The aim of this retrospective study was to examine the incidence and prognostic significance of abdominal wall metastases in patients with ovarian cancer present at the primary debulking at the entry ...sites of previous laparoscopy or paracentesis. The clinical records of 219 patients were studied. In 7 of 43 patients (16%) who had undergone laparoscopy and 3 of 30 patients (10%) who had undergone paracentesis previous to the primary debulking, an abdominal wall metastasis had developed at the entry sites. All metastases occurred in patients with FIGO stage IIIC–IV including ascites. Survival analysis using the Cox proportional hazards model showed that after adjustment for age, FIGO stage, histology, grade, ascites, and residual disease after primary debulking, the presence of abdominal wall metastases in the entry sites of previous laparoscopy or paracentesis was negatively, although not statistical significantly, correlated with survival (P= 0.14).
A search for gravitational wave burst events has been performed with the Virgo C7 commissioning run data that have been acquired in September 2005 over 5 days. It focused on unmodeled short duration ...signals in the frequency range 150 Hz to 2 kHz. A search aimed at detecting the GW emission from the merger and ring-down phases of binary black hole coalescences was also carried out. An extensive understanding of the data was required to be able to handle a burst search using the output of only one detector. A 90% confidence level upper limit on the number of expected events given the Virgo C7 sensitivity curve has been derived as a function of the signal strength, for unmodeled gravitational wave searches. The sensitivity of the analysis presented is, in terms of the root sum square strain amplitude, hrss 10-20 Hz-1/2. This can be interpreted in terms of a frequentist upper limit on the rate of detectable gravitational wave bursts at the level of 1.1 events per day at a 90% confidence level. From the binary black hole search, we obtained the distance reach at 50% and 90% efficiency as a function of the total mass of the final black hole. The maximal detection distance for non-spinning high and equal mass black hole binary system obtained by this analysis in C7 data is 2.9 ± 0.1 Mpc for a detection efficiency of 50% for a binary of total mass 80 M.
We present the high-energy-neutrino follow-up observations of the first gravitational wave transient GW150914 observed by the Advanced LIGO detectors on September 14, 2015. We search for coincident ...neutrino candidates within the data recorded by the IceCube and Antares neutrino detectors. A possible joint detection could be used in targeted electromagnetic follow-up observations, given the significantly better angular resolution of neutrino events compared to gravitational waves. We find no neutrino candidates in both temporal and spatial coincidence with the gravitational wave event. Within + or -500s of the gravitational wave event, the number of neutrino candidates detected by IceCube and Antares were three and zero, respectively. This is consistent with the expected atmospheric background, and none of the neutrino candidates were directionally coincident with GW150914. We use this nondetection to constrain neutrino emission from the gravitational-wave event.
The quantum radiation pressure and the quantum shot noise in laser-interferometric gravitational wave detectors constitute a macroscopic manifestation of the Heisenberg inequality. If quantum shot ...noise can be easily observed, the observation of quantum radiation pressure noise has been elusive, so far, due to the technical noise competing with quantum effects. Here, we discuss the evidence of quantum radiation pressure noise in the Advanced Virgo gravitational wave detector. In our experiment, we inject squeezed vacuum states of light into the interferometer in order to manipulate the quantum backaction on the 42 kg mirrors and observe the corresponding quantum noise driven displacement at frequencies between 30 and 70 Hz. The experimental data, obtained in various interferometer configurations, is tested against the Advanced Virgo detector quantum noise model which confirmed the measured magnitude of quantum radiation pressure noise.
A gravitational-wave (GW) transient was identified in data recorded by the Advanced Laser Interferometer Gravitational-wave Observatory (LIGO) detectors on 2015 September 14. The event, initially ...designated G184098 and later given the name GW150914, is described in detail elsewhere. By prior arrangement, preliminary estimates of the time, significance, and sky location of the event were shared with 63 teams of observers covering radio, optical, near-infrared, X-ray, and gamma-ray wavelengths with ground- and space-based facilities. In this Letter we describe the low-latency analysis of the GW data and present the sky localization of the first observed compact binary merger. We summarize the follow-up observations reported by 25 teams via private Gamma-ray Coordinates Network circulars, giving an overview of the participating facilities, the GW sky localization coverage, the timeline, and depth of the observations. As this event turned out to be a binary black hole merger, there is little expectation of a detectable electromagnetic (EM) signature. Nevertheless, this first broadband campaign to search for a counterpart of an Advanced LIGO source represents a milestone and highlights the broad capabilities of the transient astronomy community and the observing strategies that have been developed to pursue neutron star binary merger events. Detailed investigations of the EM data and results of the EM follow-up campaign are being disseminated in papers by the individual teams.
In August 2017, advanced Virgo joined advanced LIGO for the end of the O2 run, leading to the first gravitational waves detections with the three-detector network. This paper describes the advanced ...Virgo calibration and the gravitational wave strain reconstruction during O2. The methods are the same as the ones developed for the initial Virgo detector and have already been described in previous publications; this paper summarizes the differences and emphasis is put on estimating systematic uncertainties. Three versions of the signal have been computed for the Virgo O2 run, an online version and two post-run reprocessed versions with improved detector calibration and reconstruction algorithm. A photon calibrator has been used to establish the sign of and to make an independent partial cross-check of the systematic uncertainties. The uncertainties reached for the latest version are 5.1% in amplitude, in phase and 20 μs in timing.
Several peroxisomal proteins do not contain the previously identified tripeptide peroxisomal targeting signal (PTS) at their carboxy‐termini. One such protein is the peroxisomal 3‐ketoacyl CoA ...thiolase, of which two types exist in rat Hijikata et al. (1990) J. Biol. Chem., 265, 4600–4606. Both rat peroxisomal thiolases are synthesized as larger precursors with an amino‐terminal prepiece of either 36 (type A) or 26 (type B) amino acids, that is cleaved upon translocation of the enzyme into the peroxisome. The prepieces are necessary for import of the thiolases into peroxisomes because expression of an altered cDNA encoding only the mature thiolase, which lacks any prepiece, results in synthesis of a cytosolic enzyme. When appended to an otherwise cytosolic passenger protein, the bacterial chloramphenicol acetyltransferase (CAT), the prepieces direct the fusion proteins into peroxisomes, demonstrating that they encode sufficient information to act as peroxisomal targeting signals. Deletion analysis of the thiolase B prepiece shows that the first 11 amino acids are sufficient for peroxisomal targeting. We conclude that we have identified a novel PTS that functions at amino‐terminal or internal locations and is distinct from the C‐terminal PTS. These results imply the existence of two different routes for targeting proteins into the peroxisomal matrix.
Two types of peptide signals are known to independently target proteins into the peroxisomal matrix. One of these is a consensus C-terminal tripeptide which is conserved in many microbody proteins ...derived from diverse species. The second signal is an N-terminal sequence found in a small subset of peroxisomal proteins. We have tested 18 possible variants of the consensus tripeptide targeting signal for their ability to facilitate the transport of a cytosolic passenger protein, chloramphenicol acetyltransferase, into peroxisomes of monkey kidney cells. Our results reveal the presence of a hierarchy of preferred amino acid substitutions at each position of the tripeptide.
Objectives
The objective of this study is to develop a simple risk score to predict 30-day mortality of aortic valve replacement (AVR).
Methods
In a development set of 673 consecutive patients who ...underwent AVR between 1990 and 1993, four independent predictors for 30-day mortality were identified: body mass index (BMI) ≥30, BMI <20, previous coronary artery bypass grafting (CABG) and recent myocardial infarction. Based on these predictors, a 30-day mortality risk score—the AVR score—was developed. The AVR score was validated on a validation set of 673 consecutive patients who underwent AVR almost two decennia later in the same hospital.
Results
Thirty-day mortality in the development set was ≤2% in the absence of any predictor (class I, low risk), 2–5% in the solitary presence of BMI ≥30 (class II, mild risk), 5–15% in the solitary presence of previous CABG or recent myocardial infarction (class III, moderate risk), and >15% in the solitary presence of BMI <20, or any combination of BMI ≥30, previous CABG or recent myocardial infarction (class IV, high risk). The AVR score correctly predicted 30-day mortality in the validation set: observed 30-day mortality in the validation set was 2.3% in 487 class I patients, 4.4% in 137 class II patients, 13.3% in 30 class III patients and 15.8% in 19 class IV patients.
Conclusions
The AVR score is a simple risk score validated to predict 30-day mortality of AVR.
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