Abstract In the process of multi-target tracking, the complex underwater acoustic channel, target model mismatch, target strong maneuvering and other factors are easy to cause track interruption and ...rerun, which have a bad influence on the situation assessment and tactical decision of the Unmanned sonar system. Aiming at the problem of track interruption, this paper integrates the track adhesion algorithm into the active multi-target tracking algorithm. Simulation results show that the track adhesion algorithm can effectively improve the correct track association rate and track lifetime. By comparing the effect of the new and old methods with the sea test data, the track adhesion can effectively solve the problem of track interruption in the case of target track maneuvering and improve the track life.
Sonodynamic therapy （SDT） is an emerging approach that involves a combination of low-intensity ultrasound and specialized chemical agents known as sonosensitizers. Ultrasound can penetrate deeply ...into tissues and can be focused into a small region of a tumor to activate a sonosensitizer which offers the possibility of non-invasively eradicating solid tumors in a site-directed manner. In this article, we critically reviewed the currently accepted mechanisms of sonodynamic action and summarized the classification of sonosensitizers. At the same time, the breath of evidence from SDT-based studies suggests that SDT is promising for cancer treatment.
Pyroptosis is triggered by inflammasomes after its activation by various inflammatory stimulations, including lipopolysaccharide (LPS) and improper pH. This may result in programmed death of the ...affected cell. It is well known that NLRP1 and NLRP3 inflammasomes mediate the production of various cytokines in inflammatory disorders; however, it is still unknown whether NLRP1 and NLRP3 inflammasomes can influence the LPS‑induced pyroptosis in the progression of knee osteoarthritis (KOA). In the present study, the correlation between the NLRP inflammasomes and fibroblast‑like synoviocytes (FLSs) pyroptosis was investigated in vivo and in vitro. Human synovial samples were collected from KOA patients and the expression of NLRP1 and NLRP3 inflammasomes was analyzed. Human FLS were isolated in vitro and stimulated with LPS. To determine whether NLRP1 and NLRP3 inflammasomes are involved in FLS pyroptosis, NLRP1 and NLRP3 small interfering RNAs (siRNAs) were used. The results showed that the expression of NLRPs and inflammasome‑related proteins were upregulated and FLS stimulated with LPS+ATP resulted in cell pyroptosis. However, LPS+ATP‑induced pyroptosis was attenuated by NLRP1 and NLRP3 siRNAs. The results of the present study indicate that LPS‑induced FLS pyroptosis may be mediated by either NLRP1 or NLRP3 inflammsomes. Overall, based on the data obtained from patients and in vitro cells, the present finsings showed that NLRP1 and NLRP3 inflammasomes are highly involved in the FLS inflammation and pyroptosis. Furthermore, inhibition of NLRP1 and NLRP3 led to a remarkable reduction of pyroptosis‑related cytokines. Thus, NLRP1 and NLRP3 inflammasomes may be important in the pathogenesis of OA and may represent a novel therapeutic target.
Vanadium‐based intercalation materials have attracted considerable attention for aqueous zinc‐ion batteries (ZIBs). However, the sluggish interlaminar diffusion of zinc ions due to the strong ...electrostatic interaction, severely restricts their practical application. Herein, oxygen vacancy‐enriched V2O5 structures (Zn0.125V2O5·0.95H2O nanoflowers, Ov‐ZVO) with expanded interlamellar space and excellent structural stability are prepared for superior ZIBs. In situ electron paramagnetic resonance (EPR) and X‐ray diffraction (XRD) characterization revealed that numerous oxygen vacancies are generated at a relatively low reaction temperature because of partially escaped lattice water. In situ spectroscopy and density functional theory (DFT) calculations unraveled that the existence of oxygen vacancies lowered Zn2+ diffusion barriers in Ov‐ZVO and weakened the interaction between Zn and O atoms, thus contributing to excellent electrochemical performance. The Zn||Ov‐ZVO battery displayed a remarkable capacity of 402 mAh g−1 at 0.1 A g−1 and impressive energy output of 193 Wh kg−1 at 2673 W kg−1. As a proof of concept, the Zn||Ov‐ZVO pouch cell can reach a high capacity of 350 mAh g−1 at 0.5 A g−1, demonstrating its enormous potential for practical application. This study provides fundamental insights into formation of oxygen‐vacant nanostructures and generated oxygen vacancies improving electrochemical performance, directing new pathways toward defect‐functionalized advanced materials.
Combination of two or more therapeutic strategies with different mechanisms can cooperatively prohibit cancer development. Combination of chemotherapy and small interfering RNA (siRNA)-based therapy ...represents an example of this approach. Hypothesizing that the chemotherapeutic drug and the siRNA should be simultaneously delivered to the same tumoral cell to exert their synergistic effect, the development of delivery systems that can efficiently encapsulate two drugs and successfully deliver payloads to targeted sites via systemic administration has proven to be challenging. Here, we demonstrate an innovative “two-in-one” micelleplex approach based on micellar nanoparticles of a biodegradable triblock copolymer poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly(2-aminoethyl ethylene phosphate) to systemically deliver the siRNA and chemotherapeutic drug. We show clear evidence that the micelleplex is capable of delivering siRNA and paclitaxel simultaneously to the same tumoral cells both in vitro and in vivo. We further demonstrate that systemic administration of the micelleplex carrying polo-like kinase 1 (Plk1) specific siRNA and paclitaxel can induce a synergistic tumor suppression effect in the MDA-MB-435s xenograft murine model, requiring a thousand-fold less paclitaxel than needed for paclitaxel monotherapy delivered by the micelleplex and without activation of the innate immune response or generation of carrier-associated toxicity.
Fully homomorphic encryption (FHE) allows arbitrary computation on encrypted data and thus has potential in privacy-preserving computing. However, efficiency is still the bottleneck. In this paper we ...present an area-efficient and highly unified reconfigurable multi-core architecture (named ReMCA) for full Residue Number System (RNS) variant of Fan-Vercauteren variant of Brakerski's scheme (RNS-BFV), which employs a variable number of reconfigurable processing elements (PEs) and RNS channels. The PE unit can be flexibly configured as NTT, INTT or modular multiplier, thereby avoiding the need of other extra computational units. To reduce the computational complexity, ReMCA merges the pre/post-processing into NTT/INTT and unifies the read/write structure of NTT and INTT. Also, a conflict-free memory access pattern that doesn't need separate bit-reversal operation is proposed to optimize the memory access. Furthermore, targeting different computational requirements, a unified hardware architecture mapping model and data memory organization model are introduced, and all the computing units that RNS-BFV involved are optimized and mapped on ReMCA. ReMCA is evaluated on a Xilinx Virtex-7 FPGA platform. Running at 250MHz, it can perform 2260 homomorphic multiplication per second. When normalized to the same parameter set, the throughput and Area-Time-Products (ATPs) of ReMCA achieve <inline-formula> <tex-math notation="LaTeX">1.45\times \sim 5.51\times </tex-math></inline-formula> and <inline-formula> <tex-math notation="LaTeX">1.58\times \sim 5.12\times </tex-math></inline-formula> improvements.
One new bisabolane sesquiterpene, bisabolan-1,10,11-triol (
), one new norbisabolane sesquiterpene, 12-nor-11-acetoxybisabolen-3,6,7-triol (
), two new naturally occurring monoterpenes, (7
)- and (7
...)-1-hydroxy-3-
-menthen-9-oic acids (
and
), one new naturally occurring trichodenone, dechlorotrichodenone C (
), one new chlorine-containing trichodenone, 3-hydroxytrichodenone C (
), one new diketopiperazine, methylcordysinin A (
), and one new naturally occurring oxazole derivative, 4-oxazolepropanoic acid (
), were isolated from the culture of a marine brown alga-endophytic strain (cf44-2) of
. Their structures and relative configurations were determined by extensive 1D/2D NMR and mass spectrometric data, and the absolute configurations of
⁻
were assigned by analysis of the ECD spectra aided by quantum chemical computations. Compounds
,
,
, and
showed growth inhibition of some marine phytoplankton species and pathogenic bacteria.
The study explored the relationship between teacher assessments of students' general language-cognitive and social-emotional abilities and Chinese children's reading development over an academic ...year. A series of reading measures (including reading vocabulary, reading comprehension, and lexical inferencing ability) were administered to Chinese-speaking second graders (N = 123) across time. Meanwhile, their six head teachers and assistant head teachers were asked to complete assessments of their language-cognitive and social-emotional abilities prior to the first data collection. By utilizing multivariate analyses, the results demonstrated that teacher-assessed linguistic and social abilities contributed to children's reading abilities within and across time after autoregressive effects were controlled for. More specifically, language and cognitive abilities made a more salient contribution to reading performance over time. The study suggests that teacher assessments could have diagnostic and preventive functions for enhancing sustainable reading development among Chinese elementary-age students.
AbstractA significant feature of residual soil is the presence of a cemented structure and fissures that dominate its anisotropic behavior. Although the anisotropy of some sedimentary soils is well ...understood, that of residual soils is not. The present study investigates the strength anisotropy of granite residual soil via undrained hollow cylinder torsional shear tests for which intact and remolded hollow cylinder specimens were sheared in various principal stress directions α. The results reveal significant shear-strength anisotropy of the natural soil, whereas the remolded soil behaved almost isotropically. Expressed using the effective stress ratio at ultimate state t/s′, the shear-strength variation reached 51% for α=0–90°, within which range the highest values of t/s′ was that for α=0°. The torsional shear mode (α=45°) resulted in the lowest soil strength. The anisotropic behavior of the studied soil differs much from that of some normally consolidated sedimentary soils such that new parameters are proposed for evaluating the degree of anisotropy. The proposed parameters confirmed the marked strength anisotropy of intact granite residual soil and found the anisotropy degree of soil significantly reduced after being remolded. This study provides the most direct evidence to date for the strength anisotropy of natural granite residual soil and enhances the understanding of this soil and weathered geomaterials in general.
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