At the Belle II experiment, Aerogel RICH is used as the particle identification device that covers the forward end-cap part of the Belle II detector. We develop the readout system of Hybrid Avalanche ...Photo Detectors that are used as the photon sensors of the Aerogel RICH. We present overview of the readout system, and report the status of the mass production toward the Belle II experiment.
A
bstract
The yields and production rates of the radioisotopes
9
Li and
8
He created by cosmic muon spallation on
12
C, have been measured by the two detectors of the Double Chooz experiment. The ...identical detectors are located at separate sites and depths, which means that they are subject to different muon spectra. The near (far) detector has an overburden of ∼120 m.w.e. (∼300 m.w.e.) corresponding to a mean muon energy of 32.1 ± 2.0 GeV (63.7 ± 5.5 GeV). Comparing the data to a detailed simulation of the
9
Li and
8
He decays, the contribution of the
8
He radioisotope at both detectors is found to be compatible with zero. The observed
9
Li yields in the near and far detectors are 5.51 ± 0.51 and 7.90 ± 0.51, respectively, in units of 10
−8
μ
−1
g
−1
cm
2
. The shallow overburdens of the near and far detectors give a unique insight when combined with measurements by KamLAND and Borexino to give the first multi-experiment, data driven relationship between the
9
Li yield and the mean muon energy according to the power law
Y
=
Y
0
E
μ
/
1
GeV
α
¯
, giving
α
¯
=
0.72
±
0.06
and
Y
0
= (0.43 ± 0.11) × 10
−8
μ
−1
g
−1
cm
2
. This relationship gives future liquid scintillator based experiments the ability to predict their cosmogenic
9
Li background rates.
Hepatocellular carcinoma (HCC) develops in the context of chronic inflammatory liver disease and has an extremely poor prognosis. An immunosuppressive tumor microenvironment may contribute to ...therapeutic failure in metastatic HCC. Here, we identified unique molecular signatures pertaining to HCC disease progression and tumor immunity by analyzing genome-wide RNA-Seq data derived from HCC patient tumors and non-tumor cirrhotic tissues. Unsupervised clustering of gene expression data revealed a gradual suppression of local tumor immunity that coincided with disease progression, indicating an increasingly immunosuppressive tumor environment during HCC disease advancement. IHC examination of the spatial distribution of CD8+ T cells in tumors revealed distinct intra- and peri-tumoral subsets. Differential gene expression analysis revealed an 85-gene signature that was significantly upregulated in the peri-tumoral CD8+ T cell-excluded tumors. Notably, this signature was highly enriched with components of underlying extracellular matrix, fibrosis, and epithelial-mesenchymal transition (EMT). Further analysis condensed this signature to a core set of 23 genes that are associated with CD8+ T cell localization, and were prospectively validated in an independent cohort of HCC specimens. These findings suggest a potential association between elevated fibrosis, possibly modulated by TGF-β, PDGFR, SHH or Notch pathway, and the T cell-excluded immune phenotype. Indeed, targeting fibrosis using a TGF-β neutralizing antibody in the STAM™ model of murine HCC, we found that ameliorating the fibrotic environment could facilitate redistribution of CD8+ lymphocytes into tumors. Our results provide a strong rationale for utilizing immunotherapies in HCC earlier during treatment, potentially in combination with anti-fibrotic therapies.
Development of slow control system for the Belle II ARICH counter Yonenaga, M.; Adachi, I.; Dolenec, R. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
12/2017, Letnik:
876
Journal Article
Recenzirano
A slow control system (SCS) for the Aerogel Ring Imaging Cherenkov (ARICH) counter in the Belle II experiment was newly developed and coded in the development frameworks of the Belle II DAQ software. ...The ARICH is based on 420 Hybrid Avalanche Photo-Detectors (HAPDs). Each HAPD has 144 pixels to be readout and requires 6 power supply (PS) channels, therefore a total number of 2520 PS channels and 60,480 pixels have to be configured and controlled. Graphical User Interfaces (GUIs) with detector oriented view and device oriented view, were also implemented to ease the detector operation. The ARICH SCS is in operation for detector construction and cosmic rays tests. The paper describes the detailed features of the SCS and preliminary results of operation of a reduced set of hardware which confirm the scalability to the full detector.
Development of the ARICH monitor system for the Belle II experiment Hataya, K.; Adachi, I.; Dolenec, R. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
12/2017, Letnik:
876
Journal Article
Recenzirano
The Belle II detector is under construction at KEK in Japan. In the forward endcap region of the Belle II detector, particle identification (PID) is performed by the Aerogel Ring Imaging Cherenkov ...(ARICH) counter composed of aerogel tiles and 144-channel Hybrid Avalanche Photo-Detectors (HAPDs). The photon detection efficiency of the photosensor is important for a stable operation of the ARICH. To examine the performance of the HAPDs periodically, a monitor system using scattered photons injected by optical fibers is being developed. In this paper, we report the test using the prototype monitor system and the tests with a partially built ARICH detector.
The Double Chooz is a reactor neutrino experiment which measures the last unknown neutrino mixing angle
θ
13
. The Double Chooz experiment uses two identical detectors placed at sites far and near ...from Chooz reactor cores. The detector uses 390 low-background and high performance 10-in. Photo-Multiplier Tubes (PMTs) to detect scintillation light from gadolinium loaded liquid scintillator. In order to test and characterize the PMTs and to tune operation parameter, we developed two types of PMT test system and evaluated 400
PMTs before installation. Those PMTs fulfilled our requirements and half of them were installed in the far detector in 2009 and physics data have been successfully taken since 2011.
Abstract
The Aerogel Ring Imaging Cherenkov (ARICH) counter serves as a particle identification device in the forward end-cap region of the Belle II spectrometer. It is capable of identifying pions ...and kaons with momenta up to $4\>$GeV$\>$c$^{-1}$ by detecting Cherenkov photons emitted in the silica aerogel radiator. After the detector alignment and calibration of the probability density function, we evaluate the performance of the ARICH counter using early beam collision data. Event samples of $D^{\ast +} \to D^0 \pi^+ (D^0 \to K^-\pi^+)$ were used to determine the $\pi(K)$ efficiency and the $K(\pi)$ misidentification probability. We found that the ARICH counter is capable of separating kaons from pions with an identification efficiency of $93.5 \pm 0.6 \, \%$ at a pion misidentification probability of $10.9 \pm 0.9 \, \%$. This paper describes the identification method of the counter and the evaluation of the performance during its early operation.
A 144-channel HAPD for the Aerogel RICH at Belle II Korpar, S.; Adachi, I.; Hamada, N. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
12/2014, Letnik:
766
Journal Article
Recenzirano
A hybrid photo-detector (HAPD) has been developed for the aerogel RICH (ARICH) of the Belle II experiment. In the present contribution we report the performance tests in magnetic fields, results of ...the neutron and gamma irradiation studies, and of aging tests. We also review the production status and plans.
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