Miniaturized integrated spectrometers will have unprecedented impact on applications ranging from unmanned aerial vehicles to mobile phones, and silicon photonics promises to deliver compact, ...cost-effective devices. Mirroring its ubiquitous free-space counterpart, a silicon photonics-based Fourier transform spectrometer (Si-FTS) can bring broadband operation and fine resolution to the chip scale. Here we present the modeling and experimental demonstration of a thermally tuned Si-FTS accounting for dispersion, thermo-optic non-linearity, and thermal expansion. We show how these effects modify the relation between the spectrum and interferogram of a light source and we develop a quantitative correction procedure through calibration with a tunable laser. We retrieve a broadband spectrum (7 THz around 193.4 THz with 0.38-THz resolution consuming 2.5 W per heater) and demonstrate the Si-FTS resilience to fabrication variations-a major advantage for large-scale manufacturing. Providing design flexibility and robustness, the Si-FTS is poised to become a fundamental building block for on-chip spectroscopy.
Abstract The objective of the present study was to evaluate growth, biochemical, hematological and intestinal enzymes responses and survival of Nile tilapia juveniles fed a diet containing the ...essential oil of lemongrass Cymbopogum flexuosus (EOCF) and infected by Aeromonas hydrophila. Five diets were evaluated (in quadruplicate) with increasing levels of EOCF (0.0 - control; 0.25; 0.50; 1.0 and 2.0 mL kg diet-1). On day 45, eight fish per treatment were sampled and blood, liver and intestine samples were taken. Others eight fish per treatment were infected with A. hydrophila followed by a 15-day period of observation. Citral is the main constituent of EOCF. The inclusion of 2.0 mL EOCF kg diet-1 increased specific growth rate and survival after A. hydrophila infection and decreased feed conversion ratio of Nile tilapia. In general, higher concentrations of EOCF in the diet reduced plasma glucose and triglycerides levels, and increased plasma amino acids, alanine aminotransferase (ALT) and hepatic ALT levels, hematological parameters, and the activity of intestinal enzymes. It was concluded that the inclusion of 2.0 mL EOCF kg diet-1 improved growth performance, biochemical and physiological responses and decreased mortality of Nile tilapia after A. hydrophila infection.
Background
Microscopic inflammation and impairment of the esophageal epithelial barrier are considered relevant for perception of symptoms in patients with nonerosive reflux disease (NERD). In these ...patients, the receptor transient receptor potential vanilloid 1 (TRPV1) is overexpressed in the esophageal mucosa, but its role is not yet fully understood. We evaluated the role of TRPV1 in esophageal inflammation and mucosal barrier impairment in a murine model of NERD.
Methods
Nonerosive reflux disease was surgically induced in Swiss mice by pyloric substenosis and ligature of the gastric fundus, and the mice were killed 7 days post surgery. The experimental groups were: I, sham surgery (negative control); II, NERD untreated; III and IV, NERD + SB366791 or capsazepine (TRPV1 antagonists); and V, NERD + resiniferatoxin (for long‐term desensitization of TRPV1). The esophagus was collected for western blotting and histopathology and for evaluation of wet weight, myeloperoxidase (MPO), keratinocyte‐derived chemokine (KC), transepithelial electrical resistance (TEER), and basal permeability to fluorescein.
Key Results
Compared to sham, NERD mice had increased esophageal wet weight and MPO and KC levels. The mucosa had no ulcers but exhibited inflammation. NERD mice showed mucosal TRPV1 overexpression, a more pronounced decrease in TEER at pH 0.5 (containing pepsin and taurodeoxycholic acid), and increased basal permeability. Pharmacological modulation of TRPV1 prevented esophageal inflammation development, TEER changes by acidic exposure, and increase in esophageal permeability.
Conclusions & Inferences
The TRPV1 receptor has a critical role in esophageal inflammation and mucosal barrier impairment in NERD mice, suggesting that TRPV1 might be a pharmacological target in patients with NERD.
The TRPV1 receptor has a critical role in esophageal inflammation and mucosal barrier impairment in NERD mice, suggesting that TRPV1 might be a pharmacological target in patients with NERD.
The hydrological effects of forest cover loss are difficult to discern in the case of large‐scale basins with gradual changes and difficult to isolate when climate variability is also present. In the ...present study, we evaluated the effects of climate variability and human activity on the annual streamflow in a basin in the Amazon arc of deforestation. We statistically analyzed the components of the annual water balance and monthly streamflow and used the currently used Tomer‐Schilling, elasticity, and decomposition of Budyko‐type curve methods to separate climate‐induced changes and anthropogenic effects. Annual series of the monthly maximum and minimum streamflow, total streamflow, and total reference evapotranspiration presented statistically significant increasing trends. No significant trend was observed for precipitation. The greatest change in the average annual runoff coefficient was observed between the first (1973–1984) and second (1985–1994) analyzed periods. Even with the continuous reduction in the forested area, the third (1994–2004) and fourth analyzed periods (2003–2016) showed only relatively small changes, most likely due to the intensity of slash‐and‐burn activities and vegetation regrowth. The methods showed that deforestation was the primary cause of the streamflow changes, but with different intensities, and a small recuperation was observed in the last analyzed period. On average, the annual water yield would increase between 26% and 58% after the first time interval without the opposite effect of climate variability, which must be considered in basin management. Future research should focus on analyzing the water storage and the dependence of the precipitation‐runoff relationship from the climate.
Plain Language Summary
The effects of deforestation on water availability are difficult to discern in the case of large river basins and when there are also changes in the climate. We evaluated the effects of both, climate variability and human activities, on the annual average river flow in a water basin situated in the most deforested region of the Amazon biome. Statistical analyzes showed that there were significant increases in the average annual flow of the river and in the annual reference evapotranspiration (determined by the climate) during the years after the beginning of deforestation in the region, but not in precipitation. The greatest change in the percentage of precipitation that turns into streamflow was observed between the first (1973–1984) and second (1985–1994) analyzed periods. Even with the continuous of deforestation in the basin, the other periods (1994–2004 and 2003–2016) showed only relatively small changes, most likely due to vegetation regrowth. Three different methods showed that deforestation was the primary cause of the streamflow change, but annual streamflow would be between 26% and 58% greater without the opposite effect of climate. These results must be considered in the management of water resources in the region.
Key Points
Comparison of three methods to separate land use and climate‐induced effects on streamflow in the Itacaiúnas River basin was shown
We analyze that the intensity of slash‐and‐burn activities and vegetation regrowth, in addition to forested area, can help to explain the results
The methods show that deforestation is the primary cause of streamflow changes, but with different intensities
Brazil has a monitoring system to track annual forest conversion in the Amazon and most recently to monitor the Cerrado biome. However, there is still a gap of annual land use and land cover (LULC) ...information in all Brazilian biomes in the country. Existing countrywide efforts to map land use and land cover lack regularly updates and high spatial resolution time-series data to better understand historical land use and land cover dynamics, and the subsequent impacts in the country biomes. In this study, we described a novel approach and the results achieved by a multi-disciplinary network called MapBiomas to reconstruct annual land use and land cover information between 1985 and 2017 for Brazil, based on random forest applied to Landsat archive using Google Earth Engine. We mapped five major classes: forest, non-forest natural formation, farming, non-vegetated areas, and water. These classes were broken into two sub-classification levels leading to the most comprehensive and detailed mapping for the country at a 30 m pixel resolution. The average overall accuracy of the land use and land cover time-series, based on a stratified random sample of 75,000 pixel locations, was 89% ranging from 73 to 95% in the biomes. The 33 years of LULC change data series revealed that Brazil lost 71 Mha of natural vegetation, mostly to cattle ranching and agriculture activities. Pasture expanded by 46% from 1985 to 2017, and agriculture by 172%, mostly replacing old pasture fields. We also identified that 86 Mha of the converted native vegetation was undergoing some level of regrowth. Several applications of the MapBiomas dataset are underway, suggesting that reconstructing historical land use and land cover change maps is useful for advancing the science and to guide social, economic and environmental policy decision-making processes in Brazil.
Objective
An association between bipolar disorder and cognitive impairment has repeatedly been described, even for euthymic patients. Findings are inconsistent both across primary studies and ...previous meta‐analyses. This study reanalysed 31 primary data sets as a single large sample (N = 2876) to provide a more definitive view.
Method
Individual patient and control data were obtained from original authors for 11 measures from four common neuropsychological tests: California or Rey Verbal Learning Task (VLT), Trail Making Test (TMT), Digit Span and/or Wisconsin Card Sorting Task.
Results
Impairments were found for all 11 test‐measures in the bipolar group after controlling for age, IQ and gender (Ps ≤ 0.001, E.S. = 0.26–0.63). Residual mood symptoms confound this result but cannot account for the effect sizes found. Impairments also seem unrelated to drug treatment. Some test‐measures were weakly correlated with illness severity measures suggesting that some impairments may track illness progression.
Conclusion
This reanalysis supports VLT, Digit Span and TMT as robust measures of cognitive impairments in bipolar disorder patients. The heterogeneity of some test results explains previous differences in meta‐analyses. Better controlling for confounds suggests deficits may be smaller than previously reported but should be tracked longitudinally across illness progression and treatment.
This study assessed total mercury (THg) and methyl mercury (MeHg) concentrations, bioaccumulation and biomagnification of THg through the food web in fishes consumed by indigenous communities of ...Bacajá River, the largest tributary of the right bank of Xingu River. In total, 496 fish (22 species) were sampled. Nine species had THg concentrations above the limit recommended by the World Health Organisation (0·5 µg g−1 wet mass), and one exceeded the recommended level for Hg in predatory fishes by Brazilian law (1·0 µg g−1). The average concentration of THg increased significantly with trophic guild (herbivorous to piscivorous) and trophic level, with higher accumulation in fishes with greater total length. Ninety‐six per cent of all mercury was methylated. These results suggest that feeding habits determine THg concentrations in fishes and that Hg elimination rate is slow during growth, which allows greater accumulation. These findings show that fishes in the Bacajá River contain high concentrations of THg and MeHg.
This paper presents a life cycle assessment (LCA) comparing three forms of poly(lactic acid) (PLA) disposal: mechanical recycling, chemical recycling and composting. The LCA data was taken from lab ...scale experiments for composting and hydrolysis steps. Polymerization data in chemical recycling was obtained from computer simulation. Mechanical recycling data from lab scale were combined with the data from a plastics commercial mechanical recycling plant. The analysis considered two different product systems based on the input of the recycled PLA in the product system. Considering the categories: climate change, human toxicity and fossil depletion, the LCA showed that mechanical recycling presented the lowest environmental impact, followed by chemical recycling and composting. Among the forms of recycling, the most important input was the electricity consumption.
Protein 3-nitrotyrosine is a posttranslational modification found in many pathological conditions from acute to chronic diseases. Could 3-nitrotyrosine formation participate on the basis of these ...diseases or is it just a marker connected with the associated nitroxidative stress? In vitro and in vivo data, including proteomic research, show that protein tyrosine nitration is a selective process where only a small amount of proteins is found nitrated and one or a few tyrosine residues are modified in each. Accumulating data suggest a strong link between protein 3-nitrotyrosine and the mechanism involved in disease development. In this review, we analyze the factors determining protein 3-nitrotyrosine formation, the functional and biological outcome associated with protein tyrosine nitration, and the fate of the nitrated proteins.
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