Recent studies indicated that an anisotropic cosmic expansion may exist. In this paper, we use three data sets of type Ia supernovae (SNe Ia) to probe the isotropy of cosmic acceleration. For the ...Union2.1 data set, the direction and magnitude of the dipole are
(
l
=
309
.
3
∘
-
15
.
7
∘
+
15
.
5
∘
,
b
=
-
8
.
9
∘
-
9
.
8
∘
+
11
.
2
∘
)
, and
A
=
(
1.46
±
0.56
)
×
10
-
3
from dipole fitting method. The hemisphere comparison results are
δ
=
0.20
,
l
=
352
∘
,
b
=
-
9
∘
. For the Constitution data set, the results are
(
l
=
67
.
0
∘
-
66
.
2
∘
+
66
.
5
∘
,
b
=
-
0
.
6
∘
-
26
.
3
∘
+
25
.
2
∘
)
, and
A
=
(
4.4
±
5.0
)
×
10
-
4
for dipole fitting and
δ
=
0.56
,
l
=
141
∘
,
b
=
-
11
∘
for hemisphere comparison. For the JLA data set, no significant dipolar or quadrupolar deviation is found. We find previous works using (
l
,
b
,
A
) directly as fitting parameters may get improper results. We also explore the effects of anisotropic distributions of coordinates and redshifts on the results using Monte-Carlo simulations. We find that the anisotropic distribution of coordinates can cause dipole directions and make dipole magnitude larger. Anisotropic distribution of redshifts is found to have no significant effect on dipole fitting results.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The present article systematically investigates the laminar explosion behaviors of syngas with wider ranges of fuel concentrations (0.4 ~ 3.0 in equivalence ratio) and composition fractions (30%~70% ...in volume fraction ratio of H
2
in syngas) in a 28.73-L spherical vessel. The temporal traces of explosion overpressure and the variations of four essential explosion indices (maximum explosion pressure, explosion duration, peak pressure rise rate, and deflagration index) have been studied, the influencing factors and mechanism have been analyzed and discussed. The influences mechanism of composition and concentration on maximum explosion pressure are discussed from the viewpoint of heat loss to the vessel wall. The correlation of explosion duration to laminar burning velocity has also been discussed, the result indicates that the correlation is mainly determined by fuel composition when the burning velocity beyond certain level. The critical equivalence ratio for peak pressure rise rate in syngas explosion is determined by the maximum pressure for H
2
-enriched syngas but it is determined by explosion duration for CO-enriched syngas. Furthermore, the safety issues about syngas are also discussed upon deflagration index.
There are few data on the molecular epidemiology of cryptococcosis in China. Here we investigated the species distribution, molecular types and antifungal susceptibilities of 312 Cryptococcus ...neoformans species complex isolates from ten hospitals over 5 years. Isolates were identified by internal transcribed spacer (ITS) sequencing and by two matrix-assisted laser desorption–ionization time-of-flight mass spectrometry (MALDI-TOF MS) systems. Multilocus sequence typing (MLST) was used to verify species/variety and to designate molecular types. Susceptibility to six antifungal drugs was determined by the Sensititre YeastOne™ method. Cryptococcus neoformans was the predominant species (305/312 isolates (97.8%), all were ITS type 1, serotype A), of which 89.2% (272/305) were C. neoformans var. grubii MLST sequence type (ST) 5 and 6.2% (19/305) were ST31. Other C. neoformans var. grubii STs were rare but included six novel STs. Only two strains were C. neoformans var. neoformans (both serotype AD). Cryptococcus gattii was uncommon (n = 7, four ITS types) and comprised five MLST STs including one novel ST. For C. neoformans var. grubii, the proportion of isolates with non-wild-type MICs to fluconazole significantly rose in the fourth study year (from 0% (0/56 isolates) in the first year to 23.9% (17/71) in the fourth year), including five isolates with fluconazole MICs of ≥32 mg/L. The study has provided useful data on the species epidemiology and their genetic diversity and antifungal susceptibility. The proportional increase in isolates with non-wild-type MICs to fluconazole is noted.
Prostate cancer cells escape growth inhibition from transforming growth factor β (TGFβ) by downregulating TGFβ receptors. However, the mechanism by which cancer cells downregulate TGFβ receptors in ...prostate is not clear. Here, we showed that coordinated action of miR-21 and androgen receptor (AR) signaling had a critical role in inhibiting TGFβ receptor II (TGFBR2) expression in prostate cancer cells. Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers. Analysis of primary prostate cancers showed that increased miR-21/AR expression parallel a significantly reduced expression of TGFBR2. Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells, human prostate cancer xenografts and mouse prostate glands. Importantly, we demonstrated that miR-21 and AR regulated each other's expression resulting in a positive feedback loop. Our results indicated that miR-21/AR mediate its tumor-promoting function by attenuating TGFβ-mediated Smad2/3 activation, cell growth inhibition, cell migration and apoptosis. Together, these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2, hence inhibiting the tumor-suppressive activity of TGFβ pathway. Targeting miR-21 alone or in combination with AR may restore the tumor inhibitory activity of TGFβ in prostate cancer.
Fructose consumption and its implications on public health are currently under study. This work reviewed the metabolic fate of dietary fructose based on isotope tracer studies in humans. The mean ...oxidation rate of dietary fructose was 45.0% ± 10.7 (mean ± SD) in non-exercising subjects within 3-6 hours and 45.8% ± 7.3 in exercising subjects within 2-3 hours. When fructose was ingested together with glucose, the mean oxidation rate of the mixed sugars increased to 66.0% ± 8.2 in exercising subjects. The mean conversion rate from fructose to glucose was 41% ± 10.5 (mean ± SD) in 3-6 hours after ingestion. The conversion amount from fructose to glycogen remains to be further clarified. A small percentage of ingested fructose (<1%) appears to be directly converted to plasma TG. However, hyperlipidemic effects of larger amounts of fructose consumption are observed in studies using infused labeled acetate to quantify longer term de novo lipogenesis. While the mechanisms for the hyperlipidemic effect remain controversial, energy source shifting and lipid sparing may play a role in the effect, in addition to de novo lipogenesis. Finally, approximately a quarter of ingested fructose can be converted into lactate within a few of hours. The reviewed data provides a profile of how dietary fructose is utilized in humans.
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Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK, VSZLJ
The increasing penetration of wind power impacts and the frequency stability of power systems is presented. A doubly fed induction generator (DFIG)-based, wind power plant naturally does not provide ...frequency response, because of the decoupling between the output power and the grid frequency. DFIGs also lack of power reserve margin, because of the maximum power point tracking operation. Therefore, this study presents a novel frequency regulation by DFIG-based wind turbines to coordinate inertial control, rotor speed control and pitch angle control, under low, medium or high wind speed mode. Inertial control emulates the inertia of wind generators and supports frequency control during transient. The gain of inertial control is calculated from a creative viewpoint of protecting the wind turbine from stalling. Rotor speed control and pitch angle control enable DFIGs to reserve sufficient active power for a steady-state frequency adjustment. The numerical simulations demonstrate that the coordinated control enhances the frequency regulation capability and damps the frequency oscillations effectively.
Here, in an analysis of a 2.92 fb–1 data sample taken at 3.773 GeV with the BESIII detector operated at the BEPCII collider, we measure the absolute decay branching fractions to be B(D0 → K–e+νe) = ...(3.505 ± 0.014 ± 0.033)% and B(D0 → π–e+νe) = (0.295 ± 0.004 ± 0.003)%. From a study of the differential decay rates we obtain the products of hadronic form factor and the magnitude of the CKM matrix element $f$ $^{K}_{+}$(0)|Vcs| = 0.7172 ± 0.0025 ± 0.0035 and $f$ $^{π}_{+}$(0)|Vcd| = 0.1435 ± 0.0018 ± 0.0009.
By combining scanning tunneling microscopy and spectroscopy, angle-resolved photoemission spectroscopy, and density functional theory band calculations, we directly observe and resolve the ...one-dimensional edge states of single bilayer (BL) Bi(111) islands on clean Bi(2)Te(3) and Bi(111)-covered Bi(2)Te(3) substrates. The edge states are localized in the vicinity of step edges having an ∼2 nm wide spatial distribution in real space and reside in the energy gap of the Bi(111) BL. Our results demonstrate the existence of nontrivial topological edge states of single Bi(111) bilayer as a two-dimensional topological insulator.
The richness of optical and electronic properties of graphene attracts enormous interest. Graphene has high mobility and optical transparency, in addition to flexibility, robustness and environmental ...stability. So far, the main focus has been on fundamental physics and electronic devices. However, we believe its true potential lies in photonics and optoelectronics, where the combination of its unique optical and electronic properties can be fully exploited, even in the absence of a bandgap, and the linear dispersion of the Dirac electrons enables ultrawideband tunability. The rise of graphene in photonics and optoelectronics is shown by several recent results, ranging from solar cells and light-emitting devices to touch screens, photodetectors and ultrafast lasers. Here we review the state-of-the-art in this emerging field.
A single factorial experiment was conducted to investigate the effects of Chinese herbal medicines mixture (CHMM) on growth performance, digestive enzyme activity and immune response of Japanese ...seabass, Lateolabrax japonicus (initial weight 5.01 ± 0.32 g). The fish were fed diets containing six levels of CHMM (0, 4, 8, 12, 16 and 20 g/kg) for 4 weeks. The results showed that the weight gain rate and specific growth rate (SGR) enhanced significantly in fish fed diet containing 8 g/kg CHMM (p < .05), while the feed conversion ratio (FCR) in the 4 and 8 g/kg CHMM groups reduced significantly compared with the control (p < .05). The body crude protein levels in 8 and 16 g/kg groups were significantly higher than the control (p < .05). The pepsin, amylase and lipase activities elevated significantly in the stomach of fish fed 8 g/kg CHMM, while the erepsin and lipase in the intestine of fish in 12 and 16 g/kg groups were higher significantly than the control (p < .05). The lysozyme, alkaline phosphatase, acid phosphatase (ACP), total antioxidative capacity activities in serum of fish fed 12 g/kg CHMM were higher significantly than those in the control (p < .05), while the total superoxide dismutase (SOD), total antioxidative capacity, catalase, alkaline phosphatase (AKP) and ACP activities in hepatopancreas of fish in 12 g/kg group were all significantly higher than those in the control (p < .05). Regression analysis showed that the relationships between dietary CHMM levels and either FCR, SGR, erepsin, pepsin or lysozyme activities were best expressed by quadratic or cubic regression equations, and the optimal inclusion levels are 11.4, 10.7, 10.7, 8.4 and 10.5 g/kg for maximum FCR, SGR, erepsin, pepsin and lysozyme activities, respectively. Under the present experimental condition, the optimal supplementary level of CHMM in the diet of Japanese seabass is 8–12 g/kg.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
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