LY 300164 7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7
H-1,3-dioxolo(4,5
H)-2,3-benzodiazepine, an antagonist of AMPA/kainate receptors, at 5 mg/kg exerted a significant anticonvulsant effect, ...as regards seizure and afterdischarge durations in amygdala-kindled seizures in rats. At lower doses, LY 300164 did not exert anticonvulsant activity. Clonazepam alone (0.003–0.1 mg/kg) significantly diminished seizure severity, seizure and afterdischarge durations. Coadministration of LY 300164 (2 mg/kg) with clonazepam (0.001 mg/kg) resulted in the significant anticonvulsant activity. Seizure severity score, seizure and afterdischarge durations were reduced from 5 to 4, from 32.6 s to 12.3 s, and 42.7 s to 23.2 s. LY 300164 (2 mg/kg), clonazepam (0.001–0.1 mg/kg) and the combination of clonazepam (0.001 mg/kg) with LY 300164 (2 mg/kg) did not affect long-term memory evaluated in the passive avoidance task in rats. LY 300164 (at the subprotective dose of 2 mg/kg) significantly potentiated the anticonvulsant action of clonazepam against maximal electroshock but not against pentylenetetrazol-induced convulsions in mice. The results indicate that blockade of glutamate-mediated events at AMPA/kainate receptors may differently affect the protection offered by clonazepam, which seems dependent upon the model of experimental seizures.
It is shown that very high quality (in particular – very good real crystal structure) of the single crystals of ZnTe and Cd
1−
x
Zn
x
Te, intended to be substrates for MBE and other techniques of ...epitaxy, can be reached by an optimized physical vapor transport (PVT) technique. The obtained crystals are twin-free, the narrowness of the rocking curve nearly reaches the theoretical limit and the density of dislocations is low. The results of characterization of the crystals are presented.
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