This study investigated longitudinal patterns of psychological distress in adult survivors of childhood cancer.
Participants included 4569 adult survivors in the Childhood Cancer Survivor Study ...Cohort (CCSS) who completed the Brief Symptom Inventory-18 on three occasions between 1994 and 2010. Longitudinal latent class analysis was used to identify discrete classes of psychological distress. Predictors of class membership were examined through logistic regression modelling with odds ratios (ORs) and 95% confidence intervals (CIs) reported.
Survivors were a median of 39 years of age and 30 years from diagnosis at the most recent follow-up. Most survivors reported few or no symptoms of distress over time, although subsets of survivors reported persistently elevated (depression: 8.9%; anxiety: 4.8%; somatisation: 7.2%) or significant increases in distress symptoms over the follow-up period (depression: 10.2%; anxiety: 11.8%; somatisation: 13.0%). Increasing distress symptoms were predicted by survivor perception of worsening physical health over time (depression: OR=3.3; 95% CI=2.4-4.5; anxiety: OR=3.0; 95% CI=2.2-4.0; somatisation: OR=5.3; 95% CI=3.9-7.4). Persistent distress symptoms were also predicted by survivor perception of worsening physical health over time, as well as by worsening pain and ending analgesic use.
Subgroups of adult survivors are at-risk for chronic distress or significant increases in distress decades following their original cancer diagnosis. Routine screening of psychological distress in adult survivors of childhood cancer is warranted, especially for survivors who experience physical health morbidities.
Pigeonpea (Cajanus cajan), an important food legume crop in the semi-arid regions of the world and the second most important pulse crop in India, has an average crop productivity of 780 kg/ha. The ...relatively low crop yields may be attributed to non-availability of improved cultivars, poor crop husbandry and exposure to a number of biotic and abiotic stresses in pigeonpea growing regions. Narrow genetic diversity in cultivated germplasm has further hampered the effective utilization of conventional breeding as well as development and utilization of genomic tools, resulting in pigeonpea being often referred to as an ‘orphan crop legume'. To enable genomics-assisted breeding in this crop, the pigeonpea genomics initiative (PGI) was initiated in late 2006 with funding from Indian Council of Agricultural Research under the umbrella of Indo-US agricultural knowledge initiative, which was further expanded with financial support from the US National Science Foundation's Plant Genome Research Program and the Generation Challenge Program. As a result of the PGI, the last 3 years have witnessed significant progress in development of both genetic as well as genomic resources in this crop through effective collaborations and coordination of genomics activities across several institutes and countries. For instance, 25 mapping populations segregating for a number of biotic and abiotic stresses have been developed or are under development. An 11X-genome coverage bacterial artificial chromosome (BAC) library comprising of 69,120 clones have been developed of which 50,000 clones were end sequenced to generate 87,590 BAC-end sequences (BESs). About 10,000 expressed sequence tags (ESTs) from Sanger sequencing and ca. 2 million short ESTs by 454/FLX sequencing have been generated. A variety of molecular markers have been developed from BESs, microsatellite or simple sequence repeat (SSR)-enriched libraries and mining of ESTs and genomic amplicon sequencing. Of about 21,000 SSRs identified, 6,698 SSRs are under analysis along with 670 orthologous genes using a GoldenGate SNP (single nucleotide polymorphism) genotyping platform, with large scale SNP discovery using Solexa, a next generation sequencing technology, is in progress. Similarly a diversity array technology array comprising of ca. 15,000 features has been developed. In addition, >600 unique nucleotide binding site (NBS) domain containing members of the NBS-leucine rich repeat disease resistance homologs were cloned in pigeonpea; 960 BACs containing these sequences were identified by filter hybridization, BES physical maps developed using high information content fingerprinting. To enrich the genomic resources further, sequenced soybean genome is being analyzed to establish the anchor points between pigeonpea and soybean genomes. In addition, Solexa sequencing is being used to explore the feasibility of generating whole genome sequence. In summary, the collaborative efforts of several research groups under the umbrella of PGI are making significant progress in improving molecular tools in pigeonpea and should significantly benefit pigeonpea genetics and breeding. As these efforts come to fruition, and expanded (depending on funding), pigeonpea would move from an ‘orphan legume crop' to one where genomics-assisted breeding approaches for a sustainable crop improvement are routine.
The primary objective of this study was to evaluate the performance of the time-domain reflectometry (TDR) technique for daily evapotranspiration estimation of peanut and maize crop in a sub-humid ...region. Four independent methods were used to estimate crop evapotranspiration (ET
c
), namely, soil water balance budgeting approach, energy balance approach—(Bowen ratio), empirical methods approach, and Pan evaporation method. The soil water balance budgeting approach utilized the soil moisture measurement by gravimetric and TDR method. The empirical evapotranspiration methods such as combination approach (FAO-56 Penman–Monteith and Penman), temperature-based approach (Hargreaves–Samani), and radiation-based approach (Priestley–Taylor, Turc, Abetw) were used to estimate the reference evapotranspiration (ET
0
). The daily ET
c
determined by the FAO-56 Penman-Monteith, Priestley-Taylor, Turc, Pan evaporation, and Bowen ratio were found to be at par with the ET values derived from the soil water balance budget; while the methods Abetw, Penman, and Hargreaves-Samani were not found to be ideal for the determination of ET
c
. The study illustrates the in situ applicability of the TDR method in order to make it possible for a user to choose the best way for the optimum water consumption for a given crop in a sub-humid region. The study suggests that the FAO-56 Penman–Monteith, Turc, and Priestley–Taylor can be used for the determination of crop ET
c
using TDR in comparison to soil water balance budget.
Maintaining software reliability is the key idea for conducting quality research. This can be done by having less complex applications. While developers and other experts have made significant ...efforts in this context, the level of reliability is not the same as it should be. Therefore, further research into the most detailed mechanisms for evaluating and increasing software reliability is essential. A significant aspect of growing the degree of reliable applications is the quantitative assessment of reliability. There are multiple statistical as well as soft computing methods available in literature for predicting reliability of software. However, none of these mechanisms are useful for all kinds of failure datasets and applications. Hence finding the most optimal model for reliability prediction is an important concern. This paper suggests a novel method to substantially pick the best model of reliability prediction. This method is the combination of analytic hierarchy method (AHP), hesitant fuzzy (HF) sets and technique for order of preference by similarity to ideal solution (TOPSIS). In addition, using the different iterations of the process, procedural sensitivity was also performed to validate the findings. The findings of the software reliability prediction models prioritization will help the developers to estimate reliability prediction based on the software type.
We describe here the synthesis of a novel magnetic drug-targeting carrier characterized by a core−shell structure. The core−shell carrier combines the advantages of a magnetic core and the ...stimuli-responsive property of the thermosensitive biodegradable polymer shell (e.g., an on−off mechanism responsive to external temperature change). The composite nanoparticles are ∼8 nm in diameter with ∼3 nm shell. The lower critical solution temperature (LCST) is ∼38 °C as determined by UV−vis absorption spectroscopy. The carrier is composed of cross-linked dextran grafted with a poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide) dextran-g-poly(NIPAAm-co-DMAAm) shell and superparamagnetic Fe3O4 core. Fourier transform infrared spectroscopy (FTIR) confirmed the composition of the carrier. The synthesized magnetic carrier system has potential applications in magnetic drug-targeting delivery and magnetic resonance imaging.
Silica gel chitosan composite was prepared to perform adsorptive experiment of different heavy metal ion solutions. The characterization of chitosan + silica gel (Ch + Sg) composite was done by FTIR ...and SEM–EDS to understand the presence of active sites and to have an insight on the surface morphology. The adsorption study of heavy metal ions by Ch + Sg composite gives maximum removal percent for Cu, Pb and Ni which were obtained at pH 5 and for Hg at pH 6.The trend of removal by Ch + Sg signifies that maximum removal percent was attained at 120 min. The surface of Ch + Sg is heterogeneous for the adsorption of Hg, Ni and Cu and homogeneous for Pb adsorption. The values obtained for Pb signify that its adsorption best fitted to pseudo first order with the
R
2
value of 0.986, whereas pseudo second order best fitted to the experimental data of Cu, Ni and Hg as
R
2
values which are 0.983, 0.819 and 0.957 respectively. The values of change in entropy (⊿S) obtained for Pb, Cu, Ni and Hg are − 69.33, − 118, − 63.33 and − 98.52 J/mol K respectively. Negative values of change in enthalpy, ⊿H in (kJ/mol) are in the range of − 18.2 to − 37.66 which indicates both physical and chemical adsorption involves in the process of adsorption.
The rapid development of efficient and cost-effective catalysts is essential for the oxygen evolution reaction. Herein, nanostructured spinels LiMn
2
O
4
, delithiated λ-MnO
2
, and Li
4
Mn
5
O
12
...have been synthesized at low temperatures and are investigated as electrocatalysts for alkaline water oxidation reactions. Among the nanostructured spinels, LiMn
2
O
4
, delithiated λ-MnO
2
, and Li
4
Mn
5
O
12
, the former spinel which is classical LiMn
2
O
4
with 1/6th of the Mn replaced by Li outperforms for the OER that shows a current density of 5 mA cm
−2
at a lowest overpotential of 430 mV and Tafel slope of 74 mV per decade. Electrochemical impedance studies revealed the least value of charge transfer resistance of the Li
4
Mn
5
O
12
spinel and suggest fast reaction kinetics for the oxygen evolution reaction as compared to other spinels. The XPS and TEM of Li
4
Mn
5
O
12
, recorded after a 12-hour stability test for oxygen evolution activity, confirm that the oxidation state of Mn and the morphology of Li
4
Mn
5
O
12
remain intact even after the electrocatalytic reaction, however, it undergoes amorphization. The higher activity of Li
4
Mn
5
O
12
synthesized in the present work is attributed to the low temperature synthesis resulting in the formation of a nanostructured Li rich spinel with a high surface area, along with an increased percentage of ionic bonding and the presence of 3D Li diffusion channels. The role of Li was further supported by XPS studies that revealed a shift in Li 1s binding energy as well as quantitative reduction relative to Mn for Li
4
Mn
5
O
12
after a long term test.
The rapid development of efficient and cost-effective catalysts is essential for the oxygen evolution reaction.
The Tuting–Tidding Suture Zone (TTSZ), exposed along Dibang and Lohit river valleys in Arunachal Himalaya, NE India, is the easternmost continuation of the Indus–Tsangpo Suture Zone (ITSZ) and ...consists of ophiolites associated with metabasics and carbonates. Amphibolites, existing at the base of the ophiolite complex, were studied using whole-rock, mineral chemical analyses and pressure–temperature (P-T) pseudosection modelling to understand their metamorphic and petrogenetic history, and interpret the tectonic environment of their formation. They exhibit two-stage deformation, where D1 is depicted by polymineralic inclusion trails in former melt pools and the main foliation represents D2. Sub-alkaline tholeiitic character, high-field-strength element (HFSE) ratios and mid-oceanic ridge basalt (MORB) -like rare earth element (REE) patterns with negative Eu anomaly indicate that the protolith of these amphibolites originated in a spreading regime by extensive partial melting of a depleted mantle source at shallow depth. Petrography, mineral chemistry and P-T modelling indicate a three-stage metamorphic history for them. M1 is the prograde (c. 2.1 GPa, c. 450°C) defined by garnet centre compositions corresponding to the D1 event. The existence of former melts in the samples demarcates the M2 stage (1.4–1.8 GPa, c. 600°C). The rocks later underwent retrogression (M3: 0.8–1.0 GPa, 480–520°C), which corresponds to the D2 event. These observations suggest that the protolith of the TTSZ amphibolites originated in a mid-oceanic ridge setting, which accreted below a subduction zone where it underwent M1 metamorphism followed by M2 metamorphism, corresponding to partial melting of the rocks. Finally, the M3 event occurred during the obduction phase of the ophiolite complex, where the amphibolites were obducted as the metamorphic sole of the TTSZ ophiolites.
Emerging evidence supports the intuitive link between chronic health conditions associated with air pollution and the vulnerability of individuals and communities to COVID-19. Poor air quality ...already imposes a highly significant public health burden in Northwest India, with pollution levels spiking to hazardous levels in November and early December when rice crop residues are burned. The urgency of curtailing the COVID-19 pandemic and mitigating a potential resurgence later in the year provides even more justification for accelerating efforts to dramatically reduce open agricultural burning in India.
Abstract
An optimized empirical pseudopotential method (EPM) in conjunction with virtual crystal approximation (VCA) and the compositional disorder effect is used for simulation to extract the ...electronic material parameters of wurtzite nitride alloys to ensure excellent agreement with the experiments. The proposed direct bandgap results of group-III nitride alloys are also compared with the different density functional theories (DFT) based theoretical results. The model developed in current work, significantly improves the accuracy of calculated band gaps as compared to the ab-initio method based results. The physics of carrier transport in binary and ternary nitride materials is investigated with the help of in-house developed Monte Carlo algorithms for solution of Boltzmann transport equation (BTE) including nonlinear scattering mechanisms. Carrier–carrier scattering mechanisms defined through Coulomb-, piezoelectric-, ionized impurity-, surface roughness-scattering with acoustic and intervalley scatterings, all have been given due consideration in present model. The direct and indirect energy bandgap results have been calibrated with the experimental data and use of symmetric and asymmetric form factors associated with respective materials. The electron mobility results of each binary nitride material have been compared and contrasted with experimental results under appropriate conditions and good agreement has been found between simulated and experimental results.
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