It is well known that broilers may be infected by different
Eimeria strains at the same time and that different species infect specific parts of the gut. Cell mediated responses play a major role in ...the immune response in broilers after infection with
Eimeria species. The cell mediated responses could be intestinal site specific and if this site specific cell mediated responses differ when other parts of the intestine are infected is unknown. To investigate this in the
Eimeria infection model we analyzed the cell mediated responses to an infection with a single
Eimeria species and with a mixture of different species of
Eimeria such as
E. acervulina,
E. maxima or
E. tenella in the duodenum, jejunum and caecum. The immune parameters we measured were intestinal T-cell and macrophage population dynamics as well as local cytokine mRNA expression. These parameters were related to the amount of
Eimeria DNA that was measured in the intestine with an
Eimeria strain specific quantitative PCR.
The results showed that the strongest immune response was induced in the specific part of the intestine that was affected by each
Eimeria strain. An
E. acervulina infection mainly induced a duodenal CD8
+ T-cell and macrophage response as well as an increased IL-2, IL-4, IL-8, IL-10, and INF-γ response. An
E. maxima infection mainly induced a CD4
+ T-cell and macrophage response but also an increased IL-4, IL-8, and very strong INF-γ (300-fold) expression in duodenum and jejunum.
E. tenella induced a CD4
+ T-cell, macrophage response and an increase in the IL-2, IL-4, IL-8, IL-10, IL-18 and INF-γ response in the caecum. The infection with a mixture of
Eimeria species resulted in responses per intestinal segment that were similar to that observed following the single species infection. No synergistic or competitive effects were thus observed following a primary infection with a mixture of
Eimeria species. In contrast, we observed an accumulation of the local effects of the single infections.
On 17 August 2017, the Advanced LIGO and Virgo detectors observed the gravitational-wave event GW170817-a strong signal from the merger of a binary neutron-star system. Less than two seconds after ...the merger, a γ-ray burst (GRB 170817A) was detected within a region of the sky consistent with the LIGO-Virgo-derived location of the gravitational-wave source. This sky region was subsequently observed by optical astronomy facilities, resulting in the identification of an optical transient signal within about ten arcseconds of the galaxy NGC 4993. This detection of GW170817 in both gravitational waves and electromagnetic waves represents the first 'multi-messenger' astronomical observation. Such observations enable GW170817 to be used as a 'standard siren' (meaning that the absolute distance to the source can be determined directly from the gravitational-wave measurements) to measure the Hubble constant. This quantity represents the local expansion rate of the Universe, sets the overall scale of the Universe and is of fundamental importance to cosmology. Here we report a measurement of the Hubble constant that combines the distance to the source inferred purely from the gravitational-wave signal with the recession velocity inferred from measurements of the redshift using the electromagnetic data. In contrast to previous measurements, ours does not require the use of a cosmic 'distance ladder': the gravitational-wave analysis can be used to estimate the luminosity distance out to cosmological scales directly, without the use of intermediate astronomical distance measurements. We determine the Hubble constant to be about 70 kilometres per second per megaparsec. This value is consistent with existing measurements, while being completely independent of them. Additional standard siren measurements from future gravitational-wave sources will enable the Hubble constant to be constrained to high precision.
On 2017 August 17, the gravitational-wave event GW170817 was observed by the Advanced LIGO and Virgo detectors, and the gamma-ray burst (GRB) GRB 170817A was observed independently by the Fermi ...Gamma-ray Burst Monitor, and the Anti-Coincidence Shield for the Spectrometer for the International Gamma-Ray Astrophysics Laboratory. The probability of the near-simultaneous temporal and spatial observation of GRB 170817A and GW170817 occurring by chance is 5.0 × 10 − 8 . We therefore confirm binary neutron star mergers as a progenitor of short GRBs. The association of GW170817 and GRB 170817A provides new insight into fundamental physics and the origin of short GRBs. We use the observed time delay of ( + 1.74 0.05 ) s between GRB 170817A and GW170817 to: (i) constrain the difference between the speed of gravity and the speed of light to be between − 3 × 10 − 15 and + 7 × 10 − 16 times the speed of light, (ii) place new bounds on the violation of Lorentz invariance, (iii) present a new test of the equivalence principle by constraining the Shapiro delay between gravitational and electromagnetic radiation. We also use the time delay to constrain the size and bulk Lorentz factor of the region emitting the gamma-rays. GRB 170817A is the closest short GRB with a known distance, but is between 2 and 6 orders of magnitude less energetic than other bursts with measured redshift. A new generation of gamma-ray detectors, and subthreshold searches in existing detectors, will be essential to detect similar short bursts at greater distances. Finally, we predict a joint detection rate for the Fermi Gamma-ray Burst Monitor and the Advanced LIGO and Virgo detectors of 0.1-1.4 per year during the 2018-2019 observing run and 0.3-1.7 per year at design sensitivity.
We present results on the mass, spin, and redshift distributions with phenomenological population models using the 10 binary black hole (BBH) mergers detected in the first and second observing runs ...completed by Advanced LIGO and Advanced Virgo. We constrain properties of the BBH mass spectrum using models with a range of parameterizations of the BBH mass and spin distributions. We find that the mass distribution of the more massive BH in such binaries is well approximated by models with no more than 1% of BHs more massive than 45 M and a power-law index of = 1.3 − 1.7 + 1.4 (90% credibility). We also show that BBHs are unlikely to be composed of BHs with large spins aligned to the orbital angular momentum. Modeling the evolution of the BBH merger rate with redshift, we show that it is flat or increasing with redshift with 93% probability. Marginalizing over uncertainties in the BBH population, we find robust estimates of the BBH merger rate density of R = 53.2 − 28.2 + 55.8 Gpc−3 yr−1 (90% credibility). As the BBH catalog grows in future observing runs, we expect that uncertainties in the population model parameters will shrink, potentially providing insights into the formation of BHs via supernovae, binary interactions of massive stars, stellar cluster dynamics, and the formation history of BHs across cosmic time.
On 2017 June 8 at 02:01:16.49 UTC, a gravitational-wave (GW) signal from the merger of two stellar-mass black holes was observed by the two Advanced Laser Interferometer Gravitational-Wave ...Observatory detectors with a network signal-to-noise ratio of 13. This system is the lightest black hole binary so far observed, with component masses of 12 − 2 + 7 M and 7 − 2 + 2 M (90% credible intervals). These lie in the range of measured black hole masses in low-mass X-ray binaries, thus allowing us to compare black holes detected through GWs with electromagnetic observations. The source's luminosity distance is 340 − 140 + 140 Mpc , corresponding to redshift 0.07 − 0.03 + 0.03 . We verify that the signal waveform is consistent with the predictions of general relativity.
On 2019 April 25, the LIGO Livingston detector observed a compact binary coalescence with signal-to-noise ratio 12.9. The Virgo detector was also taking data that did not contribute to detection due ...to a low signal-to-noise ratio, but were used for subsequent parameter estimation. The 90% credible intervals for the component masses range from to ( - if we restrict the dimensionless component spin magnitudes to be smaller than 0.05). These mass parameters are consistent with the individual binary components being neutron stars. However, both the source-frame chirp mass and the total mass of this system are significantly larger than those of any other known binary neutron star (BNS) system. The possibility that one or both binary components of the system are black holes cannot be ruled out from gravitational-wave data. We discuss possible origins of the system based on its inconsistency with the known Galactic BNS population. Under the assumption that the signal was produced by a BNS coalescence, the local rate of neutron star mergers is updated to 250-2810 .
We report on the population of 47 compact binary mergers detected with a false-alarm rate of <1yr^(−1) in the second LIGO–Virgo Gravitational-Wave Transient Catalog. We observe several ...characteristics of the merging binary black hole (BBH) population not discernible until now. First, the primary mass spectrum contains structure beyond a power law with a sharp high-mass cutoff; it is more consistent with a broken power law with a break at 39.7^(+20.3)(-9.1)M or a power law with a Gaussian feature peaking at 33.1^(+4.0)(-5.6)M (90% credible interval). While the primary mass distribution must extend to ~65M or beyond, only 2.9^(+3.5)(-1.7)M% of systems have primary masses greater than 45M. Second, we find that a fraction of BBH systems have component spins misaligned with the orbital angular momentum, giving rise to precession of the orbital plane. Moreover, 12% to 44% of BBH systems have spins tilted by more than 90°, giving rise to a negative effective inspiral spin parameter, χeff. Under the assumption that such systems can only be formed by dynamical interactions, we infer that between 25% and 93% of BBHs with nonvanishing |χeff| > 0.01 are dynamically assembled. Third, we estimate merger rates, finding RBBH = 23.9^(+14.3)(-8.6) Gpc^(-3) yr^(-1) for BBHs and RBNS = 320^(+490)(-240) Gpc^(-3) yr^(-1) for binary neutron stars. We find that the BBH rate likely increases with redshift (85% credibility) but not faster than the star formation rate (86% credibility). Additionally, we examine recent exceptional events in the context of our population models, finding that the asymmetric masses of GW190412 and the high component masses of GW190521 are consistent with our models, but the low secondary mass of GW190814 makes it an outlier.
We report the observation of a compact binary coalescence involving a 22.2-24.3 M black hole and a compact object with a mass of 2.50-2.67 M (all measurements quoted at the 90% credible level). The ...gravitational-wave signal, GW190814, was observed during LIGO's and Virgo's third observing run on 2019 August 14 at 21:10:39 UTC and has a signal-to-noise ratio of 25 in the three-detector network. The source was localized to 18.5 deg2 at a distance of Mpc; no electromagnetic counterpart has been confirmed to date. The source has the most unequal mass ratio yet measured with gravitational waves, , and its secondary component is either the lightest black hole or the heaviest neutron star ever discovered in a double compact-object system. The dimensionless spin of the primary black hole is tightly constrained to ≤0.07. Tests of general relativity reveal no measurable deviations from the theory, and its prediction of higher-multipole emission is confirmed at high confidence. We estimate a merger rate density of 1-23 Gpc−3 yr−1 for the new class of binary coalescence sources that GW190814 represents. Astrophysical models predict that binaries with mass ratios similar to this event can form through several channels, but are unlikely to have formed in globular clusters. However, the combination of mass ratio, component masses, and the inferred merger rate for this event challenges all current models of the formation and mass distribution of compact-object binaries.
This paper presents the gravitational-wave measurement of the Hubble constant (H(0)) using the detections from the first and second observing runs of the Advanced LIGO and Virgo detector network. The ...presence of the transient electromagnetic counterpart of the binary neutron star GW170817 led to the first standard-siren measurement of H(0). Here we additionally use binary black hole detections in conjunction with galaxy catalogs and report a joint measurement. Our updated measurement is H(0) = 69(+16,-8) km/s Mpc (68.3% of the highest density posterior interval with a flat-in-log prior) which is an improvement by a factor of 1.04 (about 4%) over the GW170817-only value of 6(+17,-8) km/s Mpc. A significant additional contribution currently comes from GW170814, a loud and well-localized detection from a part of the sky thoroughly covered by the Dark Energy Survey. With numerous detections anticipated over the upcoming years, an exhaustive understanding of other systematic effects are also going to become increasingly important. These results establish the path to cosmology using gravitational-wave observations with and without transient electromagnetic counterparts.
The gravitational-wave signal GW190521 is consistent with a binary black hole (BBH) merger source at redshift 0.8 with unusually high component masses, 85 − 14 + 21 M and 66 − 18 + 17 M , compared to ...previously reported events, and shows mild evidence for spin-induced orbital precession. The primary falls in the mass gap predicted by (pulsational) pair-instability supernova theory, in the approximate range 65-120 M . The probability that at least one of the black holes in GW190521 is in that range is 99.0%. The final mass of the merger ( 142 − 16 + 28 M ) classifies it as an intermediate-mass black hole. Under the assumption of a quasi-circular BBH coalescence, we detail the physical properties of GW190521's source binary and its post-merger remnant, including component masses and spin vectors. Three different waveform models, as well as direct comparison to numerical solutions of general relativity, yield consistent estimates of these properties. Tests of strong-field general relativity targeting the merger-ringdown stages of the coalescence indicate consistency of the observed signal with theoretical predictions. We estimate the merger rate of similar systems to be 0.13 − 0.11 + 0.30 Gpc − 3 yr − 1 . We discuss the astrophysical implications of GW190521 for stellar collapse and for the possible formation of black holes in the pair-instability mass gap through various channels: via (multiple) stellar coalescences, or via hierarchical mergers of lower-mass black holes in star clusters or in active galactic nuclei. We find it to be unlikely that GW190521 is a strongly lensed signal of a lower-mass black hole binary merger. We also discuss more exotic possible sources for GW190521, including a highly eccentric black hole binary, or a primordial black hole binary.
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