Immunoreactive vasoactive intestinal polypeptide (VIP) was detected in a population of amacrine cells in the retina of the rat. Processes of these cells reach both the inner and outer half of the ...inner plexiform layer where they form sublayers. The VIP neurons are different from previously known amacrine cell types.
To improve the description of the ocular part of the Laurence-Moon-Bardet-Biedl syndrome.
We examined 44 Scandinavian individuals who all had retinal dystrophy plus at least 2 more of the traditional ...cardinal signs of the syndrome: obesity, hypogenitalism, polydactyly and mental retardation.
Full-field electroretinograms were obtained in 36 of the individuals and were abnormal in all. The dark adaptation thresholds were elevated by on average 3.5 log units. Symptoms of night blindness were observed at a mean age of 4 years and visual problems at daytime at 6-7 years. No one exceeding the age of 16 had a best corrected visual acuity of more than 0.1. In the fundus attenuated vessels were noted at all ages while macular pigmentations and a wax-pale optic disc appeared at age 6-7 years. Pigmentary changes in the midperiphery were noted at the earliest at 13 years of age and appeared mainly as bone spicules, however, in a minority of cases the pigmentations were atypical. Ten of the participants had been followed through a period of 9 years. Their visual acuity was reduced by on average 0.3 line (decimals) and the angle of visual fields by approximate 3 degrees (Goldmann standard object V:4e) per year through the adolescence.
The ocular disease in Laurence-Mood-Bardet-Biedl syndrome presents early, the prognosis for visual function is poor and the fundus features are atypical and varying.
Nordic research in ophthalmology Heijl, Anders; Algvere, Peep V.; Alm, Albert ...
Acta ophthalmologica Scandinavica,
June 2005, Letnik:
83, Številka:
3
Journal Article, Magazine Article
Odprti dostop
.
Nordic ophthalmologists and vision scientists are active in many fields of eye research. This is most evident at the biannual Nordic Congress of Ophthalmology, most recently held in Malmö in June ...2004. The authors here review some of the research in vision and ophthalmology presented at this meeting or published recently by Nordic scientists. This paper does not represent a comprehensive review of all Nordic research in the field, but attempts to give an overview of some of the activities underway in eye research in this part of the world.
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