Background: Awareness of people’s motivations for committing high-risk behaviors helps to explain the underlying causes and provides a framework for their use in preventive and therapeutic ...interventions. Objectives: This study aimed to evaluate the predictive model of high-risk behaviors in adolescents based on their motivations. Methods: The present research has a correlational design and uses structural equation modeling. The sample included 450 male students selected through a convenience sampling method to complete the Iranian Adolescents’ Risk-taking and Motives for Risk-taking scale. Data were analyzed using structural equation modeling. Results: The results showed that thrill-seeking, calculation, audience control, irresponsibility, and hedonistic motivation had significant relationships with high-risk behaviors. Also, except for attention-seeking, other motivations could significantly contribute to the prediction of high-risk behaviors. Also, the motivations had the strongest impact on alcohol consumption and the minimum impact on smoking. Finally, motivations generally explained 44% of the high-risk behaviors variance. Conclusions: Considering the role of motivations in doing high-risk behaviors, more attention should be given to these factors in preventive and therapeutic interventions.
Tetra amide derivatives have been synthesized in good yields via a one-pot pseudo seven-component ugi reaction of terephthalaldehyde, with 2 molecules of amines, isocyanides and ...2-(3-ethoxy-4-(ethoxycarbonyl)phenyl)acetic acid), and also by condensation of 1,4-phenylenediamine, with 2 molecules aldehyde, isocyanides and 2-(3-ethoxy-4-(ethoxycarbonyl)phenyl)acetic acid). All the newly synthesized compounds were screened for molecular docking studies. Molecular docking studies were carried out using the crystal structure of C-terminal and N-terminal Maltase-Glucoamylase enzyme. Some of the ugi adducts showed minimum binding energy and good affinity toward the active pocket of Maltase-Glucoamylase enzyme in comparison to acarbose as a standard Maltase-Glucoamylase inhibitor.
•We have designed comfortable and simple green synthesis for the provide of novel tetra amide as a biological compound in the absence of catalysts in a one-pot pseudo seven-component reaction including 1 molecule terephthalaldehyde, 2 molecules isocyanides, 2 molecules amines, 2 molecules 2-(3-ethoxy-4-(ethoxycarbonyl)phenyl)acetic acid or 1 molecule phenylenediamine, 2 molecules isocyanide, 2 molecules aldehydes, 2 molecules 2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid) via ugi pseudo seven-component reaction.•We also report molecular docking study indicated that all of the herein reported compounds could snugly occupy the active site of N-terminal and C-terminal of Human Maltase-Glucoamylase, which could make them a plausible candidate for the target site.•We believe that this combination of features and great potential as an anti-diabetic drugs.
Abstract
In this work, the parameters of cobalt oxide suspension such as conductivity, zeta potential, particle size, stability, and finally the electrophoretic behavior of particles in the absence ...and presence of polyethylenimine (
PEI
) in acetone medium were investigated. Also, the effects of washing on the stability and electrophoretic deposition of Co
3
O
4
were studied. Characterization of the obtained layer by optical microscopy revealed that there was no deposition in the suspension without
PEI
, while a uniform layer was formed in the presence of
PEI
additive. Scanning electron microscopy (
SEM
) results confirmed the uniformity of layer obtained in acetone using
PEI
additive. Moreover,
SEM
results demonstrated that more porous microstructures were obtained at longer deposition durations. The difference in the porosity of the layers, as indicated by the
SEM
micrographs, is attributed to increase in the deposition time.
Introduction: One of the basics of healthy eating is five times consumption of fruits and vegetable a day. Given the importance of recognizing effective factors of consuming fruit and vegetable in ...this group, the present study aimed to investigate high school girl's adherence to five-time serving fruits and vegetables per day in Hamadan based on the theory of planned behavior application. Materials and Methods: This descriptive-analytical study was performed on 400 girl students from high schools of Hamadan recruited with a multistage cluster sampling method. Participants filled out questionnaires including demographic variables, the theory of planned behavior constructs and a fruit and vegetable consumption measure one week later. Data analysis was performed using SPSS-18 by Chi-square, Pearson correlation and Logistic regression. Results: Fruit and vegetable consumption by female students is 3.4 times daily. Among the demographic variables, family size, mother's education, father's occupation, household income, body mass index and type of school had significant associations with fruit and vegetable consumption (P<0.05). Behavioral intention predicted 35% of the variation in daily fruit and vegetable consumption. Moreover, subjective norms, perceived behavioral control and attitude were able to predict 32% of behavioral intention. Conclusion: Fruit and vegetable consumption in female students is inadequate. The theory of planned behavior may be a useful framework to design a 5-A-Day intervention for female students.
Background and purpose: Seborrheic dermatitis (SD) is a chronic skin condition that is accompanied by scaling and itching. Stress and mental rumination followed by the disease affect the quality of ...life. The aim of this study was to investigate the effect of seborrheic dermatitis on the quality of life and to compare it with the quality of life of healthy people. Materials and methods: This study was a cross-sectional study. The study sample included 60 randomly selected patients with seborrheic dermatitis who referred to Bouali and Tooba dermatology clinics in Sari during 2019-2020. Two questionnaires (DLQI and SF-36) were used to assess general quality of life in patients. Results: The relationship between the disease and occupation was statistically significant. There was a significant relationship between smoking and seborrheic dermatitis. We also found a significant relationship between the frequency of recurrences and quality of life. The mean of physical and social function in the healthy group was higher than its value for the patient group, but the difference was not significant. Conclusion: Our study showed that age, education, occupation, and smoking are factors that contribute to seborrheic dermatitis. Moreover, the findings revealed that physical and mental health as well as quality of life were less affected in the married group compared to the single group.
Purpose - The purpose of this paper is to explore the economy of Persian Gulf countries following a post-oil economy. This is accompanied with a futurology study and planning of certain scenarios ...that can be applied to these countries.Design methodology approach - This study applies a futurology approach by investigating various scenarios to explore the Arab economy after oil. As such, a series of possible policies are proposed that can be undertaken by Arab countries depending on their public policy. Each of the suggested policies involves different scenarios that have been formed and analyzed using an era-based cellular planning system.Findings - The findings propose three main policies to be undertaken by Arab countries including: investing the oil income in miscellaneous economic baskets in order to minimize the vulnerability and maximize the profits; reducing the oil production in the coming years and transforming the one-product oil economy to a value added petrochemical economy; and seeking new sources of income and wealth. In addition, findings emphasize the necessity for using renewable and lasting wealth resources and minimizing the dependency of countries on the oil economy.Originality value - The proposed scenarios in the study can act as strategic constructs in strengthening the scenario sets in the consecutive years and help develop other scenarios in the future. As such, this paper would be of interest to governmental advisors, strategic planners and policy-makers involved in studies related to the Middle East.
Brown-Vialetto-Van Laere (BVVL) and Fazio-Londe are disorders with amyotrophic lateral sclerosis–like features, usually with recessive inheritance. We aimed to identify causative mutations in 10 ...probands. Neurological examinations, genetic analysis, audiometry, magnetic resonance imaging, biochemical and immunological testings, and/or muscle histopathology were performed. Mutations in known causative gene SLC52A3 were found in 7 probands. More importantly, only 1 mutated allele was observed in several patients, and variable expressivity and incomplete penetrance were clearly noted. Environmental insults may contribute to variable presentations. Putative causative mutations in other genes were identified in 3 probands. Two of the genes, WDFY4 and TNFSF13B, have immune-related functions. Inflammatory responses were implicated in the patient with the WDFY4 mutation. Malfunction of the immune system and mitochondrial anomalies were shown in the patient with the TNFSF13B mutation. Prevalence of heterozygous SLC52A3 BVVL causative mutations and notable variability in expressivity of homozygous and heterozygous genotypes are being reported for the first time. Identification of WDFY4 and TNFSF13B as candidate causative genes supports conjectures on involvement of the immune system in BVVL and amyotrophic lateral sclerosis.
•Only one mutated SLC52A3 allele found in several BVVL patients.•Variable expressivity and penetrance are associated with SLC52A3 mutations.•Environmental insults may contribute to presentations of BVVL pathology.•WDFY4 and TNFSF13B are candidate BVVL-causative genes.•Malfunction of the immune system may contribute to BVVL etiology.
Breast cancer (BC) is one of the most burdensome cancers worldwide. Despite advancements in diagnostic and treatment modalities, developing countries are still dealing with increasing burdens and ...existing disparities. This study provides estimates of BC burden and associated risk factors in Iran at the national and subnational levels over 30 years (1990-2019).
Data on BC burden for Iran were retrieved from the Global Burden of Disease (GBD) study from 1990 to 2019. GBD estimation methods were applied to explore BC incidence, prevalence, deaths, disability-adjusted life years (DALYs), and attributable burden to risk factors based on the GBD risk factors hierarchy. Moreover, decomposition analysis was performed to find the contribution of population growth, aging, and cause-specific incidence in the total incidence change. Age-standardized rates (per 100,000 population) and 95% uncertainty intervals (UI) were reported based on sex, age, and socio-demographic index (SDI).
Age-standardized incidence rate (ASIR) increased from 18.8 (95% UI 15.3-24.1)/100,000 in 2019 to 34.0 (30.7-37.9)/100,000 in 2019 among females and from 0.2/100,000 (0.2-0.3) to 0.3/100,000 (0.3-0.4) among males. Age-standardized deaths rate (ASDR) increased slightly among females from 10.3 (8.2-13.6)/100,000 in 1990 to 11.9 (10.8-13.1)/100,000 in 2019 and remained almost the same among males-0.2/100,000 (0.1-0.2). Age-standardized DALYs rate also increased from 320.2 (265.4-405.4) to 368.7 (336.7-404.3) among females but decreased slightly in males from 4.5 (3.5-5.8) to 4.0 (3.5-4.5). Of the 417.6% increase in total incident cases from 1990-2019, 240.7% was related to cause-specific incidence. In both genders, the BC burden increased by age, including age groups under 50 before routine screening programs, and by SDI levels; the high and high-middle SDI regions had the highest BC burden in Iran. Based on the GBD risk factors hierarchy, high fasting plasma glucose (FPG) and alcohol were estimated to have the most and the least attributed DALYs for BC among females, respectively.
BC burden increased from 1990 to 2019 in both genders, and considerable discrepancies were found among different provinces and SDI quintiles in Iran. These increasing trends appeared to be associated with social and economic developments and changes in demographic factors. Improvements in registry systems and diagnostic capacities were also probably responsible for these growing trends. Raising general awareness and improving screening programs, early detection measures, and equitable access to healthcare systems might be the initial steps to tackle the increasing trends.
Aim and Background: Today, with the growth of different dimensions of sustainable development, managers at the organizational and governmental levels have become more and more interested in the ...components of sustainable development. A healthy and productive human being is at the core of sustainable development. Many factors are contributing to sustainable development, including human, economic, social, industrial, cultural, as well as health, safety, environmental and energy (HSEE) factors. In this regard, the existence of several processing indicators is important in promoting the program and organizational goals at the micro and macro levels. Since continuous evaluation and monitoring of all indicators is not feasible, developing a set of principles to facilitate managerial decision-making processes and monitoring continuous improvement of systems is an important issue in system performance management. Due to the vital role of correct selection of principles in the sustainability of the integrated management system, it is important to consider the key components involved in this choice. The present study aimed to prioritize the HSEE processing indexes in the integrated management system (HSEE IMS) of the Ministry of Industry, Mining and Trade. Methodology: The statistical population of this study is professionals and experts with occupational health, safety, environment, and energy orientation and work experience. In this study, to obtain process, safety, health, environmental and energy processing indicators, firstly, a list of environmental, safety, health, and energy indicators was prepared and evaluated, by using a set of indicators presented in scientific and credible research and articles, the Iranian Environmental Agency, HSE Ministry of Oil, HSEE Ministry of Industry, Mine and Trade, including mining and industrial organizations, including Industrial Development and Renovation Organization of Iran (IDERO), Iranian Mines and Mining Industries Development and Renovation Organization (IMIDRO) and other sources. In the present study, being SMART is the main selection criterion for indices, which are weighted as the five main affecting criteria by the AHP method. Weighted criteria were used to prioritize the eight principles of HSEE management including policy, continuous improvement, do, check, monitoring, and measurement of the system, commitment and leadership, planning and corrective action using the fuzzy TOPSIS technique. Results: The results show that the executive strategic index with a closeness coefficient of 0.937 was selected as the first priority. Continuous improvement and corrective action with the coefficient of closeness of 0.133 and 0.108 were selected from the weaker priorities of the Eight HSEE indices, respectively. Conclusion: Appropriate selection of indicators to facilitate managerial decision-making processes, optimal monitoring of these indicators with maximum efficiency and minimum cost is possible by using multi-criteria decision-making models. Based on the results, sustainable development can be achievable by ranking and prioritizing the HSEE processing indicators to facilitate managerial decision-making processes and monitor continuous improvement of systems to protect individuals, property and reduce accidents and pollution. Keywords: Prioritization, HSEE, Sustainable Development, Fuzzy TOPSIS, Index, Weighting, AHP. Introduction Preventing health, safety, the environment, and energy injuries and accidents by taking into account the health, safety of employees, customers, contractors and others requires a unified management system structure. This system tries to create a healthy, pleasant and joyful environment free from accident, damage and waste by integration and synergy of human resources and facilities. The present study aims to key and prioritize strategic principles in the HSEE integrated management system of the Ministry of Industry, Mine and Trade to evaluate the performance based on specific processes in subsidiary industrial-productive units. Methodology In this study, to obtain safety, health, environmental, and energy processing indexes, firstly, a list of environmental, safety, health, and energy indicators was prepared and evaluated, by using a set of indicators presented in scientific and credible research and articles, the Iranian Environmental Agency, HSE Ministry of Oil, HSEE Ministry of Industry, Mine and Trade, including mining and industrial organizations, including Industrial Development and Renovation Organization of Iran (IDERO), Iranian Mines and Mining Industries Development and Renovation Organization (IMIDRO) and other sources. Then, the SMART metrics including specificity, measurability, achievability, realism and being timely have weighted as five effective criteria by the AHP. After keying the HSEE strategic indicators of the Ministry of Industry, Mining and Trade, including: policy, continuous improvement, do, check, system monitoring, commitment and leadership, planning and corrective action were selected. Initial questionnaire was prepared based on the fuzzy TOPSIS method and key indicators and research criteria. Then, the reliability (internal consistency) and validity of the questionnaire were assessed and finalized. After completing the questionnaires and receiving the information, the expertschr('39') answers in the form of verbal statements were transformed into triangular fuzzy numbers with the capability of analysis. In the present study, to obtain effective indicators for identification and evaluation of key indicators, the five SMART criteria were weighted based on the AHP method. After weighting the research criteria using the AHP method, this ratio is used for weighting the key indexes by the fuzzy TOPSIS method to rank and prioritize. Results The results show that the face validity and content validity of the questionnaire were determined by FVR = 78.08% and CVR = 88%, respectively which have acceptable validity based on Lawshe’s model. The reliability of the research questionnaire was estimated by the appropriate Cronbachchr('39')s alpha equivalent in 0.935, illustrating the intrinsic homogeneity of the evaluated indices. Regarding weighting results, research criteria, weighting criteria and indices are presented in Tables 1-2. Table1. Final weight of criteria by the AHP method Realism Achievability Timely Specificity Measurability Criterion 0.300 0.203 0.135 0.231 0.341 Final Weight Table 2. Closeness coefficient and rank of HSEE processing indicators of Ministry of Industry, Mine and Trade Ranking CCi Criterion Commitment and Leadership 0.491 3 Policy 0.403 4 Planning 0.226 5 Do 0.937 1 Monitoring 0.699 2 Check 0.193 6 Corrective Action 0.108 8 Continuous Improvment 0.133 7 Conclusion Appropriate selection of indicators to facilitate managerial decision-making processes, optimal monitoring of these indicators with maximum efficiency and minimum cost is possible using multi-criteria decision-making models. This study aimed to weight, key and prioritize HSEE process indicators for the first time in Iran at the level of the largest executive-economic system. According to the results of the study, due to the high speed and efficiency of HSEE units in subsidiary organizations, do index (CCi = 0.937) was first priority and continuous improvement (CCi = 0.133) and corrective actions (CCi = 0.108) were found as the weakest priorities of the HSEE eight indicators because of weaknesses in the regular and systematic follow-up of regulatory units or lack of appropriate tools to evaluate these indicators. The results of this study showed an interesting convergence between the weight and prioritization of SMART criteria of strategic indicators of Ministry of Industry, Mine and Trade. This conclusion can help managers select key performance indicators based on SMART criteria and help them choose sustainability indicators that prevent wasting time and cost.
An efficient one-pot synthesis of fused dihydrothiopyrano2,3-
b
indole-3-carbonitriles has been developed through ultrasound mediated reaction by simply combining malononitrile and various aldehydes ...with two indoline-2(3
H
)-thiones. The method has the advantages of high yields, short reaction time, good functional group tolerance and green reaction conditions.
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