The aim of the present study was to investigate pharmacological profiles of Z-338, a 2-salicyl amino-i, 3-thiazole 4-carboxamide derivative, in comparison with cisapride, itopride and mosapride in in ...vitro studies. Z-338 concentration-dependently stimulated contraction of isolated guinea pig gastric antrum at doses greater than 10^-6 M. The stimulating activity of Z-338 was more potent than that of other prokinetics. Electrically stimulated contraction of the gastric antrum was also concentrationdependently enhanced by Z-338 at doses more than 10^-6 M. Electrically stimulated release of ACh and contraction in the ^^3 Hcholine-preincubated gastric antrum and body were concentration.dependently increased after treatment with Z-338 (more than 10^-6 M) and cisapride (more than 10^-7 M). Z-338 reversibly inhibited human erythrocyte AChE activity. The IC_50 of Z-338 with AChE was 3 × 10^-6 M, that was about 100-fold less than that with neostigmine and physostigmine. In the receptor binding study, the.affimty for dopamine D_2 receptor of Z-338 was less than that of other prokinetics. Moreover, Z-338 showed no affinity for serotonin 5-HT_2 , 5-HT_3 or 5HT_4 receptors at 10^-4 M. These results indicate that Z-338 stimulates contraction of isolated segments of the gastric antrum through cholinergic stimulation due to its ACh release and AChE inhibition, and this action is unrelated to dopamine D_2 and serotonin 5-HT receptors.
Phys.Rev.Lett. 92 (2004) 062501 The electric quadrupole transition from the first 2+ state to the ground 0+
state in 16C is studied through measurement of the lifetime by a recoil shadow
method ...applied to inelastically scattered radioactive 16C nuclei. The measured
lifetime is 75 +- 23 ps, corresponding to a B(E2;2_1+ -> 0^+) value of 0.63 +-
0.19 e2fm4, or 0.26 +- 0.08 Weisskopf units. The transition strength is found
to be anomalously small compared to the empirically predicted value.
Structure of the neutron-rich Ge isotopes at and around N=50 has been investigated via intermediate-energy Coulomb excitation using secondary beams of 78–82Ge incident on a Pb target. The B(E2) ...values for the low-lying 2+ states have been extracted and compared with the data for neighboring isotopes around N=50. In addition, a new method of intermediate-energy two-step Coulomb excitation has been proposed as a spectroscopic tool to study the 4+ states in neutron-rich even-even nuclei. The first application of the method and its results are presented.
We measured B(E2; 0g.s.+ → 21+) values for the proton-rich 46Cr, 50Fe, and 54Ni nuclides by intermediate-energy Coulomb excitation in order to study the systematic behavior of collectivity in the ...Z=20–28 region. The present study completes the B(E2) values for the Tz=±1 even-even pair nuclei up to Z=28. The double ratios of proton and neutron matrix elements, (|Mn|/|Mp|)/(N/Z), have been extracted from the B(E2) values combining with the ones of their mirror nuclei, and compared with theoretical predictions.
Inelastic proton scattering on 16C Ong, H. J; Imai, N; Aoi, N ...
The 4th International Conference on Exotic Nuclei and Atomic Masses,
05/2005
Book Chapter
We have studied the 21+ state in neutron-rich {sr16}C via inelastic proton scattering in inverse kinematics, using a 33 MeV/nucleon beam. From the angle-integrated cross-section, the deformation ...parameter βpp′ = 0.50(8) is obtained. This value is greater than the deformation parameter deduced from the lifetime measurement. With these two result combined, the ratio of the neutron and proton quadrupole matrix elements is deduced to be approximately 7, indicating a neutron-dominant quadrupole collectivity in 16C
The electric quadrupole transition from the first 2+ state to the ground 0+ state in 16C is studied through measurement of the lifetime by a recoil shadow method applied to inelastically scattered ...radioactive 16C nuclei. The measured lifetime is 75 +- 23 ps, corresponding to a B(E2;2_1+ -> 0^+) value of 0.63 +- 0.19 e2fm4, or 0.26 +- 0.08 Weisskopf units. The transition strength is found to be anomalously small compared to the empirically predicted value.
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