Context. As the number of complex organic molecules (COMs) detected in the interstellar medium increases, it becomes even more important to place meaningful constraints on the origins and formation ...pathways of such chemical species. The molecular cloud Sagittarius B2(N) is host to several hot molecular cores in the early stage of star formation, where a great variety of COMs are detected in the gas phase. Given its exposure to the extreme conditions of the Galactic center (GC) region, Sgr B2(N) is one of the best targets to study the impact of environmental conditions on the production of COMs. Aims. Our main goal is to characterize the physico-chemical evolution of Sgr B2(N)’s sources in order to explain their chemical differences and constrain their environmental conditions. Methods. The chemical composition of Sgr B2(N)’s hot cores, N2, N3, N4, and N5 is derived by modeling their 3 mm emission spectra extracted from the Exploring Molecular Complexity with ALMA (EMoCA) imaging spectral line survey performed with the Atacama Large Millimeter/submillimeter Array (ALMA). We derived the density distribution in the envelope of the sources based on the masses computed from the ALMA dust continuum emission maps. We used the radiative transfer code RADMC-3D to compute temperature profiles and inferred the current luminosity of the sources based on the COM rotational temperatures derived from population diagrams. We used published results of 3D radiation-magnetohydrodynamical (RMHD) simulations of high-mass star formation to estimate the time evolution of the source properties. We employed the astrochemical code MAGICKAL to compute time-dependent chemical abundances in the sources and to investigate how physical properties and environmental conditions influence the production of COMs. Results. The analysis of the abundances of 11 COMs detected toward Sgr B2(N2-N5) reveals that N3 and N5 share a similar chemical composition while N2 differs significantly from the other sources. We estimate the current luminosities of N2, N3, N4, and N5 to be 2.6 × 105 L⊙, 4.5 × 104 L⊙, 3.9 × 105 L⊙, and 2.8 × 105 L⊙, respectively. We find that astrochemical models with a cosmic-ray ionization rate of 7 × 10−16 s−1 best reproduce the abundances with respect to methanol of ten COMs observed toward Sgr B2(N2-N5). We also show that COMs still form efficiently on dust grains with minimum dust temperatures in the prestellar phase as high as 15 K, but that minimum temperatures higher than 25 K are excluded. Conclusions. The chemical evolution of Sgr B2(N2-N5) strongly depends on their physical history. A more realistic description of the hot cores’ physical evolution requires a more rigorous treatment with RMHD simulations tailored to each hot core.
Searches for the prebiotically relevant cyanamide (NH2CN) towards solar-type protostars have not been reported in the literature. We present here the first detection of this species in the warm gas ...surrounding two solar-type protostars, using data from the Atacama Large Millimeter/Submillimeter Array Protostellar Interferometric Line Survey (PILS) of IRAS 16293–2422 B and observations from the IRAM Plateau de Bure Interferometer of NGC 1333 IRAS2A. We also detected the deuterated and 13C isotopologs of NH2CN towards IRAS 16293–2422 B. This is the first detection of NHDCN in the interstellar medium. Based on a local thermodynamic equilibrium analysis, we find that the deuteration of cyanamide (~1.7%) is similar to that of formamide (NH2CHO), which may suggest that these two molecules share NH2 as a common precursor. The NH2CN/NH2CHO abundance ratio is about 0.2 for IRAS 16293–2422 B and 0.02 for IRAS2A, which is comparable to the range of values found for Sgr B2. We explored the possible formation of NH2CN on grains through the NH2 + CN reaction using the chemical model MAGICKAL. Grain-surface chemistry appears capable of reproducing the gas-phase abundance of NH2CN with the correct choice of physical parameters.
Aims. We aim to investigate the chemistry of internal photon-dominated regions (PDRs) surrounding deeply embedded hypercompact (HC) and ultracompact (UC) HII regions. We search for specific tracers ...of this evolutionary stage of massive star formation that can be detected with current astronomical facilities. Methods. We modeled hot cores with embedded HC/UCHII regions (called HII region models in the article despite the fact that we do not model the HII region itself), by coupling the astrochemical code Saptarsy to a radiative transfer framework obtaining the spatio-temporal evolution of abundances as well as time-dependent synthetic spectra. In these models where we focused on the internal PDR surrounding the HII region, the gas temperature is set to the dust temperature and we do not include dynamics thus the density structure is fixed. We compared this to hot molecular core (HMC) models and studied the effect on the chemistry of the radiation field which is included in the HII region models only during the computation of abundances. In addition, we investigated the chemical evolution of the gas surrounding HII regions with models of different densities at the ionization front, different sizes of the ionized cavity and different initial abundances. Results. We obtain the time evolution of synthetic spectra for a dozen of selected species as well as ratios of their integrated intensities. We find that some molecules such as C, N2H+, CN, and HCO do not trace the inner core and so are not good tracers to distinguish the HII/PDR regions to the HMCs phase. On the contrary, C+ and O trace the internal PDRs, in the two models starting with different initial abundances, but are unfortunately currently unobservable with the current achievable spatial resolution because of the very thin internal PDR (Δ rPDR < 100 AU). The emission of these two tracers is very dependent on the size of the HII region and on the density in the PDR. In addition, we find that the abundance profiles are highly affected by the choice of the initial abundances, hence the importance to properly define them.
Hot molecular cores (HMCs) are intermediate stages of high-mass star formation and are also known for their rich chemical reservoirs and emission line spectra at (sub-)mm wavebands. Complex organic ...molecules (COMs) such as methanol (CHsub 3OH), ethanol (Csub 2Hsub 5OH), dimethyl ether (CHsub 3OCHsub 3), and methyl formate (HCOOCHsub 3) produce most of these observed lines. We aim to investigate the spectral evolution of these COMs to explore the initial evolutionary stages of high-mass star formation including HMCs. We developed various 3D models for HMCs guided by the evolutionary scenarios proposed by recent empirical and modeling studies. We then investigated the spatio-temporal variation of temperature and molecular abundances in HMCs by consistently coupling gas-grain chemical evolution with radiative transfer calculations. We explored the effects of varying physical conditions on molecular abundances including density distribution and luminosity evolution of the central protostar(s) among other parameters. Finally, we simulated the synthetic spectra for these models at different evolutionary timescales to compare with observations.
Abstract
Shoals of golden shiners (Notemigonus crysoleucas) often swim along the perimeter of their large indoor tank at dawn and dusk, and can also be trained to anticipate food arrival by swimming ...directly towards the food source at midday. In this study all golden shiners in six shoals of 8-12 fish were individually marked with a visible implant elastomer, and shoal movement was video taped in order to determine whether some individuals consistently occupied front positions even when all shoal members were of similar size and experience. There were significant correlations between all three times of day (dawn, midday, dusk) in the mean position (from 1 = first at the front of the shoal to 12 = last at the back) occupied by each fish. In each shoal, 1-3 fish were leaders: all three daily times combined, they had more than twice the occupancy rate of the front two or three positions as expected from chance. In subsequent boldness tests there was a tendency (p = 0.096) for these leaders to pass through dark U-shaped tubes more readily than non-leaders. However, after being dipnetted and transferred to a refuge, leaders did not emerge earlier than non-leaders. Individual tendencies to lead may have been underlain by a motivation to feed (which may differ even in fish of similar size and experience) or by intrinsic mobility. On the other hand, a link between leadership and risk-taking remains to be established for captive golden shiners.
Celotno besedilo
Dostopno za:
BFBNIB, DOBA, IZUM, KILJ, NMLJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Future quantum computers capable of solving relevant problems will require a large number of qubits that can be operated reliably
. However, the requirements of having a large qubit count and ...operating with high fidelity are typically conflicting. Spins in semiconductor quantum dots show long-term promise
but demonstrations so far use between one and four qubits and typically optimize the fidelity of either single- or two-qubit operations, or initialization and readout
. Here, we increase the number of qubits and simultaneously achieve respectable fidelities for universal operation, state preparation and measurement. We design, fabricate and operate a six-qubit processor with a focus on careful Hamiltonian engineering, on a high level of abstraction to program the quantum circuits, and on efficient background calibration, all of which are essential to achieve high fidelities on this extended system. State preparation combines initialization by measurement and real-time feedback with quantum-non-demolition measurements. These advances will enable testing of increasingly meaningful quantum protocols and constitute a major stepping stone towards large-scale quantum computers.
Chemotherapy-induced peripheral neuropathic pain (CIPNP) is a severe dose- and therapy-limiting side effect of widely used cytostatics that is particularly difficult to treat. Here, we report ...increased expression of the cytochrome-P450-epoxygenase CYP2J6 and increased concentrations of its linoleic acid metabolite 9,10-EpOME (9,10-epoxy-12Z-octadecenoic acid) in dorsal root ganglia (DRGs) of paclitaxel-treated mice as a model of CIPNP. The lipid sensitizes TRPV1 ion channels in primary sensory neurons and causes increased frequency of spontaneous excitatory postsynaptic currents in spinal cord nociceptive neurons, increased CGRP release from sciatic nerves and DRGs, and a reduction in mechanical and thermal pain hypersensitivity. In a drug repurposing screen targeting CYP2J2, the human ortholog of murine CYP2J6, we identified telmisartan, a widely used angiotensin II receptor antagonist, as a potent inhibitor. In a translational approach, administration of telmisartan reduces EpOME concentrations in DRGs and in plasma and reverses mechanical hypersensitivity in paclitaxel-treated mice. We therefore suggest inhibition of CYP2J isoforms with telmisartan as a treatment option for paclitaxel-induced neuropathic pain.
Psychostimulants such as cocaine have been used as performance enhancers throughout recorded history. Although psychostimulants are commonly prescribed to improve attention and cognition, a great ...deal of literature has described their ability to induce cognitive deficits, as well as addiction. How can a single drug class be known to produce both cognitive enhancement and impairment? Properties of the particular stimulant drug itself and individual differences between users have both been suggested to dictate the outcome of stimulant use. A more parsimonious alternative, which we endorse, is that dose is the critical determining factor in cognitive effects of stimulant drugs. Herein, we review several popular stimulants (cocaine, amphetamine, methylphenidate, modafinil, and caffeine), outlining their history of use, mechanism of action, and use and abuse today. One common graphic depiction of the cognitive effects of psychostimulants is an inverted U-shaped dose-effect curve. Moderate arousal is beneficial to cognition, whereas too much activation leads to cognitive impairment. In parallel to this schematic, we propose a continuum of psychostimulant activation that covers the transition from one drug effect to another as stimulant intake is increased. Low doses of stimulants effect increased arousal, attention, and cognitive enhancement; moderate doses can lead to feelings of euphoria and power, as well as addiction and cognitive impairment; and very high doses lead to psychosis and circulatory collapse. This continuum helps account for the seemingly disparate effects of stimulant drugs, with the same drug being associated with cognitive enhancement and impairment.
In many studies, consumer preferences are determined by using direct surveys. For this method social desirability is problematic. This leads to the effect that participants answer in a way that they ...perceive as desired by society. This leads to the stated importance of certain features in these studies not being reflected in real purchasing decisions. Therefore, the aim of the study is to compare consumer preferences measured by a quasi-experiment to those quantified by direct questions. Another objective is to quantify the part-worth utilities of product characteristics such as origin, price and food labels. Part-worth utilities are estimated on an interval scale with an arbitrary origin and are a measure for preferences. The real purchasing situation was simulated in a quasi-experiment using a choice-based conjoint analysis. The part-worth utilities were then compared with the results of a conventional preference assessment (Likert scale). For this purpose, 645 consumers from all over Germany were surveyed in 2014. The participants were on average 44 years old and 63% were women. The results of the conjoint analysis report the highest part-worth utility (2.853) for the lowest price (1.49€), followed by the characteristic “grown locally” (2.157). For the labels, the German organic label shows the highest part-worth utility (0.785) followed by Fairtrade/“A heart for the producer” (0.200). It is noticeable that the carbon footprint labels have negative part-worth utilities compared to tomatoes without a label (−0.130 with CO2 indication, −0.186 without CO2 indication). The price is ranked 12th in the importance of the characteristics of purchasing tomatoes in the survey with a Likert scale, whereas it is first in the evaluation of the quasi-experiment (conjoint analysis), which supports the assumption of a social desirability bias.
•The results support the assumption of a social desirability effect.•The results differ between the quasi-experiment and the two stated preference approaches.•Using a combination of methods for understanding the true behavior of consumers is important as demonstrated by this paper.•The participants in the quasi-experiment preferred tomatoes without a label to those with carbon footprint labels.•In the quasi-experiment “grown locally” shows the highest utility after price; local origin is preferred to organic.
This article contributes to the emerging literature on transparency by developing and empirically testing a theoretical framework that exphins the determinants of local government Web site ...transparency. It aims to answer the following central question: What institutional factors determine the different dimensions of government transparency? The framework distinguishes three dimensions of transparency—decision making transparency, policy information transparency, and policy outcome transparency—and hypothesizes three explanations for each: organizational capacity, political influence, and group influence on government. Results indicate that each dimension of transparency is associated with diffèrent factors. Decision-making transparency is associated with political influence; when left-wing parties are strong in the heal council, localgovernment tends to be more transparent. Policy information transparency is associated with media attention and external group pressure, and policy outcome transparency is associated with both external group pressure and the organizational capacity. The authors discuss the implications for policy and administration.
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