ABR differences before and after dialyses Niedzielska, G; Kątska, E; Sikora, P ...
International journal of pediatric otorhinolaryngology,
04/1999, Letnik:
48, Številka:
1
Journal Article
Recenzirano
The aim of the study was the objective evaluation of the hearing organ in children. Seven children aged 6–17 with end stage renal failure treated by haemodialysis were examined. Four- to five-hour ...dialyses were performed 2–3 times a week. Pure-tone audiometry was normal in five children. The reactions of brain stem responses (latency and interpeak latency) were analysed before and after haemodialyses. We conclude that the ABR differences were connected with biochemical parameters of uraemia. The present study is a preliminary one and will be continued in the future.
Numerous complications of nephrotic syndrome due to either the illness itself or repeated courses of high-dose corticosteroids have been well recognised for several score years. However, ...investigations concerning children of ex-patients are lacking. The purpose of this study was to assess physical development and health state in the group of children whose mothers had suffered from the idiopathic nephrotic syndrome during their childhood. 34 such children were studied. Thorough medical history was taken from children and their mothers and available medical documents data were obtained. Physical examination was performed and centile position of weight, height and their proportion was stated. The authors found that stillborn foetus, premature or low birth weight newborn incidence is much higher than in general population and the percentage of overweight and obesity is higher in the studied group than in general population. To confirm these findings further investigations with greater number of patients are necessary.
The study is based on clinical analysis of 207 case recordings of children with urinary tract infection (UTI) hospitalized in The Department of Pediatric Nephrology, University Hospital, Lublin in ...1995-1999. The study comprised children aged 1-18 years, average 8.8 +/- 0.4 (77.8% girls). Recurrent UTI was observed in 76.8% of children. Acute UTI was diagnosed in 20.8% of children. In 2.4% of children UTI was detected during hospitalization because of other diseases. In all children urinary X-ray examination was performed. Anatomical abnormalities were detected in 38% of children. Vesico-ureteral reflux was diagnosed in 61 children (29.5%). In 16/25 (64%) of children with vesico-ureteral reflux renal scarring was detected by radionuclide examination. In some children urodynamic examination was performed and in all of them functional abnormalities were detected.
In acute serum sickness induced with one intravenous dose of bovine serum albumin (BSA) in 40 rabbits the patterns of excretion of adrenaline (A), noradrenaline (NA), serotonin (5HT) and ...5-hydroxyindole-acetic acid (5HIAA) were studied in 24-hour urine, and the 5HT level was determined at intervals of three days. The urinary levels of biogenic amines were determined daily. Some rabbits immunized with BSA received also additionally 5HT, reserpine or parachlorphenylalanine (PCPA). Administration of BSA to rabbits caused a significant increase in the excretion of A and NA and a less evident increase in 5HT level in the blood. The greatest correlation with the course of the immune reaction was shown by the increase in NA excretion observed on the 2nd and 3rd days after BSA administration, and then between the 5th and the 12th days of the experiment. Daily subcutaneous injections of 5HT during 15 days caused a significant rise of its level in the blood and urine, and an increase of 5HIAA excretion. After reserpine or PCPA administration a significant decrease of the levels of all these amines was observed. Taking into account the results of histological examination of the kidneys, that is intensification of the inflammatory changes after 5HT administration and evident inhibition of the inflammatory process after administration of reserpine and PCPA it must be accepted that the studied amines have an important role in the pathomechanism of glomerulonephritis in acute serum sickness.
Investigations were carried out on the role of biogenic amines in the development of glomerulonephritis in rabbits using the experimental model of acute and chronic serum sickness. The animals ...immunized with foreign-species albumin received additionally 5HT and some of them were given reserpine or PCPA for reducing the level of biogenic amines. The results of histological examinations demonstrated a clear cut inhibitory effect of PCPA and reserpine on the development of inflammatory changes in the glomeruli, and their intensification with simultaneous 5HT administration. The obtained results seem to suggest a significant role of biogenic amines in the pathogenesis of inflammatory lesions developing in renal glomeruli in acute or chronic serum sickness in rabbits.
