Docetaxel is an excellent agent with a high antitumor effect for advanced/recurrent head and neck cancer. A 67-year-old male with advanced hypopharyngeal cancer (T3N2bM1: Stage IV) underwent two ...courses of superselective intra-arterial infusion of docetaxel and intravenous administration of CDDP and 5-FU. Using a coaxial technique, a microcatheter was placed in the feeding artery. Using imaging techniques docetaxel (60 mg/body and 30 mg/body) was infused into the vessels. During chemotherapy the patient received concomitant radiotherapy (50 Gy). MRI after chemoradiation showed a complete response for the primary tumor and a partial response for the neck metastasis. Grade 4 leukopenia and neutropenia and grade 3 pharyngitis/esophagitis were observed during chemoradiotherapy, but these adverse effects abated immediately and were not critical. We conclude that this superselective intra-arterial infusion of docetaxel will be useful and safe for head and neck cancer.
It is now evident that the cell cycle machinery has a variety of elements negatively regulating cell cycle progression. However, among these negative regulators in cell cycle control, only 4 have ...been shown to be consistently involved in the development of human cancers as tumor suppressors: Rb (Retinoblastoma susceptibility protein), p53, and two recently identified cyclin-dependent kinase inhibitors, P16INK4A/MTS1 and p15INK4B/MTS2. Because there are functional interrelations among these negative regulators in the cell cycle machinery, it is particularly interesting to investigate the multiplicity of inactivations of these tumor suppressors in human cancers, including leukemias/lymphomas. To address this point, we examined inactivations of these four genes in primary lymphoid malignancies by Southern blot and polymerase chain reaction-single-strand conformation polymorphism analyses. We also analyzed Rb protein expression by Western blot analysis. The p16INK4A and p15INK4B genes were homozygously deleted in 45 and 42 of 230 lymphoid tumor specimens, respectively. Inactivations of the Rb and p53 genes were 27 of 91 and 9 of 173 specimens, respectively. Forty-one (45.1%) of 91 samples examined for inactivations of all four tumor suppressors had one or more abnormalities of these four tumor-suppressor genes, indicating that dysregulation of cell cycle control is important for tumor development. Statistical analysis of interrelations among impairments of these four genes indicated that inactivations of the individual tumor-suppressor genes might occur almost independently. In some patients, disruptions of multiple tumor-suppressor genes occurred; 4 cases with p16INK4A p15INK4B and Rb inactivations; 2 cases with p16INK4A, p15INK4B, and p53 inactivations; and 1 case with Rb and p53 inactivations. It is suggested that disruptions of multiple tumor suppressors in a tumor cell confer an additional growth advantage on the tumor.
A 48-year-old woman, showing a huge tumor shadow on the right side of the chest by roentgenogram, was admitted to our hospital. CT-scan showed that the tumor, 20cm in diameter, ocuppied the lower ...half of the right thoracic cavity, and expanded to the liver. MRI suggested, direct invasion of the liver by the lung tumor through the diaphragma. From angiographic examination, the main vessels of the tumor arose from the right inferior phrenic artery. The inferior vena cava, the right inferior pulmonary artery and vein, and the right hepatic vein were intact. The pathologic diagnosis of the specimen obtained by percutaneous needle biopsy was a fibrous tumor of the pleura. An operation was performed using a midsternal and right subcostal incision to resect the tumor completely. The tumor was 19.5×16.5cm in size and 2056g in weight. Pathological features were compatible with fibrous tumor of the pleura, and results of immuno-pathological examination was Desmin & cytokeratin negative, but vimentin & CD34 positive.
We present a case report of a ruptured arteriovenous fistula (AVF) associated with neurofibromatosis type 1 (NF1). A 39-year-old man with NF1 suddenly developed a huge hematoma in the right neck ...region. Right vertebral and right extracarotid angiograms disclosed dilated, tortuous vessels and blood pooling. Therefore, superselective embolization using polyvinyl alcohol (PVA) particles and microcoils was performed to obliterate the AVF.
Recently, finite-difference schemes for solving the incompressible Navier-Stokes equations involving various kinds of boundary conditions have focused on improving their accuracy, stability and ...efficiency. A computer program for solving two-dimensional, time-dependent, incompressible viscous flows using the staggered grid in generalized coordinates named GGSTAG2D is developed by using a new formulation better than the former one (see the previous paper (I)). The 2D momentum equations of Navier-Stokes equations for the contravariant velocity components and Poisson equation for pressure are solved by applying a SMAC like time-marching scheme. The spurious errors and the numerical instabilities can be suppressed by employing the staggered grid system and QUICK upwind control volume scheme in generalized coordinates. Some numerical results of 2D square cavity flows are shown to demonstrate the reliability and robustness of the present scheme. We also show the same computation in the regular grid system, but it has more computational time and causes spurious oscillation of pressure values when it is applied to complex flow fields.
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