A coupled channel analysis of the centrally produced
K
+
K
−and
π
+
π
−final states has been performed in
pp collisions at an incident beam momentum of 450 GeV/c. The pole positions and branching ...ratios to
ππ and
K
K
of the
f
0(980),
f
0(1370),
f
0(1500) and
f
0(1710) have been determined. A systematic study of the production properties of all the resonances observed in the
π
+
π
−and
K
+
K
−channels has been performed.
The reaction pp -> pf (eta eta) ps has been studied at 450 GeV/c. For the first time a partial wave analysis of the centrally produced eta eta system has been performed. Signals for the f0(1500), ...f0(1710) and f2(2150) are observed and the decay branching fractions of these states are determined.
The aim of this study was to describe the long-term outcome of asymptomatic BRCA1/2 germline pathogenic variant (GPV) carriers with high-grade serous carcinoma (HGSC) in their risk-reducing ...salpingo-oophorectomy (RRSO) specimen.
In a previously described cohort of asymptomatic BRCA1/2 GPV carriers derived from the Hereditary Breast and Ovarian cancer in the Netherlands (HEBON) study, women with HGSC at RRSO were identified. Main outcome was ten-year disease-free survival (DFS). Secondary outcomes were time to recurrence, ten-year disease-specific survival (DSS), ten-year overall survival (OS). Patient, disease and treatment characteristics associated with recurrence were described.
The 28 included women with HGSC at RRSO were diagnosed at a median age of 55.3 years (range: 33.5–74.3). After staging, eighteen women had (FIGO) stage I, three stage II and five had stage III disease. Two women did not undergo surgical staging and were classified as unknown stage. After a median follow-up of 13.5 years (range: 9.1–24.7), six women with stage I (33%), one woman with stage II (33%), two women with stage III (40%) and none of the women with unknown stage developed a recurrence. Median time to recurrence was 6.9 years (range: 0.8–9.2 years). Ten-year DFS was 68%, ten-year DSS was 88% and ten-year OS was 82%.
Most asymptomatic BRCA1/2 GPV carriers with HGSC at RRSO were diagnosed at an early stage. Nevertheless, after a median follow-up of 13.5 years, nine of the 28 women with HGSC at RRSO developed a recurrence after a median of 6.9 years.
•Three-quarters of the asymptomatic BRCA1/2 GPV carriers with HGSC at RRSO had early stage disease.•The ten-year disease-free survival was 68%, ten-year disease-specific survival was 88% and ten-year overall-survival was 82%.•After a median follow-up of 13.5 years, recurrence rate was 32% with median time to recurrence of 6.9 years (range 0.8–9.2).•Timely RRSO remains the only reliable method of reducing mortality of HGSC in BRCA1/2 GPV carriers.
To investigate the prevalence of and clinical factors associated with high-grade serous carcinoma (HGSC) at risk-reducing salpingo-oophorectomy (RRSO) in asymptomatic
-pathogenic variant (PV) ...carriers.
We included
-PV carriers who underwent RRSO between 1995 and 2018 from the Hereditary Breast and Ovarian cancer in the Netherlands study. All pathology reports were screened, and histopathology reviews were performed for RRSO specimens with epithelial abnormalities or where HGSC developed after normal RRSO. We then compared clinical characteristics, including parity and oral contraceptive pill (OCP) use, for women with and without HGSC at RRSO.
Of the 2,557 included women, 1,624 had
, 930 had
, and three had both
-PV. The median age at RRSO was 43.0 years (range: 25.3-73.8) for
-PV and 46.8 years (27.6-77.9) for
-PV carriers. Histopathologic review confirmed 28 of 29 HGSCs and two further HGSCs from among 20 apparently normal RRSO specimens. Thus, 24 (1.5%)
-PV and 6 (0.6%)
-PV carriers had HGSC at RRSO, with the fallopian tube identified as the primary site in 73%. The prevalence of HGSC in women who underwent RRSO at the recommended age was 0.4%. Among
PV carriers, older age at RRSO increased the risk of HGSC and long-term OCP use was protective.
We detected HGSC in 1.5% (
-PV) and 0.6% (
-PV) of RRSO specimens from asymptomatic
-PV carriers. Consistent with the fallopian tube hypothesis, we found most lesions in the fallopian tube. Our results highlight the importance of timely RRSO with total removal and assessment of the fallopian tubes and show the protective effects of long-term OCP.
The reaction
pp→
p
f
(
ηη)
p
s
has been studied at 450 GeV/c. For the first time a partial wave analysis of the centrally produced
ηη system has been performed. Signals for the
f
0(1500),
f
0(1710) ...and
f
2(2150) are observed and the decay branching fractions of these states are determined.
The reactions
pp→
p
f
(
X
0)
p
s
, where
X
0 is observed decaying to
π
0
π
0
π
0
π
0 ,
π
+
π
−
π
+
π
− and
π
+
π
−
π
0
π
0 , have been studied at 450 GeV/
c. There is evidence for an
a
2(1320)
π ...decay mode of the
η
2(1645) and
η
2(1870) in the
π
+
π
−
π
0
π
0 and
π
+
π
−
π
+
π
− final states. The
f
2(1950) is consistent with being a single resonance with a dominant
f
2(1270)
ππ decay mode. The
f
0(1370) is found to decay dominantly to
ρρ while the
f
0(1500) is found to decay to
ρρ and
σσ.
A study of the
f
1(1285) and
f
1(1420) produced in central pp interactions has been performed. For the first time in a single experiment the branching fractions of both mesons in all major decay ...modes have been determined. Both the
f
1(1285) and
f
1(1420) are consistent with being produced by double Pomeron exchange.
Evidence is presented that the Pomeron acts as a non-conserved vector current. A study has been made of the azimuthal angle
φ, which is defined as the angle between the
p
T
vectors of the two ...outgoing protons, in the reaction
pp→
pp(
X
0) for those resonances (
X
0) which are compatible with being produced by double Pomeron exchange. These distributions have been compared with a model which describes the Pomeron as a non-conserved vector current and a qualitative agreement is found. In addition, when one of the particles exchanged is known to have spin 0, namely
π–Pomeron exchange, the
φ distribution is flat.
The production and decay properties of the f0(1370), f0(1500), f0(2000) and f2(1950) have been studied in central pp interactions at 450 GeV/c. The dPT, phi and |t| distributions of these resonances ...are presented. For the J = 0 states, the f0(1370) and f0(2000) have similar dPT and phi dependences. These are different to the dPT and phi dependences of the f0(980), f0(1500) and f0(1710). For the J = 2 states the f2(1950) has different dependences to the f2(1270) and f2'(1520). This shows that the dPT and phi dependences are not just J phenomen
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