Graduate nursing education faces various challenges linked to research products that must be innovative and have an impact on social well-being. Knowledge transfer is a complex multidimensional ...process requiring multiple mechanisms, methods, and measurements to be considered in graduate training. Educational institutions must have a support infrastructure and be responsible for preparing interdisciplinary syllabi, coordinating management strategies to address student learning, and providing an environment for harmonized communication among those interested in problem-solving.
Abemaciclib is an ATP-competitive, reversible kinase inhibitor selective for CDK4 and CDK6 that has shown antitumor activity as a single agent in hormone receptor positive (HR+) metastatic breast ...cancer in clinical trials. Here, we examined the mechanistic effects of abemaciclib treatment using
and
breast cancer models. Treatment of estrogen receptor positive (ER+) breast cancer cells with abemaciclib alone led to a decrease in phosphorylation of Rb, arrest at G1, and a decrease in cell proliferation. Moreover, abemaciclib exposure led to durable inhibition of pRb, TopoIIα expression and DNA synthesis, which were maintained after drug removal. Treatment of ER+ breast cancer cells also led to a senescence response as indicated by accumulation of β-galactosidase, formation of senescence-associated heterochromatin foci, and a decrease in FOXM1 positive cells. Continuous exposure to abemaciclib altered breast cancer cell metabolism and induced apoptosis. In a xenograft model of ER+ breast cancer, abemaciclib monotherapy caused regression of tumor growth. Overall these data indicate that abemaciclib is a CDK4 and CDK6 inhibitor that, as a single agent, blocks breast cancer cell progression, and upon longer treatment can lead to sustained antitumor effects through the induction of senescence, apoptosis, and alteration of cellular metabolism.
The Curitiba (Brazil)-based Project, A Hora é Agora (AHA), evaluated a comprehensive HIV control strategy among men who have sex with men (MSM) aimed at expanding access to HIV rapid testing and ...linking HIV-positive MSM to health services and treatment. AHA's approach included rapid HIV Testing Services (HTC) in one mobile testing unit (MTU); a local, gay-led, non-governmental organization (NGO); an existing government-run health facility (COA); and Internet-based HIV self-testing. The objectives of the paper were to compare a) number of MSM tested in each strategy, its positivity and linkage; b) social, demographic and behavioral characteristics of MSM accessing the different HTC and linkage services; and c) the costs of the individual strategies to diagnose and link MSM to services.
We used data for 2,681 MSM tested at COA, MTU and NGO from March 2015 to March 2017. This is a cross sectional comparison of the demographics and behavioral factors (age group, race/ethnicity, education, sexually transmitted diseases, knowledge of AHA services and previous HIV test). Absolute frequencies, percentage distributions and confidence intervals for the percentages were used, as well as unilateral statistical tests.
AHA performed 2,681 HIV tests among MSM across three in-person strategies: MTU, NGO, and COA; and distributed 4,752 HIV oral fluid tests through the self-testing platform. MTU, NGO and COA reported 365 (13.6%) HIV positive diagnoses among MSM, including 28 users with previous HIV diagnosis or on antiretroviral treatment for HIV. Of these, 89% of MSM were eligible for linkage-to-care services. Linkage support was accepted by 86% of positive MSM, of which 66.7% were linked to services in less than 90 days. The MTU resulted in the lowest cost per MSM tested ($137 per test), followed by self-testing ($247).
AHA offered MSM access to HTC through innovative strategies operating in alternative sites and schedules. It presented the Curitiba HIV/AIDS community the opportunity to monitor HIV-positive MSM from diagnosis to treatment uptake. Self-testing emerged as a feasible strategy to increase MSM access to HIV-testing through virtual tools and anonymous test kit delivery and pick-up. Cost per test findings in both the MTU and self-testing support expansion to other regions with similar epidemiological contexts.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Black and poor people are more frequently convicted of committing crimes. However, the specific role played by skin color and social class in convicting a person has yet to be clarified. This article ...aims to elucidate this issue by proposing that belonging to a lower social class facilitates the conviction of black targets and that this phenomenon is because information about social class dissimulates racial bias. Study 1 (N = 160) demonstrated that information about belonging to the lower classes increases agreement with a criminal suspect being sentenced to prison only when described as being black. Furthermore, Studies 2 (N = 170) and 3 (N = 174) show that the anti-prejudice norm inhibits discrimination against the black target when participants were asked to express individual racial prejudice, but not when they expressed cultural racial prejudice. Finally, Study 4 (N = 134) demonstrated that lower-class black targets were discriminated against to a greater degree when participants expressed either individual or cultural prejudice and showed that this occurs when racial and class anti-prejudice norms are salient. The results suggest that social class negatively affects judgments of black targets because judgment based on lower class mitigates the racist motivation of discrimination.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Graduate nursing education faces various challenges linked to research products that must be innovative and have an impact on social well-being. Knowledge transfer is a complex multidimensional ...process requiring multiple mechanisms, methods, and measurements to be considered in graduate training. Educational institutions must have a support infrastructure and be responsible for preparing interdisciplinary syllabi, coordinating management strategies to address student learning, and providing an environment for harmonized communication among those interested in problem-solving.
A educação da pós-graduação em enfermagem enfrenta diversos desafios relacionados aos produtos da pesquisa que devem ser inovadores e com impacto no bem-estar social. A transferência do conhecimento se refere a um processo complexo e multidimensional que requer diversos mecanismos, métodos e avaliações que devem ser considerados na formação em pós-graduação. As instituições educacionais devem contar com infraestrutura de apoio e considerar, como sua responsabilidade, o desenvolvimento de planos de estudo interdisciplinares, a coordenação de estratégias de gestão que abordem a aprendizagem dos estudantes e a provisão de um ambiente que desenvolva comunicação coordenada entre os interessados na solução dos problemas.
La educación del Postgrado en enfermería se enfrenta a diversos desafíos ligados a los productos de la investigación que deben ser innovadores con impacto a nivel de bienestar social. La transferencia del conocimiento se refiere a un proceso complejo y multidimensional que requiere de diversos mecanismos, métodos y mediciones que deben de ser considerados en a la formación del postgrado. Las instituciones educativas deben de contar con infraestructura de apoyo y considerar como su responsabilidad desarrollar planes de estudio interdisciplinarios, coordinación de estrategias de gestión que aborden el aprendizaje de los estudiantes y la provisión de un entorno que desarrolle comunicación coordinada entre los interesados en la solución de los problemas.
This article aims to analyze the effect of the combination of the variables - victim characteristics (skin color and normativity), observer sex, Belief in a Just World, and ambivalent sexism - on ...sexual violence victim blaming. Three studies were conducted with university students (Study 1, N=288; Study 2, N=226; Study 3, N=307), who were asked to answer some items on victim blaming, Belief in a Just World, and Ambivalent Sexism. The ANOVA and ANCOVA analyses have shown that the combination of these variables resulted in higher black and counter-normative victim blaming. The results confirmed that victim skin color, victim normativity, and the observer sex influence victim blaming for sexual violence (study 1); that bjw predicts the attribution of the victim’s accountability for sexual violence (study 2), and that only benevolent sexism, together with bjw, was responsible for predicting victim blaming for sexual violence (study 3).
Three-dimensional printed concrete (3DPC) is a relatively recent technology that may be very important in changing the traditional construction industry. The principal advantages of its use are more ...rapid construction, lower production costs, and less residues, among others. The choice of raw materials to obtain adequate behavior is more critical than for traditional concrete. In the present paper a mixture of cement, silica fume, superplasticizer, setting accelerator, filler materials, and aggregates was studied to obtain a 3DPC with high resistance at short curing times. When the optimal mixture was found, metallic fibers were introduced to enhance the mechanical properties. The fresh and hard properties of the concrete were analyzed, measuring the setting time, workability, and flexural and compressive strength. The results obtained demonstrated that the incorporation of fibers (2% in volume) enhanced the flexural and compressive strength by around 163 and 142%, respectively, compared with the mixture without fibers, at 9 h of curing. At 28 days of curing, the improvement was 79.2 and 34.7% for flexural and compressive strength, respectively.
La Universidad Pontificia Bolivariana (UPB) es una universidad de docencia con énfasis en la investigación y la innovación para la sostenibilidad. Promueve la construcción de estrategias que permitan ...transformar y proyectar nuestros intereses comunitarios por el cuidado de la casa común, nuestro planeta, generando impactos positivos en el ámbito social, económico y ambiental. Desde 2013, durante el curso de química general dirigido a estudiantes del primer semestre de ingenierías, se han desarrollado experiencias de aula orientadas al análisis de los hábitos de consumo y a la medición de la huella ecológica personal de los alumnos -entendida, según Wackernagel y Rees, como una herramienta que ayuda a planificar la sustentabilidad-, así como trabajos de sensibilización frente al uso de los aparatos eléctricos y electrónicos y a la gestión de los residuos. Los educandos han propuesto medidas enfocadas principalmente a la racionalización de recursos y a cambios en los estilos de alimentación y en la forma de transportarse. Desde el primer período académico de 2017 han realizado acciones sociales como recolección de residuos sólidos y campañas educativas con niños de educación primaria. El trabajo ha favorecido en los jóvenes la creación de una conciencia comprometida con el cuidado de nuestra única casa: la Tierra.
The goal of this research was to determine the personal, interpersonal, and sociocultural predictors of condom use among rural Indigenous adolescents. Predictor variables were selected from Bandura's ...Social Cognitive Theory and Leininger's Transcultural Theory. The sample consisted of 419 Nahuas adolescents randomly selected from the total number of neighborhood blocks in a rural community in Puebla, Mexico. The instruments had acceptable psychometric characteristics (Cronbach alpha and validity scores). Multiple linear regression models were used. Results: 56.8% of participants were female, and 50.40% were students. Mean age was M = 17.5 (SD = 0.97), and the majority (63%) identified as Catholic. Age at menarche/first ejaculation (β = -1.2,
= 0.038), attitude toward condom use (β = 0.13,
< 0.001), ethnic identity (β = 0.21,
< 0.001), and ability to negotiate condom use (β = 0.13,
= 0.003) predicted (R
= 22.3) condom use. This study provided a basis for integration of the cultural values of Indigenous adolescents within interventions for sexual health promotion.
Este artículo aborda el tema de la conflictividad entre obispados y órdenes militares, concretado en el caso de los problemas existentes entre el importante arzobispado de Toledo y la Orden Militar ...de Calatrava a partir del siglo XII. La cuestión ha sido tratada en el pasado, pero aquí se profundizará en algunos aspectos más allá de los términos del conflicto y de las concordias suscritas entre ambas entidades: la especial atención al territorio del Sur del Reino de Toledo; los fundamentos de los litigios, teniendo en cuenta la progresiva construcción histórica de los ámbitos de expansión de los dos actores en conflicto, y el cuestionamiento de la legitimidad calatrava para acometer su actuación eclesiástica.
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