Abstract
A stellar occultation by the extreme large-perihelion trans-Neptunian object (541132) Leleākūhonua (also known by the provisional designation of 2015 TG
387
) was predicted by the Lucky Star ...project and observed with the Research and Education Collaborative Occultation Network on 2018 October 20 UT. A single detection and a nearby nondetection provide constraints for the size and albedo. When a circular profile is assumed, the radius is
km, corresponding to a geometric albedo
, for an adopted absolute magnitude of
H
V
= 5.6, typical of other objects in dynamically similar orbits. The occultation also provides a high-precision astrometric constraint.
We present a method for classification of the two distinct types of electrical activity that occur during an explosive volcanic eruption: vent discharges and lightning. Vent discharges occur at the ...onset of an explosion and create a distinctive radio frequency signature called continual radio frequency. Seconds to minutes after the onset of the eruption, lightning begins to occur throughout the eruption column. We use logistic regression to classify a radio frequency impulse as being part of either a lightning flash or a period of continual radio frequency. The classifier uses the number of peaks in the amplitude envelope from 1 ms windows before and after the impulsive very high frequency waveform, with an average accuracy of 97.9%. We propose that this method could be used in an algorithm to determine when explosive eruptions occurred by identification of the distinctive signatures of vent discharges and lightning.
Plain Language Summary
We present a method for automated identification of two distinct types of electrical activity from explosive volcanic eruptions. Explosive eruptions produce lightning, just like thunderstorms. In addition, they also produce small (<4 m) spark‐like electrical discharges at the vent of a volcano, which are called vent discharges. These vent discharges occur for relatively long durations compared to the duration of a typical lightning flash (seconds vs. hundreds of milliseconds) and are thus easily distinguishable in very high frequency (30–300 MHz) electric field measurements. We use logistic regression to classify an electric field impulse as either being part of a lightning flash or a vent discharge. The classifier uses the number of peaks in the electric field signal in 1 ms time windows before and after an electric field impulse. The accuracy of the classifier is 97.9%. We explain that the classifier could be used on a low‐power lightning sensor to automatically identify that an explosive eruption had occurred. We discuss how this capability would enable a new era of volcanic lightning monitoring that would allow for new research into understanding the physical mechanisms of vent discharges to learn how they can be used during the response to an eruption.
Key Points
We created a logistic regression model that classifies electrical activity as either vent discharges or lightning with an accuracy of 97.9%
The logistic regression model uses the number of waveform peaks in 1 ms time windows preceding and succeeding an RF impulse
The model could be used to identify the characteristic pattern of electrical activity produced by explosive eruptions
A stellar occultation by the extreme large-perihelion trans-Neptunian object (541132) Lele k honua (also known by the provisional designation of 2015 TG387) was predicted by the Lucky Star project ...and observed with the Research and Education Collaborative Occultation Network on 2018 October 20 UT. A single detection and a nearby nondetection provide constraints for the size and albedo. When a circular profile is assumed, the radius is km, corresponding to a geometric albedo , for an adopted absolute magnitude of HV = 5.6, typical of other objects in dynamically similar orbits. The occultation also provides a high-precision astrometric constraint.
We report on the stellar occultation by (523764) 2014 WC510 observed on 2018 December 1 UT. This occultation campaign was part of the Research and Education Collaborative Occultation Network (RECON), ...a network of small telescopes spread over 2000 km in western USA and Canada. Light curves from six stations revealed three groups of two or more consecutive flux drops correlated in time between adjacent stations. A Bayesian model comparison reveals that a model with a double object occulting a double star is favored over alternative models considered. For the statistically favored model, we determined that the primary component of the object has a diameter dp = 181 16 km and the secondary ds = 138 32 km, assuming identical geometric albedo between the two components. The two components have a projected separation of 349 26 km. Adopting an absolute magnitude for the system of HV = 7.2 from the Minor Planet Center, we derive a geometric albedo of pV = 5.1% 1.7%. This is the smallest resonant object with an occultation size measurement and with a detected secondary from a ground-based stellar occultation, filling a region of the size versus separation parameter space of binary objects that is largely unexplored. The results show the capabilities of the unique design of the RECON experiment sensitive to small objects and close binaries. 2014 WC510 is presently at a low galactic latitude where the high surface density of stars will provide good occultation opportunities in the upcoming years.
In 2019, the Research and Education Collaborative Occultation Network (RECON) obtained multiple-chord occultation measurements of two Centaur objects: 2014 YY49 on 2019 January 28 and 2013 NL24 on ...2019 September 4. RECON is a citizen-science telescope network designed to observe high-uncertainty occultations by outer solar system objects. Adopting circular models for the object profiles, we derive a radius km and a geometric albedo for 2014 YY49 and a radius km and a geometric albedo for 2013 NL24. To the precision of these measurements, no atmosphere or rings are detected for either object. The two objects measured here are among the smallest distant objects measured with the stellar occultation technique. In addition to these geometric constraints, the occultation measurements provide astrometric constraints for these two Centaurs at a higher precision than has been feasible by direct imaging. To supplement the occultation results, we also present an analysis of color photometry from the Pan-STARRS surveys to constrain the rotational light curve amplitudes and spectral colors of these two Centaurs. We recommend that future work focus on photometry to more deliberately constrain the objects' colors and light curve amplitudes and on follow-on occultation efforts informed by this astrometry.
Abstract
In 2019, the Research and Education Collaborative Occultation Network (RECON) obtained multiple-chord occultation measurements of two Centaur objects: 2014 YY
49
on 2019 January 28 and 2013 ...NL
24
on 2019 September 4. RECON is a citizen-science telescope network designed to observe high-uncertainty occultations by outer solar system objects. Adopting circular models for the object profiles, we derive a radius
km and a geometric albedo
for 2014 YY
49
and a radius
km and a geometric albedo
for 2013 NL
24
. To the precision of these measurements, no atmosphere or rings are detected for either object. The two objects measured here are among the smallest distant objects measured with the stellar occultation technique. In addition to these geometric constraints, the occultation measurements provide astrometric constraints for these two Centaurs at a higher precision than has been feasible by direct imaging. To supplement the occultation results, we also present an analysis of color photometry from the Pan-STARRS surveys to constrain the rotational light curve amplitudes and spectral colors of these two Centaurs. We recommend that future work focus on photometry to more deliberately constrain the objects’ colors and light curve amplitudes and on follow-on occultation efforts informed by this astrometry.
A stellar occultation by the extreme large-perihelion trans-Neptunian object (541132) Lele\={a}k\={u}honua (also known by the provisional designation of 2015 TG387) was predicted by the Lucky Star ...project and observed with the Research and Education Collaborative Occultation Network on 2018 October 20 UT. A single detection and a nearby nondetection provide constraints for the size and albedo. When a circular profile is assumed, the radius is \(r={110}_{-10}^{+14}\) km, corresponding to a geometric albedo \({p}_{V}={0.21}_{-0.05}^{+0.03}\), for an adopted absolute magnitude of H V = 5.6, typical of other objects in dynamically similar orbits. The occultation also provides a high-precision astrometric constraint.
In 2019, the Research and Education Collaborative Occultation Network (RECON) obtained multiple-chord occultation measurements of two centaur objects: 2014 YY\(_{49}\) on 2019 January 28 and 2013 ...NL\(_{24}\) on 2019 September 4. RECON is a citizen-science telescope network designed to observe high-uncertainty occultations by outer solar system objects. Adopting circular models for the object profiles, we derive a radius \(r=16^{+2}_{-1}\)km and a geometric albedo \(p_V=0.13^{+0.015}_{-0.024}\) for 2014 YY\(_{49}\), and a radius \(r=66 ^{+5}_{-5}\)km and geometric albedo \(p_V = 0.045^{+0.006}_{-0.008}\) for 2013 NL\(_{24}\). To the precision of these measurements, no atmosphere or rings are detected for either object. The two objects measured here are among the smallest distant objects measured with the stellar occultation technique. In addition to these geometric constraints, the occultation measurements provide astrometric constraints for these two centaurs at a higher precision than has been feasible by direct imaging. To supplement the occultation results, we also present an analysis of color photometry from the Pan-STARRS surveys to constrain the rotational light curve amplitudes and spectral colors of these two centaurs. We recommend that future work focus on photometry to more deliberately constrain the objects' colors and light curve amplitudes, and on follow-on occultation efforts informed by this astrometry.
Different clones, protocol conditions, instruments, and scoring/readout methods may pose challenges in introducing different PD-L1 assays for immunotherapy. The diagnostic accuracy of using different ...PD-L1 assays interchangeably for various purposes is unknown. The primary objective of this meta-analysis was to address PD-L1 assay interchangeability based on assay diagnostic accuracy for established clinical uses/purposes. A systematic search of the MEDLINE database using PubMed platform was conducted using "PD-L1" as a search term for 01/01/2015 to 31/08/2018, with limitations "English" and "human". 2,515 abstracts were reviewed to select for original contributions only. 57 studies on comparison of two or more PD-L1 assays were fully reviewed. 22 publications were selected for meta-analysis. Additional data were requested from authors of 20/22 studies in order to enable the meta-analysis. Modified GRADE and QUADAS-2 criteria were used for grading published evidence and designing data abstraction templates for extraction by reviewers. PRISMA was used to guide reporting of systematic review and meta-analysis and STARD 2015 for reporting diagnostic accuracy study. CLSI EP12-A2 was used to guide test comparisons. Data were pooled using random-effects model. The main outcome measure was diagnostic accuracy of various PD-L1 assays. The 22 included studies provided 376 2×2 contingency tables for analyses. Results of our study suggest that, when the testing laboratory is not able to use an Food and Drug Administration-approved companion diagnostic(s) for PD-L1 assessment for its specific clinical purpose(s), it is better to develop a properly validated laboratory developed test for the same purpose(s) as the original PD-L1 Food and Drug Administration-approved immunohistochemistry companion diagnostic, than to replace the original PD-L1 Food and Drug Administration-approved immunohistochemistry companion diagnostic with a another PD-L1 Food and Drug Administration-approved companion diagnostic that was developed for a different purpose.
OBJECTIVE:To describe the clinical experience with noninvasive prenatal testing for fetal sex chromosomes using sequencing of maternal plasma cell-free DNA in a commercial laboratory.
METHODS:A ...noninvasive prenatal testing laboratory data set was examined for samples in which fetal sex chromosomes were reported. Available clinical outcomes were reviewed.
RESULTS:Of 18,161 samples with sex chromosome results, no sex chromosome aneuploidy was detected in 98.9% and the fetal sex was reported as XY (9,236) or XX (8,721). In 4 of 32 cases in which the fetal sex was reportedly discordant between noninvasive prenatal testing and karyotype or ultrasonogram, a potential biological reason for the discordance exists, including two cases of documented co-twin demise, one case of a maternal kidney transplant from a male donor, and one case of fetal ambiguous genitalia. In the remaining 204 samples (1.1%), one of four sex chromosome aneuploidies (monosomy X, XXX, XXY, or XYY) was detected. The frequency of false positive results for sex chromosome aneuploidies is a minimum of 0.26% and a maximum of 1.05%. All but one of the discordant sex chromosome aneuploidy results involved the X chromosome. In two putative false-positive XXX cases, maternal XXX was confirmed by karyotype. For the false-positive cases, mean maternal age was significantly higher in monosomy X (P<.001) and lower in XXX (P=.008).
CONCLUSION:Noninvasive prenatal testing results for sex chromosome aneuploidy can be confounded by maternal or fetal biological phenomena. When a discordant noninvasive prenatal testing result is encountered, resolution requires additional maternal history, detailed fetal ultrasonography, and determination of fetal and possibly maternal karyotypes.
LEVEL OF EVIDENCE:II
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