The existence of charged Higgs boson(s) is inevitable in models with two (or more) Higgs doublets. Hence, their discovery would constitute unambiguous evidence for new physics beyond the Standard ...Model (SM). Taking into account all relevant results from direct charged and neutral Higgs boson searches at LEP and the LHC, as well as the most recent constraints from flavour physics, we present a detailed analysis of the current phenomenological status of the charged Higgs sector in a variety of well-motivated two Higgs doublet models (2HDMs). We find that charged Higgs bosons as light as
75
GeV
can still be compatible with the combined data, although this implies severely suppressed charged Higgs couplings to all fermions. In more popular models, e.g. the 2HDM of Type II, we find that flavour physics observables impose a combined lower limit on the charged Higgs mass of
M
H
±
≳
600
GeV – independent of
tan
β
– which increases to
M
H
±
≳
650
GeV for
tan
β
<
1
. We furthermore find that in certain scenarios, the signature of a charged Higgs boson decaying into a lighter neutral Higgs boson and a
W
boson provides a promising experimental avenue that would greatly complement the existing LHC search programme for charged Higgs boson(s).
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The aim of this study was to determine factors affecting passive transfer in heifer calves born within 1 yr and how passive transfer influences rearing to the period of first insemination under ...commercial dairy farm conditions. Calves were divided into 4 groups based on serum immunoglobulin concentrations at 30 to 60h of life (<5, 5–10, 10–15, and >15g/L, respectively in groups 1 to 4). Calving ease, dam parity, calf body weight at birth, calf vitality, quality of colostrum, time and volume of first colostrum fed, morbidity rate and intensity of illness, growth rate, and age and efficiency of first insemination service were recorded. Plasma fibrinogen, and serum γ-globulin, IgG1, IgG2, IgM, and haptoglobin were estimated at 30 to 60h and again at 21 to 28 d of life. Additionally, the immunoglobulin index (IIg3–4) was calculated. The main cause of FPT and PFPT in the calves was poor vitality associated with dystocia and low volume of ingested colostrum. The calves born to primiparous cows were more endangered than those born to multiparous cows. The morbidity and intensity of disease course were lowest in heifer calves with serum Ig concentration exceeding 10g/L at 30 to 60h of life; these calves did not become ill before d 14 of life. Calves with >15g/L γ-globulin in serum avoided respiratory tract infections. The immunoglobulin index was lowest (0.61) in calves from group 4 and highest in calves from groups 1 and 2 (1.44 and 0.88, respectively). The suitability of this index as well as haptoglobin determination was confirmed in prediction of morbidity risk and disease intensity in growing heifer calves. Heifers with serum γ-globulin levels >10g/L at 30 to 60h of life showed better health status and reached body weights allowing first insemination sooner.
This review of bovine foetal mortality (>42 d gestation) concluded that while the majority of risk factors associated with sporadic loss operate at animal-level, e.g. foetal plurality, those that ...operate at herd-level, e.g. some foetopathogenic infections, are more likely to result in abortion outbreaks. While the causes of foetal mortality have traditionally been classified as infectious and non-infectious, in fact, the latter category is a diagnosis of exclusion, generally without determination of the non-infectious cause. This review has also established that the traditional dichotomisation of infectious agents into primary and secondary pathogens is based on a flawed premise and these terms should be discontinued. The delicate balance of the maternal gestational immune system between not rejecting the allograft (conceptus) but rejecting (attacking) foetopathogens is stage-of-pregnancy-dependent thus the timing of infection determines the clinical outcome which may result in persistent infection or foetal mortality. Utilisation of our knowledge of the materno-foetal immune responses to foetopathogenic infection has resulted in the development of numerous mono- and polyvalent vaccines for metaphylactic or prophylactic control of bovine foetal mortality. While some of these have been shown to significantly contribute to reducing the risk of both infection and foetal mortality, others have insufficient, or conflicting evidence, on efficacy. However, recent developments in vaccinology, in particular the development of subunit vaccines and those that stimulate local genital tract immunity, show greater promise.
Prebiotics and probiotics, either alone or together (synbiotics), can influence the intestinal microbiota and modulate the immune response. We aimed to investigate the effects of prebiotic and ...synbiotic administration during the early stage of development on the histological structures of central (bursa of Fabricius and thymus) and peripheral (spleen) lymphatic organs in broilers. We used 800 hatching eggs from meat-type hens (Ross 308). Prebiotics and synbiotics were administered in ovo into the air chamber of chicken eggs at d 12 incubation, as follows: prebiotic inulin (Pre1), Bi2tos (Pre2), a synbiotic composed of inulin and Lactococcus lactis subsp. lactis IBB SL1 (Syn1), a synbiotic composed of Bi2tos and L. lactis subsp. cremoris IBB SC1 (Syn2), or physiological saline (control group, C). In ovo delivery of prebiotics and synbiotics had no adverse effect on the development of the immune system in exposed chickens. Administration of Bi2tos with L. lactis subsp. cremoris (Syn2) decreased the cortex/medulla ratio in the thymus and slowed the development of the cortex in bursal follicles on d 21 posthatching, with consequent impacts on the primary lymphatic organs. The above treatment also stimulated germinal centers’ formation in the spleens of 21- and 35-day-old chickens, indicating enhanced B-cell proliferation in secondary lymphatic organs. Syn2 also caused an age-dependent increase in the spleen/bursa of Fabricius ratio. In conclusion, the in ovo administration of pre- and synbiotics at d 12 incubation can modulate the central and peripheral lymphatic organ development in broilers. This effect is more pronounced after synbiotic treatment than in prebiotic-treated groups.
A Higgs-like particle with a mass of about 126 GeV has been discovered at the LHC. Within the experimental uncertainties, the measured properties of this new state are compatible with those of the ...Higgs boson in the Standard Model (SM). While not statistically significant at present, the results show some interesting patterns of deviations from the SM predictions, in particular a higher rate in the
γγ
decay mode observed by ATLAS and CMS, and a somewhat smaller rate in the
τ
+
τ
−
mode. The LHC discovery is also compatible with the predictions of the Higgs sector of the Minimal Supersymmetric Standard Model (MSSM), interpreting the new state as either the light or the heavy
-even MSSM Higgs boson. Within the framework of the MSSM with seven free parameters (pMSSM-7), we fit the various rates of cross section times branching ratio as measured by the LHC and Tevatron experiments under the hypotheses of either the light or the heavy
-even Higgs boson being the new state around 126 GeV, with and without the inclusion of further low-energy observables. We find an overall good quality of the fits, with the best fit points exhibiting an enhancement of the
γγ
rate, as well as a small suppression of the
and
τ
+
τ
−
channels with respect to their SM expectations, depending on the details of the fit. For the fits including the whole dataset the light
-even Higgs interpretation in the MSSM results in a higher relative fit probability than the SM fit. On the other hand, we find that the present data also permit the more exotic interpretation in terms of the heavy
-even MSSM Higgs, which could give rise to experimental signatures of additional Higgs states in the near future.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Obesity and metabolic disorders are associated with systemic low-grade chronic inflammation, both in humans and animals. The aim of the study is to assess the effects of obesity and hyperinsulinemia ...on individual components of the acute-phase reaction in equine metabolic syndrome (EMS) horses. Eight mixed-breed EMS and six control, age-matched horses of both sexes were included in the study. Animals were classified as EMS or control based on the assessment of BCS, cresty neck score, and basal insulin >50 μU/mL and/or insulin responses to the oral sugar test (OST) >60 μU/mL. Peripheral venous blood was collected. The expression of proinflammatory cytokines, the concentration of circulating cytokines, and acute-phase proteins (serum amyloid A, C-reactive protein, haptoglobin, activin A, and procalcitonin) were measured. The data were analyzed using the Mann-Whitney test, whereas correlations were examined using Spearman's correlation coefficient. The tests were statistically significant if P ≤ 0.05. There were no differences in cytokine gene expression, circulating cytokine concentrations, or concentrations of acute-phase proteins between the EMS and the control groups. There was a strong correlation between the basal concentration of insulin and the serum concentrations of IL-6 (r = 0.71, P < 0.05). Activin A was positively correlated with post-OST insulin concentrations (r = 0.707, P = 0.05), indicating that this marker of inflammation could warrant further investigation in horses with EMS.
•Obesity and metabolic disorders are associated with systemic low-grade chronic inflammation.•Adipose tissue is not only an energy reservoir but an active endocrinological organ that can secrete adipocytokines and proinflammatory cytokines.•Hyperinsulinemia in horses is connected with circulated IL-6 serum concentration.•Insulin dysregulation in the course of equine metabolic syndrome is positively correlated with activin A concentration in horses.
Soybean Glycine max (L.) Merr. is a versatile crop due to its multitude of uses as a high protein meal and vegetable oil. Soybean seed traits such as seed protein and oil concentration and seed size ...are important quantitative traits. The objective of this study was to identify representative protein, oil, and seed size quantitative trait loci (QTL) in soybean. A recombinant inbred line (RIL) population consisting of 131 F6-derived lines was created from two prominent ancestors of North American soybeans (Essex and Williams) and the RILs were grown in six environments. One hundred simple sequence repeat (SSR) markers spaced throughout the genome were mapped in this population. There were a total of four protein, six oil, and seven seed size QTL found in this population. The QTL found in this study may assist breeders in marker-assisted selection (MAS) to retain current positive QTL in modern soybeans while simultaneously pyramiding additional QTL from new germplasm.
Physics at the e+e- linear collider Moortgat-Pick, G.; Baer, H.; Battaglia, M. ...
The European physical journal. C, Particles and fields,
08/2015, Letnik:
75, Številka:
8
Journal Article
Recenzirano
Odprti dostop
A comprehensive review of physics at an
e
+
e
-
linear collider in the energy range of
s
=
92
GeV–3 TeV is presented in view of recent and expected LHC results, experiments from low-energy as well ...as astroparticle physics. The report focusses in particular on Higgs-boson, top-quark and electroweak precision physics, but also discusses several models of beyond the standard model physics such as supersymmetry, little Higgs models and extra gauge bosons. The connection to cosmology has been analysed as well.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Dairy cows are exposed to increased inflammatory processes in the transition period from late pregnancy to early lactation. Essential fatty acids (EFA) and conjugated linoleic acid (CLA) are thought ...to modulate the inflammatory response in dairy cows. The present study investigated the effects of a combined EFA and CLA infusion on the fatty acid (FA) status in plasma lipids, and whether changes in the FA pattern were associated with the acute phase and inflammatory response during late pregnancy and early lactation. Rumen-cannulated Holstein cows (n = 40) were assigned from wk 9 antepartum to wk 9 postpartum to 1 of 4 treatment groups. Cows were abomasally supplemented with coconut oil (CTRL, 76 g/d), linseed and safflower oil (EFA, 78 g/d of linseed oil and 4 g/d of safflower oil; ratio of oils = 19.5:1; n-6:n-3 FA ratio = 1:3), Lutalin (CLA, 38 g/d; isomers cis-9,trans-11 and trans-10,cis-12; each 10 g/d), or both (EFA+CLA). Blood samples were taken to measure changes in FA in blood plasma on d −63, −42, 1, 28, and 56, and in plasma lipid fractions (cholesterol esters, free fatty acids, phospholipids, and triglycerides) on d −42, 1, and 56 relative to calving, and in erythrocyte membrane (EM) on d 56 after calving. Traits related to the acute phase response and inflammation were measured in blood throughout the study. Liver samples were obtained for biopsy on d −63, −21, 1, 28, and 63 relative to calving to measure the mRNA abundance of genes related to the inflammatory response. The concentrations of α-linolenic acid and n-3 FA metabolites increased in lipid fractions (especially phospholipids) and EM due to EFA supplementation with higher α-linolenic acid but lower n-3 metabolite concentrations in EFA+CLA than in EFA treatment only. Concentration of linoleic acid decreased in plasma fat toward calving and increased during early lactation in all groups. Concentration of plasma arachidonic acid was lower in EFA- than in non-EFA-treated groups in lipid fractions and EM. The cis-9,trans-11 CLA increased in all lipid fractions and EM after both CLA treatments. Plasma haptoglobin was lowered by EFA treatment before calving. Plasma bilirubin was lower in EFA and CLA than in CTRL at calving. Plasma concentration of IL-1β was higher in EFA than in CTRL and EFA+CLA at certain time points before and after calving. Plasma fibrinogen dropped faster in CLA than in EFA and EFA+CLA on d 14 postpartum. Plasma paraoxonase tended to be elevated by EFA treatment, and was higher in EFA+CLA than in CTRL on d 49. Hepatic mRNA abundance revealed time changes but no treatment effects with respect to the inflammatory response. Our data confirmed the enrichment of n-3 FA in EM by EFA treatment and the inhibition of n-3 FA desaturation by CLA treatment. The elevated n-3 FA status and reduced n-6:n-3 ratio by EFA treatment indicated a more distinct effect on the inflammatory response during the transition period than the single CLA treatment, and the combined EFA+CLA treatment caused minor additional changes on the anti-inflammatory response.
Background
3D laparoscopy has proven to be superior to the 2D approach in experimental settings. The aim of the present study was to investigate the influence of 3D laparoscopy using a novel ...head-mounted display on the performance of defined steps within a laparoscopic inguinal hernia repair. This effect was investigated both in laparoscopically advanced surgeons and in beginners.
Methods
Patients suffering from symptomatic inguinal hernia were randomly assigned to laparoscopic hernia repair using either a head-mounted 3D display or a conventional 2D laparoscopic approach. Operative performance of both groups was compared in terms of the time taken for mesh placement and for peritoneal suturing. Additionally, quality of imaging and physical discomfort were assessed.
Results
The use of a head-mounted 3D display was able to shorten the time required for placement of the mesh as well as that for peritoneal suturing, both for experienced and novice surgeons when compared to the conventional 2D approach. 3D laparoscopy was significantly superior to 2D laparoscopy in terms of depth perception, image sharpness and image contrast. Additionally, increased impairment caused by ghosting effects could not be detected in 3D laparoscopy. Evaluation of image quality was independent of experience in laparoscopic surgery. However, use of a head-mounted 3D display resulted in a significant impairment of surgeon’s comfort when compared to 2D laparoscopy. Thereby, the greatest impairment was caused by ear discomfort.
Conclusions
This is the first study examining the effect of a head-mounted 3D system on the performance of laparoscopy in a randomized controlled trial (RCT) showing a clear advantage of this system in surgical performance as well as in depth perception and image quality.
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