Lead poisoning remains the most significant environmental health hazard for US children. An estimated 1.7 million children are already affected by lead from old paint and water pipes, among other ...things.
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Dostopno za:
DOBA, IZUM, KILJ, NUK, ODKLJ, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Cutaneous pleomorphic small T-cell lymphoma is a rare, recently recognized lymphoma, different from mycosis fungoides and Sézary syndrome. Only a few cases have been reported and no treatment ...modalities have been defined. We reviewed the clinical, histologic, immunohistochemical, molecular biologic, and follow-up data of 11 primary cutaneous pleomorphic small T-cell lymphomas.
The lesions presented as red purplish nodules, tumors, or plaques. The infiltrate consisted of small pleomorphic lymphoid cells without epidermotropism in nine patients and with a propensity to infiltrate the dermis and subcutaneous fat. Most cases were CD4+/CD8-. A T-cell clone was detected in the skin lesions of nine patients tested. The mean follow-up was 70.1 months and the median follow-up was 20 months. Ten patients are alive with three having persistent lesions. Interferon alfa-2a induced partial or complete remissions in five patients. Interferon alfa-2a combined with a regimen containing doxorubicin chlorhydrate induced a complete remission in a patient suffering a relapse after cyclophosphamide and interferon alone.
Cutaneous pleomorphic small T-cell lymphoma is a well-defined type of low-grade cutaneous lymphoma with favorable prognosis. Interferon and/or chemotherapy are the treatment of choice in patients with large tumor burden.
Blindness accompanied by another handicap does not invariably disqualify a child from benefiting from mobility education. A thorough evaluation must be made to determine whether and to what extent a ...child might benefit from lessons and how the additional handicap will necessitate a change in techniques. Work with multiply handicapped blind children may cause inhibitions on the part of parents and teachers. Therefore, for the child to receive value from the lessons, conferences are essential among parents, teachers, and the mobility instructors. Mobility instruction with a multiply handicapped blind child, as well as any blind child, involves more than the techniques of travel. Improvement of the self-image as a result of increased independence usually occurs. In addition, as a result of mobility instruction, children are better able to interact actively and directly with their environment and from it to acquire meaningful information.
