The carotid-esophageal fistula is a rare and serious complication of the metallic esophageal prosthesis. A high index of suspicion is required for early diagnosis and treatment, decreasing the ...morbidity and mortality rate of this severe complication. We report a case of a 4-year-old boy presenting severe upper gastrointestinal bleeding due to a carotid-esophageal fistula, secondary to deployment of an esophageal metallic prosthesis for treatment of a recurrent stenosis. The carotid pseudo-aneurism was successfully treated with stents and coils. Although endovascular treatment is a safe and effective option, arterial stenting in children needs further studies with long-term follow-up.
Resumo
Objetivo
O objetivo deste trabalho é descrever o tratamento realizado em um paciente com lesão de escalpe, com invasão e destruição craniana, invasão da dura-máter e comprometimento cerebral.
...Método
Relata-se um caso de um paciente masculino, 54 anos, com lesões em couro cabeludo frontal, ulcerada e infectada que destruía a calota craniana, invadia a dura-máter, obstruía o terço anterior do seio sagital superior e apresentava massa que comprimia os lobos frontais. Além disso, apresentava lesões em ambas as orelhas. O paciente foi submetido à ressecção ampla e agressiva, cujo exame anatomopatológico evidenciou carcinoma espinocelular invasor na região frontal e orelha direita, e carcinoma basocelular na região auricular esquerda. Após a ressecção cirúrgica, foi realizada a reconstrução imeditata com enxerto de fáscia lata, costelas e retalho microcirúrgico de músculo grande dorsal.
Resultados
Paciente apresentou melhora clínica e estética.
Conclusão
Carcinoma de escalpe com acometimento intracraniano é uma condição extremamente grave. O tratamento é multidisciplinar, devendo sempre buscar uma ressecção completa com reconstrução do defeito da forma mais fisiológica e estética possível.
Malignant gliomas are the most prevalent primary malignant cerebral tumors. Preoperative imaging plays an important role, and the prognosis is closely related to surgical resection and histomolecular ...aspects. Our goal was to correlate Ki67 indexes with tumoral volumetry in semiautomatic segmentation on preoperative magnetic resonance images and residual fluorescence in a 5-ALA-assisted resection cohort.
We included 86 IDH-wildtype glioblastoma patients with complete preoperative imaging submitted to 5-ALA assisted resections. Clinical, surgical, and histomolecular findings were also obtained. Preoperative magnetic resonance studies were preprocessed and segmented semiautomatically on Visualization and Analysis for whole tumor (WT) on 3D FLAIR, enhancing tumor (ET), and necrotic core on 3D postgadolinium T1. We performed a linear regression analysis for Ki67 and a multivariate analysis for surgical outcomes.
Higher Ki-67 indexes correlated positively with higher WT (P = 0.048) and ET (P = 0.002). Lower Ki67 correlated with 5-ALA free margins (P = 0.045). WT and ET volumes correlated with the extent of resection (EOR; P = 0.002 and 0.002, respectively). Eloquence did not impact EOR (P = 0.14).
There is a correlation between Ki67, the metabolically active tumoral volumes (WT and ET), and 5-ALA residual fluorescence. Methodological inconsistencies are probably responsible for contradictory literature findings, and further prospective studies are needed to validate and reproduce these findings.
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