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zadetkov: 31
1.
  • New weapons to penetrate th... New weapons to penetrate the armor: Novel reagents and assays developed at the NCI RAS Initiative to enable discovery of RAS therapeutics
    Esposito, Dominic; Stephen, Andrew G.; Turbyville, Thomas J. ... Seminars in cancer biology, 02/2019, Letnik: 54
    Journal Article
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    Development of therapeutic strategies against RAS-driven cancers has been challenging due in part to a lack of understanding of the biology of the system and the ability to design appropriate assays ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP

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2.
  • RAS Nanoclusters: Dynamic S... RAS Nanoclusters: Dynamic Signaling Platforms Amenable to Therapeutic Intervention
    Van, Que N; Prakash, Priyanka; Shrestha, Rebika ... Biomolecules, 03/2021, Letnik: 11, Številka: 3
    Journal Article
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    RAS proteins are mutated in approximately 20% of all cancers and are generally associated with poor clinical outcomes. RAS proteins are localized to the plasma membrane and function as molecular ...
Celotno besedilo
Dostopno za: IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK

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3.
  • Direct Modulators of K‑Ras–... Direct Modulators of K‑Ras–Membrane Interactions
    Morstein, Johannes; Shrestha, Rebika; Van, Que N. ... ACS chemical biology, 09/2023, Letnik: 18, Številka: 9
    Journal Article
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    Protein–membrane interactions (PMIs) are ubiquitous in cellular signaling. Initial steps of signal transduction cascades often rely on transient and dynamic interactions with the inner plasma ...
Celotno besedilo
Dostopno za: IJS, KILJ, NUK, PNG, UL, UM, UPUK
4.
  • Recapitulation of cell-like... Recapitulation of cell-like KRAS4b membrane dynamics on complex biomimetic membranes
    Shrestha, Rebika; Chen, De; Frank, Peter ... iScience, 01/2022, Letnik: 25, Številka: 1
    Journal Article
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    Understanding the spatiotemporal distribution and dynamics of RAS on the plasma membrane (PM) is the key for elucidating the molecular mechanisms of the RAS signaling pathway. Single particle ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP

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5.
  • RAS internal tandem duplica... RAS internal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling
    Nelson, Andrew C.; Turbyville, Thomas J.; Dharmaiah, Srisathiyanarayanan ... Journal of biological chemistry/˜The œJournal of biological chemistry, 07/2020, Letnik: 295, Številka: 28
    Journal Article
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    The oncogene RAS is one of the most widely studied proteins in cancer biology, and mutant active RAS is a driver in many types of solid tumors and hematological malignancies. Yet the biological ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP

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6.
  • Asynchronous Reciprocal Cou... Asynchronous Reciprocal Coupling of Martini 2.2 Coarse-Grained and CHARMM36 All-Atom Simulations in an Automated Multiscale Framework
    López, Cesar A.; Zhang, Xiaohua; Aydin, Fikret ... Journal of chemical theory and computation, 08/2022, Letnik: 18, Številka: 8
    Journal Article
    Recenzirano
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    The appeal of multiscale modeling approaches is predicated on the promise of combinatorial synergy. However, this promise can only be realized when distinct scales are combined with reciprocal ...
Celotno besedilo
Dostopno za: IJS, KILJ, NUK, PNG, UL, UM
7.
  • Membrane lipids drive forma... Membrane lipids drive formation of KRAS4b-RAF1 RBDCRD nanoclusters on the membrane
    Shrestha, Rebika; Carpenter, Timothy S; Van, Que N ... Communications biology, 02/2024, Letnik: 7, Številka: 1
    Journal Article
    Recenzirano
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    The oncogene RAS, extensively studied for decades, presents persistent gaps in understanding, hindering the development of effective therapeutic strategies due to a lack of precise details on how RAS ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK
8.
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK
9.
  • Synthesis of a 35-Member St... Synthesis of a 35-Member Stereoisomer Library of Bistramide A: Evaluation of Effects on actin State, Cell Cycle and Tumor Cell Growth
    Wrona, Iwona E; Lowe, Jason T; Turbyville, Thomas J ... Journal of organic chemistry, 03/2009, Letnik: 74, Številka: 5
    Journal Article
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    Synthesis and preliminary biological evaluation of a 35-member library of bistramide A stereoisomers are reported. All eight stereoisomers of the C1−C13 tetrahydropyran fragment of the molecule were ...
Celotno besedilo
Dostopno za: IJS, KILJ, NUK, PNG, UL, UM

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10.
  • Search for Hsp90 Inhibitors... Search for Hsp90 Inhibitors with Potential Anticancer Activity:  Isolation and SAR Studies of Radicicol and Monocillin I from Two Plant-Associated Fungi of the Sonoran Desert
    Turbyville, Thomas J; Wijeratne, E. M. Kithsiri; Liu, Manping X ... Journal of natural products, 02/2006, Letnik: 69, Številka: 2
    Journal Article
    Recenzirano
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    In an effort to discover small molecule inhibitors of Hsp90, we have screened over 500 EtOAc extracts of Sonoran desert plant-associated fungi using a two-stage strategy consisting of a primary ...
Celotno besedilo
Dostopno za: IJS, KILJ, NUK, PNG, UL, UM

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zadetkov: 31

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