We describe the design and performance of the near-infrared (1.51-1.70 m), fiber-fed, multi-object (300 fibers), high resolution (R = λ/Δλ ∼ 22,500) spectrograph built for the Apache Point ...Observatory Galactic Evolution Experiment (APOGEE). APOGEE is a survey of ∼105 red giant stars that systematically sampled all Milky Way populations (bulge, disk, and halo) to study the Galaxy's chemical and kinematical history. It was part of the Sloan Digital Sky Survey III (SDSS-III) from 2011 to 2014 using the 2.5 m Sloan Foundation Telescope at Apache Point Observatory, New Mexico. The APOGEE-2 survey is now using the spectrograph as part of SDSS-IV, as well as a second spectrograph, a close copy of the first, operating at the 2.5 m du Pont Telescope at Las Campanas Observatory in Chile. Although several fiber-fed, multi-object, high resolution spectrographs have been built for visual wavelength spectroscopy, the APOGEE spectrograph is one of the first such instruments built for observations in the near-infrared. The instrument's successful development was enabled by several key innovations, including a "gang connector" to allow simultaneous connections of 300 fibers; hermetically sealed feedthroughs to allow fibers to pass through the cryostat wall continuously; the first cryogenically deployed mosaic volume phase holographic grating; and a large refractive camera that includes mono-crystalline silicon and fused silica elements with diameters as large as ∼400 mm. This paper contains a comprehensive description of all aspects of the instrument including the fiber system, optics and opto-mechanics, detector arrays, mechanics and cryogenics, instrument control, calibration system, optical performance and stability, lessons learned, and design changes for the second instrument.
The liquid-phase oxidation of ethanol to acetic acid using Au catalysts supported on various metal oxides was studied at 150°C using molecular oxygen as stoichiometric oxidant. Catalysts containing 1 ...wt% Au supported on TiO
2
, Al
2
O
3
, and ZnO were examined for ethanol oxidation. The results showed that ZnO and TiO
2
gave higher initial activities as supports for gold in ethanol oxidation, followed by Al
2
O
3
. Ethanol conversions of >90% and selectivities to acetic acid of >95% were achieved when using ZnO and TiO
2
as supports under conditions where a slight oxygen deficiency was used. With a slight excess of oxygen present initially, ethanol conversions of 99.4%, and a selectivity to acetic acid selectivity of 99.8% could be achieved. Gold leaching seemed to be very apparent with alumina as support and also, after continued use with titania-based catalysts. The use of higher initial concentrations of ethanol (range studied 5–40 mass% ethanol in water) led to higher ethyl acetate selectivities. High acetic acid selectivities were seen for relatively low (5–10 mass%) initial ethanol concentrations.
Economic adversity, scarcity, joblessness and upsurge in the price of oil have dictated the need for people to find alternative means of making a living in respect of domestic cooking energy in ...Nigeria. Therefore, this work examined charcoal production in both Makurdi and Guma LGAs of Benue state to ascertain its impact, contributions to rural livelihood and efforts in replanting trees felled for charcoal production. Villages involved in charcoal production were identified using snowball sampling techniques. A Multi-stage Sampling Technique was employed to select respondents for data collection as personal interview and semi-structured questionnaire were used. Twelve villages were selected purposively from four Council Wards out of eleven in Makurdi LGA, while six villages were selected from two Council Wards out of ten were ten in Guma LGA. Three charcoal producers and marketers were selected in each village for administration of questionnaire. Results revealed that males (85.4%, 83.7%) were higher than females (14.6%, 16.3%) in Makurdi and Guma LGAs, respectively. Youths between ages of 21-30 years (27.1% and 32.6%) in Makudri and Guma with highest level of secondary education were foremost in the business. Prosopis africana was the most preferred tree species for charcoal production in the area. Despite fewer number of Council Wards chosen in Guma LGA, yet, respondents felled as much as 132 trees per week for charcoal production against 109 trees felled in Makurdi LGA which sum up to 241 trees felled per week. The results also reveal that on weekly bases, 22 charcoal producers in Makurdi earned N25,000, while 18 in Guma LGA earned between N11, 000 - N15, 000 from charcoal business. The result further revealed that, respondents met family needs as feeding, paying school fees and purchase of motorcycle. The major health hazard encountered by respondents in Makurdi and Guma LGAs was fire burn (50% and 25%), respectively. Efforts in replanting trees in the study area was minimal through plantation forestry and agroforestry. In conclusion, charcoal production was observed to improve socio economic benefits to people. However, alternative source of livelihood should be provided for the people to mitigate the adverse effect of deforestation.Key words: Charcoal, deforestation, livelihood, Prosopis africana, wood species, Key words: Charcoal, deforestation, livelihood, Prosopis africana, wood species,
We describe the design and performance of the near-infrared (1.51–1.70 μm), fiber-fed, multi-object (300 fibers), high resolution (R = λ/Δλ ∼ 22,500) spectrograph built for the Apache Point ...Observatory Galactic Evolution Experiment (APOGEE). APOGEE is a survey of ∼10⁵ red giant stars that systematically sampled all Milky Way populations (bulge, disk, and halo) to study the Galaxy’s chemical and kinematical history. It was part of the Sloan Digital Sky Survey III (SDSS-III) from 2011 to 2014 using the 2.5 m Sloan Foundation Telescope at Apache Point Observatory, New Mexico. The APOGEE-2 survey is now using the spectrograph as part of SDSS-IV, as well as a second spectrograph, a close copy of the first, operating at the 2.5 m du Pont Telescope at Las Campanas Observatory in Chile. Although several fiber-fed, multi-object, high resolution spectrographs have been built for visual wavelength spectroscopy, the APOGEE spectrograph is one of the first such instruments built for observations in the near-infrared. The instrument’s successful development was enabled by several key innovations, including a “gang connector” to allow simultaneous connections of 300 fibers; hermetically sealed feedthroughs to allow fibers to pass through the cryostat wall continuously; the first cryogenically deployed mosaic volume phase holographic grating; and a large refractive camera that includes mono-crystalline silicon and fused silica elements with diameters as large as ∼400 mm. This paper contains a comprehensive description of all aspects of the instrument including the fiber system, optics and opto-mechanics, detector arrays, mechanics and cryogenics, instrument control, calibration system, optical performance and stability, lessons learned, and design changes for the second instrument.
We report a 30-month-old female with intrauterine growth retardation, postnatal failure to thrive, pancytopoenia and myelodysplasia with monosomy 7 in the marrow. The child succumbed to overwhelming ...sepsis, following a bone marrow transplant to facilitate chemotherapy for metastatic hepatoblastoma--a tumour that has not been previously reported in myelodysplasia syndromes. Cytogenetic, molecular and microarray analysis of peripheral blood, skin fibroblasts and bone marrow revealed unusual results, suggestive of somatic chromosome instability. A normal peripheral blood karyotype was documented in infancy. Monosomy 7 was found in the bone marrow. Molecular (microsatellite marker) results for a later peripheral blood specimen were suggestive of partial maternal isodisomy 7q, and this was supported by microarray data on single-nucleotide polymorphisms. Microarray data on gene copy number, collected for the same blood specimen, indicated cryptic mosaicism for the monosomy 7 cell line, with the monosomic line lacking the paternal copy. In fibroblasts, cytogenetic data showed mosaic partial trisomy for distal 7p.
This report describes a boy with delayed physical and mental milestones, dysmorphic features, congenital anomalies of the feet and convulsions. He was found to have translocation between long arms of ...1st and 10th chromosome. Such a 1:10 translocation with phenotypic consequences has not been reported in Indian literature so far.
Programmed death 1 (PD1) inhibitors are now a foundation of medical management of metastatic melanoma. This study sought to determine whether circulating tumour DNA (ctDNA) provides useful early ...response and prognostic information.
We evaluated the relationship between pre-treatment and early on treatment ctDNA and outcome in melanoma patients treated with PD1 inhibitors alone or in combination with ipilimumab.
ctDNA was detected in 40/76 patients (53%) at baseline, and correlated with stage, LDH levels, disease volume and ECOG performance. RECIST response was 72% (26/36) in group A (undetectable ctDNA at baseline), 77% (17/22) in group B (elevated ctDNA at baseline but undetectable within 12 weeks of therapy) and 6% (1/18) in group C (elevated ctDNA at baseline and remained elevated during treatment). The median PFS was not reached in groups A and B and was 2.7 months for group C hazard ratio (HR) 0.09; P < 0.001 for group A versus C, and 0.16; P < 0.001 for group B versus C. The median OS was not reached for groups A and B and was 9.2 months for group C (HR 0.02; P < 0.001 for group A versus C and 0.14; P < 0.001 for group B versus C). The poor outcome measures associated with group C remained significant in multivariate analysis adjusted for LDH, performance status, tumour stage and disease volume. The predictive value for ctDNA for response was confirmed in a separate validation cohort (n = 29, P < 0.01).
Longitudinal assessment of ctDNA in metastatic melanoma patients receiving treatment with PD1 inhibitors is an accurate predictor of tumour response, PFS and OS. Patients who had a persistently elevated ctDNA on therapy had a poor prognosis, and this may guide combination and sequencing of subsequent therapies.
Integrated sequencing strategies have provided a broader understanding of the genomic landscape and molecular classifications of multiple cancer types and have identified various therapeutic ...opportunities across cancer subsets. Despite pivotal advances in the characterization of genomic alterations in glioblastoma, targeted agents have shown minimal efficacy in clinical trials to date, and patient survival remains poor. In this review, we highlight potential reasons why targeting single alterations has yielded limited clinical efficacy in glioblastoma, focusing on issues of tumor heterogeneity and pharmacokinetic failure. We outline strategies to address these challenges in applying precision medicine to glioblastoma and the rationale for applying targeted combination therapy approaches that match genomic alterations with compounds accessible to the central nervous system.
Abortion is a common but controversial phenomenon globally. The discourse on the legality of abortion remains intricate, leaving a substantial number of women restricted from accessing safe abortion. ...There are evidence of an association between restrictive abortion laws, unsafe abortions, and maternal mortality in low-and middle-income countries (LMICs). We explore how restrictive abortion laws violate women's right to health and bodily integrity. We used Carol Bacchi's policy framework to analyze how restrictive abortion laws have been discursively framed (problematization); the assumptions that underpinned the representation; the consequences of the representation; what was left unproblematic; how the representation could be questioned, disrupted and replaced. We found that most of these laws are based on morality and the limited number of women in politics has made them objects rather than subjects in decision-making process. Therefore, we recommend a holistic approach to abortion laws with women leading the process to achieve reproductive justice.
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