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zadetkov: 123
1.
  • Regulation of TORC1 in Resp... Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2
    Demetriades, Constantinos; Doumpas, Nikolaos; Teleman, Aurelio A. Cell, 02/2014, Letnik: 156, Številka: 4
    Journal Article
    Recenzirano
    Odprti dostop

    TOR complex 1 (TORC1) is a potent anabolic regulator of cellular growth and metabolism. When cells have sufficient amino acids, TORC1 is active due to its lysosomal localization mediated via the Rag ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP

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2.
  • Molecular mechanisms of metabolic regulation by insulin in Drosophila
    Teleman, Aurelio A Biochemical journal, 01/2010, Letnik: 425, Številka: 1
    Journal Article
    Recenzirano

    The insulin signalling pathway is highly conserved from mammals to Drosophila. Insulin signalling in the fly, as in mammals, regulates a number of physiological functions, including carbohydrate and ...
Preverite dostopnost
3.
  • Metabolites Regulate Cell S... Metabolites Regulate Cell Signaling and Growth via Covalent Modification of Proteins
    Figlia, Gianluca; Willnow, Philipp; Teleman, Aurelio A. Developmental cell, 07/2020, Letnik: 54, Številka: 2
    Journal Article
    Recenzirano
    Odprti dostop

    Metabolites affect cell growth in two different ways. First, they serve as building blocks for biomass accumulation. Second, metabolites regulate the activity of growth-relevant signaling pathways. ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP

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4.
  • Selective 40S Footprinting ... Selective 40S Footprinting Reveals Cap-Tethered Ribosome Scanning in Human Cells
    Bohlen, Jonathan; Fenzl, Kai; Kramer, Günter ... Molecular cell, 08/2020, Letnik: 79, Številka: 4
    Journal Article
    Recenzirano
    Odprti dostop

    Translation regulation occurs largely during the initiation phase. Here, we develop selective 40S footprinting to visualize initiating 40S ribosomes on endogenous mRNAs in vivo. This reveals the ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP

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5.
  • Phosphorylation of ribosoma... Phosphorylation of ribosomal protein S6 differentially affects mRNA translation based on ORF length
    Bohlen, Jonathan; Roiuk, Mykola; Teleman, Aurelio A Nucleic acids research, 12/2021, Letnik: 49, Številka: 22
    Journal Article
    Recenzirano
    Odprti dostop

    Abstract Phosphorylation of Ribosomal Protein S6 (RPS6) was the first post-translational modification of the ribosome to be identified and is a commonly-used readout for mTORC1 activity. Although the ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK

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6.
  • Lysosomal recruitment of TS... Lysosomal recruitment of TSC2 is a universal response to cellular stress
    Demetriades, Constantinos; Plescher, Monika; Teleman, Aurelio A Nature communications, 02/2016, Letnik: 7, Številka: 1
    Journal Article
    Recenzirano
    Odprti dostop

    mTORC1 promotes cell growth and is therefore inactivated upon unfavourable growth conditions. Signalling pathways downstream of most cellular stresses converge on TSC1/2, which serves as an ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK

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7.
  • Translation acrobatics: how... Translation acrobatics: how cancer cells exploit alternate modes of translational initiation
    Sriram, Ashwin; Bohlen, Jonathan; Teleman, Aurelio A EMBO reports, October 2018, Letnik: 19, Številka: 10
    Journal Article
    Recenzirano
    Odprti dostop

    Recent work has brought to light many different mechanisms of translation initiation that function in cells in parallel to canonical cap‐dependent initiation. This has important implications for ...
Celotno besedilo
Dostopno za: FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK

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8.
  • PRRC2 proteins impact trans... PRRC2 proteins impact translation initiation by promoting leaky scanning
    Bohlen, Jonathan; Roiuk, Mykola; Neff, Marilena ... Nucleic acids research, 04/2023, Letnik: 51, Številka: 7
    Journal Article
    Recenzirano
    Odprti dostop

    Abstract Roughly half of animal mRNAs contain upstream open reading frames (uORFs). These uORFs can represent an impediment to translation of the main ORF since ribosomes usually bind the mRNA cap at ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK
9.
Celotno besedilo
Dostopno za: EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
10.
  • DENR-MCTS1 heterodimerizati... DENR-MCTS1 heterodimerization and tRNA recruitment are required for translation reinitiation
    Ahmed, Yasar Luqman; Schleich, Sibylle; Bohlen, Jonathan ... PLoS biology, 06/2018, Letnik: 16, Številka: 6
    Journal Article
    Recenzirano
    Odprti dostop

    The succession of molecular events leading to eukaryotic translation reinitiation-whereby ribosomes terminate translation of a short open reading frame (ORF), resume scanning, and then translate a ...
Celotno besedilo
Dostopno za: DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK

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zadetkov: 123

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