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zadetkov: 30
1.
  • Arsenic co-carcinogenesis: ... Arsenic co-carcinogenesis: Inhibition of DNA repair and interaction with zinc finger proteins
    Zhou, Xixi; Speer, Rachel M.; Volk, Lindsay ... Seminars in cancer biology, 11/2021, Letnik: 76
    Journal Article
    Recenzirano
    Odprti dostop

    Arsenic is widely present in the environment and is associated with various population health risks including cancers. Arsenic exposure at environmentally relevant levels enhances the mutagenic ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
2.
  • Transcription-coupled nucle... Transcription-coupled nucleotide excision repair: New insights revealed by genomic approaches
    Duan, Mingrui; Speer, Rachel M.; Ulibarri, Jenna ... DNA repair, 07/2021, Letnik: 103
    Journal Article
    Recenzirano
    Odprti dostop

    •Genome-wide DNA damage mapping methods reveal new insights into TC-NER.•Genome-scale CRISPR-Cas9 screens identify new TC-NER factors.•Mutational strand asymmetry provides important information to ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
3.
  • Arsenic and UVR co-exposure... Arsenic and UVR co-exposure results in unique gene expression profile identifying key co-carcinogenic mechanisms
    Speer, Rachel M; Yu, Hui; Zhou, Xixi ... Toxicology and applied pharmacology, 01/2024, Letnik: 482
    Journal Article
    Recenzirano

    Changes in gene expression underlie many pathogenic endpoints including carcinogenesis. Metals, like arsenic, alter gene expression; however, the consequences of co-exposures of metals with other ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
4.
  • Hexavalent Chromium Targets... Hexavalent Chromium Targets Securin to Drive Numerical Chromosome Instability in Human Lung Cells
    Toyoda, Jennifer H; Martino, Julieta; Speer, Rachel M ... International journal of molecular sciences, 12/2023, Letnik: 25, Številka: 1
    Journal Article
    Recenzirano
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    Hexavalent chromium Cr(VI) is a known human lung carcinogen with widespread exposure in environmental and occupational settings. Despite well-known cancer risks, the molecular mechanisms of ...
Celotno besedilo
Dostopno za: IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
5.
  • Arsenic and cancer: Evidence and mechanisms
    Speer, Rachel M; Zhou, Xixi; Volk, Lindsay B ... Advances in pharmacology (1990), 01/2023, Letnik: 96
    Journal Article
    Recenzirano

    Arsenic is a potent carcinogen and poses a significant health concern worldwide. Exposure occurs through ingestion of drinking water and contaminated foods and through inhalation due to pollution. ...
Celotno besedilo
Dostopno za: OILJ
6.
  • Particulate Hexavalent Chro... Particulate Hexavalent Chromium Inhibits E2F1 Leading to Reduced RAD51 Nuclear Foci Formation in Human Lung Cells
    Speer, Rachel M; Toyoda, Jennifer H; Croom-Perez, Tayler J ... Toxicological sciences, 04/2021, Letnik: 181, Številka: 1
    Journal Article
    Recenzirano
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    Abstract Lung cancer is the leading cause of cancer death; however, the mechanisms of lung carcinogens are poorly understood. Metals, including hexavalent chromium Cr(VI), induce chromosome ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK

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7.
  • A comparison of particulate... A comparison of particulate hexavalent chromium cytotoxicity and genotoxicity in human and leatherback sea turtle lung cells from a one environmental health perspective
    Speer, Rachel M.; Wise, Sandra S.; Croom-Perez, Tayler J. ... Toxicology and applied pharmacology, 08/2019, Letnik: 376
    Journal Article
    Recenzirano
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    Evaluating health risks of environmental contaminants can be better achieved by considering toxic impacts across species. Hexavalent chromium Cr(VI) is a marine pollutant and global environmental ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP

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8.
  • Transcriptomic analysis rev... Transcriptomic analysis reveals particulate hexavalent chromium regulates key inflammatory pathways in human lung fibroblasts as a possible mechanism of carcinogenesis
    Kouokam, J. Calvin; Speer, Rachel M.; Meaza, Idoia ... Toxicology and applied pharmacology, April 2024, 2024-Apr, 2024-04-00, 20240401, Letnik: 485
    Journal Article
    Recenzirano

    Hexavalent chromium Cr(VI) is considered a major environmental health concern and lung carcinogen. However, the exact mechanism by which Cr(VI) causes lung cancer in humans remains unclear. Since ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
9.
  • Particulate hexavalent chro... Particulate hexavalent chromium alters microRNAs in human lung cells that target key carcinogenic pathways
    Speer, Rachel M.; Meaza, Idoia; Toyoda, Jennifer H. ... Toxicology and applied pharmacology, 03/2022, Letnik: 438
    Journal Article
    Recenzirano
    Odprti dostop

    Hexavalent chromium Cr(VI) is a global environmental pollutant and human lung carcinogen. However, the mechanisms of Cr(VI) carcinogenesis are not well defined. Cr(VI)-altered gene expression has ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
10.
  • A whale of a tale: whale ce... A whale of a tale: whale cells evade the driving mechanism for hexavalent chromium-induced chromosome instability
    Lu, Haiyan; Toyoda, Jennifer H; Wise, Sandra S ... Toxicological sciences, 04/2024, Letnik: 199, Številka: 1
    Journal Article
    Recenzirano

    Chromosome instability, a hallmark of lung cancer, is a driving mechanism for hexavalent chromium Cr(VI) carcinogenesis in humans. Cr(VI) induces structural and numerical chromosome instability in ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK
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zadetkov: 30

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