► Short-term exposures to ozone have been proven to affect childhood asthma. ► Epidemiological studies confirmed that ozone exposure influence asthma development. ► Causality between ozone and ...childhood asthma is still to prove.
Protecting the health of children and the environment is an essential objective for the health policies of any modern society, being also crucial for a sustainable development, according to the World Health Organization. Evaluating the risk of developing childhood asthma is one of the four priority issues identified by the European Commission, according to the European Union Environment and Health Action Plan.
Accordingly, this review aimed to update information concerning the effects of exposure to ozone on childhood asthma, thus helping in the development of strategies for further research. Studies have been demonstrating strong associations between the exposure to ozone and asthma. However, the complexity of exposure patterns, the changes in the vulnerability of children at various stages of development, and the practical limitations of research, lead to a still incomplete understanding of the ozone impact on the health of children. Difficulties on the interpretation of epidemiological studies to evaluate chronic effects are mainly due to an absence of studies designed specifically to address this question and to inherent limitations in characterizing exposure. The more rigorous studies provided new evidences for chronic effects of ozone on small airway function and possibly on asthma, but substantial uncertainties remain.
Maritime sector is expected to continue growing significantly in line with world trade, however its impacts on environmental, social and human health are not yet fully known. Thus, this study aimed ...to estimate the external costs of in-port shipping emissions (NOx, SO2, CO2, VOCs and PM2.5) and accomplish a comprehensive eco-efficiency evaluation of four ports in Portugal (Leixões, Setúbal, Sines and Viana do Castelo) during 2013. External costs were based on the external cost factors from BeTa, CAFE and NEEDS projects and from Song (2014). Eco-efficiency evaluation was based on environmental, social and economic criteria. Results showed higher externalities for Sines and Setúbal (2.0E+02 million €), followed by Leixões (1.8E+02 million €), and Viana do Castelo (6.3 million €). NOx, SO2, and PM2.5 were the pollutants with the highest externalities. Sines port showed the best overall eco-efficiency. Although Setúbal port showed higher performance than Viana do Castelo port based on the economic data, when social and environmental aspects were considered the results changed. This shows the importance of performing a more comprehensive analysis using social and environmental indicators. The combination of all these indicators is highly important to support the implementation of policies for the abatement of shipping in-port emissions.
•Eco-efficiency evaluation was based on environmental, social and economic criteria.•External costs were based on the external cost factors from BeTa, CAFE and NEEDS projects.•NOx, SO2, and PM2.5 were the pollutants with the highest externalities.•Findings of this study can support new port policies to control ship emissions.
Shoulder rehabilitation is a process that requires physical therapy sessions to recover the mobility of the affected limbs. However, these sessions are often limited by the availability and cost of ...specialized technicians, as well as the patient's travel to the session locations. This paper presents a novel smartphone-based approach using a pose estimation algorithm to evaluate the quality of the movements and provide feedback, allowing patients to perform autonomous recovery sessions. This paper reviews the state of the art in wearable devices and camera-based systems for human body detection and rehabilitation support and describes the system developed, which uses MediaPipe to extract the coordinates of 33 key points on the patient's body and compares them with reference videos made by professional physiotherapists using cosine similarity and dynamic time warping. This paper also presents a clinical study that uses QTM, an optoelectronic system for motion capture, to validate the methods used by the smartphone application. The results show that there are statistically significant differences between the three methods for different exercises, highlighting the importance of selecting an appropriate method for specific exercises. This paper discusses the implications and limitations of the findings and suggests directions for future research.
Respirasomes are macromolecular assemblies of the respiratory chain complexes I, III and IV in the inner mitochondrial membrane. We determined the structure of supercomplex I
III
IV
from bovine heart ...mitochondria by cryo-EM at 9 Å resolution. Most protein-protein contacts between complex I, III and IV in the membrane are mediated by supernumerary subunits. Of the two Rieske iron-sulfur cluster domains in the complex III dimer, one is resolved, indicating that this domain is immobile and unable to transfer electrons. The central position of the active complex III monomer between complex I and IV in the respirasome is optimal for accepting reduced quinone from complex I over a short diffusion distance of 11 nm, and delivering reduced cytochrome
to complex IV. The functional asymmetry of complex III provides strong evidence for directed electron flow from complex I to complex IV through the active complex III monomer in the mammalian supercomplex.
Context. The chemical composition of stars that have orbiting planets provides important clues about the frequency, architecture, and composition of exoplanet systems. Aims. We explore the ...possibility that stars from different galactic populations that have different intrinsic abundance ratios may produce planets with a different overall composition. Methods. We compiled abundances for Fe, O, C, Mg, and Si in a large sample of solar neighbourhood stars that belong to different galactic populations. We then used a simple stoichiometric model to predict the expected iron-to-silicate mass fraction and water mass fraction of the planet building blocks, as well as the summed mass percentage of all heavy elements in the disc. Results. Assuming that overall the chemical composition of the planet building blocks will be reflected in the composition of the formed planets, we show that according to our model, discs around stars from different galactic populations, as well as around stars from different regions in the Galaxy, are expected to form rocky planets with significantly different iron-to-silicate mass fractions. The available water mass fraction also changes significantly from one galactic population to another. Conclusions. The results may be used to set constraints for models of planet formation and chemical composition. Furthermore, the results may have impact on our understanding of the frequency of planets in the Galaxy, as well as on the existence of conditions for habitability.
The epidemiological demands of aging point to the need for characterizing older adults regarding health and disability. This systematic review aims to summarize the indicators (instruments) ...identifying different components of disability as a result of aging exposition in community-dwelling older adults, considering the International Classification of Functioning, Disability, and Health framework. Taking the PRISMA 2020 recommendations as a reference, studies with community-dwelling older adults, reporting the development and/or age disability modifications were included. Two reviewers analyzed the observational studies searched in the MEDLINE, CINAHL, Web of Science, Scopus, and Embase databases. Of the 137 potentially eligible studies, 49 were included in this review. Several indicators (instruments) demonstrated older adults’ disabilities according to the different domains of the ICF. Objective measures assessed Body Structures, Body Functions, and Environmental Factors and included handgrip strength (dynamometry, n = 8), cognitive function (Mini-Mental State examination, n = 7), gait speed (walk test, n = 6), and endurance (Chair stand-test, n = 4). Self-reported measures assessed Activities and Participation, but not the Body Structures, and included the basic and instrumental activities of daily living (ADL) (the Katz Index of ADL, n = 4 studies, the Lawton and Brody Instrumental ADL, n = 4 studies). The summary of the measures gathered can guide researchers and health professionals to select indicators (instruments) to assess and monitor older adults’ disabilities resulting from aging exposition, to support the development of new wearables, and to provide improvements to the existing ones, allowing the tailored assessment of different health and disability dimensions.
Aims.
The derivation of spectroscopic parameters for M dwarf stars is very important in the fields of stellar and exoplanet characterization. The goal of this work is the creation of an automatic ...computational tool able to quickly and reliably derive the
T
eff
and Fe/H of M dwarfs using optical spectra obtained by different spectrographs with different resolutions.
Methods.
ODUSSEAS (Observing Dwarfs Using Stellar Spectroscopic Energy-Absorption Shapes) is based on the measurement of the pseudo equivalent widths for more than 4000 stellar absorption lines and on the use of the machine learning Python package “scikit-learn” for predicting the stellar parameters.
Results.
We show that our tool is able to derive parameters accurately and with high precision, having precision errors of ~30 K for
T
eff
and ~0.04 dex for Fe/H. The results are consistent for spectra with resolutions of between 48 000 and 115 000 and a signal-to-noise ratio above 20.
A new thiazolyl peptide, kocurin (1), was isolated from culture broths of a marine-derived Kocuria palustris. Its structural elucidation was accomplished using a combination of spectroscopic and ...chemical methods, including HRMS, extensive 1D and 2D NMR analysis, MS/MS fragmentation, and chemical degradation and Marfey's analysis of the resulting amino acid residues. The structure herein reported corrects that previously assigned to PM181104 (3). Kocurin displayed activity against methicillin-resistant Staphylococcus aureus (MRSA), with MIC values in the submicromolar range.
Exposures to a wide spectrum of air pollutants were associated to several effects on children's health. Exposure assessment can be used to establish where and how air pollutants' exposures occur. ...However, a realistic estimation of children's exposures to air pollution is usually a great ethics challenge, especially for young children, because they cannot intentionally be exposed to contaminants and according to Helsinki declaration, they are not old enough to make a decision on their participation. Additionally, using adult surrogates introduces bias, since time–space–activity patterns are different from those of children. From all the different available approaches for exposure assessment, the microenvironmental (ME) modelling (indirect approach, where personal exposures are estimated or predicted from microenvironment measurements combined with time–activity data) seemed to be the best to assess children's exposure to air pollution as it takes into account the varying levels of pollution to which an individual is exposed during the course of the day, it is faster and less expensive. Thus, this review aimed to explore the use of the ME modelling approach methodology to assess children's exposure to air pollution. To meet this goal, a total of 152 articles, published since 2002, were identified and titles and abstracts were scanned for relevance. After exclusions, 26 articles were fully reviewed and main characteristics were detailed, namely: (i) study design and outcomes, including location, study population, calendar time, pollutants analysed and purpose; and (ii) data collection, including time–activity patterns (methods of collection, record time and key elements) and pollution measurements (microenvironments, methods of collection and duration and time resolution). The reviewed studies were from different parts of the world, confirming the worldwide application, and mostly cross-sectional. Longitudinal studies were also found enhancing the applicability of this approach. The application of this methodology on children is different from that on adults because of data collection, namely the methods used for collecting time–activity patterns must be different and the time–activity patterns are itself different, which leads to select different microenvironments to the data collection of pollutants' concentrations. The most used methods to gather information on time–activity patterns were questionnaires and diaries, and the main microenvironments considered were home and school (indoors and outdoors). Although the ME modelling approach in studies to assess children’s exposure to air pollution is highly encouraged, a validation process is needed, due to the uncertainties associated with the application of this approach.
•The effect of ILs as adjuvants in ABS composed of PEG and salts is investigated.•The partition behavior of antioxidants, alkaloids and amino acids is evaluated.•The influence of the IL is stronger ...in the partition of more hydrophobic biomolecules.•The partition of hydrophobic biomolecules is driven by differences in hydrophobicity.•There is a linear dependence between the partition of biomolecules and their KOW.
Aqueous biphasic systems (ABS) have been largely investigated for the extraction, separation and/or purification of biomolecules. Recently, the use of ionic liquids (ILs) as additives in conventional polymer-based ABS was proposed to overcome the limited range of polarities of the coexisting phases. However, the impact of ILs on the partitioning of biomolecules on IL additivated ABS is not universal and is still poorly understood. Aiming at obtaining additional insights on this matter, the effects of the chemical structure of the IL, tie-line length (TLL) and biomolecule nature upon the partition of a series of model biomolecules were investigated. For this purpose, ternary ABS (composed of polyethylene glycol (PEG) 400, citrate buffer at pH 7.0, and water), and several quaternary ABS (composed of PEG 400, citrate buffer at pH 7.0, water and ILs at 5wt%), were prepared using different chloride-based ILs (C4mimCl, C4mpyrCl, C4mpipCl, P4444Cl and N4444Cl). The partition of a wide range of biomolecules in these systems (gallic acid, vanillic acid, eugenol, nicotine, caffeine, l-tryptophan, l-phenylalanine and l-tyrosine), used here as molecular probes, was studied. These solutes were chosen due to their wide range of polarities. The results obtained support the concept that ILs, when used as adjuvants in polymer-based ABS, change the coexisting phases’ characteristics and modify the partition behavior of biomolecules. In general, a positive effect derived from the use of ILs as adjuvants in PEG-salt systems is observed, particularly when dealing with more hydrophobic biomolecules, whereas IL + salt ABS perform better in the extraction of more hydrophilic biomolecules. The favourable partition of more hydrophilic biomolecules in IL + salt ABS seems to be ruled by specific interactions with the IL, while the favourable partition of more hydrophobic biomolecules in PEG + salt and PEG + salt + IL seems to be governed by the differences in the phases hydrophobicities. It is shown that ILs preferentially migrate to the PEG-rich phase, and that there is a correlation between the partition coefficients of the biomolecules and ILs and the biomolecules octanol-water partition coefficients.
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