Interest inventories are commonly used for career and organizational decision-making. Though it is widely assumed that interest fit predicts job satisfaction, previous meta-analyses reported ...non-significant relations between interest fit and job satisfaction. However, past meta-analyses were limited by several critical issues, including low statistical power and inconsistent inclusion criteria. In this updated meta-analysis, we systematically reviewed the link between interest fit and job satisfaction across 105 studies spanning over 65 years (k = 194, N = 39,602). Results revealed a statistically significant, positive relation between interest fit and overall job satisfaction that was slightly lower than expected (ρ = 0.19, 95% CI: 0.16, 0.21). Yet moderation analyses revealed the strength of the relation was notably stronger for satisfaction facets capturing how people evaluate their career choice in general. Overall, these results suggest a need to reconceptualize the applied importance of vocational interests. Although we report clear evidence that interest fit predicts job satisfaction, interest fit is more strongly related to performance outcomes and satisfaction with one's overall career path. We conclude by presenting a series of recommendations for improving the use of interest assessments in career and organizational settings.
•We conducted a comprehensive meta-analysis on interest fit and job satisfaction.•Interest fit significantly predicts overall job satisfaction.•The relation is strongest for satisfaction with one's job choice and organization.•Findings suggest a need to reconceptualize the importance of vocational interests.•We review how interest fit predicts career outcomes to differing degrees.
Human epidermal growth factor receptor 2 (HER2) is a transmembrane glycoprotein receptor with intracellular tyrosine kinase activity. Its alterations, including mutation, amplification and ...overexpression, could result in oncogenic potential and have been detected in many cancers such as non-small-cell lung cancer (NSCLC). Such alterations are, in general, considered markers of poor prognosis. Anti-HER2 antibody-drug conjugates, e.g. trastuzumab deruxtecan (T-DXd, DS-8201) and disitamab vedotin (RC48), were recently approved for HER2-positive breast and gastric cancers. Meanwhile, several HER2-targeted drugs, such as T-DXd, neratinib, afatinib, poziotinib and pyrotinib, have been evaluated in patients with advanced NSCLC, with several of them demonstrating clinical benefit. Therefore, identifying HER2 alterations is pivotal for NSCLC patients to benefit from these targeted therapies. Recent guidelines on HER2 testing were developed for breast and gastric cancer, however, and have not been fully established for NSCLC. The expert group here reached a consensus on HER2 alteration testing in NSCLC with the focus on clinicopathologic characteristics, therapies, detection methods and diagnostic criteria for HER2-altered NSCLC patients. We hope this consensus could improve the clinical management of NSCLC patients with HER2 alterations.
•Human epidermal growth factor receptor 2 (HER2) alterations lead to poor prognosis in non-small-cell lung cancer (NSCLC).•Identifying HER2 alterations is pivotal to guide the anti-HER2-targeted therapies in NSCLC.•The requirements for HER2 mutation, amplification or expression testing are distinct in NSCLC.•This consensus fills the gap in the criteria for HER2 alteration testing in NSCLC.
This work deals with the tracking control problem of a class of unknown nonaffine dynamic systems that involve unpredictable sensor and actuation failures. As the control inputs enter into and ...influence the dynamic behavior of the nonaffine system through a nonlinear and implicit way, control design for such system becomes quite challenging. The underlying problem becomes even more complex if the system dynamics are unavailable for control design yet involving unanticipated sensor and/or actuator faults. In this work, a structurally simple and computationally inexpensive control scheme is proposed to achieve uniformly ultimately bounded (UUB) stable tracking control of a class of nonaffine systems. The proposed control is of a generalized PI form and is able to accommodate both sensor and actuator faults. The effectiveness of the proposed control strategy is confirmed by theoretical analysis and numerical simulations.
High-precision radiometric calibration (RC) coefficients are required to retrieve reliable water quality parameter products in turbid inland/coastal waters. However, unreliable RC coefficients when ...satellite sensors lack accurate and in-time RC may lead to pronounced uncertainties in the products through error propagation. To address this issue, a novel approach for estimating water quality parameters, taking suspended particulate matter (SPM) as a case, was proposed by coupling the procedures of RC and SPM model development. The coupled models were established using digital numbers (DNs) from target sensors and "in-situ" SPM measurements from concurrent well-calibrated reference sensors, with the RC coefficients introduced as unknown model parameters. The approach was tested and validated in varied Chinese inland/coastal regions, including the Hongze lake (HL), Taihu lake (TL), and Hangzhou bay (HB). The results show: (1) the DN-based SPM models can achieve a degree of accuracy comparable to reflectance-based SPM models with determination coefficients (R
) of 0.94, 0.92, and 0.72, and root-mean-square errors (RMSE) of 7.02 mg/L, 15.73 mg/L, and 619.2 mg/L for the HL, TL, and HB, respectively, and the biases less than 3% between the derived and official gain RC coefficients; (2) the uncertainty of SPM products increases exponentially as the RC uncertainty increases for exponential reflectance-based SPM models; (3) the DN-based SPM models are less sensitive to the uncertainties of atmospheric correction and RC coefficients, while the reflectance-based models suffer deeply. This study provides encouraging results to the improvement of SPM retrieval using the DN-based models by coupling RC and SPM retrieving processes, especially for sensors without precise RC coefficients.
Novel hierarchical ZnO nanostructures, porous ZnO nanobelts, and nanoparticle chains are prepared from a precursor of synthetic bilayered basic zinc acetate (BLBZA) nanobelts. BLBZA nanobelts are ...obtained by a simple synthetic route under mild conditions. X‐ray diffraction, scanning electron microscopy, transmission electron microscopy, infrared spectroscopy, and thermal analysis are used to characterize the BLBZA nanobelts and ZnO nanostructures. The obtained BLBZA precursor consists of a lamellar structure with two interlayer distances of 1.33 and 2.03 nm, exhibits a beltlike morphology, and has widths of 200 to 600 nm, thicknesses of 10 to 50 nm, and lengths of up to 50 μm. Refluxing an aqueous dispersion of BLBZA nanobelts at 120 °C for 12 h leads to the formation of well‐defined hierarchical ZnO nanostructures. The time‐dependent shape‐evolution process suggests that spindlelike ZnO particles form first, and then the ringlike nanosheets grow heterogeneously on the backbone of these spindles. In addition, calcination in air can remove ligand molecules and intercalated water molecules from BLBZA nanobelts, resulting in the formation of porous ZnO nanobelts and nanoparticle chains. The BLBZA nanobelts serve as templates during the transformation to form ZnO beltlike nanoparticle chains without morphological deformation. Photoluminescence results show that both the as‐synthesized hierarchical ZnO nanostructures and porous ZnO nanobelts show a narrow and sharp UV emission at 390 nm and a broad blue–green emission at above 466 nm when excited by UV light.
Layered basic zinc acetate nanobelts (see figure) are prepared by using a simple aqueous synthetic method under mild conditions. Novel hierarchical ZnO nanostructures and porous ZnO nanobelts and nanoparticle chains are obtained from these layered basic zinc acetate nanobelts by refluxing and calcination, respectively.
A total of 391 simple sequence repeat (SSR) markers designed from genomic DNA libraries, 24 derived from existing GenBank genes or ESTs, and five derived from bacterial artificial chromosome (BAC) ...end sequences were developed. In contrast to SSRs derived from EST sequences, those derived from genomic libraries were a superior source of polymorphic markers, given that the mean number of tandem repeats in the former was significantly less than that of the latter (P<0.01). The 420 newly developed SSRs were mapped in one or more of five soybean mapping populations: 'Minsoy' x 'Noir 1', 'Minsoy' x 'Archer', 'Archer' x 'Noir 1', 'Clark' x 'Harosoy', and A81-356022 x PI468916. The JoinMap software package was used to combine the five maps into an integrated genetic map spanning 2,523.6 cM of Kosambi map distance across 20 linkage groups that contained 1,849 markers, including 1,015 SSRs, 709 RFLPs, 73 RAPDs, 24 classical traits, six AFLPs, ten isozymes, and 12 others. The number of new SSR markers added to each linkage group ranged from 12 to 29. In the integrated map, the ratio of SSR marker number to linkage group map distance did not differ among 18 of the 20 linkage groups; however, the SSRs were not uniformly spaced over a linkage group, clusters of SSRs with very limited recombination were frequently present. These clusters of SSRs may be indicative of gene-rich regions of soybean, as has been suggested by a number of recent studies, indicating the significant association of genes and SSRs. Development of SSR markers from map-referenced BAC clones was a very effective means of targeting markers to marker-scarce positions in the genome.
The mechanism of high superconducting transition temperatures (Tc) in bismuthates remains under debate despite more than 30 years of extensive research. Our angle-resolved photoemission spectroscopy ...studies on Ba0.51K0.49BiO3 reveal an unexpectedly 34% larger bandwidth than in conventional density functional theory calculations. This can be reproduced by calculations that fully account for long-range Coulomb interactions-the first direct demonstration of bandwidth expansion due to the Fock exchange term, a long-accepted and yet uncorroborated fundamental effect in many body physics.Furthermore, we observe an isotropic superconducting gap with 2Δ0/kBTc=3.51±0.05, and strong electron-phonon interactions with a coupling constant λ∼1.3±0.2. These findings solve a long-standing mystery-Ba0.51K0.49BiO3 is an extraordinary Bardeen-Cooper-Schrieffer superconductor, where long-range Coulomb interactions expand the bandwidth, enhance electron-phonon coupling, and generate the high Tc. Such effects will also be critical for finding new superconductors.
Anthracnose (ANT) and angular leaf spot (ALS) caused by Colletotrichum lindemuthianum and Pseudocercospora griseola, respectively, are devastating diseases of common bean around the world. Therefore, ...breeders are constantly searching for new genes with broad-spectrum resistance against ANT and ALS. This study aimed to characterize the genetic resistance of California Dark Red Kidney (CDRK) to C. lindemuthianum races 73, 2047, and 3481 and P. griseola race 63-39 through inheritance, allelism testing, and molecular analyses. Genetic analysis of response to ANT and ALS in recombinant inbred lines (RILs) from a CDRK × Yolano cross (CY) showed that the resistance of CDRK cultivar is conferred by a single dominant loci, which we named CoPv01CDRK/PhgPv01CDRK. Allelism tests performed with race 3481showed that the resistance gene in CDRK is independent of the Co-1 and Co-AC. We conducted co-segregation analysis in genotypes of 110 CY RILs and phenotypes of the RILs in response to different races of the ANT and ALS pathogens. The results revealed that CoPv01CDRK and PhgPv01CDRK are coinherited, conferring resistance to all races. Genetic mapping of the CY population placed the CoPv01CDRK/PhgPv01CDRK loci in a 245 Kb genomic region at the end of Pv01. By genotyping 19 RILs from the CY population using three additional markers, we fine-mapped the CoPv01CDRK/PhgPv01CDRK loci to a smaller genomic region of 33 Kb. This 33 Kb region harbors five predicted genes based on the common bean reference genome. These results can be applied in breeding programs to develop bean cultivars with ANT and ALS resistance using marker-assisted selection.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Key message
We finely mapped the rust resistance gene
R
12
to a 0.1248-cM region, identified a potential R
12
candidate gene in the XRQ reference genome, and developed three diagnostic SNP markers ...for
R
12
.
Rust is a devastating disease in sunflower that is damaging to the sunflower production globally. Identification and utilization of host-plant resistance are proven to be preferable means for disease control. The rust resistance gene
R
12
with broad-spectrum specificity to rust was previously localized to a 2.4 Mb region on sunflower chromosome 11. To understand the molecular mechanism of resistance, we conducted whole-genome sequencing of RHA 464 (
R
12
donor line) and reference genome-based fine mapping of the gene
R
12
. Overall, the 213 markers including 186 SNPs and 27 SSRs' were identified from RHA 464 sequences and used to survey polymorphisms between the parents HA 89 and RHA 464. Saturation mapping identified 26 new markers positioned in the
R
12
region, and fine mapping with a large population of 2004 individuals positioned
R
12
at a genetic distance of 0.1248 cM flanked by SNP markers C11_150451336 and S11_189205190. One gene, HanXRQChr11g0348661, with a defense-related NB-ARC-LRR domain, was identified in the XRQr1.0 genome assembly in the
R
12
region; it is predicted to be a potential
R
12
candidate gene. Comparative analysis clearly distinguished
R
12
from the rust
R
14
gene located in the vicinity of the
R
12
gene on chromosome 11. Three diagnostic SNP markers, C11_147181749, C11_147312085, and C11_149085167, specific for
R
12
were developed in the current study, facilitating more accurate and efficient selection in sunflower rust resistance breeding. The current study provides a new genetic resource and starting point for cloning
R
12
in the future.
Personality traits and vocational interests capture different aspects of human individuality that intersect in certain ways. In this longitudinal study, we examined developmental relations between ...the Big 5 traits and RIASEC vocational interests over 4 timepoints from late adolescence to young adulthood (age 16-24) in a sample of Icelandic youth (N = 485) well-representative of the total student population. Results showed that interests and personality traits were similarly stable over time, but showed different patterns of mean-level change. There was evidence of personality maturation but a lack of cumulative changes in interest levels. For the most part, gender differences in developmental trends were minimal. In addition, latent growth curve analyses revealed broad and specific correlated changes between personality and interests. Changes in general factors of personality and interests were moderately related (r = .32), but stronger correlated changes were found among specific personality-interest pairs that share situational content. Overall, results reveal how interests and personality are related across different types of continuity and change. While there was little correspondence between group-level changes, substantial correlated change occurred at the individual level. This means that when a person's personality changes, their interests tend to change in predictable ways (and vice versa). Integrative theories that link different aspects of psychological functioning can benefit by incorporating these findings.
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