The performance evaluation of public charging service quality is frequently viewed as the multiple attribute group decision-making (MAGDM) issue. In this paper, an extended TOPSIS model is ...established to provide a new means to solve the performance evaluation of public charging service quality. The TOPSIS method integrated with FUCOM method in probabilistic hesitant fuzzy circumstance is applied to rank the optional alternatives and a numerical example for performance evaluation of public charging service quality is used to test the newly proposed method’s practicability with the comparison with other methods. The results display that the approach is uncomplicated, valid and simple to compute. The main results of this paper: (1) A novel PHF-TOPSIS method is proposed; (2) The extended TOPSIS method is developed in the probabilistic hesitant fuzzy environment; (3) The FUCOM method is used to obtain the attribute weight; (4) The normalization process of the original data has adapted the latest method to verify the precision; (5) The built models and methods are useful for other selection issues and evaluation issues.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Objectives
To evaluate the performance of a novel three-dimensional (3D) joint convolutional and recurrent neural network (CNN-RNN) for the detection of intracranial hemorrhage (ICH) and its five ...subtypes (cerebral parenchymal, intraventricular, subdural, epidural, and subarachnoid) in non-contrast head CT.
Methods
A total of 2836 subjects (ICH/normal, 1836/1000) from three institutions were included in this ethically approved retrospective study, with a total of 76,621 slices from non-contrast head CT scans. ICH and its five subtypes were annotated by three independent experienced radiologists, with majority voting as reference standard for both the subject level and the slice level. Ninety percent of data was used for training and validation, and the rest 10% for final evaluation. A joint CNN-RNN classification framework was proposed, with the flexibility to train when subject-level or slice-level labels are available. The predictions were compared with the interpretations from three junior radiology trainees and an additional senior radiologist.
Results
It took our algorithm less than 30 s on average to process a 3D CT scan. For the two-type classification task (predicting bleeding or not), our algorithm achieved excellent values (≥ 0.98) across all reporting metrics on the subject level. For the five-type classification task (predicting five subtypes), our algorithm achieved > 0.8 AUC across all subtypes. The performance of our algorithm was generally superior to the average performance of the junior radiology trainees for both two-type and five-type classification tasks.
Conclusions
The proposed method was able to accurately detect ICH and its subtypes with fast speed, suggesting its potential for assisting radiologists and physicians in their clinical diagnosis workflow.
Key Points
• A 3D joint CNN-RNN deep learning framework was developed for ICH detection and subtype classification, which has the flexibility to train with either subject-level labels or slice-level labels.
• This deep learning framework is fast and accurate at detecting ICH and its subtypes.
• The performance of the automated algorithm was superior to the average performance of three junior radiology trainees in this work, suggesting its potential to reduce initial misinterpretations.
To better understand the mechanical properties and influence mechanism of hydroxyl‐terminated polybutadiene (HTPB) propellant under various confining pressures, the uniaxial tension tests with low to ...medium strain rate and various confining pressures were carried out. The coupling effects of strain rate and confining pressure on mechanical properties were presented. Meanwhile, the confining pressure influence mechanism was analyzed and revealed using the meso numerical simulation method and scanning electron microscopy images of fracture surfaces. The meso damage evolution processes under various confining pressures were presented. The results show that strain rate and confining pressure affect mechanical responses of HTPB propellant significantly. As confining pressure increases, the maximum tension strength and fracture strength increase. The maximum tension strain and failure strain vary slightly with confining pressure under low strain rate, while they increase significantly with confining pressure at medium strain rate. The fracture energy density increases with the increase of strain rate and confining pressure. Meanwhile, the value of saturation pressure depends on strain rate. The confining pressure influence mechanism is to suppress dewetting damage initiation and evolution. Besides, the failure mode of HTPB propellant under different confining pressures is still particles dewetting.
The coupling effects of confining pressure and strain rate on the mechanical properties of HTPB propellant were studied. The confining pressure influence mechanism was revealed using meso numerical simulation method.
The relationship between serum cholesterol level and development of hepatocellular carcinoma (HCC) remains unclear. We investigated the effects of serum cholesterol level on development of liver ...tumors in mice.
We performed studies with C57BL/6J mice, mice with disruption of the low-density lipoprotein receptor gene (Ldlr−/−mice), and mice with conditional deletion of nature killer (NK) cells (NKdele mice). Some C57BL/6J and NKdele mice were given injections of diethylinitrosamine to induce liver tumor formation. Mice were placed on a normal diet (ND) or high-cholesterol diet (HCD) to induce high serum levels of cholesterol. We also studied mice with homozygous disruption of ApoE (ApoE−/− mice), which spontaneously develop high serum cholesterol. C57BL/6J and NKdele mice on the ND or HCD were implanted with Hep1-6 (mouse hepatoma) cells and growth of xenograft tumors and lung metastases were monitored. Blood samples were collected from mice and analyzed by biochemistry and flow cytometry; liver and tumor tissues were collected and analyzed by histology, immunohistochemistry, and RNA-sequencing analysis. NK cells were isolated from mice and analyzed for cholesterol content, lipid raft formation, immune signaling, and changes in functions. We obtained matched tumor tissues and blood samples from 30 patients with HCC and blood samples from 40 healthy volunteers; levels of cholesterol and cytotoxicity of NK cells were measured.
C57BL/6J mice on HCD and ApoE−/− mice with high serum levels of cholesterol developed fewer and smaller liver tumors and lung metastases after diethylinitrosamine injection or implantation of Hep1-6 cells than mice on ND. Liver tumors from HCD-fed mice and ApoE−/− mice had increased numbers of NK cells compared to tumors from ND-fed mice. NKdele mice or mice with antibody-based depletion for NK cells showed similar tumor number and size in ND and HCD groups after diethylinitrosamine injection or implantation of Hep1-6 cells. NK cells isolated from C57BL/6J mice fed with HCD had increased expression of NK cell–activating receptors (natural cytotoxicity triggering receptor 1 and natural killer group 2, member D), markers of effector function (granzyme B and perforin), and cytokines and chemokines compared with NK cells from mice on ND; these NK cells also had enhanced cytotoxic activity against mouse hepatoma cells, accumulated cholesterol, increased lipid raft formation, and immune signaling activation. NK cells isolated from HCD-fed Ldlr−/− mice did not have increased cholesterol content or cytotoxic activity against mouse hepatoma cells compared with ND-fed Ldlr−/− mice. Serum levels of cholesterol correlated with number and activity of NK cells isolated from human HCCs.
Mice with increased serum levels of cholesterol due to an HCD or genetic disruption of ApoE develop fewer and smaller tumors after injection of hepatoma cells or a chemical carcinogen. We found cholesterol to accumulate in NK cells and activate their effector functions against hepatoma cells. Strategies to increase cholesterol uptake by NK cells can be developed for treatment of HCC.
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Coronavirus disease 2019 (COVID-19) has recently emerged as a global threat. Understanding workers' knowledge, attitudes, and practices (KAP) regarding this new infectious disease is crucial to ...preventing and controlling it. This study aimed to assess KAP regarding COVID-19 during the outbreak among workers in China. The present study was part of a cross-sectional online survey study conducted based on a large labor-intensive factory, which has 180,000 workers from various Chinese provinces, from 2 February 2020 to 7 February 2020. KAP related to COVID-19 were measured by 32 items, each item was measured with an agree/disagree/unclear format, and only correct responses were given 1 point. KAP regarding COVID-19 were measured with 20 items, 6 items and 6 items, respectively. A total of 123,768 valid responses (68.8%) were included in the analysis. Generally, the levels of knowledge (mean: 16.3 out of 20 points), attitudes (mean: 4.5 out of 6 points), and practices (mean: 5.8 out of 6 points) related to COVID-19 were high. Only 36,373 respondents (29.4%) disagreed that gargling with salt water is effective in protecting against COVID-19. Moreover, older respondents had decreased levels of knowledge and practices related to COVID-19 (both P values for the trend <0.001), while better-educated respondents had increased levels of knowledge and practices related to COVID-19 (both P values for the trend <0.001). These results suggest that Chinese workers are highly aware of COVID-19, but health authorities still need to provide correct information on COVID-19 prevention and strengthen health interventions, particularly for older and less-educated workers.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Smut, the most important sugarcane fungal disease in China, is caused by Sporisorium scitamineum. Smut infection causes severe cane and sugar yield loss. Whole-plant resistance response is ...characterized by the expression of a large number of pathogenesis-related proteins and genes. Here, proteomic analysis by isobaric tag for relative and absolute quantification was conducted to identify differentially expressed proteins of two sugarcane varieties with contrasting resistance to smut, i.e. Yacheng71-374 (smut-susceptible) and GT29 (smut-resistant) following S. scitamineum infection. A total of 125 and 290 proteins were found differentially expressed after whip appearance in Yacheng71-374 and GT29 sugarcane varieties. Increased up-regulation of peroxidase and catalase and proteins involved in photosynthesis, calcium signaling, abscisic acid biosynthesis, and protein metabolism, were observed in GT29 as compared to Yacheng71-374, suggesting their potential involvement in smut defense mechanism(s) in sugarcane. The expression level of five important defense-related enzymes i.e. chitinase, glucanase, catalase, superoxide dismutase, and phenylalanine ammonia-lyase was analyzed by RT-qPCR. The expression of these enzymes was found enhanced considerably in GT29 as compared to Yacheng71-374 for up to six months following pathogen infection. These results provide new molecular insights into long-term responses of sugarcane to smut infection, a much over-looked aspect of sugarcane smut disease.
Magnetorheological elastomers (MREs) with outstanding magnetic-control properties are highly desirable for applications such as vibration attenuation, smart sensing, and soft robots. However, the low ...strength and thermolability of these materials still restrict their application in attenuating the vibration of large-scale devices. In this paper, we prepared an MRE based on ethylene-propylene-diene monomer (EPDM)/methylvinyl silicone rubber (MVQ) polymer blends. The resulting MRE showed good thermostability and mechanical properties. Good interfacial interaction and particle dispersion were achieved by modifying the surface of carbonyl iron powder (CIP) with silica coating by the sol-gel method. The compatibility between the EPDM and MVQ was promoted using silane coupling agents. Moreover, the resulting MRE had high mechanical strength and elongation at break. The dynamic viscoelastic properties of the MRE were tested using a rheometer. The influences of frequency, strain, matrices, temperature, and magnetic fields were discussed comprehensively, and relevant physical mechanisms were proposed. Finally, thermal aging tests were performed to evaluate the heat resistance of the MRE. Analytical results showed that the resulting MRE could be significantly applied to reduce the vibration of large devices because of its excellent mechanical properties and thermostability.
The 2019 novel coronavirus has spread rapidly around the world. Cancer patients seem to be more susceptible to infection and disease deterioration, but the factors affecting the deterioration remain ...unclear. We aimed to develop an individualized model for prediction of coronavirus disease (COVID‐19) deterioration in cancer patients. The clinical data of 276 cancer patients diagnosed with COVID‐19 in 33 designated hospitals of Hubei, China from December 21, 2019 to March 18, 2020, were collected and randomly divided into a training and a validation cohort by a ratio of 2:1. Cox stepwise regression analysis was carried out to select prognostic factors. The prediction model was developed in the training cohort. The predictive accuracy of the model was quantified by C‐index and time‐dependent area under the receiver operating characteristic curve (t‐AUC). Internal validation was assessed by the validation cohort. Risk stratification based on the model was carried out. Decision curve analysis (DCA) were used to evaluate the clinical usefulness of the model. We found age, cancer type, computed tomography baseline image features (ground glass opacity and consolidation), laboratory findings (lymphocyte count, serum levels of C‐reactive protein, aspartate aminotransferase, direct bilirubin, urea, and d‐dimer) were significantly associated with symptomatic deterioration. The C‐index of the model was 0.755 in the training cohort and 0.779 in the validation cohort. The t‐AUC values were above 0.7 within 8 weeks both in the training and validation cohorts. Patients were divided into two risk groups based on the nomogram: low‐risk (total points ≤ 9.98) and high‐risk (total points > 9.98) group. The Kaplan‐Meier deterioration‐free survival of COVID‐19 curves presented significant discrimination between the two risk groups in both training and validation cohorts. The model indicated good clinical applicability by DCA curves. This study presents an individualized nomogram model to individually predict the possibility of symptomatic deterioration of COVID‐19 in patients with cancer.
This is the first study to present a nomogram model to individually predict the deterioration of COVID‐19 in cancer patients. Clinical symptoms, computed tomography image features, cancer types, and comorbidities were incorporated in the model. Risk stratification was carried out targeting cancer populations for COVID‐19 deterioration. Cancer type was a critical factor affecting symptomatic deterioration. The COVID‐19 patients with lymphoma had the highest risk score for symptomatic deterioration.
Extensive studies indicated that caveolin is a key regulator in multiple cellular processes. Recently, growing evidence demonstrated that caveolin is critically involved in tumor progression. Since ...no relevant bibliometric study has been published, we performed a bibliometric and visual analysis to depict the knowledge framework of research related to the involvement of caveolin in cancer.
Relevant studies published in English during 2003-2022 were obtained from the Web of Science Core Collection database. Three programs (VOSviewer, CiteSpace, and R-
) and the website of bibliometrics (http://bibliometric.com/) were applied to construct networks based on the analysis of countries, institutions, authors, journals, references, and keywords.
A total of 2,463 documents were extracted and identified. The United States had the greatest number of publications and total citations, and Thomas Jefferson University was the most productive institution. Michael P. Lisanti was the most influential scholar in this research domain.
was the journal with the most publications on this subject. The most local-cited document was the article titled "Caveolin-1 in oncogenic transformation, cancer, and metastasis." A comprehensive analysis has been conducted based on keywords and cited references. Initially, the research frontiers were predominantly "signal transduction", "human breast cancer," "oncogenically transformed cells," "tumor suppressor gene," and "fibroblasts." While in recent years, the research emphasis has shifted to "tumor microenvironment," "epithelial mesenchymal transition," "nanoparticles," and "stem cells."
Taken together, our bibliometric analysis shows that caveolin continues to be of interest in cancer research. The hotspots and research frontiers have evolved from the regulation of cancer signaling, to potential targets of cancer therapy and novel techniques. These results can provide a data-based reference for the guidance of future research.
Growth arrest-specific 5 (GAS5) was reported to be implicated and aberrantly express in multiple cancers. However, the expression and mechanism of action of GAS5 were largely poor understood in ...endometrial carcinoma.
According to the result of real-time reverse-transcriptase polymerase chain reaction (RT-PCR) and flow cytometry analysis, we identified that GAS5 was down-regulated in endometrial cancer cells and stimulated the apoptosis of endometrial cancer cells. To investigate the expression of GAS5, PTEN and miR-103, RT-PCR was performed. And we found that the expression of PTEN was up-regulated when endometrial cancer cells overexpressed GAS5. The prediction of bioinformatics online revealed that GAS5 could bind to miR-103, which was further found to be regulated by GAS5. Finally, we found that miR-103 mimic could decrease the mRNA and protein levels of PTEN through luciferase reporter assay and western blotting, and GAS5 plasmid may reverse this regulation effect in endometrial cancer cells.
In summary, we demonstrate that GAS5 acts as an tumor suppressor lncRNA in endometrial cancer. Through inhibiting the expression of miR-103, GAS5 significantly enhanced the expression of PTEN to promote cancer cell apoptosis, and, thus, could be an important mediator in the pathogenesis of endometrial cancer.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
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