Comprehensive Summary
Efficient and stable blue luminescent organic materials are highly demanded in the field of organic light‐emitting diodes (OLEDs) but still remain challenging. In this work, two ...new sky‐blue luminescent molecules comprised of electron acceptor of benzophenone and electron donors of spiroacridine‐9,9'‐fluorene and carbazole are designed and synthesized, and their thermal stability, electrochemical behaviors, photophysical properties, carrier transport ability and electroluminescence performance are investigated. They exhibit distinct merits of aggregation‐induced delayed fluorescence with high solid‐state photoluminescence quantum yields, balanced bipolar carrier transport and high horizontal dipole ratios. Highly efficient OLEDs using both molecules as emitters are obtained, which radiate strong sky‐blue light and provide outstanding external quantum efficiencies of up to 33.3% with small roll‐offs.
Two new sky‐blue luminescent molecules comprised of electron acceptor of benzophenone and electron donors of spiroacridine‐9,9'‐fluorene and carbazole are designed and synthesized, which exhibit distinct merits of aggregation‐induced delayed fluorescence with high solid‐state photoluminescence quantum yields, balanced bipolar carrier transport, high horizontal dipole ratios and outstanding external quantum efficiencies.
Intracellular pH (pHi) is an important parameter associated with cellular behaviors and pathological conditions. Sensing pHi and monitoring its changes in live cells are essential but challenging due ...to the lack of effective probes. We herein report a pH-sensitive fluorogen for pHi sensing and tracking. The dye is a tetraphenylethene–cyanine adduct (TPE-Cy). It is biocompatible and cell-permeable. Upon diffusing into cells, it responds sensitively to pHi in the entire physiological range, visualizing the acidic and basic compartments with intense red and blue emissions, respectively. The ratiometric signal of the red and blue channels can thus serve as an indicator for local proton concentration. The utility of TPE-Cy in pHi imaging and monitoring is demonstrated with the use of confocal microscopy, ratiometric analysis, and flow cytometry.
Anti-Kasha's process in organic luminogens has attracted many attentions since its discovery. However, only limited examples of anti-Kasha's rule have been reported and anti-Kasha triplet energy ...transfer (ET) is even less-touched. Benefiting from anti-Kasha's rule, this work provided an efficient strategy to realize excitation wavelength dependent (Ex-De) afterglow in a host-guest system. The host has almost imperceptible RTP upon 365 nm excitation and guest is totally RTP inactive, while the doping host-guest system exhibits Ex-De afterglow with improved quantum yields. Anti-Kasha triplet ET process is realized from the higher excited triplet state T
of host to the lowest excited singlet state S
of the aggregated/unimolecular guest. ET efficiency in the doping system could be tuned by simply changing its processing methods to guide host and guest to adopt denser or looser intermolecular packing. The strategy of anti-Kasha triplet ET endows the host-guest doping system with multiple stimuli-responsive properties, including Ex-De afterglow, mechano-, and thermal-triggered afterglow behaviors. The corresponding applications of these properties are also realized in multiple information anti-counterfeiting and display.
Surface immobilization provides a useful platform for biosensing, drug screening, tissue engineering and other chemical and biological applications. However, some of the used reactions are ...inefficient and/or complicated, limiting their applications in immobilization. Herein, we use a spontaneous and catalyst-free amino-yne click bioconjugation to generate activated ethynyl group functionalized surfaces for fast immobilization of native proteins and cells. Biomolecules, such as bovine serum albumin (BSA), human IgG and a peptide of C(RGDfK), could be covalently immobilized on the surfaces in as short as 30 min. Notably, the bioactivity of the anchored biomolecules remains intact, which is verified by efficiently capturing target antibodies and cells from the bulk solutions. This strategy represents an alternative for highly efficient surface biofunctionalization.
Fast surface immobilization of native bioconjugates through a spontaneous amino-yne click reaction is realized.
Luminogens with high photoluminescence efficiencies and high triplet (T1) energy levels are desired to achieve high‐performance white organic light‐emitting diodes (WOLEDs). In this work, a sky‐blue ...luminogen (DCB‐BP‐SFAC) with enhanced delayed fluorescence in aggregated state, bipolar carrier transport ability and high T1 energy level is developed. DCB‐BP‐SFAC exhibits bright sky‐blue electroluminescence (EL) in both non‐doped and doped OLEDs with maximum external quantum efficiencies of 14.8% and 23.5%. DCB‐BP‐SFAC can function as efficient host for green, orange and red phosphorescent materials as well as thermally activated delayed fluorescence emitters with excellent EL performance. In addition, fluorescence/phosphorescence hybrid and all‐fluorescence WOLEDs with a single emissive layer are fabricated by adopting DCB‐BP‐SFAC as emitter and host simultaneously. The all‐fluorescence WOLED shows two‐color warm‐white light with good EL efficiencies of 47.1 cd A−1, 46.2 lm W−1, and 19.1%. The excellent performance of these OLEDs demonstrates the great application potential of DCB‐BP‐SFAC in practical display and lighting devices.
A multifunctional luminogen DCB‐BP‐SFAC with delayed fluorescence and bipolar carrier transport not only function efficiently in sky‐blue organic light‐emitting diodes (OLEDs) but also work well as host for phosphorescent materials and thermally activated delayed fluorescence emitters. Fluorescence/phosphorescence hybrid white OLEDs and all‐fluorescence white OLEDs with a single emissive layer using DCB‐BP‐SFAC as both host and emitter are achieved.
AIE-based cancer theranostics Gao, Meng; Tang, Ben Zhong
Coordination chemistry reviews,
01/2020, Letnik:
402
Journal Article
Recenzirano
Display omitted
•AIE-based cancer diagnostic imaging is featured with a high signal-to-noise ratio.•AIE-based theranostics can achieve image-guided precise cancer treatment.•The cancer therapy ...process can be in situ monitored and evaluated.
Theranostics with simultaneous diagnosis and therapy functions are potential to greatly improve the therapeutic efficacy and reduce side effects. Fluorescence imaging has significant advantages in terms of high sensitivity, easy operation, and good biocompatibility. However, traditional fluorophores usually suffer from serious self-quenching after local accumulation at a high concentration. In contrary, the aggregation-induced emission fluorogens (AIEgens) are ideal for construction of cancer theranostics with advantages of high emission efficiency in the aggregate state. Therefore, the combination of AIEgens and different therapy modules provides a great opportunity for image-guided precise cancer treatment, which can efficiently ablate cancer cells both in vitro and in vivo. In this review, we will discuss the most recent progress of AIE-based cancer theranostics with representative examples.
•A dual-mode freshness indicator based on DPA-Au/CuNCs was fabricated.•Simultaneous monitoring of ammonia and temperature was achieved for the first time.•Applications for in-situ and visual ...monitoring the seafood freshness.
Seafood is highly perishable and monitoring its freshness this thus an important issue. For the first time, the current study developed a dual-mode freshness indicator based on d-penicillamine capped bimetallic gold/copper nanoclusters (DPA-Au/CuNCs) as a response probe for simultaneous monitoring of ammonia and temperatures to assess seafood freshness. Results indicated that the prepared DPA-Au/CuNCs have good sensitivity toward ammonia, with a limit of detection of 0.14 ppm. The indicator as a gas sensor for ammonia vapour detection exhibited highly recognizable fluorescence colour changes and the variations from white to yellow were observed with increasing storage temperature under natural light. For confirming its practical applications, the indicator was used to simultaneously monitor ammonia and temperatures during the storage of shrimp and fish, showing good potential for practical applications in evaluating seafood freshness for the food industry.
Light scattering and absorption both contribute to the UV-vis extinction quantified with a UV-vis spectrophotometer, but they differ drastically in their causes and effects. The existing optical ...studies have generally focused on the fluorescence and total photon extinction of the aggregation-induced-emission (AIE) materials. The effects of aggregation on the light absorption and scattering of AIE luminogens (AIEgens) are essentially unexplored. Herein, we reported a spectroscopic study of the structures and properties of AIE aggregates using the combination of UV-vis, fluorescence, and polarized resonance synchronous spectroscopy (PRS2) methods. Optical activities including the light absorption extinction, scattering extinction, and absorbance-normalized fluorescence emission have been quantified for the first time for the AIE aggregates prepared with an in-house prepared AIEgen 2-((4-(diphenylamino)biphenyl-4-yl)methylene)malononitrile (TPMN). Absorption extinction dominates the entire UV-vis extinction spectrum obtained with the dissolved TPMN. For the UV-vis spectrum acquired with TPMN aggregates, however, scattering extinction accounts for up to 35% of the peak photon extinction at 480 nm. This number rises to 100% in the wavelength region beyond 580 nm. Sample incubation increases the light scattering extinction, scattering depolarization, and fluorescence emission of the TPMN aggregates, but reduces their light absorption extinction. With its ability to provide information inaccessible with the existing techniques, this work demonstrates that PRS2 is a powerful tool for AIE materials in quantifying their optical properties and monitoring their aggregation/disaggregation processes.
Light scattering and absorption both contribute to the UV-vis extinction quantified with a UV-vis spectrophotometer, but they differ drastically in their causes and effects.
Aggregation-induced emission (AIE)-featuring Au(
i
) complexes are superior probes for physiological environment monitoring in living organisms owing to their excellent biocompatibility and efficient ...luminescent properties. However, the intrinsic obstacle of poor water stability and lack of response to biological stimuli greatly restrict their practical application in biological systems. Herein, water-stable and pH-responsive Au(
i
)-disulfide nanoparticles (NPs) with AIE characteristics were designed. The NPs were prepared by integrating a pH-responsive moiety, cysteine (Cys), into Au(
i
)-thiolate (SR) complexes, and the Au(
i
)-SR-Cys structure was formed through disulfide bonds. Hydrophilic Cys was located on the outer layer of the NPs, endowing the spherical NPs with high stability and remarkable monodispersity in water. In addition, Cys endowed the NPs with pH-responsive characteristics. These unique advantages enable them to hold great promise as luminescent probes to monitor intragastric acidity in an acid suppression therapy. To the best of our knowledge, this work is the first example of luminescent Au(
i
) materials to monitor physiological changes.
The water-stable and pH-responsive Au(
i
)-disulfide NPs serve as a luminescent probe for monitoring intragastric acidity in an acid-suppressed therapy.
High refractive index polymers (HRIPs) have drawn attention for their optoelectronic applications and HRIPs with excellent transparency and facile preparation are highly demanded. Herein, ...sulfur-containing all organic HRIPs with refractive indices up to 1.8433 at 589 nm and excellent optical transparency even in one hundred micrometre scale in the visual and RI region as well as high weight-average molecular weights (up to 44500) are prepared by our developed organobase catalyzed polymerization of bromoalkynes and dithiophenols in yields up to 92%. Notably, the fabricated optical transmission waveguides using the resultant HRIP with the highest refractive index display a reduced propagation loss compared with that generated by the commercial material of SU-8. In addition, the tetraphenylethylene containing polymer not only exhibits a reduced propagation loss, but also is used to examine the uniformity and continuity of optical waveguides with naked eyes because of its aggregation-induced emission feature.
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