We analyzed numerically computed velocity autocorrelation functions and generalized frequency spectra of charge distribution in homogeneous DNA sequences at finite temperature. The autocorrelation ...function and generalized frequency spectrum (frequency-dependent diffusion coefficient) are phenomenologically introduced based on the functional of mean-square displacement of the charge in DNA. The charge transfer in DNA was modeled in the framework of the semi-classical Holstein model. In this model, DNA is represented by a chain of oscillators placed into thermostat at a given temperature that is provided by the additional Langevin term. Correspondence to the real DNA is provided by choice of the force parameters, which are calculated with quantum-chemical methods. We computed the diffusion coefficient for all homogenous DNA chains with respect to the temperature and found a special scaling of independent variables that the temperature dependence of the diffusion coefficient for different homogenous DNA is almost similar. Our calculations suggest that for all the sequences, only one parameter of the system is mainly responsible for the charge kinetics. The character of individual motions contributing to the charge mobility and temperature-dependent regimes of charge distribution is determined.
The work attempts to reconstruct the chemical composition and energy value of the diet in Yakutia based on data provided by A. Middendorff (1842–1845) and V. Seroshevsky (1896). Our study enabled to ...establish the daily diet of pastoralists in the first half of the 19th century (prior to the introduction of bread into the diet of this region) and the late 19th century (during the transitional period, which is associated with the introduction of crop farming and an increase in the consumption of flour-based foods). The diet of the affluent segment of the population of Yakutia in the pastoral period (before the second half of the 19th century) can be described as a protein-fat diet, dominated by protein and fat with low carbohydrate content. Fat metabolism is a key element of adaptation in a cold climate. Hence the high-fat content of the diet served as an advantage for adaptation for the pastoralists when settling in North-Eastern Siberia with its extremely cold climate. This circumstance is one of the primary conditions which facilitated extensive expansion of the pastoral population of Yakutia in North-Eastern Siberia in the 17th–19th century. The introduction of crop farming in the region was characterised by a change in the diet of the residents of the region (pine tree sap was replaced with flour-based foods). The reconstruction of the diet showed that during this period, the diet in Yakutia resembled the so-called paleo diet. However, over the past 100 years, the diet in North-Eastern Siberia has drastically changed from a paleo diet to a post-industrial diet, which has affected the health of the population.
To manage the increasing complexity of automation software, new development methods are needed. The model-driven development (MDD) approaches are very promising here. However, switching to the MDD in ...industrial software development practice is complicated, and required efforts are often very high. Therefore, the MDD approaches are still far from the widespread industrial usage. With the presented approach the next steps towards the industrial application of MDD technologies are performed. The approach is not intended to replace existing development practices in industry, but it aims at the step-by-step introduction of MDD technologies into industrial software development.
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