Furfural is an organic compound that is widely used in the chemical industry for manufacturing various products, such as pharmaceuticals, pesticides, and solvents. Furfural production from biomass ...feedstocks can be achieved through various conversion pathways (e.g., pyrolysis or hydrolysis), however, it requires further investigation to reduce the total cost and meet the market needs. This study proposes a multi-objective decision making framework to compare techno-economic and environmental aspects of pyrolysis and hydrolysis technologies for furfural production from sugar beet pulp. Life cycle assessment method is applied for investigating the environmental impacts of converting organic materials to intermediate bioproducts (e.g., bio-oil) on-site, near collection area, using a portable refinery unit. The techno-economic assessment employs an optimization model for minimizing the upstream and midstream costs (e.g., collection, transportation, and production). Sustainability assessments are conducted on a real case study in southern Idaho, USA, to evaluate and verify the methodology and demonstrate the application of this study. The results show that the total cost for furfural production, using pyrolysis and hydrolysis, are approximately $846 and $980 per metric ton, and total emission is 267 and 1095 kg CO2 eq. per metric ton, respectively. Therefore, the pyrolysis pathway results in lower emissions and costs due to the high-water demand and low energy-density feedstock transportation associated with the hydrolysis pathway. It is concluded that portable operations near collection sites can reduce the total costs and emissions, and consequently stimulate sustainable furfural production by addressing upstream and midstream challenges.
Conventional approaches to local economic development are failing to address deepening polarisation both within and between city regions across advanced capitalist economies. At the same time, ...austerity urbanism, particularly in the UK, presents challenges for urban authorities facing reduced budgets to meet increased demands on public services. Municipalities are beginning to experiment with creative responses to these crises, such as taking more interventionist and entrepreneurial roles in developing local economies, generating alternative sources of revenue or financialising existing assets. Rooted in a Polanyian perspective and building on the concepts of the entrepreneurial state and grounded city, we identify an embryonic alternative approach – what we call ‘entrepreneurial municipalism’ – as a policy pathway towards resolving enduring socioeconomic problems where neoliberal urban-entrepreneurial strategies have failed. We situate entrepreneurial municipalism as one strand in an assemblage of new municipalist interventions, between radical urban social movements and more neoliberal strategies such as financialised municipal entrepreneurialism. Drawing on original research on the Liverpool City Region, we explore how local authorities are working with social enterprises to harness place-based assets in ways which de-commodify land, labour and capital and re-embed markets back into society. Finally, we draw upon Polanyi as our guide to disentangle differences in approach amongst divergent forms of municipalist statecraft and to critically evaluate entrepreneurial municipalism as a possible trajectory towards the grounded city.
Uninstrumented in-situ fusion of pediatric spondylolisthesis harbors a significant risk of suboptimal outcome. We suggest that reduction and instrumented fusion with deliberate protective measures ...against neurologic insult should be considered for the treatment of low-grade slips to intermediate-grade slips. This retrospective review of the clinical and radiographic data of 13 consecutively treated pediatric patients describes our experience with this approach. Eleven patients were pain free at the most recent follow-up and showed an average sustained correction in percent slip of 39%. This technique provides a safe alternative to in-situ fusion with the potential for improved outcomes.
The current study assessed performance validity on the Stroop Color and Word Test (Stroop) in mild traumatic brain injury (TBI) using criterion‐groups validation. The sample consisted of 77 patients ...with a reported history of mild TBI. Data from 42 moderate–severe TBI and 75 non‐head‐injured patients with other clinical diagnoses were also examined. TBI patients were categorized on the basis of Slick, Sherman, and Iverson (1999) criteria for malingered neurocognitive dysfunction (MND). Classification accuracy is reported for three indicators (Word, Color, and Color–Word residual raw scores) from the Stroop across a range of injury severities. With false‐positive rates set at approximately 5%, sensitivity was as high as 29%. The clinical implications of these findings are discussed.
We characterized decadal changes in the amplitude and shape of the seasonal cycle of atmospheric CO2 with three kinds of analysis. First, we calculated the trends in the seasonal cycle of measured ...atmospheric CO2 at observation stations in the National Oceanic and Atmospheric Administration Climate Monitoring and Diagnostic Laboratory network. Second, we assessed the impact of terrestrial ecosystems in various localities on the mean seasonal cycle of CO2 at observation stations using the Carnegie‐Ames‐Stanford Approach terrestrial biosphere model and the Goddard Institute for Space Studies (GISS) atmospheric tracer transport model. Third, we used the GISS tracer model to quantify the contribution of terrestrial sources and sinks to trends in the seasonal cycle of atmospheric CO2 for the period 1961–1990, specifically examining the effects of biomass burning, emissions from fossil fuel combustion, and regional increases in net primary production (NPP). Our analysis supports results from previous studies that indicate a significant positive increase in the amplitude of the seasonal cycle of CO2 at Arctic and subarctic observation stations. For stations north of 55°N the amplitude increased at a mean rate of 0.66% yr−1 from 1981 to 1995. From the analysis of ecosystem impacts on the mean seasonal cycle we find that tundra, boreal forest, and other northern ecosystems are responsible for most of the seasonal variation in CO2 at stations north of 55°N. The effects of tropical biomass burning on trends in the seasonal cycle are minimal at these stations, probably because of strong vertical convection in equatorial regions. From 1981 to 1990, fossil fuel emissions contributed a trend of 0.20% yr−1 to the seasonal cycle amplitude at Mauna Loa and less than 0.10% yr−1 at stations north of 55°N. To match the observed amplitude increases at Arctic and subarctic stations with NPP increases, we find that north of 30°N a 1.7 Pg C yr−1 terrestrial sink would be required. In contrast, over regions south of 30°N, even large NPP increases and accompanying terrestrial sinks would be insufficient to account for the increase in high‐latitude amplitudes.
A rapid, non-invasive urine test for early stage alcohol-induced liver disease (ALD) would permit risk stratification and treatment of high-risk individuals before ALD leads to irreversible liver ...damage and death. Urinary metabolomic studies were carried out to identify ALD-associated metabolic biomarkers using Ppara-null mouse model that is susceptible to ALD development on chronic alcohol consumption. Two successive studies were conducted to evaluate the applicability of mass spectrometry-based metabolomics in identification of ALD-specific signatures and to examine the robustness of these biomarkers against genetic background. Principal components analysis of ultraperformance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC-ESI-QTOFMS)-generated urinary metabolic fingerprints showed that alcohol-treated wild-type and Ppara-null mice could be distinguished from control animals. It also showed that a combined endogenous biomarker panel helps to identify subjects with ALD as well as those at risk of developing ALD even without any information on alcohol intake or genetics. Quantitative analysis showed that increased excretion of indole-3-lactic acid and phenyllactic acid was a genetic background-independent signature exclusively associated with ALD pathogenesis in Ppara-null mice that showed liver pathologies similar to those observed in early stages of human ALD. These findings demonstrated that mass spectrometry-based metabolomic analysis could help in the identification of ALD-specific signatures, and that metabolites such as indole-3-lactic acid and phenyllactic acid, may serve as robust noninvasive biomarkers for early stages of ALD.
Open surgery remains the gold standard by which endovascular treatment of superficial chronic venous insufficiency is measured. This meta-analysis of randomized controlled trials reviews the current ...evidence base, comparing open and endovascular treatment of varicose veins. Systematic review of studies reporting duplex scan follow-up after open surgical, laser (endovenous laser therapy EVLT), or radiofrequency (VNUS Closure device, VNUS Medical Technologies, San Jose, CA) treatment of refluxing great saphenous veins was completed. Primary outcome measures were occlusion and complication rates and time taken to resume work. No significant difference in recurrence rates at 3 months between open surgery and EVLT (RR 2.19, 95% CI 0.99-4.85, p = .05) or VNUS device (RR 7.57; 95% CI 0.42-136.02) were found. Return to work is significantly faster following VNUS (by 8.24 days; 95% CI 10.50-5.97) or EVLT (by 5.02 days; 95% CI 6.52-3.52). Endovascular treatment of varicose veins is safe and effective and offers the significant advantage of rapid recovery.
Background:
Oblique injuries are known to be a common cause of time out of play for professional baseball players, and prior work has suggested that injury rates may be on the rise in Major League ...Baseball (MLB).
Purpose:
To better understand the current incidence of oblique injuries, determine their impact based on time out of play, and to identify common injury patterns that may guide future injury prevention programs.
Study Design:
Descriptive epidemiological study.
Methods:
Using the MLB Health and Injury Tracking System, all oblique injuries that resulted in time out of play in MLB and Minor League Baseball (MiLB) during the 2011 to 2015 seasons were identified. Player demographics such as age, position/role, and handedness were included. Injury-specific factors analyzed included the following: date of injury, timing during season, days missed, mechanism, side, treatment, and reinjury status.
Results:
A total of 996 oblique injuries occurred in 259 (26%) MLB and 737 (74%) MiLB players. Although the injury rate was steady in MiLB, the MLB injury rate declined (P = .037). A total of 22,064 days were missed at a mean rate of 4413 days per season and 22.2 days per injury. The majority of these occurred during batting (n = 455, 46%) or pitching (n = 348, 35%), with pitchers losing 5 days more per injury than batters (P < .001). The leading side was injured in 77% of cases and took 5 days longer to recover from than trailing side injuries (P = .009). Seventy-nine (7.9%) players received either a corticosteroid or platelet-rich plasma injection, and the mean recovery time was 11 days longer compared with those who did not receive an injection (P < .001).
Conclusion:
Although the rate of abdominal oblique injuries is on the decline in MLB, this is not the case for MiLB, and these injuries continue to represent a significant source of time out of play in professional baseball. The vast majority of injuries occur on the lead side, and these injuries result in the greatest amount time out of play. The benefit of injections for the treatment of oblique injuries remains unknown.