Introdução/objetivo: A Doença de Chagas (DC) é uma doença endêmica no Brasil, principalmente em regiões de clima semiárido, mas devido ao maior número dos movimentos migratórios, essa patologia tem ...deslocado seu eixo epidemiológico e desafiado os órgãos de saúde pública. Nessa perspectiva, este estudo tem como objetivo analisar as características epidemiológicas da DC no Estado do Rio Grande do Norte, nos últimos 5 anos. Métodos: Estudo retrospectivo e descritivo, o qual mostrou uma análise epidemiológica da DC no Estado do Rio Grande do Norte. Foram utilizados base de dados secundários da Subcoordenadoria de Vigilância Epidemiológica (SUVIGE) da Secretaria Estadual da Saúde Pública do Estado do Rio Grande do Norte (SESAP/RN) e do SINAN, do DATASUS e do Departamento de Análise de Saúde e Vigilância de Doenças Não Transmissíveis para fazer o levantamento das informações. Resultados: No estado do Rio Grande do Norte entre os anos de 2018 a 2022, foram notificados 495 casos de DC crônica. Nesse período, registrou-se 107 óbitos (letalidade de 21.61%), com grande predominância na 2° Unidade Regional de Saúde Pública (a qual abrange 26 municípios da região oeste do estado, com sede no município de Mossoró), com 52 óbitos (quase 50% dos casos). Observa-se que um pouco mais de ⅕ foram os registros de morte em comparação aos registros de casos. Bem como, verificou-se predominância do sexo masculino, o qual também obteve maior número de óbitos com ⅔ das ocorrências. Em torno de 24,2% das mortes acontecem na faixa etária dos 50 aos 59 anos. No entanto, também há registros de óbitos em pessoas a partir dos 35 anos, o que mostra uma redução na expectativa de vida da população em idade produtiva. As medidas de tendência central dos dados apresentaram uma média de 99 registros/ano, mediana de 90 registros e desvio padrão de 35,82, o que representa uma assimetria na distribuição dos dados, e pode ser resultado de uma diminuição no registro dos casos DC no período da pandemia (2020 e 2021). Conclusão: A DC no Estado do Rio Grande do Norte é responsável por vários óbitos anualmente em grupos de indivíduos que ainda estão em fase produtiva. Ser do sexo masculino, ter idade entre 50 e 59 anos e ser residente da mesorregião do Oeste Potiguar revelou ser fator de risco associado a maior chance de óbito do DC. Estratégias de saúde pública com ações mais efetivas na região de Mossoró e no seu entorno são necessárias a fim de melhorar o controle da DC nessa região.
Abstract Aim The present study focused on nine patients with hepatocellular carcinoma (HCC) associated with Child A liver cirrhosis undergoing first-line liver resection and salvage liver ...transplantation (SLT) for liver tumor recurrence. Patients and methods Forty-six patients with HCC underwent liver transplantation (OLT); 37 (80.5%) were primary liver transplantations (PLTs) and 9 (19.5%) were SLTs. All patients who underwent SLT received minor transabdominal liver resections. Results The posttransplant 1-, 3-, and 5-year overall survival rates for SLT (88.9%, 88.9%, and 88.9%) were similar to those for PLT (78%, 62.7%, and 62.7%). Four (10.8%) patients in the PLT group had HCC recurrence, while there was zero recurrence in the SLT group. The 1-, 3-, 5-year disease-free survival rates for PLT (89%, 74%, and 74%) were similar to those for SLT (100%, 100%, and 100%). The 1-, 3-, 5-year disease-free survival rates after PLT were 89%, 74%, and 74%, and after SLT were 100%, 100%, and 100%, respectively. The operative mortality, intraperioperative bleeding, operative time, intensive care unit stay, in-hospital stay, and overall incidence of postoperative complications were similar in the two groups. Conclusions In our experience, SLT for HCC is a feasible procedure with similar results in terms of overall survival, disease-free survival, and postoperative complications to those reported for patients who underwent PLT at our institute. An important role exists for SLT as shown by the fact that such a strategy has been used in the 20% of the patients undergoing OLT for HCC.
Context. Wide-field Spitzer surveys allow identification of thousands of potentially high-z submillimeter galaxies (SMGs) through their bright 24 μm emission and their mid-IR colors. Aims. We want to ...determine the average properties of such $z\sim2$ Spitzer-selected SMGs by combining millimeter, radio, and infrared photometry for a representative IR-flux ($\lambda_{\rm rest}\sim 8\,\mu$m) limited sample of SMG candidates. Methods. A complete sample of 33 sources believed to be starbursts (“5.8 μm-peakers”) was selected in the (0.5 deg2) J1046+56 field with selection criteria F24\,\mu m > 400 μJy, the presence of a redshifted stellar emission peak at 5.8 μm, and $r^\prime_{\rm Vega}$ > 23. The field, part of the SWIRE Lockman Hole field, benefits from very deep VLA/GMRT 20 cm, 50 cm, and 90 cm radio data (all 33 sources are detected at 50 cm), and deep 160 μm and 70 μm Spitzer data. The 33 sources, with photometric redshifts ~$1.5{-}2.5$, were observed at 1.2 mm with IRAM-30m/MAMBO to an rms ~0.7–0.8 mJy in most cases. Their millimeter, radio, 7-band Spitzer, and near-IR properties were jointly analyzed. Results. The entire sample of 33 sources has an average 1.2 mm flux density of $1.56 \pm 0.22$ mJy and a median of 1.61 mJy, so the majority of the sources can be considered SMGs. Four sources have confirmed 4σ detections, and nine were tentatively detected at the 3σ level. Because of its 24 μm selection, our sample shows systematically lower $F_{\rm 1.2\,mm}/F_{\rm 24\,\mu m}$ flux ratios than classical SMGs, probably because of enhanced PAH emission. A median FIR SED was built by stacking images at the positions of 21 sources in the region of deepest Spitzer coverage. Its parameters are $T_{\rm dust} = 37 \pm 8$ K, $L_{\rm FIR} = 2.5 \times 10^{12}\,L_{\odot}$, and SFR = 450 $M_{\odot}$ yr-1. The FIR-radio correlation provides another estimate of LFIR for each source, with an average value of $4.1 \times 10^{12}\,L_{\odot}$; however, this value may be overestimated because of some AGN contribution. Most of our targets are also luminous star-forming BzK galaxies which constitute a significant fraction of weak SMGs at $1.7 \lesssim z \lesssim 2.3.$ Conclusions. Spitzer 24 μm-selected starbursts and AGN-dominated ULIRGs can be reliably distinguished using IRAC-24 μm SEDs. Such “5.8 μm-peakers” with F24~\mu m > 400 μJy have $L_{\rm FIR}\,\gtrsim 10^{12}\,L_{\odot}$. They are thus $z \sim 2$ ULIRGs, and the majority may be considered SMGs. However, they have systematically lower 1.2 mm/24 μm flux density ratios than classical SMGs, warmer dust, comparable or lower IR/mm luminosities, and higher stellar masses. About 2000-3000 “5.8 μm-peakers” may be easily identifiable within SWIRE catalogues over 49 deg2.
Developmental dysplasia of the hip (DDH) represents a spectrum of anatomical abnormalities of the hip. The objective of this manuscript is to report the atypical presentation pattern of developmental ...dysplasia of the hip present in a family group in Rio Grande do Norte and to emphasize the importance of early diagnosis performed through the Ortolani and Barlow maneuvers. Both orthopedic clinical tests are essential in screening for changes in the hip joint in the newborn and should preferably be performed from birth to approximately three months of age. In addition, requesting complementary ultrasound of the hip could be indicated. Pediatric patients with developmental hip dysplasia treated at the Children’s Rehabilitation Center were atypical clinical cases because they had male predominance in a family group in Rio Grande do Norte/RN, Brazil. It is concluded that this report emphasizes the need for early and adequate clinical evaluation by the physician for all newborns, regardless of gender, as well as the creation of a protocol which meets the suspicion parameters for requesting an ultrasound of the hip joint in newborns in order to diagnose and treat this condition early, thus reducing the need for surgical treatment and its complications.
A Displasia do Desenvolvimento do Quadril (DDQ) representa um espectro de anormalidades anatômicas do quadril. Nessa direção, o objetivo deste manuscrito é relatar o padrão de apresentação atípica da displasia do desenvolvimento do quadril presente em um grupo familiar do Rio Grande do Norte e enfatizar a importância do diagnóstico precoce, realizado por intermédio das manobras de Ortolani e Barlow. Ambos os testes clínicos ortopédicos são essenciais no rastreamento de alterações da articulação coxofemoral no recém-nascido e devem ser executados, preferencialmente, desde o nascimento até, aproximadamente, os três meses de idade. Além da solicitação complementar de exames ultrassonográficos do quadril, quando indicados. Os pacientes pediátricos com displasia do desenvolvimento do quadril atendidos no Centro de Reabilitação Infantil (CRI) foram casos clínicos atípicos, por apresentarem predominância masculina em um grupo familiar no Rio Grande do Norte/RN, Brasil. Conclui-se que este relato enfatiza a necessidade de avaliação clínica precoce e adequada do médico para todos os recém-nascidos, independentemente do sexo, como também a criação de um protocolo que atenda parâmetros de suspeição para a solicitação de ecografia da articulação coxofemoral em recém-nascidos, com o intuito de diagnosticar e tratar precocemente, assim reduzindo a necessidade do tratamento cirúrgico e suas complicações.
We present a search for Herschel-PACS counterparts of dust-obscured, high-redshift objects previously selected at submillimeter and millimeter wavelengths in the Great Observatories Origins Deep ...Survey North field. We detect 22 of 56 submillimeter galaxies (39%) with a SNR of $\geq$3 at 100 $\mu$m down to 3.0 mJy, and/or at 160 $\mu$m down to 5.7 mJy. The fraction of SMGs seen at 160 $\mu$m is higher than that at 100 $\mu$m. About 50% of radio-identified SMGs are associated with PACS sources. We find a trend between the SCUBA/PACS flux ratio and redshift, suggesting that these flux ratios could be used as a coarse redshift indicator. PACS undetected submm/mm selected sources tend to lie at higher redshifts than the PACS detected ones. A total of 12 sources (21% of our SMG sample) remain unidentified and the fact that they are blank fields at Herschel-PACS and VLA 20 cm wavelength may imply higher redshifts for them than for the average SMG population (e.g., $z>3-4$). The Herschel-PACS imaging of these dust-obscured starbursts at high-redshifts suggests that their far-infrared spectral energy distributions have significantly different shapes than template libraries of local infrared galaxies.
Background: Several studies have provided evidence of a strong association between asthma and allergic or nonallergic rhinitis, leading to the hypothesis that allergic rhinitis (AR) and asthma ...represent a continuum of the same disease.
Aim: The aims of our study were: (i) to measure the comorbidity of AR and asthma and asthma‐like symptoms and (ii) to assess whether asthma, AR, and their coexistence share a common pattern of individual risk factors.
Methods: The subjects are participants from the Italian multicentre, cross‐sectional survey on respiratory symptoms in the young adult general population (Italian Study of Asthma in Young Adults, ISAYA). The relationship between individual risk factors and asthma, AR and their coexistence, was studied by means of a multinomial logistic regression.
Results: About 60% of asthmatics reported AR. On the other hand, subjects with AR presented an eightfold risk of having asthma compared to subjects without AR. Age was negatively associated with asthma OR = 0.89, 95% confidence interval (CI): 0.82–0.96, AR (OR = 0.92, 95% CI: 0.86–0.98), and asthma associated with AR (OR = 0.83, 95% CI: 0.79–0.88). The risk of AR without asthma was significantly higher in the upper social classes (OR = 1.23, 95% CI: 1.08–1.39). Active current smoking exposure was positively associated with asthma alone (OR = 1.24, 95% CI: 1.09–1.41) and negatively associated with AR with (OR = 0.69, 95% CI: 0.54–0.88) or without (OR = 0.76, 95% CI: 0.69–0.84) asthma.
Conclusions: Asthma and AR coexist in a substantial percentage of patients; bronchial asthma and AR, when associated, seem to share the same risk factors as AR alone while asthma without AR seems to be a different condition, at least with respect to some relevant risk factors.
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