Biochar is known for the improvement of soil health, fertility, crop productivity, and quality in many agro-ecosystems globally, but information regarding fodder yield, quality, and soil microbial ...activity responses to biochar application remains very limited. The objective of this study was to prepare biochar from invasive weeds, i.e., Parthenium hysterophorus L. and Lantana camara L., and use it as a soil amendment along with inorganic fertilizers for oats (Avena sativa L.) growth, fodder yield, quality, and soil microbial activities in a two-year pot experiment. Treatments were comprised of control, 100% RDF (Recommended dose of fertilizers), 75% RDF along with three doses (2.5, 5.0, and 10 t/ha) of Parthenium hysterophorus L. biochar (PB) and Lantana camara L. biochar (LB), PB (10 t/ha), and LB (10 t/ha). Results showed that application of 75% RDF along with 10 t/ha LB gave significantly higher green (∼8%) and dry (∼7.8%) fodder yield and crude protein (∼6%) and decreased acid detergent fibre (ADF) and neutral detergent fibre (NDF) by 5.70 and 6.04% as compared to the 100% RDF treatment. The same treatment had a significantly higher population of bacteria (7.33 × 108 colony forming unit (CFU)/g soil), alkaline phosphatase activity (19.56 μg pNP/g soil/h), microbial biomass carbon (156.67 μg/g soil) and dehydrogenase activity (12.59 μg TPF/g/24 h), whereas the maximum fungal population (13.33 × 104 CFU/g soil) and acid phosphatase activity (14.45 μg pNP/g soil/h) were found in 75% RDF along with 10 t/ha PB and control treatment, respectively. This study concluded that application of invasive weed biochar along with inorganic fertilizers can benefit fodder yield and quality of oats by increasing plant height and number of tillers directly and by improving nutrient availability and water holding capacity (WHC) of soil indirectly, besides improving soil health. The findings from this study will provide a potential strategy for invasive weed management.
•LB was moderately superior to PB in terms of fodder yield and quality.•Application of biochar at 2.5 t/ha saved 25% fertilizers.•Biochars applied plots had higher soil enzymatic activities than fertilizer alone.•Making biochar would be a promising way to manage invasive weeds for environmental sustainability.
The homeobox gene Prox1 is crucial for mammalian lymphatic vascular development. In the absence of Prox1, lymphatic endothelial cells (LECs) are not specified. The maintenance of LEC identity also ...requires the constant expression of Prox1. However, the mechanisms controlling the expression of this gene in LECs remain poorly understood. The SRY-related gene Sox18 is required to induce Prox1 expression in venous LEC progenitors. Although Sox18 is also expressed in embryonic arteries, these vessels do not express Prox1, nor do they give rise to LECs. This finding suggests that some venous endothelial cell-specific factor is required for the activation of Prox1. Here we demonstrate that the nuclear hormone receptor Coup-TFII is necessary for the activation of Prox1 in embryonic veins by directly binding a conserved DNA domain in the regulatory region of Prox1. In addition, we show that the direct interaction between nuclear hormone receptors and Prox1 is also necessary for the maintenance of Prox1 expression during early stages of LEC specification and differentiation.
•Mn1-xZnxFe2O4 nanoparticles were successfully prepared by co-precipitation method.•Phase analysis confirms the cubic spinel structure.•Crystallite size and lattice constant decreases with increasing ...zinc concentration.•Magnetic properties are decreasing with increasing zinc concentration.•Faraday rotation and Verdet constant decreases with increasing zinc substitution.
Mn1-xZnxFe2O4 nanoparticles (x=0.1, 0.3, 0.5, 0.7 and 0.9) were synthesized using chemical co-precipitation method. X-ray diffraction (XRD) analysis confirmed the cubic spinel structure of synthesized nanoparticles. The crystallite size and lattice parameter were found to decrease with increase in zinc substitution. Surface morphology by scanning electron microscope (SEM) and energy dispersive analysis of X-ray (EDAX) confirmed the presence of substituted metal ions in all the samples. Magnetic parameters at room temperature using vibrating sample magnetometer (VSM) are found to decrease with increasing zinc substitution. Faraday rotation of Mn1-xZnxFe2O4 nanoferrofluids is found to vary with zinc substitution under applied magnetic field. Verdet constant obtained from Faraday rotation are found to vary from 5.35 to 2.71deg./Tcm with zinc substitution.
Not all obese adults have cardiometabolic abnormalities. It is unknown whether this is true in children and, if true, whether children who have metabolically healthy overweight/obesity (MHO) will ...also have favorable cardiometabolic profiles in adulthood. These aspects were examined in 1,098 individuals who participated as both children (aged 5-17 years) and adults (aged 24-43 years) in the Bogalusa Heart Study between 1997 and 2002 in Bogalusa, Louisiana. MHO was defined as being in the top body mass index quartile, while low density lipoprotein cholesterol, triglycerides, mean arterial pressure, and glucose were in the bottom 3 quartiles, and high density lipoprotein cholesterol was in the top 3 quartiles. Forty-six children (4.2%) had MHO, and they were more likely to retain MHO status in adulthood compared with children in other categories (P < 0.0001). Despite markedly increased obesity in childhood and in adulthood, these same MHO children and adults showed a cardiometabolic profile generally comparable to that of nonoverweight/obese children (P > 0.05 in most cases). Moreover, there was no difference in carotid intima-media thickness in adulthood between MHO children and nonoverweight/obese children. Further, carotid intima-media thickness in adulthood was lower in MHO children than in metabolically abnormal, overweight/obese children (P = 0.003). In conclusion, the MHO phenotype starts in childhood and continues into adulthood.
The circulatory system consists of the heart, blood vessels and lymphatic vessels, which function in parallel to provide nutrients and remove waste from the body. Vascular function depends on valves, ...which regulate unidirectional fluid flow against gravitational and pressure gradients. Severe valve disorders can cause mortality and some are associated with severe morbidity. Although cardiac valve defects can be treated by valve replacement surgery, no treatment is currently available for valve disorders of the veins and lymphatics. Thus, a better understanding of valves, their development and the progression of valve disease is warranted. In the past decade, molecules that are important for vascular function in humans have been identified, with mouse studies also providing new insights into valve formation and function. Intriguing similarities have recently emerged between the different types of valves concerning their molecular identity, architecture and development. Shear stress generated by fluid flow has also been shown to regulate endothelial cell identity in valves. Here, we review our current understanding of valve development with an emphasis on its mechanobiology and significance to human health, and highlight unanswered questions and translational opportunities.
Summary
Short leukocyte telomere length (LTL) is associated with atherosclerosis in adults and diminished survival in the elderly. LTL dynamics are defined by LTL at birth, which is highly variable, ...and its age‐dependent attrition thereafter, which is rapid during the first 20 years of life. We examined whether age‐dependent LTL attrition during adulthood can substantially affect individuals' LTL ranking (e.g., longer or shorter LTL) in relation to their peers. We measured LTL in samples donated 12 years apart on average by 1156 participants in four longitudinal studies. We observed correlations of 0.91–0.96 between baseline and follow‐up LTLs. Ranking individuals by deciles revealed that 94.1% (95% confidence interval of 92.6–95.4%) showed no rank change or a 1 decile change over time. We conclude that in adults, LTL is virtually anchored to a given rank with the passage of time. Accordingly, the links of LTL with atherosclerosis and longevity appear to be established early in life. It is unlikely that lifestyle and its modification during adulthood exert a major impact on LTL ranking.
A large component of the Indian economy is still in the unorganised (or informal) sector. The emergence of new intermediaries leveraging the Internet has contributed significantly to organising the ...hitherto unorganised sector. We discuss the case of the Indian real estate industry and elucidate how Internet-based intermediaries have mitigated the problems associated with the unorganised nature of the industry. The three primary problems associated with the unorganised nature of the industry are adverse selection, moral hazard, and weak contract enforcement. Leaders representing four leading real estate platforms discuss how organising the real estate business as a platform business model helps mitigate these risks.
This study attempts to integrate a Surface Water (SW) model Soil and Water Assessment Tool (SWAT) with an existing steady-state, single layer, unconfined heterogeneous aquifer Analytic Element Method ...(AEM) based Ground Water (GW) model, named Bluebird AEM engine, for a comprehensive assessment of SW and GW resources and its management. The main reason for integrating SWAT with the GW model is that the SWAT model does not simulate the distribution and dynamics of GW levels and recharge rates. To overcome this issue, often the SWAT model is coupled with the numerical GW model (either using MODFLOW or FEFLOW), wherein the spatial and temporal patterns of the interactions are better captured and assessed. However, the major drawback in integrating the two models (SWAT with—MODFLOW/FEM) is its conversion from Hydrological Response Unit’s (HRU)/sub-basins to grid/elements. To couple them, a spatial translation system is necessary to move the inputs and outputs back and forth between the two models due to the difference in discretization. Hence, for effective coupling of SW and GW models, it may be desirable to have both models with a similar spatial discretization and reduce the need for rigorous numerical techniques for solving the PDEs. The objective of this paper is to test the proof of concept of integrating a distributed hydrologic model with an AEM model at the same spatial units, primarily focused on surface water and groundwater interaction with a shallow unconfined aquifer. Analytic Element Method (AEM) based GW models seem to be ideal for coupling with SWAT due to their innate character to consider the HRU, sub-basin, River, and lake boundaries as individual analytic elements directly without the need for any further discretization or modeling units. This study explores the spatio-temporal patterns of groundwater (GW) discharge rates to a river system in a moist-sub humid region with SWAT-AEM applied to the San Jacinto River basin (SJRB) in Texas. The SW-GW interactions are explored throughout the watershed from 2000–2017 using the integrated SWAT-AEM model, which is tested against stream flow and GW levels. The integrated SWAT-AEM model results show good improvement in predicting the stream flow (R2 = 0.65–0.80) and GW levels as compared to the standalone SWAT model. Further, the integrated model predicted the low flows better compared to the standalone SWAT model, thus accounting for the SW-GW interactions. Almost 80% of the stream network experiences an increase in groundwater discharge rate between 2000 and 2017 with an annual average GW discharge rate of 1853 Mm3/year. The result from the study seems promising for potential applications of SWAT-AEM coupling in regions with considerable SW-GW interactions.
Water resource development opens up opportunities for improving smallholder farmer livelihoods in sub-Saharan Africa; however, implementation of water resource interventions to ensure sustainability ...hinges on the availability of sufficient quantity and quality data for monitoring, analysis and planning. Such data is often acquired through instrumentation of water resources (e.g. stream flow monitoring) or the use of hydrological models. In sub-Saharan Africa, data scarcity has limited the ability to monitor and make appropriate decisions for water resource allocation and use. Data derived from remote sensing has been considered a viable option to fill this gap; however, there is limited research in the region that evaluate the quality of the remotely sensed based datasets. This study evaluated actual evapotranspiration (AET) estimates derived from Advanced Very High Resolution Radiometer (AVHRR AET) images and Moderate Resolution Imaging Spectrometer (MOD16 AET) images using estimates from a grid-based Soil and Water Assessment Tool (SWAT). The SWAT model was set up for the entire country of Ethiopia, and calibrated and validated using observed streamflow at several meso-scale watersheds in which satisfactory model performance was obtained. AET estimates from the calibrated and validated SWAT model were then used to evaluate remotely sensed based AET for three landscapes. The AVHRR AET better agreed with the SWAT-simulated AET than the MOD16 AET, although the AVHRR AET overestimated the SWAT-simulated AET in all of the landscapes. Both remotely sensed AET products showed better agreement with the SWAT-simulated AET over agriculture dominated landscapes compared to grassland and forest dominated landscapes. The findings of the study suggest that remotely sensed based AET may help to fine-tune hydrological models in agricultural landscapes in data-scarce regions to improve studies on the impacts of water management interventions aiming to ensure environmental sustainability while enhancing agricultural production, and household income and nutrition.
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•AVHRR AET was better than MOD16 AET compared to SWAT-simulated AET.•Both AET products performed well over agriculture dominated landscapes.•Both AET products performed poorly in forest dominated and bimodal rainfall areas.•RS AET is promising to study water management in rainfed farming systems in Africa.
Purpose
The present study made an attempt to develop copper nanoparticles (Cu-NP) with antifungal property using green synthesis method. Copper oxide nanoparticles (CuO-NPs) botanically synthesized ...using Neem leaf extract (
Azadirachta indica
A. Juss) were characterized by using different techniques like; UV–visible spectrophotometry, FTIR, XRD, SEM and TEM.
Methods
Materials were chosen the disease free and fresh
Azadirachta indica
A. Juss were collected and identified at Center of Biodiversity and Taxonomy. The plant samples were vigorously washed with distilled water then shade dried followed by sterilization with 0.1% mercuric chloride for 20 s and again it was washed with distilled water. 15 g powder form of plant material was added to 200 ml double distilled, CO
2
free and deionized water and kept in shaker at 80°C and 1500 rpm for six hours. After agitation, the extract was separated by regular centrifugation at 10,000 rpm followed by filtration by using whatmann filter paper. The final volume of 100 ml of supernatant was collected as pure extract and stored in cool place for further use.
Results
The final results confirm a significant inhibition of CuO-NPs for the test fungi. Additionally, CuO-NPs demonstrated an enhanced effect when combined with Neem leaf extract. A total of 20–30% improvement in activity was noticed after combination, which correlates with commonly used synthetic fungicides. The toxicity results reveal that
A. indica
extract and their combined fractions with CuO-NP were less toxic to the test seeds of experimental plant while as bulk Cu followed by biosynthesized CuO-NPs influenced the germination rate as compared to control pots.
Conclusions
The study drops a concern of research and offers a promising route of developing Copper based green fungicides that can help to combat with modern issues of synthetic fungicides. An average size of 80 ± 15 nm monoclinic cupric oxide (CuO) and cubic cuprous oxides (Cu
2
O) nanocrystals that existed in mixed form were successfully developed.
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