Abstract Study Objective To describe our 10 years of experience with childhood choroid plexus tumors (CPTs). Design Retrospective chart analysis. Setting Operating room and pediatric intensive care ...unit (PICU) of a university hospital. Patients 18 infants and children undergoing CPT surgery from 1995 to 2004, 11 of whom were younger than 12 months. Measurements Perioperative hematologic and coagulation data were measured as well as estimated red cell volume variations (as a reliable index of blood loss) in the perioperative period, together with coagulation parameters. Results Greater blood loss was recorded in the infant group vs older children (percentage of estimated red cell volume loss, 1.31 ± 1.79% vs 0.20 ± 0.17% P < 0.01 and 1.50 ± 1.86% vs 0.29 ± 0.21% P < 0.01 on PICU admission and after 72 hours, respectively). Platelet count decrease was similarly noted (51.60 ± 28.06 vs 27.57 ± 11.98, P < 0.05, as percentage of preoperative count). Patients operated on in the neonatal period showed the highest blood loss and related coagulation impairment. Conclusion Younger CPT surgery patients present an increased risk versus their older counterparts of massive bleeding resulting in hemodynamic instability and coagulative impairment.
Targeting CD8+ T cells prevents psoriasis development Di Meglio, Paola, PhD; Villanova, Federica, PhD; Navarini, Alexander A., MD, PhD ...
Journal of allergy and clinical immunology,
07/2016, Letnik:
138, Številka:
1
Journal Article
Recenzirano
Odprti dostop
Importantly, in the absence of T-cell expansion upon transplantation, which did not occur in one of the experiments we performed, we did not observe any epidermal pathology, in terms of both ...papillomatosis and frequency of proliferating keratinocytes (see Fig E1 in this article's Online Repository at www.jacionline.org). ...the accumulation of epidermal T cells induces both keratinocyte hyperproliferation and onset of papillomatosis, 2 hallmarks of psoriasis, thereby further confirming the role of intraepidermal T cells as key effectors in psoriasis. Psoriatic CD8+ T cells have been previously characterized in terms of their cytokine production; however, little distinction has been made between those residing in the dermis and the epidermis in the absence of post-isolation in vitro culture. ...to obtain a faithful functional characterization of psoriatic CD8+ T cells, we isolated T cells from the epidermis and the dermis of psoriasis lesions and performed intracellular cytokine staining and fluorescence-activated cell sorting analyses.
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