximation formula is introduced (similar to a formula for adjusted R2, but applicable to the entire Pareto trade-off curve). Second, we derive a novel technique for the regularization of Pareto-optimal predictor weights (borrowed from the field of machine learning), which is designed to produce predictor weights that are less vulnerable to shrinkage (similar to ridge regression and adapted from the elastic net technique). Both approaches-the proposed Pareto shrinkage formula and the proposed regularization technique-are then evaluated using Monte Carlo simulation. Recommendations are provided for approximating potential diversity-performance trade-off curves in personnel selection, while accounting for shrinkage.
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