To describe the process of becoming aware of and acting on personal cardiovascular (CVD) risk in type 2 diabetes (T2D).
A purposive sample of 14 persons living with T2D participated in ...semi-structured, open-ended, in-dept interviews. The interviews were analysed with grounded theory.
The analysis identified the core category "Balancing emotions, integrating knowledge and understanding to achieve risk awareness and act on it." Five categories describe the movement from not being aware of the risk of cardiovascular disease (CVD) to becoming aware of this risk and taking action to reduce it. Persons with T2D need to transform their knowledge and experience of CVD risk and incorporate it in their individual situations. Emotional and existential experiences of CVD risk can lead to awareness about the severity of the condition and contribute to increased motivation for self-management. However, an overly high emotional response can be overwhelming and may result in insufficient self-management.
Persons with T2D seemed not to fully grasp their increased risk of CVD or recognize that self-management activities were aimed at reducing this risk. However, their awareness of CVD risk gradually increased as they came to understand the severity of T2D and became more emotionally and existentially engaged.
Central to evolution is the concept of a common ancestry from which all life has emerged over immense time scales, but learning and teaching temporal aspects of evolution remain challenging. This ...study investigated students’ interpretation of evolutionary time when engaging with a multi-touch tabletop application called DeepTree, a dynamic visualization of a phylogenetic tree. Specifically, we explored how interactive finger-based zooming (zooming “in” and “out”) influenced students’ interpretation of evolutionary time, and how temporal information and relationships were conceptualized during interaction. Transcript analysis of videotaped interview data from ten secondary school students while they interacted with DeepTree revealed that zooming was interpreted in two ways: as spatially orientated (movement within the tree itself), or as time-orientated (movement in time). Identified misinterpretations included perceiving an implicit coherent timeline along the y-axis of the tree, that the zooming time duration in the virtual tree was linearly correlated to real time, and that more branch nodes correspond to a longer time. Sources for erroneous interpretations may lie in transferring everyday sensory experiences (e.g., physical movements and observing tree growth) to understanding abstract evolution concepts. Apart from estimating the occurrence of dinosaurs, DeepTree was associated with an improvement in interpretation of relative order of evolutionary events. Although highly promising, zooming interaction in DeepTree does not facilitate an intuitive understanding of evolutionary time. However, the opportunity to combine visual and bodily action in emerging technologies such as Deep Tree suggests a high pedagogical potential of further development of zooming features for optimal scientific understanding.
Purpose
To compare exposure to formaldehyde, nitrogen dioxide, ozone and terpenes among office workers with and without sick building syndrome and the odds ratio for exposure. Are there significant ...differences?
Methods
In this cross-sectional study of office workers, we investigated the associations between exposure to formaldehyde, nitrogen dioxide, ozone, α-pinene, and
d
-limonene using a case–control analysis. Data on perceived general, mucosal, and skin symptoms were obtained by questionnaires. Personal exposure measurements of the compounds were performed among cases and controls, and the odds ratios for exposures to the substances, both singly and in combination, were investigated.
Results
Exposures varied for formaldehyde between 0.23 and 45 µg/m
3
, nitrogen dioxide between 0.26 and 110 µg/m
3
, ozone between <16 and 165 µg/m
3
, α-pinene between 0.2 and 170 µg/m
3
, and
d
-limonene between 0.8 and 1,400 µg/m
3
. No consistent differences in exposure odds ratios were found between cases and controls or for individual symptoms.
Background
Macroevolutionary time is a difficult idea to grasp and is considered to be a threshold concept in teaching and learning evolution. One way of addressing this subject is to use animations ...that represent evolutionary time. The aim of this descriptive and exploratory study was to investigate how various representations of time in an animation affect the way undergraduate students comprehend different temporal aspects of hominin evolution. Two factors, namely differences in timelines (the number of timelines with different scales) and the mode of the default animated time rate (either constant throughout the animation or decreasing as the animation progressed) were combined to give four different time representations. The temporal aspects were investigated using undergraduate students’ ability to find events at specific times, to comprehend relative order, to comprehend concurrent events, to estimate the duration of time intervals and their ability to compare the lengths of time intervals.
Results
The results revealed that “finding events at specific times” near to the end of the animation (closer to present time), where the sequence of events appeared very quickly, was more difficult for groups working with animations with only one timeline. We also found that the ability to comprehend concurrent events can be impaired if several timelines are displayed and the animation speed is relatively high. The ability to estimate the duration of a time interval was more difficult for groups working with animations with only one timeline, especially at the end of the animation where the sequence of events occurred quickly. Making correct comparisons of time intervals was relatively independent of which animation was used with one notable exception: groups working with an animation featuring several timelines and a decreasing default animated time rate performed worst at comparing events with intervals that spanned parts of the timeline with different scales.
Conclusions
Our results indicate that the choice of animation should depend on the teaching intention. However, a visualization with several timelines, and an animated time which slowed down toward present time, generated the best results for the majority of items tested. Temporal scale shift may interfere with the perception of time in cases where durations are compared.
The Covid-19 pandemic has generated new experiences of intensive care. It has entailed new working methods, treatment strategies, and ethical dilemmas. The aim of this study was to describe intensive ...care nurses’ experiences of Covid-19 care and its ethical challenges. Data collection consisted of 11 individual semi-structured interviews and a qualitative content analysis was used. The COREQ checklist was followed. Three main themes emerged: to meet Covid-19 patients’ needs for specifically tailored intensive care; to have a changed approach to the excluded relatives is unethical, but defensible; and to strive to protect ethical values needs to be considered as good enough. In conclusion, ICU nurses shouldered a heavy burden in taking responsibility for the safety of these patients, continuously learning about new treatment strategies. Caring for Covid-19 patients was to strive to make the best of the situation.
Despite the importance of emotions in science education, research on affect remains sparse. A promising direction is to explore the role of immersive visualisation in evoking affective responses. We ...investigate whether touch-based zooming interaction with a tabletop visualisation of the tree of life evokes various affective responses, particularly, the epistemic affective responses of awe, curiosity, surprise, and confusion. Ten students participated in semi-structured interviews while interacting with the visualisation. Verbal utterances and interactions with the visual interface were videorecorded. Students' verbal and non-verbal affective responses in relation to five evolutionary themes were analysed. Results revealed that students expressed all four affective responses while engaging the zooming feature, with awe and surprise most frequently uttered. Most affective responses were associated with the themes of biological relationships and evolutionary time. Awe was highly associated with evolutionary time, surprise with biological relationships, and confusion with both these conceptual themes. For eight participants, awe was the initial affective response generated after exposure to the dynamic tree of life. The study demonstrates that interacting with an immersive visualisation through zooming can induce affective responses in relation to multiple conceptual themes in evolution. The findings provide insight into multidirectional interconnections between affect, dynamic visualisation, and biology concepts.
This study focuses on the variability in chemical exposures for individuals working in office buildings. The study involved eight office buildings with 79 participants, and exposures were measured ...using personal samplers for volatile organic compounds, aldehydes, amines, nitrogen dioxide, ozone, and particles. Ventilation was assessed in each individual office. "Variability among buildings" and "variability among individuals" were evaluated for any component (of the 123) measured in samples from at least 20 persons, using variance component analysis and principal component analysis. Interpersonal differences explained the major part of the variance for 78% of the compounds versus between-buildings differences for 14% of the compounds. For 8% of compounds, the variation was explained in equal amounts by the differences among individuals and among buildings. This study illustrates the necessity for individualised measurements (versus stationary measurements in building) to estimate personal exposures. These results also support the conclusion that in case-referent studies of "sick building syndrome" (SBS), referents to SBS cases can be randomised for building location.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
This article addresses problems that complicate attempts to compare methods when several factors may be associated with an effect, but it is not known which factors are relevant. Chemicals that may ...contribute to 'sick building syndrome' (SBS), and thus should be sampled in investigations of SBS, are not currently known. A study was undertaken to compare the utility of three adsorbents (Carbopack B, Chromosorb 106 and Tenax TA) for detecting differences in personal chemical exposure to volatile organic compounds in indoor air, between persons with and without SBS symptoms (cases and controls). On the basis of office workers' responses to a questionnaire, 15 cases and 15 controls were chosen. They simultaneously carried diffusive samplers with adsorbents during a week at work, and the acquired samples were analysed by gas chromatography/mass spectrometry (GC/MS). The adsorbents were then compared in terms of their ability to separate cases and controls in partial least square discriminant analysis (PLS-DA) models. This method of comparison takes into account detected differences in chemical exposure between cases and controls measured with the different adsorbents. Tenax TA gave the best PLS-DA models for separating cases and controls, but a combination of measurements with Tenax TA and Carbopack B gave better PLS-DA models than models based on measurements from either adsorbent alone. Adding measurements from Chromosorb 106 did not improve the results.
Epigenetic dysregulation may influence disease progression. Here we explore whether epigenetic alterations in human pancreatic islets impact insulin secretion and type 2 diabetes (T2D). In islets, ...5,584 DNA methylation sites exhibit alterations in T2D cases versus controls and are associated with HbA1c in individuals not diagnosed with T2D. T2D-associated methylation changes are found in enhancers and regions bound by β-cell-specific transcription factors and associated with reduced expression of e.g. CABLES1, FOXP1, GABRA2, GLR1A, RHOT1, and TBC1D4. We find RHOT1 (MIRO1) to be a key regulator of insulin secretion in human islets. Rhot1-deficiency in β-cells leads to reduced insulin secretion, ATP/ADP ratio, mitochondrial mass, Ca
, and respiration. Regulators of mitochondrial dynamics and metabolites, including L-proline, glycine, GABA, and carnitines, are altered in Rhot1-deficient β-cells. Islets from diabetic GK rats present Rhot1-deficiency. Finally, RHOT1methylation in blood is associated with future T2D. Together, individuals with T2D exhibit epigenetic alterations linked to mitochondrial dysfunction in pancreatic islets.
PDF
