, a plant native to the Indian subcontinent has a variety of biological activities. Curcumin is the most abundant and biologically active compound with many therapeutic properties. Demethoxycurcumin ...(DMC) and bisdemethoxycurcumin (BDMC) - the two other bioactive components present in
, besides curcumin, are collectively termed curcuminoids. Apart from the well-known curcumin, BDMC also has been reported to possess promising biological and pharmacological effects, but very little scientific evidence on its safety assessment has been published.
The present study was undertaken to determine the safety of pure BDMC from
extract in rodents which comprises of general toxicity (both four weeks and three months duration), reproductive/developmental toxicity and genotoxicity studies.
The Good Laboratory Practice studies were carried out in accordance with the test guidelines established by the Organization for Economic Cooperation and Development.
No treatment-related adverse findings were seen in general toxicity testing and a no observed adverse effect level (NOAEL) of 1000 mg/kg/day was established after four weeks (sub-acute) and three-months (sub-chronic) dosing. Evaluation of fertility, embryo-fetal, and post-natal reproductive and developmental parameters also showed no adverse findings with a NOAEL of 1000 mg/kg/day established. The results of genotoxicity as evaluated by
reverse mutation assay, and
micronucleus test in mice indicate that BDMC did not induce any genotoxic effects.
Oral administration of BDMC is safe in rodents and non-mutagenic, with no adverse effects under experimental conditions.
Obesity, a condition accompanying abnormal or excessive accumulation of fat in the body has become a major public health concern globally. Various herbs hailed from traditional systems of medicine ...like Ayurveda have gained importance in recent years to combat obesity. One such herb Cyperus rotundus (nutgrass), is known for its beneficial effects in obesity, in Ayurveda. Cirpusins® a patented extract from the dried rhizomes of Cyperus rotundus (standardized for minimum of 6% total identified stilbenes - Piceatannol, Scirpusin A & Scirpusin B) and BioPerine®, a bioavailability enhancer, obtained from the dried fruits of Piper nigrum (standardized to minimum 95% piperine). In this study, we examined the pharmacokinetic profile and bioavailability of Cirpusins® in Sprague-Dawley rats at two different doses (45 and 90 mg/kg) in the presence and absence of BioPerine® respectively. The results signifies that addition of BioPerine® (0.45 mg/kg) with Cirpusins® (45 mg/kg) enhances the bioavailability by reducing the effective dose of Cirpusins® (90 mg/kg) to half.
