This study was designed to assess the mechanical properties of two calcium carbonate tempers, limestone and burnt shell. These tempers have been previously compared, in separate studies, to ...silicate-based grit or sand temper and, relative to the latter, are assumed to possess similar mechanical properties. However, their simultaneous use at the Morrison Village site begs the question: do these two calcium carbonate tempers indeed possess similar mechanical properties? In order to assess their performance characteristics, a side-by-side controlled experimental test was conducted to determine the degree of similarity in providing increased vessel strength and toughness.
Standardized ceramic test samples were systematically prepared via a set, explicit protocol. An Instron Series IX universal testing machine configured with a four-point flexural test jig was used to perform a flexural strength test of the test samples. The Instron load and deflection data were used to calculate three values related to mechanical performance: peak load, modulus of rupture, and modulus of elasticity.
All four comparative tests clearly show substantial differences in peak load, modulus of rupture, and modulus of elasticity. These differences are statistically significant for each performance attribute in every iteration of the experiment and as indicated by Mann-Whitney U Tests.
These results do not support the hypothesis that limestone and burnt shell offer the same performance characteristics. These results have implications for our understanding of prehistoric human selection of temper and the evolution of ceramic technology. Although both carbonate-based tempers are currently thought to offer the same benefits during the initial phase of pottery production, their contrasting post firing properties would have provided distinct benefits in different contexts. Future assessments of the Morrison Village ceramic assemblage should focus on residue analysis, or other functional indicators, to support or falsify this hypothesis.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Declining mitochondrial function and homeostasis is a hallmark of aging. It is appreciated that the role of mitochondria is much more complex than generating reactive oxygen species to cause ...aging-related tissue damage. More recent literature describes that the ability of mitochondria to undergo fission or fusion events with each other impacts aging processes. A dynamic balance of mitochondrial fission and fusion events is required to sustain critical cellular functions including cell cycle. Specifically, cell cycle regulators modulate molecular activities of the mitochondrial fission (and fusion) machinery towards regulating cell cycle progression. In this review, we discus literature leading to our understanding on how shifts in the dynamic balance of mitochondrial fission and fusion can modulate progression through, exit from, and re-entry to the cell cycle or in undergoing senescence. Importantly, core regulators of mitochondrial fission or fusion are emerging as crucial stem cell regulators. We discuss the implication of such regulation in stem cells in the context of aging, given that aberrations in adult stem cells promote aging. We also propose a few hypotheses that may provide direction for further understanding about the roles of mitochondrial fission-fusion dynamics in aging biology.
•Mitochondria are dynamic organelles primarily due to their fission-fusion ability.•Mitochondrial fission-fusion dynamics is regulated during cell cycle.•Mitochondrial fission-fusion dynamics regulates cell cycle.•Mitochondrial fission-fusion influences stem cell self-renewal and differentiation.•Mitochondrial fission-fusion dynamics is modulated during aging.
Von Economo neurons (VENs) are specialized projection neurons with a characteristic spindle-shaped soma and thick basal and apical dendrites. VENs have been described in restricted cortical regions, ...with their most frequent appearance in layers III and V of the anterior cingulate cortex, anterior insula, and frontopolar cortex of humans, great apes, macaque monkeys, elephants, and some cetaceans. Recently, a ubiquitous distribution of VENs was reported in various cortical areas in the pygmy hippopotamus, one of the closest living relatives of cetaceans. That finding suggested that VENs might not be unique to only a few species that possess enlarged brains. In the present analysis, we assessed the phylogenetic distribution of VENs within species representative of the superordinal clade that includes cetartiodactyls and perissodactyls, as well as afrotherians. In addition, the distribution of fork cells that are often found in close proximity to VENs was also assessed. Nissl-stained sections from the frontal pole, anterior cingulate cortex, anterior insula, and occipital pole of bowhead whale, cow, sheep, deer, horse, pig, rock hyrax, and human were examined using stereologic methods to quantify VENs and fork cells within layer V of all four cortical regions. VENs and fork cells were found in each of the species examined here with species-specific differences in distributions and densities. The present results demonstrated that VENs and fork cells were not restricted to highly encephalized or socially complex species, and their repeated emergence among distantly related species seems to represent convergent evolution of specialized pyramidal neurons. The widespread phylogenetic presence of VENs and fork cells indicates that these neuron morphologies readily emerged in response to selective forces,whose variety and nature are yet to be identified.
Upright walking absent a bent-hip-bent-knee gait requires lumbar lordosis, a ubiquitous feature in all hominids for which it can be observed. Its first appearance is therefore a central problem in ...human evolution. Atelids, which use the tail during suspension, exhibit demonstrable lordosis and can achieve full extension of their hind limbs during terrestrial upright stance. Although obviously homoplastic with hominids, the pelvic mechanisms facilitating lordosis appear largely similar in both taxa with respect to abbreviation of upper iliac height coupled with broad sacral alae. Both provide spatial separation of the most caudal lumbar(s) from the iliac blades. A broad sacrum is therefore a likely facet of earliest hominid bipedality. All tailed monkeys have broad alae. By contrast all extant apes have very narrow sacra, which promote "trapping" of their most caudal lumbars to achieve lower trunk rigidity during suspension. The alae in the tailless proconsul Ekembo nyanzae appear to have been quite broad, a character state that may have been primitive in Miocene hominoids not yet adapted to suspension and, by extension, exaptive for earliest bipedality in the hominid/panid last common ancestor. This hypothesis receives strong support from other anatomical systems preserved in Ardipithecus ramidus.
BACKGROUND:The precise etiology of cam impingement continues to be incompletely understood. The prevailing hypothesis posits that the deformity arises as a developmental injury prior to skeletal ...maturation. There is a possible evolutionary role, with an aspherical femoral head affording upright humans better stability. We set out to identify the antiquity of the cam deformity to better understand the comparative roles of modern behavior and evolution in its development.
METHODS:We used 249 physical specimens of femora from the Libben osteological collection, a set of bones from an ancient population who lived between the eighth and the eleventh century. These femora were photographed in four different orientations, and six specific proximal femoral angles were measured. The values were also compared with those from modern human femora using the Student t test, with a two-tailed p value of 0.05 denoting significance.
RESULTS:In total, 249 femora from 175 individuals were included in the final analysis. The ages of the individuals ranged between seventeen and fifty-five years. Interobserver and intraobserver correlation was good or excellent for all variables measured. Compared with modern populations, ancient human hips were significantly more anteverted (19.96° versus 12.85°; p < 0.001) and varus (true neck-shaft angle, 121.96° versus 129.23°; p < 0.001). The alpha angle was significantly lower in ancient humans (35.33° versus 45.61°; p < 0.001), and none of the ancient femora met the modern criteria for a cam deformity (an alpha angle of >50°).
CONCLUSIONS AND CLINICAL RELEVANCE:It appears that the cam deformity was nonexistent among ancient humans and is perhaps predominantly a product of modern-day stresses. Further clinical investigation into behavioral modifications in adolescence is warranted to potentially prevent the development of deformity and impingement.
Caves and Culture Spurlock, Linda B; Prufer, Olaf H; Pigott, Thomas R
2013
eBook
A collection of the last forty years of research on Ohio's caves and rockshelters Caves and Culture seeks to address a number of important problems, specifically the use of rockshelters by humans ...through time and transcontinental continuities. It presents new and updated, unreported research from such Ohio caves and rockshelters as Stow Rockshelter (Stow), Peters Cave (Ross County), Hendricks Cave (Wyandotte County), and Chesser Cave (Athens), among others. Caves and Culture is primarily focused on the archaeological research of Dr. Olaf H. Prufer and his associates as they investigated and explored caves in Ohio since 1964. Spurlock and her co-editors report, sometimes reclaim, and frequently reinterpret data that will be useful to the understanding of Ohio archaeology for decades to come. Anyone with interest in local or regional (Midwestern or midcontinental) prehistory will appreciate this exploration into Ohio's history.
The Antiquity of the Cam Deformity Moats, Allison R., BS; Badrinath, Raghav, BS; Cooperman, Daniel, MD ...
Journal of bone and joint surgery. American volume,
08/2015, Letnik:
97, Številka:
16
Journal Article
Recenzirano
Background The precise etiology of cam impingement continues to be incompletely understood. The prevailing hypothesis posits that the deformity arises as a developmental injury prior to skeletal ...maturation. There is a possible evolutionary role, with an aspherical femoral head affording upright humans better stability. We set out to identify the antiquity of the cam deformity to better understand the comparative roles of modern behavior and evolution in its development. Methods We used 249 physical specimens of femora from the Libben osteological collection, a set of bones from an ancient population who lived between the eighth and the eleventh century. These femora were photographed in four different orientations, and six specific proximal femoral angles were measured. The values were also compared with those from modern human femora using the Student t test, with a two-tailed p value of 0.05 denoting significance. Results In total, 249 femora from 175 individuals were included in the final analysis. The ages of the individuals ranged between seventeen and fifty-five years. Interobserver and intraobserver correlation was good or excellent for all variables measured. Compared with modern populations, ancient human hips were significantly more anteverted (19.96° versus 12.85°; p < 0.001) and varus (true neck-shaft angle, 121.96° versus 129.23°; p < 0.001). The alpha angle was significantly lower in ancient humans (35.33° versus 45.61°; p < 0.001), and none of the ancient femora met the modern criteria for a cam deformity (an alpha angle of >50°). Conclusions and Clinical Relevance It appears that the cam deformity was nonexistent among ancient humans and is perhaps predominantly a product of modern-day stresses. Further clinical investigation into behavioral modifications in adolescence is warranted to potentially prevent the development of deformity and impingement.
Gene knockout of the master regulator of mitochondrial fission, Drp1, prevents neoplastic transformation. Also, mitochondrial fission and its opposing process of mitochondrial fusion are emerging as ...crucial regulators of stemness. Intriguingly, stem/progenitor cells maintaining repressed mitochondrial fission are primed for self-renewal and proliferation. Using our newly derived carcinogen transformed human cell model, we demonstrate that fine-tuned Drp1 repression primes a slow cycling 'stem/progenitor-like state', which is characterized by small networks of fused mitochondria and a gene-expression profile with elevated functional stem/progenitor markers (Krt15, Sox2 etc) and their regulators (Cyclin E). Fine tuning Drp1 protein by reducing its activating phosphorylation sustains the neoplastic stem/progenitor cell markers. Whereas, fine-tuned reduction of Drp1 protein maintains the characteristic mitochondrial shape and gene-expression of the primed 'stem/progenitor-like state' to accelerate neoplastic transformation, and more complete reduction of Drp1 protein prevents it. Therefore, our data highlights a 'goldilocks' level of Drp1 repression supporting stem/progenitor state dependent neoplastic transformation.
We report the observation of the doubly strange b baryon Omega_b- in the decay channel Omega_b- to J/psi Omega-, with J/psi to mu+ mu- and Omega- to Lambda K-, in $p\bar{p}$ collisions at ...$\sqrt{s}=1.96$ TeV. Using approximately 1.3 fb$^{-1}$ of data collected with the D0 detector at the Fermilab Tevatron Collider, we observe 17.8 +/- 4.9 (stat) +/- 0.8 (syst) Omega_b- signal events at a mass of 6.165 +/- 0.010 (stat) +/- 0.013(syst.) GeV. The significance of the observed signal is 5.4 sigma, corresponding to a probability of 6.7 x 10^{-8} of it arising from a background fluctuation.
Purpose This study was designed to assess the mechanical properties of two calcium carbonate tempers, limestone and burnt shell. These tempers have been previously compared, in separate studies, to ...silicate-based grit or sand temper and, relative to the latter, are assumed to possess similar mechanical properties. However, their simultaneous use at the Morrison Village site begs the question: do these two calcium carbonate tempers indeed possess similar mechanical properties? In order to assess their performance characteristics, a side-by-side controlled experimental test was conducted to determine the degree of similarity in providing increased vessel strength and toughness. Methods Standardized ceramic test samples were systematically prepared via a set, explicit protocol. An Instron Series IX universal testing machine configured with a four-point flexural test jig was used to perform a flexural strength test of the test samples. The Instron load and deflection data were used to calculate three values related to mechanical performance: peak load, modulus of rupture, and modulus of elasticity. Results All four comparative tests clearly show substantial differences in peak load, modulus of rupture, and modulus of elasticity. These differences are statistically significant for each performance attribute in every iteration of the experiment and as indicated by Mann-Whitney U Tests. Conclusions These results do not support the hypothesis that limestone and burnt shell offer the same performance characteristics. These results have implications for our understanding of prehistoric human selection of temper and the evolution of ceramic technology. Although both carbonate-based tempers are currently thought to offer the same benefits during the initial phase of pottery production, their contrasting post firing properties would have provided distinct benefits in different contexts. Future assessments of the Morrison Village ceramic assemblage should focus on residue analysis, or other functional indicators, to support or falsify this hypothesis.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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