Given the overwhelming quantity of information available from the environment, how do young learners know what to learn about and what to ignore? We found that 11-month-old infants (N = 110) used ...violations of prior expectations as special opportunities for learning. The infants were shown events that violated expectations about object behavior or events that were nearly identical but did not violate expectations. The sight of an object that violated expectations enhanced learning and promoted information-seeking behaviors; specifically, infants learned more effectively about objects that committed violations, explored those objects more, and engaged in hypothesis-testing behaviors that reflected the particular kind of violation seen. Thus, early in life, expectancy violations offer a wedge into the problem of what to learn.
The purpose of the protocol was to reduce the treatment burden in clinical stage I (CSI) seminoma by offering risk-adapted treatment. The protocol aimed to prospectively validate the proposed risk ...factors for relapse, stromal invasion of the rete testis and tumor diameter >4cm, and to evaluate the efficacy of one course of adjuvant carboplatin.
From 2007 to 2010, 897 patients were included in a prospective, population-based, risk-adapted treatment protocol implementing one course of adjuvant carboplatin AUC7 (n = 469) or surveillance (n = 422). In addition, results from 221 patients receiving carboplatin between 2004 and 2007 are reported.
At a median follow-up of 5.6 years, 69 relapses have occurred. Stromal invasion of the rete testis hazard ratio (HR) 1.9, P = 0.011 and tumor diameter >4cm (HR 2.7, P < 0.001) were identified as risk factors predicting relapse. In patients without risk factors, the relapse rate (RR) was 4.0% for patients managed by surveillance and 2.2% in patients receiving adjuvant carboplatin. In patients with one or two risk factors, the RR was 15.5% in patients managed by surveillance and 9.3% in patients receiving adjuvant carboplatin. We found no increased RR in patients receiving carboplatin <7 × AUC compared with that in patients receiving ≥7 × AUC.
Stromal invasion in the rete testis and tumor diameter >4cm are risk factors for relapse in CSI seminoma. Patients without risk factors have a low RR and adjuvant therapy is not justified in these patients. The efficacy of adjuvant carboplatin is relatively low and there is need to explore more effective adjuvant treatment options in patients with high-risk seminoma. The data do not support the concept of a steep dose response for adjuvant carboplatin.
Abstract
Here we present 1701 light curves of 1550 unique, spectroscopically confirmed Type Ia supernovae (SNe Ia) that will be used to infer cosmological parameters as part of the Pantheon+ SN ...analysis and the Supernovae and
H
0
for the Equation of State of dark energy distance-ladder analysis. This effort is one part of a series of works that perform an extensive review of redshifts, peculiar velocities, photometric calibration, and intrinsic-scatter models of SNe Ia. The total number of light curves, which are compiled across 18 different surveys, is a significant increase from the first Pantheon analysis (1048 SNe), particularly at low redshift (
z
). Furthermore, unlike in the Pantheon analysis, we include light curves for SNe with
z
< 0.01 such that SN systematic covariance can be included in a joint measurement of the Hubble constant (
H
0
) and the dark energy equation-of-state parameter (
w
). We use the large sample to compare properties of 151 SNe Ia observed by multiple surveys and 12 pairs/triplets of “SN siblings”—SNe found in the same host galaxy. Distance measurements, application of bias corrections, and inference of cosmological parameters are discussed in the companion paper by Brout et al., and the determination of
H
0
is discussed by Riess et al. These analyses will measure
w
with ∼3% precision and
H
0
with ∼1 km s
−1
Mpc
−1
precision.
SWENOTECA has since 1998 offered patients with clinical stage I (CS I) nonseminoma, adjuvant chemotherapy with one course of bleomycin, etoposide and cisplatin (BEP). The aim has been to reduce the ...risk of relapse, sparing patients the need of toxic salvage treatment. Initial results on 312 patients treated with one course of adjuvant BEP, with a median follow-up of 4.5 years, have been previously published. We now report mature and expanded results.
In a prospective, binational, population-based risk-adapted treatment protocol, 517 Norwegian and Swedish patients with CS I nonseminoma received one course of adjuvant BEP. Patients with lymphovascular invasion (LVI) in the primary testicular tumor were recommended one course of adjuvant BEP. Patients without LVI could choose between surveillance and one course of adjuvant BEP. Data for patients receiving one course of BEP are presented in this study.
At a median follow-up of 7.9 years, 12 relapses have occurred, all with IGCCC good prognosis. The latest relapse occurred 3.3 years after adjuvant treatment. The relapse rate at 5 years was 3.2% for patients with LVI and 1.6% for patients without LVI. Five-year cause-specific survival was 100%.
The updated and expanded results confirm a low relapse rate following one course of adjuvant BEP in CS I nonseminoma. One course of adjuvant BEP should be considered a standard treatment in CS I nonseminoma with LVI. For patients with CS I nonseminoma without LVI, one course of adjuvant BEP is also a treatment option.
ABSTRACT
Progressive increases in the precision of the Hubble-constant measurement via Cepheid-calibrated Type Ia supernovae (SNe Ia) have shown a discrepancy of ∼4.4σ with the current value inferred ...from Planck satellite measurements of the cosmic microwave background radiation and the standard $\Lambda $cold dark matter (ΛCDM) cosmological model. This disagreement does not appear to be due to known systematic errors and may therefore be hinting at new fundamental physics. Although all of the current techniques have their own merits, further improvement in constraining the Hubble constant requires the development of as many independent methods as possible. In this work, we use SNe II as standardisable candles to obtain an independent measurement of the Hubble constant. Using seven SNe II with host-galaxy distances measured from Cepheid variables or the tip of the red giant branch, we derive H$_0= 75.8^{+5.2}_{-4.9}$ km s−1 Mpc−1 (statistical errors only). Our value favours that obtained from the conventional distance ladder (Cepheids + SNe Ia) and exhibits a difference of 8.4 km s−1 Mpc−1 from the Planck + ΛCDM value. Adding an estimate of the systematic errors (2.8 km s−1 Mpc−1) changes the ∼1.7σ discrepancy with Planck +ΛCDM to ∼1.4σ. Including the systematic errors and performing a bootstrap simulation, we confirm that the local H0 value exceeds the value from the early Universe with a confidence level of 95 per cent. As in this work, we only exchange SNe II for SNe Ia to measure extragalactic distances, we demonstrate that there is no evidence that SNe Ia are the source of the H0 tension.
We evaluated the performance of the MinION DNA sequencer in-flight on the International Space Station (ISS), and benchmarked its performance off-Earth against the MinION, Illumina MiSeq, and PacBio ...RS II sequencing platforms in terrestrial laboratories. Samples contained equimolar mixtures of genomic DNA from lambda bacteriophage, Escherichia coli (strain K12, MG1655) and Mus musculus (female BALB/c mouse). Nine sequencing runs were performed aboard the ISS over a 6-month period, yielding a total of 276,882 reads with no apparent decrease in performance over time. From sequence data collected aboard the ISS, we constructed directed assemblies of the ~4.6 Mb E. coli genome, ~48.5 kb lambda genome, and a representative M. musculus sequence (the ~16.3 kb mitochondrial genome), at 100%, 100%, and 96.7% consensus pairwise identity, respectively; de novo assembly of the E. coli genome from raw reads yielded a single contig comprising 99.9% of the genome at 98.6% consensus pairwise identity. Simulated real-time analyses of in-flight sequence data using an automated bioinformatic pipeline and laptop-based genomic assembly demonstrated the feasibility of sequencing analysis and microbial identification aboard the ISS. These findings illustrate the potential for sequencing applications including disease diagnosis, environmental monitoring, and elucidating the molecular basis for how organisms respond to spaceflight.
Abstract
With
Cosmicflows-
4, distances are compiled for 55,877 galaxies gathered into 38,065 groups. Eight methodologies are employed, with the largest numbers coming from the correlations between ...the photometric and kinematic properties of spiral galaxies (TF) and elliptical galaxies (FP). Supernovae that arise from degenerate progenitors (type Ia SNe) are an important overlapping component. Smaller contributions come from distance estimates from the surface brightness fluctuations of elliptical galaxies and the luminosities and expansion rates of core-collapse supernovae (SNe II). Cepheid period–luminosity relation and tip of the red giant branch observations founded on local stellar parallax measurements along with the geometric maser distance to NGC 4258 provide the absolute scaling of distances. The assembly of galaxies into groups is an important feature of the study in facilitating overlaps between methodologies. Merging between multiple contributions within a methodology and between methodologies is carried out with Bayesian Markov chain Monte Carlo procedures. The final assembly of distances is compatible with a value of the Hubble constant of
H
0
= 74.6 km s
−1
Mpc
−1
with the small statistical error of ±0.8 km s
−1
Mpc
−1
but a large potential systematic error of ∼3 km s
−1
Mpc
−1
. Peculiar velocities can be inferred from the measured distances. The interpretation of the field of peculiar velocities is complex because of large errors on individual components and invites analyses beyond the scope of this study.
Poor psychological and physical resilience in response to stress drives a great deal of health care utilization. Mind-body interventions can reduce stress and build resiliency. The rationale for this ...study is therefore to estimate the effect of mind-body interventions on healthcare utilization.
Estimate the effect of mind body training, specifically, the Relaxation Response Resiliency Program (3RP) on healthcare utilization.
Retrospective controlled cohort observational study.
Major US Academic Health Network.
All patients receiving 3RP at the MGH Benson-Henry Institute from 1/12/2006 to 7/1/2014 (n = 4452), controls (n = 13149) followed for a median of 4.2 years (.85-8.4 yrs).
Utilization as measured by billable encounters/year (be/yr) stratified by encounter type: clinical, imaging, laboratory and procedural, by class of chief complaint: e.g., Cardiovascular, and by site of care delivery, e.g., Emergency Department. Subgroup analysis by propensity score matched pre-intervention utilization rate.
At one year, total utilization for the intervention group decreased by 43% 53.5 to 30.5 be/yr (p <0.0001). Clinical encounters decreased by 41.9% 40 to 23.2 be/yr, imaging by 50.3% 11.5 to 5.7 be/yr, lab encounters by 43.5% 9.8 to 5.6, and procedures by 21.4% 2.2 to 1.7 be/yr, all p < 0.01. The intervention group's Emergency department (ED) visits decreased from 3.6 to 1.7/year (p<0.0001) and Hospital and Urgent care visits converged with the controls. Subgroup analysis (identically matched initial utilization rates-Intervention group: high utilizing controls) showed the intervention group significantly reduced utilization relative to the control group by: 18.3% across all functional categories, 24.7% across all site categories and 25.3% across all clinical categories.
Mind body interventions such as 3RP have the potential to substantially reduce healthcare utilization at relatively low cost and thus can serve as key components in any population health and health care delivery system.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The violation‐of‐expectation method has been used in thousands of studies examining the breadth and depth of preverbal infants' knowledge and cognitive capacities. In this commentary, we review ...evidence that supports the violation‐of‐expectation method as an important tool for infant research that has strong construct validity. We show that this method reveals infants' expectations, produces reliable results across study designs and stimuli, and is grounded in theories of learning. We support and encourage the use of this method to continue to unveil the scope and sophistication of infant cognition.
Abstract Type Iax supernovae (SNe Iax) are the largest known class of peculiar white dwarf SNe, distinct from normal Type Ia supernovae (SNe Ia). The unique properties of SNe Iax, especially their ...strong photospheric lines out to extremely late times, allow us to model their optical spectra and derive the physical parameters of the long-lasting photosphere. We present an extensive spectral timeseries, including 21 new spectra, of SN Iax 2014dt from +11 to +562 days after maximum light. We are able to reproduce the entire timeseries with a self-consistent, nearly unaltered deflagration explosion model from Fink et al. using TARDIS , an open source radiative-transfer code. We find that the photospheric velocity of SN 2014dt slows its evolution between +64 and +148 days, which closely overlaps the phase when we see SN 2014dt diverge from the normal spectral evolution of SNe Ia (+90 to +150 days). The photospheric velocity at these epochs, ∼400–1000 km s −1 , may demarcate a boundary within the ejecta below which the physics of SNe Iax and normal SNe Ia differ. Our results suggest that SN 2014dt is consistent with a weak deflagration explosion model that leaves behind a bound remnant and drives an optically thick, quasi-steady-state wind creating the photospheric lines at late times. The data also suggest that this wind may weaken at epochs past +450 days, perhaps indicating a radioactive power source that has decayed away.
PDF
