Summary
Systemic plasmacytosis is characterized by plasma cell proliferation in multiple organs including skin, and by polyclonal hypergammaglobulinaemia. Hyperviscosity‐related retinopathy has never ...been described with this condition, to our knowledge. We report a case of systemic plasmacytosis in a 49‐year‐old Japanese woman, who presented with fever, multiple erythematous plaques, hypergammaglobulinaemia, renal failure and bilateral retinal haemorrhage. Reduction of immunoglobulin with oral steroid reversed the retinopathy related to hyperviscosity syndrome. When marked hypergammaglobulinaemia is found in a patient with systemic plasmacytosis, funduscopic examination should be performed to reveal early asymptomatic retinal changes, because the retinopathy is treatable by control of the underlying disease.
1 Department of Hematology and Oncology
2 Department of Dermatology
3 Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan Key words: drug-induced ...hypersensitivity syndrome, immunorestitution disease, acute myeloid leukemia, chemotherapy, hematopoietic recovery
Correspondence: Mineo Kurokawa, MD, PhD. Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Phone: international +81.3.5800-9092. Fax: international +81.3.58408667. E-mail: kurokawa-tky{at}umin.ac.jp
Drug-induced hypersensitivity syndrome (DIHS) is a rare but severe life-threatening, drug-induced, systemic hypersensitivity reaction. We report two patients who developed DIHS during treatment for acute myeloid leukemia. Awareness of DIHS is necessary when systemic eruptions and high fever occur in leukemic patients, especially with rapid hematopoietic recovery after chemotherapies.
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