A
bstract
A
θ
13
oscillation analysis based on the observed antineutrino rates at the Double Chooz far and near detectors for different reactor power conditions is presented. This approach provides a ...so far unique simultaneous determination of
θ
13
and the total background rates without relying on any assumptions on the specific background contributions. The analysis comprises 865 days of data collected in both detectors with at least one reactor in operation. The oscillation results are enhanced by the use of 24.06 days (12.74 days) of reactor-off data in the far (near) detector. The analysis considers the
ν
¯
e
interactions up to a visible energy of 8.5 MeV, using the events at higher energies to build a cosmogenic background model considering fast-neutrons interactions and
9
Li decays. The background-model-independent determination of the mixing angle yields sin
2
(2
θ
13
) = 0
.
094 ± 0
.
017, being the best-fit total background rates fully consistent with the cosmogenic background model. A second oscillation analysis is also performed constraining the total background rates to the cosmogenic background estimates. While the central value is not significantly modified due to the consistency between the reactor-off data and the background estimates, the addition of the background model reduces the uncertainty on
θ
13
to 0.015. Along with the oscillation results, the normalization of the anti-neutrino rate is measured with a precision of 0.86%, reducing the 1.43% uncertainty associated to the expectation.
Abstract A search for the rare leptonic decay $${{{B} ^+}} \!\rightarrow {\mu ^+} {\mu ^-} {\mu ^+} {{\upnu } _\mu } $$ B+→μ+μ-μ+νμ is performed using proton-proton collision data corresponding to an ...integrated luminosity of $$4.7 \, {\hbox {fb}}^{-1}$$ 4.7fb-1 collected by the LHCb experiment. The search is carried out in the region where the lowest of the two $${\mu ^+\mu ^-} $$ μ+μ- mass combinations is below $$980 {\mathrm {\,MeV\!/}c^2} $$ 980MeV/c2 . The data are consistent with the background-only hypothesis and an upper limit of $$1.6 \times 10^{-8}$$ 1.6×10-8 at 95% confidence level is set on the branching fraction in the stated kinematic region.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Bose–Einstein correlations of like-sign charged hadrons produced in deep-inelastic electron and positron scattering are studied in the HERMES experiment using nuclear targets of
1
H,
2
H,
3
He,
4
He, ...N, Ne, Kr, and Xe. A Gaussian approach is used to parametrize a two-particle correlation function determined from events with at least two charged hadrons of the same sign charge. This correlation function is compared to two different empirical distributions that do not include the Bose–Einstein correlations. One distribution is derived from unlike-sign hadron pairs, and the second is derived from mixing like-sign pairs from different events. The extraction procedure used simulations incorporating the experimental setup in order to correct the results for spectrometer acceptance effects, and was tested using the distribution of unlike-sign hadron pairs. Clear signals of Bose–Einstein correlations for all target nuclei without a significant variation with the nuclear target mass are found. Also, no evidence for a dependence on the invariant mass
W
of the photon-nucleon system is found when the results are compared to those of previous experiments.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Opitz BBB/G syndrome (OS) is a heterogenous malformation syndrome mainly characterised by hypertelorism and hypospadias. In addition, patients may present with several other defects of the ventral ...midline such as cleft lip and palate and congenital heart defects. The syndrome-causing gene encodes the X-linked E3 ubiquitin ligase MID1 that mediates ubiquitin-specific modification and degradation of the catalytic subunit of the translation regulator protein phosphatase 2A (PP2A). Here, we show that the MID1 protein also associates with elongation factor 1α (EF-1α) and several other proteins involved in mRNA transport and translation, including RACK1, Annexin A2, Nucleophosmin and proteins of the small ribosomal subunits. Mutant MID1 proteins as found in OS patients lose the ability to interact with EF-1α. The composition of the MID1 protein complex was determined by several independent methods: (1) yeast two-hybrid screening and (2) immunofluorescence, (3) a biochemical approach involving affinity purification of the complex, (4) co-fractionation in a microtubule assembly assay and (5) immunoprecipitation. Moreover, we show that the cytoskeleton-bound MID1/translation factor complex specifically associates with G- and U-rich RNAs and incorporates MID1 mRNA, thus forming a microtubule-associated ribonucleoprotein (RNP) complex. Our data suggest a novel function of the OS gene product in directing translational control to the cytoskeleton. The dysfunction of this mechanism would lead to malfunction of microtubule-associated protein translation and to the development of OS.
Background: A budesonide/formoterol single inhaler has been developed for convenient treatment of patients whose asthma is inadequately controlled by inhaled glucocorticosteroids alone.
Objectives: ...To compare long-term safety and efficacy of budesonide/formoterol single inhaler with budesonide plus formoterol via separate inhalers in adults with asthma.
Methods: In this open, randomized, parallel-group 6-month extension conducted in a subset of centres from a previous 6-month study, patients (
n=321) received two inhalations bid of budesonide/formoterol (Symbicort
® Turbuhaler
®) 160/4.5 μg delivered dose or corresponding doses of budesonide (Pulmicort
® Turbuhaler
®) plus formoterol (Oxis
® Turbuhaler
®) via separate inhalers.
Results: Significantly fewer patients receiving budesonide/formoterol single inhaler withdrew compared with budesonide plus formoterol (9
vs. 19%,
P =0.008). Incidence and severity of AEs were low and similar in both groups. No clinically important differences between groups, or changes, were identified in laboratory measurements, vital signs or ECG. Treatments produced similar improvements in lung function, ACQ scores and Mini AQLQ domains that were maintained throughout 12 months.
Conclusions: Budesonide/formoterol in a single inhaler is as safe and effective in the long-term treatment of asthma as budesonide plus formoterol via separate inhalers. The lower number of withdrawals with budesonide/formoterol may reflect better adherence to treatment compared with budesonide plus formoterol.
A search for CP violation in Λb0→pK− and Λb0→pπ− decays is presented using a sample of pp collisions collected with the LHCb detector and corresponding to an integrated luminosity of 3.0fb−1. The CP ...-violating asymmetries are measured to be ACPpK−=−0.020±0.013±0.019 and ACPpπ−=−0.035±0.017±0.020, and their difference ACPpK−−ACPpπ−=0.014±0.022±0.010, where the first uncertainties are statistical and the second systematic. These are the most precise measurements of such asymmetries to date.
A
bstract
A measurement of the inclusive
W
→
μν
production cross-section using data from
pp
collisions at a centre-of-mass energy of
s
=
7
TeV is presented. The analysis is based on an integrated ...luminosity of about 1
.
0 fb
−1
recorded with the LHCb detector. Results are reported for muons with a transverse momentum greater than 20 GeV/
c
and pseudorapidity between 2.0 and 4.5. The
W
+
and
W
−
production cross-sections are measured to be
σ
W
+
→
μ
+
ν
=
861.0
±
2.0
±
11.2
±
14.7
p
b
,
σ
W
−
→
μ
−
ν
¯
=
675.8
±
1.9
±
8.8
±
11.6
p
b
,
where the first uncertainty is statistical, the second is systematic and the third is due to the luminosity determination. Cross-section ratios and differential distributions as functions of the muon pseudorapidity are also presented. The ratio of
W
+
to
W
−
cross-sections in the same fiducial kinematic region is determined to be
σ
W
+
→
μ
+
ν
σ
W
−
→
μ
−
ν
¯
=
1.274
±
0.005
±
0.009
,
where the uncertainties are statistical and systematic, respectively. Results are in good agreement with theoretical predictions at next-to-next-to-leading order in perturbative quantum chromodynamics.
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