Herein, a series of face-capped (Tr2M3)4L4 (Tr = cycloheptatrienyl cationic ring; M = metal; L = organosulfur ligand) tetrahedral cages 1–3 functionalized with 12 appended crown ether moieties were ...designed and synthesized. The reversible binding of ammonium cations with peripheral crown ether moieties to adjust internal guest-binding was realized. Combination of a bisammonium linker and cage 3 led to the formation of a supramolecular gel SPN1 via host–guest interactions between the crown ether moieties and ammonium salts. The obtained supramolecular gel exhibited multiple-stimuli responsiveness, injectability, and excellent self-healing properties and could be further developed to a SPN1-based drug delivery system. In addition, the storage modulus of SPN1 was 20 times higher than that of the model gel without Pd–Pd bonded blocks, and SPN1 had better self-healing properties compared with the latter, demonstrating the importance of such cages in improving mechanical strength without losing the dynamic properties of the material. The cytotoxicity in vitro of the drug-loaded (doxorubicin or methotrexate) SPN1 was significantly improved compared to that of free drugs.
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•The biocompatible Bio-MOF-1 was obtained by microwave-assisted method.•Bio-MOF-1 exhibited effective and selective adsorption toward Ag+ ions.•The adsorption mechanisms were ...confirmed by characterizations and DFT calculation.•The silver-loaded Bio-MOF-1 could be used as antimicrobial agent.
In this work, Bio-MOF-1 was adopted to remove and recover the Ag+ ions in the corresponding wastewater, which exhibited excellent Ag+ ions adsorption ability with adsorption capacity up to 655.3 mg/g. The adsorption kinetics, isotherm and thermodynamic parameters confirmed the adsorption process was dominated by multilayer chemisorption. The Ag+ ions adsorption behavior over Bio-MOF-1 was spontaneous, exothermic and orderly. In addition, Bio-MOF-1 displayed efficiently selective sorption toward Ag+ with the presence of the co-existence ions (including Cu2+, Ni2+, Co2+, Zn2+, Pd2+, Cd2+, Pt2+ and Au3+), in which the selective sorption efficiency could reach > 99.9% toward Ag+ with the distribution coefficients up to 1.4 × 107 mL/g. The possible adsorption mechanism of Bio-MOF-1 towards Ag+ mainly involved ion exchange, electrostatic and coordinative interactions, which was further analyzed by both experimental determination and Density Functional Theory (DFT) calculations. In particular, the Bio-MOF-1 adsorptively saturated with Ag+ could be used as the antimicrobial agent for long time (40.0 h) inhibition of the Escherichia coli (E. coli) growth. This work proposed and affirmed the possibility that mining resource was recovered from wastewater to produce the highly valued products.
Since
leaves are rich in bioactive constitutes, particularly volatile compounds, there are higher demands for high-quality dried medicinal and aromatic peppermint products. This study aimed to assess ...the drying kinetics of hot air thin layer drying
leaves and exploring the effects of hot air-drying temperatures on the textural properties and sensory quality. According to our results, the Midilli model is the best model representing the hot air-drying process. The effective moisture diffusivity (Deff) and activation energy (Ea) of the hot air-drying process were determined as 7.51 × 10
-3.03 × 10
m
/s and 57.98 KJ/moL, respectively. The changes of textural and aromatic profiles of dried
leaves were subsequently evaluated by the SEM, GC-MS and E-nose technology. Changes in leaf cellular membrane structures were observed in this study, indicating that the loss of moisture content induced the shrinkage of leaf cells during the hot air-drying process. Moreover, the altered profile of volatile compounds was identified at the different drying temperatures. As a result of the GC-MS analysis, increasing the content of D-carvone from 61.89%, 69.25% and 78.2% resulted in drying temperatures of 35 °C, 45 °C and 55 °C, respectively; while a decreasing trend of other volatile compounds, including D-Limonene, cineole and l-caryophyllene was detected as drying temperature elevated. Finally, the aromatic profile was evaluated by E-nose, and results of the flavor radar fingerprint and PCA showed that aromatic profiles were significantly altered by the drying process. The overall results elucidated that the hot air thin layer drying at 35 °C efficiently improved the final quality of dried
leaves by maintaining flavor properties.
Malignant tumors seriously threaten people's health and life worldwide. Natural products, with definite pharmacological effects and known chemical structures, present dual advantages of Chinese herbs ...and chemotherapeutic drug. Some of them exhibit favorable anti-cancer activity. Natural products were categorized into eight classes according to their chemical structures, including alkaloids, terpenoids and volatile oils, inorganic salts, phenylpropanoids, flavonoids and isoflavones, quinone, saponins and polysaccharides. The review focused on the latest advances in anti-cancer activity of representative natural products for every class. Additionally, anti-cancer molecular mechanism and derivatization of natural products were summarized in detail, which would provide new core structures and new insights for anti-cancer new drug development.
In this paper, we investigate a
-dimensional Bogoyavlenskii-Kadontsev-Petviashili equation in a fluid, plasma or ferromagnetic thin film. Through the Bell polynomials, Hirota method and symbolic ...computation, the one- and two-kink-soliton solutions are derived. Bäcklund transformation, Lax pair and conservation laws are presented. Elastic collisions including the oblique, parallel, unidirectional and bidirectional collisions between the two-kink solitons are discussed. In addition, the relation between the velocities and wave numbers of the two-kink solitons are analysed. When wave numbers
, the velocities in the x axis, increase with wave numbers
increasing. With
increasing,
increase when
, while decrease when
.
, the velocities in the y axis, increase with
increasing and
decreasing.
In order to better remove the interfering substances in the vegetables, a type of tetraethylenepentamine modified multi-wall carbon nanotubes has been prepared. As-prepared materials contain ...amino-groups and organic chains, and magnetism is endowed by using physical blending method. Taking the magnetic tetraethylenepentamine modified multi-walled carbon nanotubes as matrix clean-up agents and combining with GC-MS, a modified QuEChERS method was established for the pesticide residues analysis in cucumber. The recoveries of 10 pesticide targets were 73.5%–114.2%, and the RSDs were between 4.9% and 18.6%, which could meet the requirements of food safety testing. Compared with the traditional clean-up materials, the prepared materials exhibited better clean-up performance while simplifying the pretreatment process. Given the excellent clean-up performance of the proposed materials, it was expected to be used in the clean-up process of other samples with complex contents.
•Magnetic tetraethylenepentamine modified MWCNTs were designed and prepared.•As-prepared M-TP-MWCNTs exhibited efficient clean-up performance.•M-TP-MWCNTs can effectively remove the matric interferences in cucumber.•A modified QuEChERS method was developed, validated and applied.
Arteriovenous fistula is the preferred vascular access for hemodialysis patients. High-flow arteriovenous fistula may cause high-output heart failure. Various procedures are used to reduce high-flow ...arteriovenous fistula. This study aimed to assess the efficacy of proximal artery restriction combined with distal artery ligation on flow reduction for high-flow arteriovenous fistula and on cardiac function and echocardiographic changes in patients undergoing hemodialysis.
A retrospective analysis was performed on data collected from the medical records of patients undergoing hemodialysis with heart failure and high-flow arteriovenous fistula between May 2018 and May 2021. Thirty-one patients were treated with proximal artery restriction (banding juxta-anastomosis of the proximal artery) combined with distal artery ligation (anastomosis distal artery ligation). Changes in the Acute Dialysis Quality Initiative Workgroup cardiac function class, blood pressure, and echocardiography before and 6 months after flow restriction were compared, and post-intervention primary patency was followed-up.
The technical success rate of the surgery was 100%, and no surgery-related adverse events occurred. Blood flow and blood flow/cardiac output decreased significantly after flow restriction. Blood flow decreased from 2047.21 ± 398.08 mL/min to 1001.36 ± 240.42 mL/min, and blood flow/cardiac output decreased from 40.18% ± 6.76% to 22.34% ± 7.21% (P < .001). Post-intervention primary patency of arteriovenous fistula at 6, 12, and 24 months was 96.8%, 93.5%, and 75.2%, respectively. The Acute Dialysis Quality Initiative Workgroup cardiac function class improved significantly after 6 months of flow restriction (P < .001). The systolic and diastolic left heart function improved, as evidenced by a significant decrease in left atrial volume index, left ventricular end-diastolic/end-systolic diameters, left ventricular end-diastolic volume, left ventricular mass index, cardiac output, and cardiac index and an increase in lateral peak velocity of longitudinal contraction, average septal-lateral s', and lateral early diastolic peak velocity after flow restriction (P < .05). Systolic pulmonary artery pressure decreased from 32.36 ± 8.56 mmHg to 27.57 ± 8.98 mmHg (P < .05), indicating an improvement in right heart function.
Proximal artery restriction combined with distal artery ligation effectively reduced the blood flow of high-flow arteriovenous fistula and improved cardiac function.
A series of iron oxide sorbents with novel structures of three-dimensionally ordered macropores (3DOM), ranging in size from 60 to 550 nm, were fabricated and creatively used as sorbents for the ...removal of H2S at medium temperatures of 300–350 °C. Evaluation tests using thermogravimetric analysis (TGA) and a fixed-bed reactor showed that, in comparison to the iron oxide sorbent prepared by a conventional mixing method, the fabricated iron oxide sorbent with a 3DOM structure exhibited much higher reactivity and efficiency, as well as high sorbent utilization with low regeneration temperature. The excellent performance of 3DOM iron oxide as a sulfur sorbent is attributed to its special texture, i.e., the open and interconnected macroporous, large surface area, and nanoparticles of iron oxide, which are revealed by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and nitrogen adsorption techniques. The investigation results of the pore effect on the performance of the sorbent show that sorbents with pores size around 150 nm in diameter revealed the best performance. The reason is that pores of this size are large enough to allow gas to pass through even if the channel is partially blocked during the reaction process while remaining a large surface area that can provide more active sites for the reaction.
An eco-friendly and practical method for the ultrasonic multicomponent synthesis of diverse (Z)-β-iodo vinylthiocyanates from cheap and commercially available alkynes, molecular iodine, and KSCN ...through an intermolecular H-bonding assistance strategy was developed.
Background
Long noncoding RNA (lncRNA) Z38 has been shown to promote cell proliferation and tumorigenesis in breast cancer. However, expression pattern and prognostic value of lncRNA Z38 in breast ...cancer patients remain elusive.
Methods
The expression levels of SPRY4‐IT1 in 110 self‐paired specimens of breast cancer and adjacent normal breast tissues were measured by quantitative real‐time PCR (qRT‐PCR), and its correlation with overall survival of patients with breast cancer was further statistically analyzed.
Results
Compared with normal breast tissues, Z38 was upregulated in breast cancer tissues. Furthermore, of 110 breast cancer patients, high Z38 expression was significantly associated with tumor‐node‐metastasis stage and lymph node metastasis. Further analysis using the Cox regression model revealed that Z38 expression was an independent prognostic factor of overall survival in patients with breast cancer (hazard ratio=4.74, 95% confidence interval 2.41‐9.32). The nomogram presents a good prediction of the probability of overall survival of breast cancer patients (c‐index: 0.792), and its predictive efficiency was further confirmed by the calibration curve.
Conclusion
Our data highlighted the potential of lncRNA Z38 as novel candidate biomarker to identify patients with breast cancer at high risk of tumor death.
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